NO312432B1 - Farmasöytisk emulsjon som er egnet for parenteral administrering av bioaktive steroider - Google Patents
Farmasöytisk emulsjon som er egnet for parenteral administrering av bioaktive steroider Download PDFInfo
- Publication number
- NO312432B1 NO312432B1 NO19950794A NO950794A NO312432B1 NO 312432 B1 NO312432 B1 NO 312432B1 NO 19950794 A NO19950794 A NO 19950794A NO 950794 A NO950794 A NO 950794A NO 312432 B1 NO312432 B1 NO 312432B1
- Authority
- NO
- Norway
- Prior art keywords
- pregnan
- oil
- castor oil
- steroids
- emulsion
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title claims abstract description 31
- 230000000975 bioactive effect Effects 0.000 title claims abstract description 12
- 238000007911 parenteral administration Methods 0.000 title claims abstract description 9
- 239000008251 pharmaceutical emulsion Substances 0.000 title description 2
- 239000000839 emulsion Substances 0.000 claims abstract description 54
- 150000002632 lipids Chemical class 0.000 claims abstract description 36
- 239000004359 castor oil Substances 0.000 claims abstract description 33
- 235000019438 castor oil Nutrition 0.000 claims abstract description 33
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims abstract description 33
- 239000002904 solvent Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- AURFZBICLPNKBZ-YZRLXODZSA-N 3alpha-hydroxy-5beta-pregnan-20-one Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-YZRLXODZSA-N 0.000 claims description 16
- AURFZBICLPNKBZ-UHFFFAOYSA-N Pregnanolone Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 AURFZBICLPNKBZ-UHFFFAOYSA-N 0.000 claims description 16
- 229950007402 eltanolone Drugs 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 9
- SESFRYSPDFLNCH-UHFFFAOYSA-N benzyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCC1=CC=CC=C1 SESFRYSPDFLNCH-UHFFFAOYSA-N 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 8
- 235000012424 soybean oil Nutrition 0.000 claims description 7
- CYKYBWRSLLXBOW-GDYGHMJCSA-N 5-alpha-THDOC Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CC[C@H]21 CYKYBWRSLLXBOW-GDYGHMJCSA-N 0.000 claims description 6
- QGXBDMJGAMFCBF-HLUDHZFRSA-N 5α-Androsterone Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 QGXBDMJGAMFCBF-HLUDHZFRSA-N 0.000 claims description 6
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 6
- 239000008158 vegetable oil Substances 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000007764 o/w emulsion Substances 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 239000008215 water for injection Substances 0.000 claims description 5
- 239000000654 additive Substances 0.000 claims description 4
- 229960002903 benzyl benzoate Drugs 0.000 claims description 4
- DUHUCHOQIDJXAT-OLVMNOGESA-N 3-hydroxy-(3-α,5-α)-Pregnane-11,20-dione Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1=O DUHUCHOQIDJXAT-OLVMNOGESA-N 0.000 claims description 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 235000019445 benzyl alcohol Nutrition 0.000 claims description 3
- 229940057917 medium chain triglycerides Drugs 0.000 claims description 3
- 229920001993 poloxamer 188 Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- AURFZBICLPNKBZ-GRWISUQFSA-N 3beta-hydroxy-5beta-pregnan-20-one Chemical compound C([C@H]1CC2)[C@@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-GRWISUQFSA-N 0.000 claims description 2
- YCLWEYIBFOLMEM-AGIMVQGUSA-N 4,5-dihydrocortisone Chemical compound C1C(=O)CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC21 YCLWEYIBFOLMEM-AGIMVQGUSA-N 0.000 claims description 2
- QGXBDMJGAMFCBF-UHFFFAOYSA-N Etiocholanolone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC21 QGXBDMJGAMFCBF-UHFFFAOYSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 229960003305 alfaxalone Drugs 0.000 claims description 2
- 229940061641 androsterone Drugs 0.000 claims description 2
- AURFZBICLPNKBZ-SYBPFIFISA-N brexanolone Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-SYBPFIFISA-N 0.000 claims description 2
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims description 2
- 229960005205 prednisolone Drugs 0.000 claims description 2
- 239000008345 purified egg yolk phospholipid Substances 0.000 claims description 2
- DIJBBUIOWGGQOP-QGVNFLHTSA-N pregnenolone sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 DIJBBUIOWGGQOP-QGVNFLHTSA-N 0.000 claims 1
- 239000000203 mixture Substances 0.000 description 26
- 238000009472 formulation Methods 0.000 description 15
- 239000012071 phase Substances 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 241000700159 Rattus Species 0.000 description 8
- 206010002091 Anaesthesia Diseases 0.000 description 7
- 230000037005 anaesthesia Effects 0.000 description 7
- 230000003444 anaesthetic effect Effects 0.000 description 7
- 230000002526 effect on cardiovascular system Effects 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 238000001802 infusion Methods 0.000 description 6
- 239000003981 vehicle Substances 0.000 description 6
- 241000282472 Canis lupus familiaris Species 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 235000019198 oils Nutrition 0.000 description 5
- 239000003549 soybean oil Substances 0.000 description 5
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 4
- 230000007059 acute toxicity Effects 0.000 description 4
- 231100000403 acute toxicity Toxicity 0.000 description 4
- 238000011835 investigation Methods 0.000 description 4
- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 4
- 150000003904 phospholipids Chemical class 0.000 description 4
- 239000008389 polyethoxylated castor oil Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 150000003626 triacylglycerols Chemical class 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- 239000003240 coconut oil Substances 0.000 description 3
- 235000019864 coconut oil Nutrition 0.000 description 3
- 235000012343 cottonseed oil Nutrition 0.000 description 3
- 239000002385 cottonseed oil Substances 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 150000004665 fatty acids Chemical group 0.000 description 3
- 235000021588 free fatty acids Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 239000002960 lipid emulsion Substances 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- -1 steroid compounds Chemical class 0.000 description 3
- 102000002322 Egg Proteins Human genes 0.000 description 2
- 108010000912 Egg Proteins Proteins 0.000 description 2
- 235000004443 Ricinus communis Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000013345 egg yolk Nutrition 0.000 description 2
- 210000002969 egg yolk Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000011514 reflex Effects 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 239000008159 sesame oil Substances 0.000 description 2
- 235000011803 sesame oil Nutrition 0.000 description 2
- 230000004622 sleep time Effects 0.000 description 2
- 238000013222 sprague-dawley male rat Methods 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- GMVPRGQOIOIIMI-UHFFFAOYSA-N (8R,11R,12R,13E,15S)-11,15-Dihydroxy-9-oxo-13-prostenoic acid Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CCCCCCC(O)=O GMVPRGQOIOIIMI-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 101100102516 Clonostachys rogersoniana vern gene Proteins 0.000 description 1
- 235000015655 Crocus sativus Nutrition 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- 206010011703 Cyanosis Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010024264 Lethargy Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229960000711 alprostadil Drugs 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000021324 borage oil Nutrition 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000004581 coalescence Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000001687 destabilization Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000008344 egg yolk phospholipid Substances 0.000 description 1
- 229940068998 egg yolk phospholipid Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000003193 general anesthetic agent Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000036543 hypotension Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002869 intravenous anesthetic agent Substances 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 150000004667 medium chain fatty acids Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000008063 pharmaceutical solvent Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000009101 premedication Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- GMVPRGQOIOIIMI-DWKJAMRDSA-N prostaglandin E1 Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O GMVPRGQOIOIIMI-DWKJAMRDSA-N 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000036387 respiratory rate Effects 0.000 description 1
- 230000001020 rhythmical effect Effects 0.000 description 1
- 230000028527 righting reflex Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 239000004248 saffron Substances 0.000 description 1
- 235000013974 saffron Nutrition 0.000 description 1
- 230000007958 sleep Effects 0.000 description 1
- 230000036578 sleeping time Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Dispersion Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE19939302295A SE9302295D0 (sv) | 1993-07-02 | 1993-07-02 | New pharmaceutical composition |
| PCT/SE1994/000656 WO1995001162A1 (en) | 1993-07-02 | 1994-07-01 | Pharmaceutical emulsions containing bioactive steroids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO950794D0 NO950794D0 (no) | 1995-03-01 |
| NO950794L NO950794L (no) | 1995-03-01 |
| NO312432B1 true NO312432B1 (no) | 2002-05-13 |
Family
ID=20390504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19950794A NO312432B1 (no) | 1993-07-02 | 1995-03-01 | Farmasöytisk emulsjon som er egnet for parenteral administrering av bioaktive steroider |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0659072B1 (xx) |
| JP (1) | JPH08505400A (xx) |
| KR (1) | KR100343272B1 (xx) |
| CN (1) | CN1103216C (xx) |
| AT (1) | ATE208190T1 (xx) |
| AU (1) | AU679762B2 (xx) |
| CA (1) | CA2143667A1 (xx) |
| DE (1) | DE69428967T2 (xx) |
| DK (1) | DK0659072T3 (xx) |
| EE (1) | EE03146B1 (xx) |
| ES (1) | ES2167369T3 (xx) |
| FI (1) | FI113745B (xx) |
| NO (1) | NO312432B1 (xx) |
| NZ (1) | NZ268449A (xx) |
| PT (1) | PT659072E (xx) |
| RU (1) | RU2141313C1 (xx) |
| SE (1) | SE9302295D0 (xx) |
| SG (1) | SG46239A1 (xx) |
| WO (1) | WO1995001162A1 (xx) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120322781A1 (en) | 2010-01-14 | 2012-12-20 | Umecrine Mood Ab | Pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one with improved storage and solubility properties |
| CN104622806B (zh) * | 2015-02-04 | 2018-03-16 | 北京蓝丹医药科技有限公司 | 一种丙泮尼地药物组合物及其制备方法 |
| CN108434090A (zh) * | 2017-02-14 | 2018-08-24 | 高药品股份有限公司 | 以生理脂肪为基剂的类固醇药膏 |
| CN111281877A (zh) * | 2018-11-22 | 2020-06-16 | 南京诺瑞特医药科技有限公司 | 神经活性类固醇的新制剂 |
| JP2022514991A (ja) * | 2018-12-10 | 2022-02-16 | ハロー・サイエンス・エル・エル・シー | 安定な麻酔薬製剤および関連する剤形 |
| CN114344309B (zh) * | 2021-12-30 | 2024-02-06 | 南京迈诺威医药科技有限公司 | 一种别孕烷醇酮衍生物自乳化制剂及其制备方法 |
| WO2024012361A1 (zh) * | 2022-07-11 | 2024-01-18 | 江苏恩华药业股份有限公司 | 阿法沙龙脂肪乳注射液及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1379730A (en) * | 1970-12-17 | 1975-01-08 | Glaxo Lab Ltd | Pharmaceutical compositions |
| SE8600632D0 (sv) * | 1986-02-13 | 1986-02-13 | Kabivitrum Ab | Novel pharmaceutical composition |
| AU614465B2 (en) * | 1989-04-05 | 1991-08-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
| JP2785981B2 (ja) * | 1989-11-20 | 1998-08-13 | 株式会社資生堂 | 乳化組成物 |
-
1993
- 1993-07-02 SE SE19939302295A patent/SE9302295D0/xx unknown
-
1994
- 1994-07-01 PT PT94920633T patent/PT659072E/pt unknown
- 1994-07-01 AU AU71351/94A patent/AU679762B2/en not_active Ceased
- 1994-07-01 EP EP94920633A patent/EP0659072B1/en not_active Expired - Lifetime
- 1994-07-01 NZ NZ268449A patent/NZ268449A/en unknown
- 1994-07-01 DK DK94920633T patent/DK0659072T3/da active
- 1994-07-01 AT AT94920633T patent/ATE208190T1/de not_active IP Right Cessation
- 1994-07-01 CA CA002143667A patent/CA2143667A1/en not_active Abandoned
- 1994-07-01 KR KR1019950700823A patent/KR100343272B1/ko not_active IP Right Cessation
- 1994-07-01 WO PCT/SE1994/000656 patent/WO1995001162A1/en active IP Right Grant
- 1994-07-01 ES ES94920633T patent/ES2167369T3/es not_active Expired - Lifetime
- 1994-07-01 JP JP7503436A patent/JPH08505400A/ja not_active Ceased
- 1994-07-01 CN CN94190450A patent/CN1103216C/zh not_active Expired - Fee Related
- 1994-07-01 SG SG1996001441A patent/SG46239A1/en unknown
- 1994-07-01 RU RU95108891A patent/RU2141313C1/ru not_active IP Right Cessation
- 1994-07-01 DE DE69428967T patent/DE69428967T2/de not_active Expired - Fee Related
- 1994-11-23 EE EE9400408A patent/EE03146B1/xx not_active IP Right Cessation
-
1995
- 1995-03-01 NO NO19950794A patent/NO312432B1/no not_active IP Right Cessation
- 1995-03-01 FI FI950942A patent/FI113745B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EE03146B1 (et) | 1999-02-15 |
| PT659072E (pt) | 2002-04-29 |
| EP0659072B1 (en) | 2001-11-07 |
| KR100343272B1 (ko) | 2002-11-23 |
| SE9302295D0 (sv) | 1993-07-02 |
| CA2143667A1 (en) | 1995-01-12 |
| EP0659072A1 (en) | 1995-06-28 |
| FI950942A (fi) | 1995-03-01 |
| ATE208190T1 (de) | 2001-11-15 |
| AU679762B2 (en) | 1997-07-10 |
| KR950702825A (ko) | 1995-08-23 |
| JPH08505400A (ja) | 1996-06-11 |
| FI950942A0 (fi) | 1995-03-01 |
| AU7135194A (en) | 1995-01-24 |
| DE69428967D1 (de) | 2001-12-13 |
| FI113745B (fi) | 2004-06-15 |
| SG46239A1 (en) | 1998-02-20 |
| ES2167369T3 (es) | 2002-05-16 |
| CN1103216C (zh) | 2003-03-19 |
| WO1995001162A1 (en) | 1995-01-12 |
| CN1111445A (zh) | 1995-11-08 |
| NO950794D0 (no) | 1995-03-01 |
| RU2141313C1 (ru) | 1999-11-20 |
| DE69428967T2 (de) | 2002-04-04 |
| DK0659072T3 (da) | 2002-02-18 |
| NZ268449A (en) | 1996-05-28 |
| NO950794L (no) | 1995-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |