MX9800800A - Compuestos, intermedios de naftilo y dihidronaftilo, composiciones y metodos. - Google Patents

Compuestos, intermedios de naftilo y dihidronaftilo, composiciones y metodos.

Info

Publication number
MX9800800A
MX9800800A MX9800800A MX9800800A MX9800800A MX 9800800 A MX9800800 A MX 9800800A MX 9800800 A MX9800800 A MX 9800800A MX 9800800 A MX9800800 A MX 9800800A MX 9800800 A MX9800800 A MX 9800800A
Authority
MX
Mexico
Prior art keywords
alkyl
compounds
pyrrolidinyl
present
methods
Prior art date
Application number
MX9800800A
Other languages
English (en)
Other versions
MXPA98000800A (es
Inventor
Jeffrey Alan Dodge
Kennan Joseph Fahey
Charles David Jones
Charles Willis Lugar
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MXPA98000800A publication Critical patent/MXPA98000800A/es
Publication of MX9800800A publication Critical patent/MX9800800A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invencion proporciona compuestos de la formula (I) en donde R1 es -H, -OH, -O(alquilo de 1 a 4 átomos de carbono), -OCOC6H5 -OCO(alquilo de 1 a 6 átomos de carbono) o -OSO2(alquilo de 4 a 6 átomo de carbono); R2 es alquilo de 1 a 6 átomos de carbono o cicloalquilo de 5 a 7 átomos de carbono que esta opcionalmente sustituido con 1 a 3 sustituyentes seleccionados del grupo que consiste de alquilo de 1 a 4 átomos de carbono alcoxi de 1 a 4 átomos de carbono, hidroxi, amino, nitro y halo; X es -CH(OH)- o - CH2-; M es -CH2CH2- o -CH=CH-; n es 2 o 3; y R3 es 1-piperidinilo, 1-pirrolidinilo, metil-pirrolidinilo, dimetilo-1-pirrolidinilo, 4-morfolino, dimetilamino, dietilamino o 1 haxametilenimino; o una sal farmacéuticamente aceptables del mismo. También se proporcionan métodos para utilizar los compuestos de la presente invencion para los tratamientos de diversas indicaciones médicas asociadas con el síndrome postmenstrual, enfermedad fibroide uterina, endometrosis y proliferacion de células del modulo liso aortal. La presente invencion proporciona composiciones farmacéuticas de compuestos de la formula (I), así como compuestos intermediarios para la preparacion de los mismos.
MX9800800A 1995-07-31 1996-07-26 Compuestos, intermedios de naftilo y dihidronaftilo, composiciones y metodos. MX9800800A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US001682 1987-01-09
US168295P 1995-07-31 1995-07-31
PCT/US1996/012387 WO1997004763A1 (en) 1995-07-31 1996-07-26 Naphthyl and dihydronaphthyl intermediates, compounds, compositions, and methods

Publications (2)

Publication Number Publication Date
MXPA98000800A MXPA98000800A (es) 1998-04-01
MX9800800A true MX9800800A (es) 1998-04-30

Family

ID=21697295

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9800800A MX9800800A (es) 1995-07-31 1996-07-26 Compuestos, intermedios de naftilo y dihidronaftilo, composiciones y metodos.

Country Status (21)

Country Link
US (1) US5811421A (es)
EP (1) EP0761659B1 (es)
JP (1) JPH11510798A (es)
KR (1) KR19990036006A (es)
CN (1) CN1198668A (es)
AT (1) ATE240948T1 (es)
AU (1) AU703317B2 (es)
BR (1) BR9609844A (es)
CA (1) CA2228178A1 (es)
CZ (1) CZ289605B6 (es)
DE (1) DE69628246T2 (es)
ES (1) ES2198462T3 (es)
HU (1) HUP9802408A3 (es)
IL (1) IL122748A0 (es)
MX (1) MX9800800A (es)
NO (1) NO310186B1 (es)
NZ (1) NZ315174A (es)
PL (1) PL324816A1 (es)
RU (1) RU2167158C2 (es)
TR (1) TR199800132T1 (es)
WO (1) WO1997004763A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2214070C (en) * 1996-08-29 2006-03-14 Eli Lilly And Company Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods
CA2213814A1 (en) * 1996-08-29 1998-02-28 Henry Uhlman Bryant Naphthalene compounds, intermediates, formulations, and methods
CA2214929A1 (en) * 1996-09-26 1998-03-26 Charles Willis Lugar, Iii Naphthofluorene compounds, intermediates, compositions and methods
CA2214935A1 (en) * 1996-09-26 1998-03-26 Henry Uhlman Bryant Benzofluorene compounds, intermediates, compositions, and methods
CA2214931A1 (en) * 1996-09-26 1998-03-26 Henry Uhlman Bryant Tetrahydrobenzo-a-fluorene compounds and method of use
US5916916A (en) * 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
CA2217810A1 (en) * 1996-10-10 1998-04-10 Eli Lilly And Company 2-aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods
WO1998048806A1 (en) * 1997-04-25 1998-11-05 Eli Lilly And Company Indene compounds having activity as serms
JP2001513501A (ja) 1997-08-07 2001-09-04 イーライ・リリー・アンド・カンパニー エストロゲン阻害活性を有する１−［４−（置換アルコキシ）ベンジル］ナフタレン化合物
US5929090A (en) * 1997-09-12 1999-07-27 Eli Lilly And Company 2-aryl-3-aminoaryloxynaphthy1 compounds, intermediates, compositions and methods
US6249683B1 (en) 1999-04-08 2001-06-19 Qualcomm Incorporated Forward link power control of multiple data streams transmitted to a mobile station using a common power control channel
US6610705B1 (en) * 2000-03-31 2003-08-26 Council Of Scientific And Industrial Research Process for the preparation of diaryl naphthyl methanes
PT1401446E (pt) * 2001-05-22 2005-05-31 Lilly Co Eli Derivados de tetrahidroquinolina para a inibicao de doencas associadas com a privacao de estrogenio ou com uma resposta fisiologica aberrante ao estrogenio endogeno
JP2004531562A (ja) * 2001-05-22 2004-10-14 イーライ・リリー・アンド・カンパニー ２−置換１，２，３，４−テトラヒドロキノリンおよびその誘導体、組成物ならびに方法
EP1709023B1 (en) * 2004-01-22 2009-11-11 Eli Lilly And Company Selective estrogen receptor modulators
EP1709022A1 (en) * 2004-01-22 2006-10-11 Eli Lilly And Company Selective estrogen receptor modulators
CA2611712C (en) * 2005-06-14 2014-05-13 Baylor University Combretastatin analogs with tubulin binding activity
EA026675B1 (ru) 2010-06-16 2017-05-31 Эндорешерш, Инк. Способы лечения или предотвращения эстрогензависимых заболеваний

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US3274213A (en) * 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
US3396169A (en) * 1966-10-26 1968-08-06 Upjohn Co Substituted 2-phenyl-1-(tertiary-aminoalkoxy) phenyl-3, 4-dihydronaphthalenes
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JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
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US7501441B1 (en) * 1994-09-20 2009-03-10 Eli Lilly And Company Naphthyl compounds, intermediates, processes, compositions, and methods
US5554628A (en) * 1994-09-20 1996-09-10 Eli Lilly And Company Method for minimizing the uterothrophic effect of tamoxifen and tamoxifen analogs
US6391892B1 (en) * 1995-03-10 2002-05-21 Eli Lilly And Company Naphthyl pharmaceutical compounds

Also Published As

Publication number Publication date
US5811421A (en) 1998-09-22
EP0761659B1 (en) 2003-05-21
HUP9802408A2 (hu) 1999-01-28
CZ289605B6 (cs) 2002-03-13
DE69628246T2 (de) 2004-03-25
NZ315174A (en) 1999-07-29
ES2198462T3 (es) 2004-02-01
AU703317B2 (en) 1999-03-25
WO1997004763A1 (en) 1997-02-13
KR19990036006A (ko) 1999-05-25
BR9609844A (pt) 1999-03-09
DE69628246D1 (de) 2003-06-26
HUP9802408A3 (en) 1999-06-28
NO310186B1 (no) 2001-06-05
CZ27698A3 (cs) 1998-07-15
EP0761659A1 (en) 1997-03-12
AU6682196A (en) 1997-02-26
NO980395L (no) 1998-03-26
IL122748A0 (en) 1998-08-16
PL324816A1 (en) 1998-06-22
CA2228178A1 (en) 1997-02-13
ATE240948T1 (de) 2003-06-15
NO980395D0 (no) 1998-01-29
CN1198668A (zh) 1998-11-11
JPH11510798A (ja) 1999-09-21
TR199800132T1 (xx) 1998-05-21
RU2167158C2 (ru) 2001-05-20

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