NO312465B1 - CTL4A reseptorprotein, DNA fusjonsproteiner og anvendelse derav samt in vitro fremgangsmåte, monoklonealt antistoff,kinesisk hamster-ovariecellelinje og farmasöytisk preparat - Google Patents

CTL4A reseptorprotein, DNA fusjonsproteiner og anvendelse derav samt in vitro fremgangsmåte, monoklonealt antistoff,kinesisk hamster-ovariecellelinje og farmasöytisk preparat Download PDF

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Publication number
NO312465B1
NO312465B1 NO19934801A NO934801A NO312465B1 NO 312465 B1 NO312465 B1 NO 312465B1 NO 19934801 A NO19934801 A NO 19934801A NO 934801 A NO934801 A NO 934801A NO 312465 B1 NO312465 B1 NO 312465B1
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Prior art keywords
ctla4
cells
amino acid
fusion protein
cell
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NO19934801A
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English (en)
Norwegian (no)
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NO934801D0 (no
NO934801L (no
Inventor
Peter S Linsley
Jeffrey A Ledbetter
Nitin K Damle
William Brady
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO934801D0 publication Critical patent/NO934801D0/no
Publication of NO934801L publication Critical patent/NO934801L/no
Publication of NO312465B1 publication Critical patent/NO312465B1/no

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/32Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

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NO19934801A 1991-06-27 1993-12-23 CTL4A reseptorprotein, DNA fusjonsproteiner og anvendelse derav samt in vitro fremgangsmåte, monoklonealt antistoff,kinesisk hamster-ovariecellelinje og farmasöytisk preparat NO312465B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72361791A 1991-06-27 1991-06-27
PCT/US1992/005202 WO1993000431A1 (fr) 1991-06-27 1992-06-16 Recepteur ctl4a proteines de fusion contenant ce recepteur et utilisations correspondantes

Publications (3)

Publication Number Publication Date
NO934801D0 NO934801D0 (no) 1993-12-23
NO934801L NO934801L (no) 1994-02-21
NO312465B1 true NO312465B1 (no) 2002-05-13

Family

ID=24907003

Family Applications (4)

Application Number Title Priority Date Filing Date
NO19934801A NO312465B1 (no) 1991-06-27 1993-12-23 CTL4A reseptorprotein, DNA fusjonsproteiner og anvendelse derav samt in vitro fremgangsmåte, monoklonealt antistoff,kinesisk hamster-ovariecellelinje og farmasöytisk preparat
NO20020491A NO318806B1 (no) 1991-06-27 2002-01-30 Opploselig CTLA4-molekyl, CTLA4Ig-fusjonsprotein, anvendelse og fremgangsmate for fremstilling derav samt farmasoytisk sammensetning, isolert nukleinsyremolekyl, plasmid, vertsvektorsystem, monoklonalt antistoff og in vitro fremgangsmate for regulering av funksjonelle CTLA4 positive T-celle interaksjoner med B7 positive celler.
NO2007013C NO2007013I2 (no) 1991-06-27 2007-11-14 CTL4A reseptorprotein, DNA fusjonsproteiner og anvendelse derav samt in vitro fremgangsmåte, monoklonealt antistoff, kinesisk hamsterovariecellelinje og farmasøytisk preparat.
NO2012001C NO2012001I2 (no) 1991-06-27 2012-01-09 Ipilimumab (INN) - krav I basispatent

Family Applications After (3)

Application Number Title Priority Date Filing Date
NO20020491A NO318806B1 (no) 1991-06-27 2002-01-30 Opploselig CTLA4-molekyl, CTLA4Ig-fusjonsprotein, anvendelse og fremgangsmate for fremstilling derav samt farmasoytisk sammensetning, isolert nukleinsyremolekyl, plasmid, vertsvektorsystem, monoklonalt antistoff og in vitro fremgangsmate for regulering av funksjonelle CTLA4 positive T-celle interaksjoner med B7 positive celler.
NO2007013C NO2007013I2 (no) 1991-06-27 2007-11-14 CTL4A reseptorprotein, DNA fusjonsproteiner og anvendelse derav samt in vitro fremgangsmåte, monoklonealt antistoff, kinesisk hamsterovariecellelinje og farmasøytisk preparat.
NO2012001C NO2012001I2 (no) 1991-06-27 2012-01-09 Ipilimumab (INN) - krav I basispatent

Country Status (21)

Country Link
US (1) US5434131A (fr)
EP (1) EP0606217B2 (fr)
JP (6) JP3722375B2 (fr)
KR (1) KR100238712B1 (fr)
AT (1) ATE170562T1 (fr)
AU (1) AU661854B2 (fr)
CA (2) CA2110518C (fr)
DE (2) DE122007000078I2 (fr)
DK (1) DK0606217T4 (fr)
ES (1) ES2123001T5 (fr)
FI (2) FI112082B (fr)
IE (2) IE922111A1 (fr)
IL (4) IL159364A (fr)
LU (1) LU91375I2 (fr)
MX (1) MX9203605A (fr)
NL (1) NL300303I2 (fr)
NO (4) NO312465B1 (fr)
NZ (2) NZ264712A (fr)
PT (1) PT100637B (fr)
WO (1) WO1993000431A1 (fr)
ZA (1) ZA924782B (fr)

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