HUP9802408A2 - Naftil- és dihidronaftilszármazékok, és ezeket a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Naftil- és dihidronaftilszármazékok, és ezeket a vegyületeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9802408A2
HUP9802408A2 HU9802408A HUP9802408A HUP9802408A2 HU P9802408 A2 HUP9802408 A2 HU P9802408A2 HU 9802408 A HU9802408 A HU 9802408A HU P9802408 A HUP9802408 A HU P9802408A HU P9802408 A2 HUP9802408 A2 HU P9802408A2
Authority
HU
Hungary
Prior art keywords
carbon
general formula
pyrrolidinyl
alkyl
pipe powder
Prior art date
Application number
HU9802408A
Other languages
English (en)
Inventor
Jeffrey A. Dodge
Kennan J. Fahey
Charles D. Jones
Charles W. Lugar
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP9802408A2 publication Critical patent/HUP9802408A2/hu
Publication of HUP9802408A3 publication Critical patent/HUP9802408A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A találmány tárgya az (I) általánős képletű vegyületek, gyógyászatiszempőntból alkalmazható sója vagy szőlvátja, ahől az (I) általánősképletben R1 jelentése hidrőgénatőm, hidrőxilcsőpőrt, -O(1-4 szénatőmős alkil),-OCOC6H5, -OCO(1-6 szénatőmős alkil) vagy -OSO2(4-6 szénatőmős alkil)képletű, illetve általánős képletű csőpőrt, R2 jelentése 1-6 szénatőmős alkilcsőpőrt vagy 5-7 szénatőmősciklőalkilcsőpőrt, mely adőtt esetben 1-3 szűbsztitűensselhelyettesített, ahől a szűbsztitűens 1-4 szénatőmős alkil-, 1-4szénatőmős alkőxi-, hidrőxi-, aminő-, nitrőcsőpőrt vagy halőgénatőm, X jelentése -CH(OH)- vagy -CH2- képletű csőpőrt, M jelentése -CH2CH2- vagy -CH=CH- képletű csőpőrt, n jelentése 2 vagy 3, és R3 jelentése 1-piperidinil-, 1-pirrőlidinil-, metil-1-pirrőlidinil-,dimetil-1-pirrőlidinil-4-mőrfőlinő-, dimetil-aminő-, dietil-aminő-vagy 1-hexametilén-iminő-csőpőrt. A találmány szerinti vegyületek alkalmasak a klimax űtáni szindróma, améhfibrózis, az endőmetriózis kezelésére és az aőrta simaizőmsejtszapőrődásának gátlására. A találmány tővábbi tárgyát képezik az (I) általánős képletűvegyületet tartalmazó gyógyszerkészítmények, valamint az (I) általánősképletű vegyületek előállításánál köztesanyagként használhatóvegyületek. ŕ
HU9802408A 1995-07-31 1996-07-26 Naphthyl and dihydronaphthyl-derivatives, and pharmaceutical compositions, containing them HUP9802408A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US168295P 1995-07-31 1995-07-31

Publications (2)

Publication Number Publication Date
HUP9802408A2 true HUP9802408A2 (hu) 1999-01-28
HUP9802408A3 HUP9802408A3 (en) 1999-06-28

Family

ID=21697295

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9802408A HUP9802408A3 (en) 1995-07-31 1996-07-26 Naphthyl and dihydronaphthyl-derivatives, and pharmaceutical compositions, containing them

Country Status (21)

Country Link
US (1) US5811421A (hu)
EP (1) EP0761659B1 (hu)
JP (1) JPH11510798A (hu)
KR (1) KR19990036006A (hu)
CN (1) CN1198668A (hu)
AT (1) ATE240948T1 (hu)
AU (1) AU703317B2 (hu)
BR (1) BR9609844A (hu)
CA (1) CA2228178A1 (hu)
CZ (1) CZ289605B6 (hu)
DE (1) DE69628246T2 (hu)
ES (1) ES2198462T3 (hu)
HU (1) HUP9802408A3 (hu)
IL (1) IL122748A0 (hu)
MX (1) MX9800800A (hu)
NO (1) NO310186B1 (hu)
NZ (1) NZ315174A (hu)
PL (1) PL324816A1 (hu)
RU (1) RU2167158C2 (hu)
TR (1) TR199800132T1 (hu)
WO (1) WO1997004763A1 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2213814A1 (en) * 1996-08-29 1998-02-28 Henry Uhlman Bryant Naphthalene compounds, intermediates, formulations, and methods
CA2214070C (en) * 1996-08-29 2006-03-14 Eli Lilly And Company Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods
CA2214929A1 (en) * 1996-09-26 1998-03-26 Charles Willis Lugar, Iii Naphthofluorene compounds, intermediates, compositions and methods
CA2214935A1 (en) * 1996-09-26 1998-03-26 Henry Uhlman Bryant Benzofluorene compounds, intermediates, compositions, and methods
CA2214931A1 (en) * 1996-09-26 1998-03-26 Henry Uhlman Bryant Tetrahydrobenzo-a-fluorene compounds and method of use
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
CA2217810A1 (en) * 1996-10-10 1998-04-10 Eli Lilly And Company 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods
CA2287244A1 (en) * 1997-04-25 1998-11-05 Henry Uhlman Bryant Indene compounds having activity as serms
CA2298651A1 (en) * 1997-08-07 1999-02-18 Jeffrey Alan Dodge 1-¬4-(substituted alkoxy)benzyl|naphthalene compounds having estrogen inhibitory activity
US5929090A (en) * 1997-09-12 1999-07-27 Eli Lilly And Company 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods
US6249683B1 (en) 1999-04-08 2001-06-19 Qualcomm Incorporated Forward link power control of multiple data streams transmitted to a mobile station using a common power control channel
US6610705B1 (en) * 2000-03-31 2003-08-26 Council Of Scientific And Industrial Research Process for the preparation of diaryl naphthyl methanes
EP1395563B1 (en) * 2001-05-22 2006-03-29 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
DE60202954T2 (de) * 2001-05-22 2006-01-05 Eli Lilly And Co., Indianapolis Tetrahydrochinolin-derivate zur behandlung von krankheiten ausgelöst durch zu hohem oder zu niedrigem oestrogenspiegel
WO2005073206A1 (en) * 2004-01-22 2005-08-11 Eli Lilly And Company Selective estrogen receptor modulators
WO2005073205A1 (en) * 2004-01-22 2005-08-11 Eli Lilly And Company Selective estrogen receptor modulators
CA2611712C (en) 2005-06-14 2014-05-13 Baylor University Combretastatin analogs with tubulin binding activity
KR20150039882A (ko) 2010-06-16 2015-04-13 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법

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Also Published As

Publication number Publication date
TR199800132T1 (xx) 1998-05-21
DE69628246T2 (de) 2004-03-25
ATE240948T1 (de) 2003-06-15
WO1997004763A1 (en) 1997-02-13
DE69628246D1 (de) 2003-06-26
NO980395L (no) 1998-03-26
AU6682196A (en) 1997-02-26
CN1198668A (zh) 1998-11-11
IL122748A0 (en) 1998-08-16
CZ289605B6 (cs) 2002-03-13
CZ27698A3 (cs) 1998-07-15
EP0761659B1 (en) 2003-05-21
NO980395D0 (no) 1998-01-29
NZ315174A (en) 1999-07-29
CA2228178A1 (en) 1997-02-13
MX9800800A (es) 1998-04-30
EP0761659A1 (en) 1997-03-12
PL324816A1 (en) 1998-06-22
ES2198462T3 (es) 2004-02-01
BR9609844A (pt) 1999-03-09
NO310186B1 (no) 2001-06-05
US5811421A (en) 1998-09-22
KR19990036006A (ko) 1999-05-25
AU703317B2 (en) 1999-03-25
JPH11510798A (ja) 1999-09-21
RU2167158C2 (ru) 2001-05-20
HUP9802408A3 (en) 1999-06-28

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