GB1379730A - Pharmaceutical compositions - Google Patents

Pharmaceutical compositions

Info

Publication number
GB1379730A
GB1379730A GB6006770A GB6006770A GB1379730A GB 1379730 A GB1379730 A GB 1379730A GB 6006770 A GB6006770 A GB 6006770A GB 6006770 A GB6006770 A GB 6006770A GB 1379730 A GB1379730 A GB 1379730A
Authority
GB
United Kingdom
Prior art keywords
water
fatty
soluble
esters
employed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6006770A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB6006770A priority Critical patent/GB1379730A/en
Priority to FR7145228A priority patent/FR2118120B1/fr
Priority to CA130,273A priority patent/CA970281A/en
Priority to BE776788A priority patent/BE776788A/en
Priority to IL38375A priority patent/IL38375A/en
Priority to AT1082571A priority patent/AT333963B/en
Priority to DE19712162593 priority patent/DE2162593A1/en
Priority to NL7117255A priority patent/NL7117255A/xx
Priority to IE1595/71A priority patent/IE36705B1/en
Priority to AU36959/71A priority patent/AU471022B2/en
Priority to ZA718463A priority patent/ZA718463B/en
Priority to US263133A priority patent/US3917830A/en
Publication of GB1379730A publication Critical patent/GB1379730A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

1379730 Steroid anaesthetic compositions GLAXO LABORATORIES Ltd 16 Dec 1971 [17 Dec 1970] 60067/70 Heading ASB An anaesthetic composition suitable for use by injection comprises 3a-hydroxy-5a-pregnane-11, 20-dione in solution in an inert organic liquid injection medium. Water-soluble organic liquids may be employed, in which case water may be present in the solution. Specified watersoluble organic liquids are C 1 -C 6 diof polyhydric alcohols, glycerol formal, water-soluble amides (e.g. nicotinamide or N-#-hydroxyethyl lactomide) and water-soluble esters, e.g. ethyl lactate. Alternatively, water-insoluble organic liquids may be employed, especially oils such as fatty alcohols and their esters, fatty acid esters (including alkyl esters of fatty acids and vegetable oils) and hydrocarbons (including liquid paraffin, squalane, n-dodecane, n-hexadecane). Such oil solutions of steroid may be employed in the form of an aqueous emulsion wherein the oil is the continuous of the disperse phase. Such emulsions may contain a surface active component, e.g. a polyoxyethylated derivative of a fatty glyceride oil, a polyoxyethylene ether of a fatty alcohol, or polyoxyethylenepolyoxypropylene ether, a polyoxyethylated fatty acid ester of sorbiton or mannitan, a polyethylene glycol ester of a fatty acid or a phospholified. Additional ingredients which may be present are emulsion stabilising agents, surface disordering agents and additional steroids. Water-soluble substances such as dextrose, glycerol and sodium chloride, serving to render the compositions approximately isotonic with blood, may also be present. The composition may be made up in unit dosage form.
GB6006770A 1970-12-17 1970-12-17 Pharmaceutical compositions Expired GB1379730A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB6006770A GB1379730A (en) 1970-12-17 1970-12-17 Pharmaceutical compositions
FR7145228A FR2118120B1 (en) 1970-12-17 1971-12-16
CA130,273A CA970281A (en) 1970-12-17 1971-12-16 Anesthetic composition containing an anesthetic steroid
BE776788A BE776788A (en) 1970-12-17 1971-12-16 PHARMACEUTICAL PREPARATIONS WITH ANESTHESIC ACTIVITY
IL38375A IL38375A (en) 1970-12-17 1971-12-16 Anaesthetic compositions comprising a solution of 3alpha-hydroxy-5alpha-pregnane-11,20-dione in organic solvent
AT1082571A AT333963B (en) 1970-12-17 1971-12-16 PROCESS FOR THE MANUFACTURING OF ANASTHESIS INJECTABLE PREPARATIONS
DE19712162593 DE2162593A1 (en) 1970-12-17 1971-12-16 Medicinal compositions containing 3 alpha-hydroxy-5-alpha-pregnane-11,20-dione
NL7117255A NL7117255A (en) 1970-12-17 1971-12-16
IE1595/71A IE36705B1 (en) 1970-12-17 1971-12-16 Pharmaceutical compositions
AU36959/71A AU471022B2 (en) 1970-12-17 1971-12-16 Pharmaceutical compositions containing 3-hydroxy-5-pregnane 11, 2-dione
ZA718463A ZA718463B (en) 1970-12-17 1971-12-17 Improvements in or relating to pharmaceutical preparations having anaesthetic activity
US263133A US3917830A (en) 1970-12-17 1972-06-15 Steroidal anaesthetic composition for intraveneous injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6006770A GB1379730A (en) 1970-12-17 1970-12-17 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
GB1379730A true GB1379730A (en) 1975-01-08

Family

ID=10484946

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6006770A Expired GB1379730A (en) 1970-12-17 1970-12-17 Pharmaceutical compositions

Country Status (11)

Country Link
AT (1) AT333963B (en)
AU (1) AU471022B2 (en)
BE (1) BE776788A (en)
CA (1) CA970281A (en)
DE (1) DE2162593A1 (en)
FR (1) FR2118120B1 (en)
GB (1) GB1379730A (en)
IE (1) IE36705B1 (en)
IL (1) IL38375A (en)
NL (1) NL7117255A (en)
ZA (1) ZA718463B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3893847A4 (en) * 2018-12-10 2022-11-02 Halo Science LLC Stable formulations of anesthetics and associated dosage forms

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5581735A (en) * 1978-12-14 1980-06-20 Kao Corp Emulsifier composition
JP2655190B2 (en) * 1989-06-21 1997-09-17 エスエス製薬 株式会社 Ointment containing corticosteroid
SE9302295D0 (en) * 1993-07-02 1993-07-02 Kabi Pharmacia Ab NEW PHARMACEUTICAL COMPOSITION
US6787530B1 (en) 1996-08-23 2004-09-07 Monash University Use of pregnane-diones as analgesic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL91070C (en) * 1900-01-01
DE1262509B (en) * 1962-04-19 1968-03-07 Hoechst Ag Process for the production of aqueous solutions of steroid hormones
FR6555M (en) * 1967-05-03 1968-12-23

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3893847A4 (en) * 2018-12-10 2022-11-02 Halo Science LLC Stable formulations of anesthetics and associated dosage forms

Also Published As

Publication number Publication date
FR2118120B1 (en) 1976-04-16
IE36705L (en) 1972-06-17
FR2118120A1 (en) 1972-07-28
IE36705B1 (en) 1977-02-02
BE776788A (en) 1972-06-16
IL38375A0 (en) 1972-02-29
IL38375A (en) 1976-07-30
AU471022B2 (en) 1976-04-08
NL7117255A (en) 1972-06-20
ZA718463B (en) 1973-08-29
CA970281A (en) 1975-07-01
ATA1082571A (en) 1976-04-15
DE2162593A1 (en) 1972-07-06
AU3695971A (en) 1973-06-21
AT333963B (en) 1976-12-27

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees