NO310186B1 - Naftyl og dihydronaftyl mellomprodukter, forbindelser, sammensetninger og anvendelse av forbindelsene - Google Patents
Naftyl og dihydronaftyl mellomprodukter, forbindelser, sammensetninger og anvendelse av forbindelsene Download PDFInfo
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- NO310186B1 NO310186B1 NO19980395A NO980395A NO310186B1 NO 310186 B1 NO310186 B1 NO 310186B1 NO 19980395 A NO19980395 A NO 19980395A NO 980395 A NO980395 A NO 980395A NO 310186 B1 NO310186 B1 NO 310186B1
- Authority
- NO
- Norway
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compounds
- solvate
- formula
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 164
- 239000000203 mixture Substances 0.000 title description 44
- 125000005046 dihydronaphthyl group Chemical group 0.000 title description 3
- 239000000543 intermediate Substances 0.000 title description 3
- 125000001624 naphthyl group Chemical group 0.000 title description 2
- 150000003839 salts Chemical class 0.000 claims abstract description 39
- 238000002360 preparation method Methods 0.000 claims abstract description 31
- 201000009273 Endometriosis Diseases 0.000 claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
- 201000010260 leiomyoma Diseases 0.000 claims abstract description 13
- 206010027304 Menopausal symptoms Diseases 0.000 claims abstract description 12
- 230000004663 cell proliferation Effects 0.000 claims abstract description 12
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract description 9
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 9
- 206010046798 Uterine leiomyoma Diseases 0.000 claims abstract description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 7
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims abstract description 7
- 208000010579 uterine corpus leiomyoma Diseases 0.000 claims abstract description 7
- 201000007954 uterine fibroid Diseases 0.000 claims abstract description 7
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims abstract description 3
- 239000000262 estrogen Substances 0.000 claims description 50
- 229940011871 estrogen Drugs 0.000 claims description 49
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- 230000002401 inhibitory effect Effects 0.000 claims description 4
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- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 10
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- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US168295P | 1995-07-31 | 1995-07-31 | |
| PCT/US1996/012387 WO1997004763A1 (en) | 1995-07-31 | 1996-07-26 | Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO980395D0 NO980395D0 (no) | 1998-01-29 |
| NO980395L NO980395L (no) | 1998-03-26 |
| NO310186B1 true NO310186B1 (no) | 2001-06-05 |
Family
ID=21697295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19980395A NO310186B1 (no) | 1995-07-31 | 1998-01-29 | Naftyl og dihydronaftyl mellomprodukter, forbindelser, sammensetninger og anvendelse av forbindelsene |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5811421A (xx) |
| EP (1) | EP0761659B1 (xx) |
| JP (1) | JPH11510798A (xx) |
| KR (1) | KR19990036006A (xx) |
| CN (1) | CN1198668A (xx) |
| AT (1) | ATE240948T1 (xx) |
| AU (1) | AU703317B2 (xx) |
| BR (1) | BR9609844A (xx) |
| CA (1) | CA2228178A1 (xx) |
| CZ (1) | CZ289605B6 (xx) |
| DE (1) | DE69628246T2 (xx) |
| ES (1) | ES2198462T3 (xx) |
| HU (1) | HUP9802408A3 (xx) |
| IL (1) | IL122748A0 (xx) |
| MX (1) | MX9800800A (xx) |
| NO (1) | NO310186B1 (xx) |
| NZ (1) | NZ315174A (xx) |
| PL (1) | PL324816A1 (xx) |
| RU (1) | RU2167158C2 (xx) |
| TR (1) | TR199800132T1 (xx) |
| WO (1) | WO1997004763A1 (xx) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2214070C (en) * | 1996-08-29 | 2006-03-14 | Eli Lilly And Company | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods |
| CA2213814A1 (en) * | 1996-08-29 | 1998-02-28 | Henry Uhlman Bryant | Naphthalene compounds, intermediates, formulations, and methods |
| CA2214935A1 (en) * | 1996-09-26 | 1998-03-26 | Henry Uhlman Bryant | Benzofluorene compounds, intermediates, compositions, and methods |
| CA2214929A1 (en) * | 1996-09-26 | 1998-03-26 | Charles Willis Lugar, Iii | Naphthofluorene compounds, intermediates, compositions and methods |
| CA2214931A1 (en) * | 1996-09-26 | 1998-03-26 | Henry Uhlman Bryant | Tetrahydrobenzo-a-fluorene compounds and method of use |
| CA2217810A1 (en) * | 1996-10-10 | 1998-04-10 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods |
| US5916916A (en) * | 1996-10-10 | 1999-06-29 | Eli Lilly And Company | 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods |
| AU7467398A (en) * | 1997-04-25 | 1998-11-24 | Eli Lilly And Company | Indene compounds having activity as serms |
| AU8683398A (en) * | 1997-08-07 | 1999-03-01 | Eli Lilly And Company | 1-{4-(substituted alkoxy)benzyl}naphthalene compounds having estrogen inhibitoryactivity |
| US5929090A (en) * | 1997-09-12 | 1999-07-27 | Eli Lilly And Company | 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods |
| US6249683B1 (en) | 1999-04-08 | 2001-06-19 | Qualcomm Incorporated | Forward link power control of multiple data streams transmitted to a mobile station using a common power control channel |
| US6610705B1 (en) * | 2000-03-31 | 2003-08-26 | Council Of Scientific And Industrial Research | Process for the preparation of diaryl naphthyl methanes |
| WO2002094268A1 (en) * | 2001-05-22 | 2002-11-28 | Eli Lilly And Company | Tetrahydroquinolin derivatives for the inhibition of diseases associated with estrogen deprivation or with an aberrant physiological response to endogenous estrogen |
| WO2002094788A1 (en) * | 2001-05-22 | 2002-11-28 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
| US20070111988A1 (en) * | 2004-01-22 | 2007-05-17 | Eli Lilly And Company | Selective estrogen receptor modulators |
| US20070066595A1 (en) * | 2004-01-22 | 2007-03-22 | Dodge Jeffrey A | Selective estrogen receptor modulators |
| EP1896391B1 (en) * | 2005-06-14 | 2015-08-12 | Baylor University | Combretastatin analogs with tubulin binding activity |
| KR101731008B1 (ko) | 2010-06-16 | 2017-04-27 | 앙도르쉐르슈 인코포레이티드 | 에스트로겐-관련 질병의 치료 또는 예방 방법 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274213A (en) * | 1961-09-05 | 1966-09-20 | Upjohn Co | Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes |
| US3396169A (en) * | 1966-10-26 | 1968-08-06 | Upjohn Co | Substituted 2-phenyl-1-(tertiary-aminoalkoxy) phenyl-3, 4-dihydronaphthalenes |
| US3862232A (en) * | 1963-07-03 | 1975-01-21 | Upjohn Co | 1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof |
| US3313853A (en) * | 1963-10-16 | 1967-04-11 | Upjohn Co | 2-(tertiaryaminoalkoxyphenyl)-3, 4-dihydronaphthalenes and 2-(tertiaryaminoalkoxyphenyl) -3, 4- dihydro -1(2h)-naphthalenones |
| US3293263A (en) * | 1963-12-09 | 1966-12-20 | Upjohn Co | Diphenylbenzocycloalkenes |
| US3320271A (en) * | 1964-06-01 | 1967-05-16 | Upjohn Co | 1, 2-diphenyl-3, 4-dihydronaphthalenes and 2, 3-diphenylindenes |
| GB1138163A (en) * | 1965-05-21 | 1968-12-27 | Bristol Myers Co | Benzothiophene derivatives having anti-fertility properties |
| US3394125A (en) * | 1965-10-23 | 1968-07-23 | Bristol Myers Co | 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group |
| US3483293A (en) * | 1967-12-15 | 1969-12-09 | Upjohn Co | Method for controlling birds and rodents |
| US3567737A (en) * | 1968-01-02 | 1971-03-02 | Upjohn Co | Derivatives of (2-cycloalkyl-1-phenyl-3,4-dihydronaphthalenes and) 2 - cycloalkyl - 1 - phenyl - 1,2,3,4 - tetrahydro-naphthalenes |
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4230862A (en) * | 1975-10-28 | 1980-10-28 | Eli Lilly And Company | Antifertility compounds |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| GB8311678D0 (en) * | 1983-04-28 | 1983-06-02 | Ici Plc | Phenol derivatives |
| US4859695A (en) * | 1986-06-10 | 1989-08-22 | Merck & Co., Inc. | Antiestrogen agents having anabolic activity in animals |
| GB8705174D0 (en) * | 1987-03-05 | 1987-04-08 | Ici Plc | Heterocyclic compounds |
| US5013761A (en) * | 1988-06-03 | 1991-05-07 | Eli Lilly And Company | Serotonin antagonists |
| US5395842A (en) * | 1988-10-31 | 1995-03-07 | Endorecherche Inc. | Anti-estrogenic compounds and compositions |
| US5254568A (en) * | 1990-08-09 | 1993-10-19 | Council Of Scientific & Industrial Research | Benzopyrans as antiestrogenic agents |
| DE4117512A1 (de) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
| US6756388B1 (en) * | 1993-10-12 | 2004-06-29 | Pfizer Inc. | Benzothiophenes and related compounds as estrogen agonists |
| US7501441B1 (en) * | 1994-09-20 | 2009-03-10 | Eli Lilly And Company | Naphthyl compounds, intermediates, processes, compositions, and methods |
| US5554628A (en) * | 1994-09-20 | 1996-09-10 | Eli Lilly And Company | Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs |
| US6391892B1 (en) * | 1995-03-10 | 2002-05-21 | Eli Lilly And Company | Naphthyl pharmaceutical compounds |
-
1996
- 1996-07-16 US US08/679,593 patent/US5811421A/en not_active Expired - Fee Related
- 1996-07-22 DE DE69628246T patent/DE69628246T2/de not_active Expired - Fee Related
- 1996-07-22 EP EP96305344A patent/EP0761659B1/en not_active Expired - Lifetime
- 1996-07-22 AT AT96305344T patent/ATE240948T1/de not_active IP Right Cessation
- 1996-07-22 ES ES96305344T patent/ES2198462T3/es not_active Expired - Lifetime
- 1996-07-26 IL IL12274896A patent/IL122748A0/xx unknown
- 1996-07-26 WO PCT/US1996/012387 patent/WO1997004763A1/en not_active Application Discontinuation
- 1996-07-26 NZ NZ315174A patent/NZ315174A/xx unknown
- 1996-07-26 KR KR1019980700670A patent/KR19990036006A/ko not_active Application Discontinuation
- 1996-07-26 BR BR9609844A patent/BR9609844A/pt not_active Application Discontinuation
- 1996-07-26 RU RU98103465/04A patent/RU2167158C2/ru active
- 1996-07-26 MX MX9800800A patent/MX9800800A/es unknown
- 1996-07-26 JP JP9507821A patent/JPH11510798A/ja not_active Withdrawn
- 1996-07-26 CN CN96197331A patent/CN1198668A/zh active Pending
- 1996-07-26 TR TR1998/00132T patent/TR199800132T1/xx unknown
- 1996-07-26 HU HU9802408A patent/HUP9802408A3/hu unknown
- 1996-07-26 CA CA002228178A patent/CA2228178A1/en not_active Abandoned
- 1996-07-26 PL PL96324816A patent/PL324816A1/xx unknown
- 1996-07-26 CZ CZ1998276A patent/CZ289605B6/cs not_active IP Right Cessation
- 1996-07-26 AU AU66821/96A patent/AU703317B2/en not_active Ceased
-
1998
- 1998-01-29 NO NO19980395A patent/NO310186B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69628246D1 (de) | 2003-06-26 |
| AU6682196A (en) | 1997-02-26 |
| BR9609844A (pt) | 1999-03-09 |
| EP0761659A1 (en) | 1997-03-12 |
| JPH11510798A (ja) | 1999-09-21 |
| CZ27698A3 (cs) | 1998-07-15 |
| DE69628246T2 (de) | 2004-03-25 |
| TR199800132T1 (xx) | 1998-05-21 |
| NO980395L (no) | 1998-03-26 |
| RU2167158C2 (ru) | 2001-05-20 |
| EP0761659B1 (en) | 2003-05-21 |
| IL122748A0 (en) | 1998-08-16 |
| CZ289605B6 (cs) | 2002-03-13 |
| PL324816A1 (en) | 1998-06-22 |
| KR19990036006A (ko) | 1999-05-25 |
| MX9800800A (es) | 1998-04-30 |
| AU703317B2 (en) | 1999-03-25 |
| WO1997004763A1 (en) | 1997-02-13 |
| HUP9802408A3 (en) | 1999-06-28 |
| NZ315174A (en) | 1999-07-29 |
| CA2228178A1 (en) | 1997-02-13 |
| NO980395D0 (no) | 1998-01-29 |
| US5811421A (en) | 1998-09-22 |
| ES2198462T3 (es) | 2004-02-01 |
| HUP9802408A2 (hu) | 1999-01-28 |
| ATE240948T1 (de) | 2003-06-15 |
| CN1198668A (zh) | 1998-11-11 |
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Legal Events
| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |
Free format text: LAPSED IN JANUARY 2003 |