PT2143715E - Processo para obtenção de enantiómeros puros de um derivado de piridazinona - Google Patents

Processo para obtenção de enantiómeros puros de um derivado de piridazinona Download PDF

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Publication number
PT2143715E
PT2143715E PT09013140T PT09013140T PT2143715E PT 2143715 E PT2143715 E PT 2143715E PT 09013140 T PT09013140 T PT 09013140T PT 09013140 T PT09013140 T PT 09013140T PT 2143715 E PT2143715 E PT 2143715E
Authority
PT
Portugal
Prior art keywords
pure enantiomers
obtaining pure
pyridazinone derivative
pyridazinone
derivative
Prior art date
Application number
PT09013140T
Other languages
English (en)
Inventor
Reijo Backstrom
Mika Timmerbacka
Jorma Lehtonen
Veli Pekka Tanninen
Jukka Kaukonen
Riikka Hyppoelae
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Publication of PT2143715E publication Critical patent/PT2143715E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
PT09013140T 1996-03-27 1997-03-27 Processo para obtenção de enantiómeros puros de um derivado de piridazinona PT2143715E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9606474.6A GB9606474D0 (en) 1996-03-27 1996-03-27 Method for obtaining pure enantiomers of a pyridazinone derivative

Publications (1)

Publication Number Publication Date
PT2143715E true PT2143715E (pt) 2011-10-11

Family

ID=10791141

Family Applications (3)

Application Number Title Priority Date Filing Date
PT97914347T PT894087E (pt) 1996-03-27 1997-03-27 Processo para obtencao de enantiomeros puros de um derivado de piridazinona
PT05010245T PT1619186E (pt) 1996-03-27 1997-03-27 Processo para obtenção de enantiómeros puros de um derivado de piridazinona
PT09013140T PT2143715E (pt) 1996-03-27 1997-03-27 Processo para obtenção de enantiómeros puros de um derivado de piridazinona

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PT97914347T PT894087E (pt) 1996-03-27 1997-03-27 Processo para obtencao de enantiomeros puros de um derivado de piridazinona
PT05010245T PT1619186E (pt) 1996-03-27 1997-03-27 Processo para obtenção de enantiómeros puros de um derivado de piridazinona

Country Status (23)

Country Link
US (1) US6180789B1 (pt)
EP (3) EP2143715B1 (pt)
JP (3) JP4179630B2 (pt)
AT (3) ATE525361T1 (pt)
AU (1) AU715887B2 (pt)
BR (1) BR9708353A (pt)
CA (1) CA2250062C (pt)
CZ (3) CZ295002B6 (pt)
DE (2) DE69739858D1 (pt)
DK (2) DK2143715T3 (pt)
ES (3) ES2343525T3 (pt)
GB (1) GB9606474D0 (pt)
HU (1) HU227541B1 (pt)
MX (1) MXPA98007851A (pt)
NO (1) NO312193B1 (pt)
NZ (1) NZ332010A (pt)
PL (3) PL190573B1 (pt)
PT (3) PT894087E (pt)
SI (2) SI2143715T1 (pt)
SK (3) SK285362B6 (pt)
TR (1) TR199801921T2 (pt)
WO (1) WO1997035841A2 (pt)
ZA (1) ZA972729B (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia
FI105389B (fi) * 1998-04-23 2000-08-15 Orion Yhtymae Oyj Menetelmä levosimendaaniannon siedettävyyden seuraamiseksi
FI104718B (fi) 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US5905078A (en) * 1998-06-19 1999-05-18 Orion Corporation Use of a pyridazinone derivative
FI109659B (fi) 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
US20080091023A1 (en) * 2006-08-03 2008-04-17 Nurit Perlman Processes for optical resolution of 1-phenyl-1,2,3,4-tetrahydroisoquinoline
AU2010272364B2 (en) 2009-07-14 2014-04-10 Cipla Limited Process for preparing levosimendan and intermediates for use in the process
JP5482926B2 (ja) * 2011-02-28 2014-05-07 株式会社リコー 伝送管理装置
CN103554033A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 一种消旋体(±)- 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的拆分方法
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
EP3424908A1 (en) * 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Process for preparation of levosimendan
US11760730B2 (en) 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
AU581324B2 (en) 1985-07-05 1989-02-16 Smith Kline & French Laboratories Limited Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Also Published As

Publication number Publication date
SK131698A3 (en) 2000-04-10
DE69739858D1 (de) 2010-06-02
SK285362B6 (sk) 2006-11-03
GB9606474D0 (en) 1996-06-05
ES2243988T3 (es) 2005-12-01
PL329068A1 (en) 1999-03-15
AU2162697A (en) 1997-10-17
NO984487D0 (no) 1998-09-25
ATE299867T1 (de) 2005-08-15
DK2143715T3 (da) 2011-12-05
ATE465154T1 (de) 2010-05-15
NZ332010A (en) 2000-02-28
BR9708353A (pt) 1999-08-03
SK285364B6 (sk) 2006-11-03
CA2250062A1 (en) 1997-10-02
JP2008179645A (ja) 2008-08-07
JP2011236251A (ja) 2011-11-24
PL190574B1 (pl) 2005-12-30
EP0894087A2 (en) 1999-02-03
WO1997035841A2 (en) 1997-10-02
EP1619186B1 (en) 2010-04-21
PT1619186E (pt) 2010-06-04
HUP9904150A3 (en) 2000-11-28
CZ304198A3 (cs) 1999-03-17
DE69733748D1 (de) 2005-08-25
EP1619186A1 (en) 2006-01-25
CZ295001B6 (cs) 2005-05-18
JP4179630B2 (ja) 2008-11-12
JP4825825B2 (ja) 2011-11-30
EP0894087B1 (en) 2005-07-20
PL190573B1 (pl) 2005-12-30
TR199801921T2 (xx) 1998-12-21
MXPA98007851A (es) 2006-06-07
NO312193B1 (no) 2002-04-08
JP5277295B2 (ja) 2013-08-28
ZA972729B (en) 1997-10-30
SI0894087T1 (en) 2005-10-31
AU715887B2 (en) 2000-02-10
CZ294964B6 (cs) 2005-04-13
EP2143715B1 (en) 2011-09-21
US6180789B1 (en) 2001-01-30
CA2250062C (en) 2006-11-14
EP2143715A1 (en) 2010-01-13
DK0894087T3 (da) 2005-09-19
DE69733748T2 (de) 2006-04-20
PL189963B1 (pl) 2005-10-31
SI2143715T1 (sl) 2012-01-31
ES2370760T3 (es) 2011-12-22
CZ295002B6 (cs) 2005-05-18
JP2000515492A (ja) 2000-11-21
NO984487L (no) 1998-11-26
WO1997035841A3 (en) 1998-01-22
PT894087E (pt) 2005-09-30
HU227541B1 (en) 2011-08-29
ES2343525T3 (es) 2010-08-03
ATE525361T1 (de) 2011-10-15
SK285363B6 (sk) 2006-11-03
HUP9904150A2 (hu) 2000-09-28

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