NO312193B1 - Fremgangsmåte for fremstilling av optisk vesentlig rene enantiomerer av et pyridazinonderivat, fremgangsmåte for denoptiske opplösningen av et pyridazinonderovat, krystallinskpolymorf form av et pyridazinonderivat og en fremgangsmåte foroppnå - Google Patents

Fremgangsmåte for fremstilling av optisk vesentlig rene enantiomerer av et pyridazinonderivat, fremgangsmåte for denoptiske opplösningen av et pyridazinonderovat, krystallinskpolymorf form av et pyridazinonderivat og en fremgangsmåte foroppnå Download PDF

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Publication number
NO312193B1
NO312193B1 NO19984487A NO984487A NO312193B1 NO 312193 B1 NO312193 B1 NO 312193B1 NO 19984487 A NO19984487 A NO 19984487A NO 984487 A NO984487 A NO 984487A NO 312193 B1 NO312193 B1 NO 312193B1
Authority
NO
Norway
Prior art keywords
methyl
tetrahydro
oxo
phenyl
hydrazono
Prior art date
Application number
NO19984487A
Other languages
English (en)
Norwegian (no)
Other versions
NO984487D0 (no
NO984487L (no
Inventor
Mika Timmerbacka
Jorma Lehtonen
Veli Pekka Tanninen
Esa Muttonen
Jukka Kaukonen
Riikka Hyppoelae
Reijo Baeckstroem
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of NO984487D0 publication Critical patent/NO984487D0/no
Publication of NO984487L publication Critical patent/NO984487L/no
Publication of NO312193B1 publication Critical patent/NO312193B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D237/00Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO19984487A 1996-03-27 1998-09-25 Fremgangsmåte for fremstilling av optisk vesentlig rene enantiomerer av et pyridazinonderivat, fremgangsmåte for denoptiske opplösningen av et pyridazinonderovat, krystallinskpolymorf form av et pyridazinonderivat og en fremgangsmåte foroppnå NO312193B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9606474.6A GB9606474D0 (en) 1996-03-27 1996-03-27 Method for obtaining pure enantiomers of a pyridazinone derivative
PCT/FI1997/000196 WO1997035841A2 (en) 1996-03-27 1997-03-27 Method for obtaining pure enantiomers of a pyridazinone derivative

Publications (3)

Publication Number Publication Date
NO984487D0 NO984487D0 (no) 1998-09-25
NO984487L NO984487L (no) 1998-11-26
NO312193B1 true NO312193B1 (no) 2002-04-08

Family

ID=10791141

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19984487A NO312193B1 (no) 1996-03-27 1998-09-25 Fremgangsmåte for fremstilling av optisk vesentlig rene enantiomerer av et pyridazinonderivat, fremgangsmåte for denoptiske opplösningen av et pyridazinonderovat, krystallinskpolymorf form av et pyridazinonderivat og en fremgangsmåte foroppnå

Country Status (23)

Country Link
US (1) US6180789B1 (de)
EP (3) EP2143715B1 (de)
JP (3) JP4179630B2 (de)
AT (3) ATE465154T1 (de)
AU (1) AU715887B2 (de)
BR (1) BR9708353A (de)
CA (1) CA2250062C (de)
CZ (3) CZ294964B6 (de)
DE (2) DE69733748T2 (de)
DK (2) DK0894087T3 (de)
ES (3) ES2343525T3 (de)
GB (1) GB9606474D0 (de)
HU (1) HU227541B1 (de)
MX (1) MXPA98007851A (de)
NO (1) NO312193B1 (de)
NZ (1) NZ332010A (de)
PL (3) PL189963B1 (de)
PT (3) PT2143715E (de)
SI (2) SI0894087T1 (de)
SK (3) SK285362B6 (de)
TR (1) TR199801921T2 (de)
WO (1) WO1997035841A2 (de)
ZA (1) ZA972729B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A (fi) 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia
FI105389B (fi) * 1998-04-23 2000-08-15 Orion Yhtymae Oyj Menetelmä levosimendaaniannon siedettävyyden seuraamiseksi
FI104718B (fi) 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US5905078A (en) * 1998-06-19 1999-05-18 Orion Corporation Use of a pyridazinone derivative
FI109659B (fi) 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
EP1943248A2 (de) * 2006-08-03 2008-07-16 Teva Pharmaceutical Industries Ltd. Formen der solifenacin-base und ihre herstellung
JP5747030B2 (ja) * 2009-07-14 2015-07-08 シプラ・リミテッド レボシメンダンの製造方法及びその方法で用いる中間体
JP5482926B2 (ja) * 2011-02-28 2014-05-07 株式会社リコー 伝送管理装置
CN103554033A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 一种消旋体(±)- 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的拆分方法
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
EP3424908A1 (de) * 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Verfahren zur herstellung von levosimendan
US11760730B2 (en) * 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
US4946842A (en) 1985-07-05 1990-08-07 Smith Kline & French Laboratories Limited Novel guanidino pyridazinones as cardiac stimulants
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Also Published As

Publication number Publication date
MXPA98007851A (es) 2006-06-07
EP2143715A1 (de) 2010-01-13
DE69739858D1 (de) 2010-06-02
US6180789B1 (en) 2001-01-30
JP4179630B2 (ja) 2008-11-12
JP2008179645A (ja) 2008-08-07
JP2011236251A (ja) 2011-11-24
CA2250062C (en) 2006-11-14
PT894087E (pt) 2005-09-30
HUP9904150A3 (en) 2000-11-28
EP2143715B1 (de) 2011-09-21
ATE465154T1 (de) 2010-05-15
AU2162697A (en) 1997-10-17
DK2143715T3 (da) 2011-12-05
WO1997035841A3 (en) 1998-01-22
JP5277295B2 (ja) 2013-08-28
PL189963B1 (pl) 2005-10-31
PL329068A1 (en) 1999-03-15
TR199801921T2 (xx) 1998-12-21
SK285363B6 (sk) 2006-11-03
SI2143715T1 (sl) 2012-01-31
PT2143715E (pt) 2011-10-11
NO984487D0 (no) 1998-09-25
ES2243988T3 (es) 2005-12-01
SK285362B6 (sk) 2006-11-03
JP4825825B2 (ja) 2011-11-30
GB9606474D0 (en) 1996-06-05
HUP9904150A2 (hu) 2000-09-28
ATE299867T1 (de) 2005-08-15
CZ304198A3 (cs) 1999-03-17
DE69733748D1 (de) 2005-08-25
DK0894087T3 (da) 2005-09-19
JP2000515492A (ja) 2000-11-21
CZ295001B6 (cs) 2005-05-18
DE69733748T2 (de) 2006-04-20
ES2343525T3 (es) 2010-08-03
SI0894087T1 (en) 2005-10-31
NO984487L (no) 1998-11-26
CZ294964B6 (cs) 2005-04-13
EP1619186A1 (de) 2006-01-25
HU227541B1 (en) 2011-08-29
CZ295002B6 (cs) 2005-05-18
NZ332010A (en) 2000-02-28
EP0894087A2 (de) 1999-02-03
AU715887B2 (en) 2000-02-10
PL190573B1 (pl) 2005-12-30
PL190574B1 (pl) 2005-12-30
WO1997035841A2 (en) 1997-10-02
PT1619186E (pt) 2010-06-04
ATE525361T1 (de) 2011-10-15
ES2370760T3 (es) 2011-12-22
BR9708353A (pt) 1999-08-03
SK131698A3 (en) 2000-04-10
SK285364B6 (sk) 2006-11-03
CA2250062A1 (en) 1997-10-02
EP1619186B1 (de) 2010-04-21
EP0894087B1 (de) 2005-07-20
ZA972729B (en) 1997-10-30

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