DK0894087T3 - Fremgangsmåde til opnåelse af rene enantiomerer af et pyridazinonderivat - Google Patents

Fremgangsmåde til opnåelse af rene enantiomerer af et pyridazinonderivat

Info

Publication number
DK0894087T3
DK0894087T3 DK97914347T DK97914347T DK0894087T3 DK 0894087 T3 DK0894087 T3 DK 0894087T3 DK 97914347 T DK97914347 T DK 97914347T DK 97914347 T DK97914347 T DK 97914347T DK 0894087 T3 DK0894087 T3 DK 0894087T3
Authority
DK
Denmark
Prior art keywords
pure enantiomers
obtaining pure
pyridazinone derivative
pyridazinone
derivative
Prior art date
Application number
DK97914347T
Other languages
English (en)
Inventor
Mika Timmerbacka
Jorma Lehtonen
Veli Pekka Tanninen
Esa Muttonen
Jukka Kaukonen
Riikka Hyppoelae
Reijo Baeckstroem
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Application granted granted Critical
Publication of DK0894087T3 publication Critical patent/DK0894087T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
DK97914347T 1996-03-27 1997-03-27 Fremgangsmåde til opnåelse af rene enantiomerer af et pyridazinonderivat DK0894087T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9606474.6A GB9606474D0 (en) 1996-03-27 1996-03-27 Method for obtaining pure enantiomers of a pyridazinone derivative
PCT/FI1997/000196 WO1997035841A2 (en) 1996-03-27 1997-03-27 Method for obtaining pure enantiomers of a pyridazinone derivative

Publications (1)

Publication Number Publication Date
DK0894087T3 true DK0894087T3 (da) 2005-09-19

Family

ID=10791141

Family Applications (2)

Application Number Title Priority Date Filing Date
DK09013140.0T DK2143715T3 (da) 1996-03-27 1997-03-27 Fremgangsmåde til at tilvejebringe rene enantiomerer af et pyridazinonderivat
DK97914347T DK0894087T3 (da) 1996-03-27 1997-03-27 Fremgangsmåde til opnåelse af rene enantiomerer af et pyridazinonderivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK09013140.0T DK2143715T3 (da) 1996-03-27 1997-03-27 Fremgangsmåde til at tilvejebringe rene enantiomerer af et pyridazinonderivat

Country Status (23)

Country Link
US (1) US6180789B1 (da)
EP (3) EP1619186B1 (da)
JP (3) JP4179630B2 (da)
AT (3) ATE299867T1 (da)
AU (1) AU715887B2 (da)
BR (1) BR9708353A (da)
CA (1) CA2250062C (da)
CZ (3) CZ295002B6 (da)
DE (2) DE69739858D1 (da)
DK (2) DK2143715T3 (da)
ES (3) ES2343525T3 (da)
GB (1) GB9606474D0 (da)
HU (1) HU227541B1 (da)
MX (1) MXPA98007851A (da)
NO (1) NO312193B1 (da)
NZ (1) NZ332010A (da)
PL (3) PL190573B1 (da)
PT (3) PT894087E (da)
SI (2) SI2143715T1 (da)
SK (3) SK285362B6 (da)
TR (1) TR199801921T2 (da)
WO (1) WO1997035841A2 (da)
ZA (1) ZA972729B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia
FI105389B (fi) * 1998-04-23 2000-08-15 Orion Yhtymae Oyj Menetelmä levosimendaaniannon siedettävyyden seuraamiseksi
FI104718B (fi) * 1998-06-18 2000-03-31 Orion Yhtymae Oyj [[4-(2-atsido-3-metyyli-5-oksotetrahydrofuran-2-yyli)fenyyli]hydratsono]propaanidinitriili käytettäväksi referenssiaineena levosimendaanierien analyysissä
US5905078A (en) * 1998-06-19 1999-05-18 Orion Corporation Use of a pyridazinone derivative
FI109659B (fi) 1999-09-10 2002-09-30 Orion Yhtymae Oyj Levosimendaanin farmaseuttisia liuoksia
WO2008019055A2 (en) * 2006-08-03 2008-02-14 Teva Pharmaceutical Industries Ltd. Processes for optical resolution of 1-phenyl-1,2,3,4-tetrahydroisoquinoline
JP5747030B2 (ja) 2009-07-14 2015-07-08 シプラ・リミテッド レボシメンダンの製造方法及びその方法で用いる中間体
JP5482926B2 (ja) * 2011-02-28 2014-05-07 株式会社リコー 伝送管理装置
CN103554033A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 一种消旋体(±)- 6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的拆分方法
CN103554032A (zh) * 2013-11-12 2014-02-05 江苏正大清江制药有限公司 高光学纯度(-)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2h)-哒嗪酮的制备方法
ITMI20132185A1 (it) * 2013-12-23 2015-06-24 Edmond Pharma Srl Polimorfi di levosimendan
EP3424908A1 (en) * 2017-07-07 2019-01-09 Melody Healthcare Pvt. Ltd. Process for preparation of levosimendan
US11760730B2 (en) * 2021-01-11 2023-09-19 Navinta, Llc Process for the preparation of high purity Levosimendan

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1211589A (en) * 1968-08-06 1970-11-11 Ici Ltd Enantiomer isolation process
AU581324B2 (en) 1985-07-05 1989-02-16 Smith Kline & French Laboratories Limited Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones
GB8903130D0 (en) * 1989-02-11 1989-03-30 Orion Yhtymae Oy Substituted pyridazinones
GB2251615B (en) * 1991-01-03 1995-02-08 Orion Yhtymae Oy (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]pro panedinitrile
GB9606474D0 (en) * 1996-03-27 1996-06-05 Orion Yhytmo Oy Method for obtaining pure enantiomers of a pyridazinone derivative
FI973804A (fi) * 1997-09-26 1999-03-27 Orion Yhtymae Oy Levosimendaanin oraalisia koostumuksia

Also Published As

Publication number Publication date
DE69739858D1 (de) 2010-06-02
HUP9904150A2 (hu) 2000-09-28
CZ304198A3 (cs) 1999-03-17
DE69733748D1 (de) 2005-08-25
BR9708353A (pt) 1999-08-03
HUP9904150A3 (en) 2000-11-28
CA2250062C (en) 2006-11-14
CZ295001B6 (cs) 2005-05-18
EP2143715A1 (en) 2010-01-13
JP2000515492A (ja) 2000-11-21
SI0894087T1 (en) 2005-10-31
PT894087E (pt) 2005-09-30
PL190573B1 (pl) 2005-12-30
SK285364B6 (sk) 2006-11-03
CZ294964B6 (cs) 2005-04-13
EP0894087B1 (en) 2005-07-20
DE69733748T2 (de) 2006-04-20
EP0894087A2 (en) 1999-02-03
US6180789B1 (en) 2001-01-30
AU715887B2 (en) 2000-02-10
WO1997035841A2 (en) 1997-10-02
CA2250062A1 (en) 1997-10-02
SK285362B6 (sk) 2006-11-03
JP2008179645A (ja) 2008-08-07
JP2011236251A (ja) 2011-11-24
MXPA98007851A (es) 2006-06-07
TR199801921T2 (xx) 1998-12-21
JP5277295B2 (ja) 2013-08-28
PL189963B1 (pl) 2005-10-31
JP4825825B2 (ja) 2011-11-30
DK2143715T3 (da) 2011-12-05
ES2343525T3 (es) 2010-08-03
SI2143715T1 (sl) 2012-01-31
ZA972729B (en) 1997-10-30
GB9606474D0 (en) 1996-06-05
NZ332010A (en) 2000-02-28
EP1619186B1 (en) 2010-04-21
ES2370760T3 (es) 2011-12-22
ES2243988T3 (es) 2005-12-01
ATE465154T1 (de) 2010-05-15
PL329068A1 (en) 1999-03-15
ATE299867T1 (de) 2005-08-15
SK131698A3 (en) 2000-04-10
AU2162697A (en) 1997-10-17
PT1619186E (pt) 2010-06-04
NO984487D0 (no) 1998-09-25
NO984487L (no) 1998-11-26
EP2143715B1 (en) 2011-09-21
SK285363B6 (sk) 2006-11-03
EP1619186A1 (en) 2006-01-25
CZ295002B6 (cs) 2005-05-18
PT2143715E (pt) 2011-10-11
WO1997035841A3 (en) 1998-01-22
HU227541B1 (en) 2011-08-29
ATE525361T1 (de) 2011-10-15
NO312193B1 (no) 2002-04-08
JP4179630B2 (ja) 2008-11-12
PL190574B1 (pl) 2005-12-30

Similar Documents

Publication Publication Date Title
DK0894087T3 (da) Fremgangsmåde til opnåelse af rene enantiomerer af et pyridazinonderivat
IL114028A0 (en) A method for obtaining pure enantiomers of 6-(4-amino-phenyl)-5- methyl-pyridazin 3(2H) one
ATE231128T1 (de) Verbindungen mit kondensierten ringen, verfahren zu ihrer herstellung und ihre anwendung
EA200100074A1 (ru) Способ лечения легочной гипертензии
DE69904729D1 (de) Verfahren zur herstellung und reinigung von mischungen von fluoranverbindungen und aufzeichnungsmaterial welches die genannten fluoranmischungen enthält
MX9703363A (es) Nuevos derivados de pirimidiniloxi- y pirimidinilamino etilfenil-dioxolano.
EA200200100A1 (ru) Способ лечения или профилактики вазоспазма коронарного трансплантата
CA2037098A1 (en) Hexahydrobenz ¢cd! indoles and processes for preparation thereof
AU2001247812A1 (en) Arthropodicidal carboxanilides