NO312996B1 - Hormonell, östroprogestativ trisekvensiell kombinasjon og fremgangsmåte for fremstilling av en slik - Google Patents
Hormonell, östroprogestativ trisekvensiell kombinasjon og fremgangsmåte for fremstilling av en slik Download PDFInfo
- Publication number
- NO312996B1 NO312996B1 NO19971449A NO971449A NO312996B1 NO 312996 B1 NO312996 B1 NO 312996B1 NO 19971449 A NO19971449 A NO 19971449A NO 971449 A NO971449 A NO 971449A NO 312996 B1 NO312996 B1 NO 312996B1
- Authority
- NO
- Norway
- Prior art keywords
- estradiol
- hormonal
- dose
- estroprogestative
- combination according
- Prior art date
Links
- 230000003054 hormonal effect Effects 0.000 title claims description 11
- 238000000034 method Methods 0.000 title claims description 8
- 239000007983 Tris buffer Substances 0.000 title 1
- 229960005309 estradiol Drugs 0.000 claims description 45
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 23
- 229930182833 estradiol Natural products 0.000 claims description 21
- 229960004190 nomegestrol acetate Drugs 0.000 claims description 19
- IIVBFTNIGYRNQY-YQLZSBIMSA-N nomegestrol acetate Chemical group C1=C(C)C2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 IIVBFTNIGYRNQY-YQLZSBIMSA-N 0.000 claims description 19
- 239000000203 mixture Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000000583 progesterone congener Substances 0.000 claims description 10
- 239000000262 estrogen Substances 0.000 claims description 9
- 229940011871 estrogen Drugs 0.000 claims description 8
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000008119 colloidal silica Substances 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 230000001076 estrogenic effect Effects 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- ZVVGLAMWAQMPDR-WVEWYJOQSA-N (8r,9s,13s,14s,17s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol;hydrate Chemical compound O.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 ZVVGLAMWAQMPDR-WVEWYJOQSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 229960003851 estradiol hemihydrate Drugs 0.000 claims description 2
- FETSQPAGYOVAQU-UHFFFAOYSA-N glyceryl palmitostearate Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O FETSQPAGYOVAQU-UHFFFAOYSA-N 0.000 claims description 2
- 229940046813 glyceryl palmitostearate Drugs 0.000 claims description 2
- 238000005469 granulation Methods 0.000 claims description 2
- 230000003179 granulation Effects 0.000 claims description 2
- 239000008024 pharmaceutical diluent Substances 0.000 claims description 2
- 239000008213 purified water Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 230000021615 conjugation Effects 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims 1
- 229940068196 placebo Drugs 0.000 description 31
- 239000000902 placebo Substances 0.000 description 31
- 238000011282 treatment Methods 0.000 description 13
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 12
- 206010060800 Hot flush Diseases 0.000 description 9
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- 208000033830 Hot Flashes Diseases 0.000 description 7
- 230000009245 menopause Effects 0.000 description 7
- 229940109239 creatinine Drugs 0.000 description 6
- 206010006298 Breast pain Diseases 0.000 description 5
- 208000006662 Mastodynia Diseases 0.000 description 5
- 210000004696 endometrium Anatomy 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 206010046788 Uterine haemorrhage Diseases 0.000 description 4
- 230000004872 arterial blood pressure Effects 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002559 palpation Methods 0.000 description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 108010071619 Apolipoproteins Proteins 0.000 description 3
- 102000007592 Apolipoproteins Human genes 0.000 description 3
- 206010049816 Muscle tightness Diseases 0.000 description 3
- LCYXYLLJXMAEMT-SAXRGWBVSA-N Pyridinoline Chemical compound OC(=O)[C@@H](N)CCC1=C[N+](C[C@H](O)CC[C@H](N)C([O-])=O)=CC(O)=C1C[C@H](N)C(O)=O LCYXYLLJXMAEMT-SAXRGWBVSA-N 0.000 description 3
- 230000003187 abdominal effect Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000036470 plasma concentration Effects 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 102000004411 Antithrombin III Human genes 0.000 description 2
- 108090000935 Antithrombin III Proteins 0.000 description 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 2
- 108010049003 Fibrinogen Proteins 0.000 description 2
- 102000008946 Fibrinogen Human genes 0.000 description 2
- 206010030247 Oestrogen deficiency Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 229960005348 antithrombin iii Drugs 0.000 description 2
- 239000003114 blood coagulation factor Substances 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000010072 bone remodeling Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 230000004882 diastolic arterial blood pressure Effects 0.000 description 2
- 230000002357 endometrial effect Effects 0.000 description 2
- 229940012952 fibrinogen Drugs 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000005906 menstruation Effects 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 230000004873 systolic arterial blood pressure Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 102000005666 Apolipoprotein A-I Human genes 0.000 description 1
- 108010059886 Apolipoprotein A-I Proteins 0.000 description 1
- 102000018619 Apolipoproteins A Human genes 0.000 description 1
- 108010027004 Apolipoproteins A Proteins 0.000 description 1
- 102000018616 Apolipoproteins B Human genes 0.000 description 1
- 108010027006 Apolipoproteins B Proteins 0.000 description 1
- 206010003439 Artificial menopause Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- ZAHDXEIQWWLQQL-IHRRRGAJSA-N Deoxypyridinoline Chemical compound OC(=O)[C@@H](N)CCCC[N+]1=CC(O)=C(C[C@H](N)C([O-])=O)C(CC[C@H](N)C(O)=O)=C1 ZAHDXEIQWWLQQL-IHRRRGAJSA-N 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- 238000008214 LDL Cholesterol Methods 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 102000004067 Osteocalcin Human genes 0.000 description 1
- 108090000573 Osteocalcin Proteins 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 102000013566 Plasminogen Human genes 0.000 description 1
- 108010051456 Plasminogen Proteins 0.000 description 1
- 101800004937 Protein C Proteins 0.000 description 1
- 102000017975 Protein C Human genes 0.000 description 1
- 229940096437 Protein S Drugs 0.000 description 1
- 102000029301 Protein S Human genes 0.000 description 1
- 108010066124 Protein S Proteins 0.000 description 1
- 108010094028 Prothrombin Proteins 0.000 description 1
- 102100027378 Prothrombin Human genes 0.000 description 1
- 101800001700 Saposin-D Proteins 0.000 description 1
- RUJWZZRJSQGFCW-OGPYDZPMSA-N [(8s,9s,10r,13s,14s,17r)-17-acetyl-6,13-dimethyl-3-oxo-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl] acetate;(8r,9s,13s,14s,17s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1.C1=C(C)C2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RUJWZZRJSQGFCW-OGPYDZPMSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000000923 atherogenic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 201000006828 endometrial hyperplasia Diseases 0.000 description 1
- 229960003575 estradiol acetate Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 102000036124 hormone binding proteins Human genes 0.000 description 1
- 108091011044 hormone binding proteins Proteins 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 238000005470 impregnation Methods 0.000 description 1
- 230000000938 luteal effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- -1 natural estrogen Chemical compound 0.000 description 1
- 230000000422 nocturnal effect Effects 0.000 description 1
- 230000027758 ovulation cycle Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000009291 secondary effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9509364A FR2737411B1 (fr) | 1995-08-01 | 1995-08-01 | Nouveaux medicaments hormonaux et leur utilisation pour la correction des carences estrogeniques |
| PCT/IB1996/000754 WO1997004784A1 (fr) | 1995-08-01 | 1996-07-29 | Nouveaux medicaments hormonaux et leur utilisation pour la correction des carences estrogeniques |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO971449D0 NO971449D0 (no) | 1997-03-26 |
| NO971449L NO971449L (no) | 1997-05-30 |
| NO312996B1 true NO312996B1 (no) | 2002-07-29 |
Family
ID=9481610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19971449A NO312996B1 (no) | 1995-08-01 | 1997-03-26 | Hormonell, östroprogestativ trisekvensiell kombinasjon og fremgangsmåte for fremstilling av en slik |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US5891867A (xx) |
| EP (1) | EP0783310B1 (xx) |
| JP (1) | JPH10507207A (xx) |
| KR (1) | KR100450649B1 (xx) |
| CN (1) | CN1138547C (xx) |
| AP (1) | AP829A (xx) |
| AR (1) | AR004502A1 (xx) |
| AT (1) | ATE225659T1 (xx) |
| AU (1) | AU722355B2 (xx) |
| BR (1) | BR9606549A (xx) |
| CA (1) | CA2201368C (xx) |
| CZ (1) | CZ289706B6 (xx) |
| DE (1) | DE69624214T2 (xx) |
| DK (1) | DK0783310T3 (xx) |
| DZ (1) | DZ2078A1 (xx) |
| ES (1) | ES2184880T3 (xx) |
| FR (1) | FR2737411B1 (xx) |
| HK (1) | HK1005227A1 (xx) |
| HU (1) | HU229843B1 (xx) |
| IL (1) | IL120558A (xx) |
| MA (1) | MA23946A1 (xx) |
| MX (1) | MX9702381A (xx) |
| MY (1) | MY117307A (xx) |
| NO (1) | NO312996B1 (xx) |
| OA (1) | OA10411A (xx) |
| PT (1) | PT783310E (xx) |
| RU (1) | RU2188641C2 (xx) |
| TN (1) | TNSN96101A1 (xx) |
| TW (1) | TW473390B (xx) |
| WO (1) | WO1997004784A1 (xx) |
| ZA (1) | ZA966545B (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030355A1 (fr) * | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Medicament contraceptif a base d'un progestatif et d'un estrogene et son mode de preparation |
| FR2754179B1 (fr) * | 1996-10-08 | 1998-12-24 | Theramex | Nouvelle composition hormononale et son utilisation |
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| WO2001030356A1 (fr) | 1999-10-25 | 2001-05-03 | Laboratoire Theramex | Composition hormonale a base d'un progestatif et d'un estrogene et son utilisation |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| FR2814074B1 (fr) * | 2000-09-15 | 2003-03-07 | Theramex | Nouvelles compositions estro-progestatives topiques a effet systemique |
| US20020151732A1 (en) * | 2001-01-05 | 2002-10-17 | Claes Ohlsson | Estrogen receptors |
| EP1390038A2 (en) * | 2001-05-16 | 2004-02-25 | Endeavor Pharmaceuticals | Treatment of conditions relating to hormone deficiencies by administration of progestins |
| WO2003049744A1 (en) | 2001-12-05 | 2003-06-19 | Barr Laboratories, Inc. | Oral contraceptives to prevent pregnancy and diminish premenstrual symptomatology |
| US7008979B2 (en) * | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
| WO2005007112A2 (en) * | 2003-07-16 | 2005-01-27 | Duramed Pharmaceuticals, Inc. | Methods of hormonal treatment utilizing contraceptive regimens with continuous estrogen administration |
| US20070111975A1 (en) | 2004-10-07 | 2007-05-17 | Duramed Pharmaceuticals, Inc. | Methods of Hormonal Treatment Utilizing Ascending-Dose Extended Cycle Regimens |
| US8022053B2 (en) * | 2004-11-02 | 2011-09-20 | Bayer Schering Pharma Aktiengesellschaft | Oral solid dosage forms containing a low dose of estradiol |
| PE20081895A1 (es) * | 2007-03-26 | 2009-01-26 | Theramex | Regimen anticonceptivo oral |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4390531A (en) * | 1981-08-10 | 1983-06-28 | Syntex Pharmaceuticals International Ltd. | Method of contraception using peak progestogen dosage |
| US4826831A (en) * | 1983-08-05 | 1989-05-02 | Pre Jay Holdings Limited | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens |
| FR2695826B1 (fr) * | 1992-09-21 | 1995-01-06 | Theramex | Nouvelles compositions pharmaceutiques à base de dérivés de nomégestrol et leurs procédés d'obtention. |
-
1995
- 1995-08-01 FR FR9509364A patent/FR2737411B1/fr not_active Expired - Fee Related
-
1996
- 1996-07-22 MA MA24321A patent/MA23946A1/fr unknown
- 1996-07-26 MY MYPI96003099A patent/MY117307A/en unknown
- 1996-07-29 EP EP96923018A patent/EP0783310B1/fr not_active Expired - Lifetime
- 1996-07-29 RU RU97108279/14A patent/RU2188641C2/ru active
- 1996-07-29 MX MX9702381A patent/MX9702381A/es active IP Right Grant
- 1996-07-29 CZ CZ1997967A patent/CZ289706B6/cs not_active IP Right Cessation
- 1996-07-29 WO PCT/IB1996/000754 patent/WO1997004784A1/fr not_active Application Discontinuation
- 1996-07-29 BR BR9606549A patent/BR9606549A/pt not_active Application Discontinuation
- 1996-07-29 PT PT96923018T patent/PT783310E/pt unknown
- 1996-07-29 US US08/817,329 patent/US5891867A/en not_active Expired - Lifetime
- 1996-07-29 IL IL12055896A patent/IL120558A/en not_active IP Right Cessation
- 1996-07-29 ES ES96923018T patent/ES2184880T3/es not_active Expired - Lifetime
- 1996-07-29 AT AT96923018T patent/ATE225659T1/de active
- 1996-07-29 CN CNB96191100XA patent/CN1138547C/zh not_active Expired - Lifetime
- 1996-07-29 HU HU9900612A patent/HU229843B1/hu unknown
- 1996-07-29 DK DK96923018T patent/DK0783310T3/da active
- 1996-07-29 AP APAP/P/1997/000979A patent/AP829A/en active
- 1996-07-29 KR KR1019970702125A patent/KR100450649B1/ko not_active IP Right Cessation
- 1996-07-29 CA CA2201368A patent/CA2201368C/fr not_active Expired - Lifetime
- 1996-07-29 AU AU63674/96A patent/AU722355B2/en not_active Expired
- 1996-07-29 DE DE69624214T patent/DE69624214T2/de not_active Expired - Lifetime
- 1996-07-29 JP JP9507406A patent/JPH10507207A/ja not_active Ceased
- 1996-07-30 DZ DZ960122A patent/DZ2078A1/fr active
- 1996-07-31 AR ARP960103818A patent/AR004502A1/es not_active Application Discontinuation
- 1996-08-01 ZA ZA966545A patent/ZA966545B/xx unknown
- 1996-08-01 TN TNTNSN96101A patent/TNSN96101A1/fr unknown
- 1996-09-24 TW TW085111673A patent/TW473390B/zh not_active IP Right Cessation
-
1997
- 1997-03-26 NO NO19971449A patent/NO312996B1/no not_active IP Right Cessation
- 1997-04-01 OA OA60985A patent/OA10411A/fr unknown
-
1998
- 1998-05-25 HK HK98104497A patent/HK1005227A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |