IE36705L - Anaesthetic composition containing pregnane derivatives - Google Patents
Anaesthetic composition containing pregnane derivativesInfo
- Publication number
- IE36705L IE36705L IE711595A IE159571A IE36705L IE 36705 L IE36705 L IE 36705L IE 711595 A IE711595 A IE 711595A IE 159571 A IE159571 A IE 159571A IE 36705 L IE36705 L IE 36705L
- Authority
- IE
- Ireland
- Prior art keywords
- water
- fatty
- soluble
- esters
- employed
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 230000003444 anaesthetic effect Effects 0.000 title abstract 3
- 150000003126 pregnane derivatives Chemical class 0.000 title 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 4
- 229930195729 fatty acid Natural products 0.000 abstract 4
- 239000000194 fatty acid Substances 0.000 abstract 4
- 239000007788 liquid Substances 0.000 abstract 4
- 239000003921 oil Substances 0.000 abstract 4
- 235000019198 oils Nutrition 0.000 abstract 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 239000000839 emulsion Substances 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- -1 fatty acid esters Chemical class 0.000 abstract 3
- 239000000243 solution Substances 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 150000002191 fatty alcohols Chemical class 0.000 abstract 2
- DCAYPVUWAIABOU-UHFFFAOYSA-N hexadecane Chemical compound CCCCCCCCCCCCCCCC DCAYPVUWAIABOU-UHFFFAOYSA-N 0.000 abstract 2
- 238000002347 injection Methods 0.000 abstract 2
- 239000007924 injection Substances 0.000 abstract 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 abstract 2
- JNYAEWCLZODPBN-KVTDHHQDSA-N (2r,3r,4r)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@@H](O)[C@H]1O JNYAEWCLZODPBN-KVTDHHQDSA-N 0.000 abstract 1
- DUHUCHOQIDJXAT-OLVMNOGESA-N 3-hydroxy-(3-α,5-α)-Pregnane-11,20-dione Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1=O DUHUCHOQIDJXAT-OLVMNOGESA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000008121 dextrose Substances 0.000 abstract 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N dodecane Chemical compound CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 229940116333 ethyl lactate Drugs 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 229940074076 glycerol formal Drugs 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 229940057995 liquid paraffin Drugs 0.000 abstract 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 abstract 1
- 229940094933 n-dodecane Drugs 0.000 abstract 1
- 229960003966 nicotinamide Drugs 0.000 abstract 1
- 235000005152 nicotinamide Nutrition 0.000 abstract 1
- 239000011570 nicotinamide Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 229940051841 polyoxyethylene ether Drugs 0.000 abstract 1
- 229920000056 polyoxyethylene ether Polymers 0.000 abstract 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 229940032094 squalane Drugs 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 150000005846 sugar alcohols Polymers 0.000 abstract 1
- 235000015112 vegetable and seed oil Nutrition 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
1379730 Steroid anaesthetic compositions GLAXO LABORATORIES Ltd 16 Dec 1971 [17 Dec 1970] 60067/70 Heading ASB An anaesthetic composition suitable for use by injection comprises 3a-hydroxy-5a-pregnane-11, 20-dione in solution in an inert organic liquid injection medium. Water-soluble organic liquids may be employed, in which case water may be present in the solution. Specified watersoluble organic liquids are C 1 -C 6 diof polyhydric alcohols, glycerol formal, water-soluble amides (e.g. nicotinamide or N-#-hydroxyethyl lactomide) and water-soluble esters, e.g. ethyl lactate. Alternatively, water-insoluble organic liquids may be employed, especially oils such as fatty alcohols and their esters, fatty acid esters (including alkyl esters of fatty acids and vegetable oils) and hydrocarbons (including liquid paraffin, squalane, n-dodecane, n-hexadecane). Such oil solutions of steroid may be employed in the form of an aqueous emulsion wherein the oil is the continuous of the disperse phase. Such emulsions may contain a surface active component, e.g. a polyoxyethylated derivative of a fatty glyceride oil, a polyoxyethylene ether of a fatty alcohol, or polyoxyethylenepolyoxypropylene ether, a polyoxyethylated fatty acid ester of sorbiton or mannitan, a polyethylene glycol ester of a fatty acid or a phospholified. Additional ingredients which may be present are emulsion stabilising agents, surface disordering agents and additional steroids. Water-soluble substances such as dextrose, glycerol and sodium chloride, serving to render the compositions approximately isotonic with blood, may also be present. The composition may be made up in unit dosage form.
[GB1379730A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB6006770A GB1379730A (en) | 1970-12-17 | 1970-12-17 | Pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE36705L true IE36705L (en) | 1972-06-17 |
| IE36705B1 IE36705B1 (en) | 1977-02-02 |
Family
ID=10484946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1595/71A IE36705B1 (en) | 1970-12-17 | 1971-12-16 | Pharmaceutical compositions |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT333963B (en) |
| AU (1) | AU471022B2 (en) |
| BE (1) | BE776788A (en) |
| CA (1) | CA970281A (en) |
| DE (1) | DE2162593A1 (en) |
| FR (1) | FR2118120B1 (en) |
| GB (1) | GB1379730A (en) |
| IE (1) | IE36705B1 (en) |
| IL (1) | IL38375A (en) |
| NL (1) | NL7117255A (en) |
| ZA (1) | ZA718463B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5581735A (en) * | 1978-12-14 | 1980-06-20 | Kao Corp | Emulsifier composition |
| JP2655190B2 (en) * | 1989-06-21 | 1997-09-17 | エスエス製薬 株式会社 | Ointment containing corticosteroid |
| SE9302295D0 (en) * | 1993-07-02 | 1993-07-02 | Kabi Pharmacia Ab | NEW PHARMACEUTICAL COMPOSITION |
| US6787530B1 (en) | 1996-08-23 | 2004-09-07 | Monash University | Use of pregnane-diones as analgesic agents |
| AU2019396217A1 (en) * | 2018-12-10 | 2021-07-08 | Halo Science LLC | Stable formulations of anesthetics and associated dosage forms |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL91070C (en) * | 1900-01-01 | |||
| DE1262509B (en) * | 1962-04-19 | 1968-03-07 | Hoechst Ag | Process for the production of aqueous solutions of steroid hormones |
| FR6555M (en) * | 1967-05-03 | 1968-12-23 |
-
1970
- 1970-12-17 GB GB6006770A patent/GB1379730A/en not_active Expired
-
1971
- 1971-12-16 BE BE776788A patent/BE776788A/en unknown
- 1971-12-16 NL NL7117255A patent/NL7117255A/xx unknown
- 1971-12-16 AU AU36959/71A patent/AU471022B2/en not_active Expired
- 1971-12-16 IL IL38375A patent/IL38375A/en unknown
- 1971-12-16 IE IE1595/71A patent/IE36705B1/en unknown
- 1971-12-16 AT AT1082571A patent/AT333963B/en not_active IP Right Cessation
- 1971-12-16 CA CA130,273A patent/CA970281A/en not_active Expired
- 1971-12-16 DE DE19712162593 patent/DE2162593A1/en active Pending
- 1971-12-16 FR FR7145228A patent/FR2118120B1/fr not_active Expired
- 1971-12-17 ZA ZA718463A patent/ZA718463B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL38375A0 (en) | 1972-02-29 |
| ATA1082571A (en) | 1976-04-15 |
| FR2118120B1 (en) | 1976-04-16 |
| AU471022B2 (en) | 1976-04-08 |
| GB1379730A (en) | 1975-01-08 |
| ZA718463B (en) | 1973-08-29 |
| BE776788A (en) | 1972-06-16 |
| CA970281A (en) | 1975-07-01 |
| IE36705B1 (en) | 1977-02-02 |
| AT333963B (en) | 1976-12-27 |
| DE2162593A1 (en) | 1972-07-06 |
| FR2118120A1 (en) | 1972-07-28 |
| AU3695971A (en) | 1973-06-21 |
| NL7117255A (en) | 1972-06-20 |
| IL38375A (en) | 1976-07-30 |
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