DE69532079D1 - Benzofuranverbindungen, präparate und verfahren - Google Patents

Benzofuranverbindungen, präparate und verfahren

Info

Publication number
DE69532079D1
DE69532079D1 DE69532079T DE69532079T DE69532079D1 DE 69532079 D1 DE69532079 D1 DE 69532079D1 DE 69532079 T DE69532079 T DE 69532079T DE 69532079 T DE69532079 T DE 69532079T DE 69532079 D1 DE69532079 D1 DE 69532079D1
Authority
DE
Germany
Prior art keywords
alkyl
pyrrolidino
compounds
formula
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69532079T
Other languages
English (en)
Other versions
DE69532079T2 (de
Inventor
Henry Uhlman Bryant
George Joseph Cullinan
Jeffrey Alan Dodge
Kennan Joseph Fahey
Charles David Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of DE69532079D1 publication Critical patent/DE69532079D1/de
Publication of DE69532079T2 publication Critical patent/DE69532079T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69532079T 1994-09-20 1995-09-18 Benzofuranverbindungen, präparate und verfahren Expired - Fee Related DE69532079T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/309,271 US6703407B1 (en) 1994-09-20 1994-09-20 Benzofuran compounds, compositions, and methods
US309271 1994-09-20
PCT/US1995/012348 WO1996009040A1 (en) 1994-09-20 1995-09-18 Benzofuran compounds, compositions, and methods

Publications (2)

Publication Number Publication Date
DE69532079D1 true DE69532079D1 (de) 2003-12-11
DE69532079T2 DE69532079T2 (de) 2004-08-26

Family

ID=23197477

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69532079T Expired - Fee Related DE69532079T2 (de) 1994-09-20 1995-09-18 Benzofuranverbindungen, präparate und verfahren

Country Status (7)

Country Link
US (2) US6703407B1 (de)
EP (1) EP0774966B1 (de)
AT (1) ATE253567T1 (de)
AU (1) AU3727795A (de)
DE (1) DE69532079T2 (de)
ES (1) ES2210316T3 (de)
WO (1) WO1996009040A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10204082A (ja) * 1996-10-25 1998-08-04 Eli Lilly & Co 選択的エストロゲンレセプターモジュレーターとしての活性を有する置換されたベンゾ［ｂ］チオフェン化合物
US6465445B1 (en) 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
WO2000045806A1 (en) * 1999-02-03 2000-08-10 Eli Lilly And Company α1-ADRENERGIC RECEPTOR ANTAGONISTS
WO2001035946A2 (en) * 1999-11-15 2001-05-25 New Millennium Pharmaceutical Research, Inc. Intranasal administration of raloxifene and tamoxifen
EP1113007A1 (de) * 1999-12-24 2001-07-04 Pfizer Inc. Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten
CA2444787A1 (en) * 2001-05-22 2002-11-28 Eli Lilly And Company Tetrahydroquinolin derivatives for the inhibition of diseases associated with estrogen deprivation or with an aberrant physiological response to endogenous estrogen
US7078541B2 (en) * 2002-02-07 2006-07-18 Galileo Pharmaceuticals, Inc. Benzofuran derivatives
US6653346B1 (en) * 2002-02-07 2003-11-25 Galileo Pharmaceuticals, Inc. Cytoprotective benzofuran derivatives
US6784205B2 (en) * 2002-03-01 2004-08-31 Sunesis Pharmaceuticals, Inc. Compounds that modulate the activity of PTP-1B and TC-PTP
CA2512663A1 (en) 2003-02-25 2004-09-10 Eli Lilly And Company Crystalline non-solvated 1-(4-(2-piperidinylethoxy)phenoxy)-2-(4-methanesulfonylphenyl)-6-hydroxynaphthalene hydrochloride
UA82875C2 (en) * 2003-04-30 2008-05-26 Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives and method for controlling insects
EP1631561B1 (de) 2003-05-07 2010-08-18 General Electric Company Zusammensetzungen und verfahren zur in vivo abbildung von loeslichen beta-amyloid
US20040223912A1 (en) * 2003-05-07 2004-11-11 Montalto Michael Christopher Compositions and methods for non-invasive imaging of soluble beta-amyloid
EP1709023B1 (de) 2004-01-22 2009-11-11 Eli Lilly And Company Selektive östrogen-rezeptor-modulatoren
CA2802761C (en) 2010-06-16 2017-01-03 Endorecherche, Inc. Methods of treating or preventing estrogen-related diseases

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3396169A (en) 1966-10-26 1968-08-06 Upjohn Co Substituted 2-phenyl-1-(tertiary-aminoalkoxy) phenyl-3, 4-dihydronaphthalenes
US3274213A (en) 1961-09-05 1966-09-20 Upjohn Co Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3, 4-dihydronaphthalenes
US3862232A (en) 1963-07-03 1975-01-21 Upjohn Co 1-(p-hydroxyphenyl)-2-phenyl-6-(2-diethylaminoethoxy)-3,4-dihydronaphthalene and the salts thereof
US3313853A (en) 1963-10-16 1967-04-11 Upjohn Co 2-(tertiaryaminoalkoxyphenyl)-3, 4-dihydronaphthalenes and 2-(tertiaryaminoalkoxyphenyl) -3, 4- dihydro -1(2h)-naphthalenones
US3293263A (en) 1963-12-09 1966-12-20 Upjohn Co Diphenylbenzocycloalkenes
US3320271A (en) 1964-06-01 1967-05-16 Upjohn Co 1, 2-diphenyl-3, 4-dihydronaphthalenes and 2, 3-diphenylindenes
GB1138163A (en) 1965-05-21 1968-12-27 Bristol Myers Co Benzothiophene derivatives having anti-fertility properties
US3394125A (en) * 1965-10-23 1968-07-23 Bristol Myers Co 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US3483293A (en) 1967-12-15 1969-12-09 Upjohn Co Method for controlling birds and rodents
US3567737A (en) 1968-01-02 1971-03-02 Upjohn Co Derivatives of (2-cycloalkyl-1-phenyl-3,4-dihydronaphthalenes and) 2 - cycloalkyl - 1 - phenyl - 1,2,3,4 - tetrahydro-naphthalenes
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US3983245A (en) * 1975-02-06 1976-09-28 Smithkline Corporation Certain 4-(3-azacycloalkoxy or azacycloalkylmethoxy)benzoylbenzofurans or benzothiophenes
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4230862A (en) 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
EP0062503A1 (de) * 1981-04-03 1982-10-13 Eli Lilly And Company Benzothiophen-Verbindungen und Verfahren zu ihrer Herstellung
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4418068A (en) 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
GB8311678D0 (en) 1983-04-28 1983-06-02 Ici Plc Phenol derivatives
US4851554A (en) * 1987-04-06 1989-07-25 University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzofuran derivatives
US5254568A (en) 1990-08-09 1993-10-19 Council Of Scientific & Industrial Research Benzopyrans as antiestrogenic agents
DE4122484A1 (de) 1991-07-06 1993-01-07 Teves Gmbh Alfred Schaltungsanordnung zur erkennung von radsensordefekten
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
US5354861A (en) * 1992-11-04 1994-10-11 National University Of Singapore 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5484798A (en) * 1994-09-20 1996-01-16 Eli Lilly And Company Benzothiopene compounds, compositions, and method of inhibiting restenosis
US5622974A (en) * 1995-03-10 1997-04-22 Eli Lilly And Company α-substituted-3-benzyl-benzofurans
US5523309A (en) * 1995-03-10 1996-06-04 Eli Lilly And Company Benzofuran pharmaceutical compounds
JP4111352B2 (ja) 1996-05-21 2008-07-02 新日鐵住金ステンレス株式会社 ステンレス鋼の高清浄化精錬法

Also Published As

Publication number Publication date
DE69532079T2 (de) 2004-08-26
US6407243B1 (en) 2002-06-18
ES2210316T3 (es) 2004-07-01
EP0774966A1 (de) 1997-05-28
US6703407B1 (en) 2004-03-09
EP0774966A4 (de) 1998-01-07
WO1996009040A1 (en) 1996-03-28
ATE253567T1 (de) 2003-11-15
EP0774966B1 (de) 2003-11-05
AU3727795A (en) 1996-04-09

Similar Documents

Publication Publication Date Title
DE69532079D1 (de) Benzofuranverbindungen, präparate und verfahren
NZ294177A (en) 1-aralkyl-, 2-aryl-substituted naphthyl derivatives and pharmaceutical formulations
CA2228997A1 (en) Benzothiophene compounds
ATE234094T1 (de) 2-phenyl-3-aroylbenzothiophene zur behandlung der menstruellen symptome
ATE255570T1 (de) 1-aryloxy-2-arylnaphthylverbindungen, zwischenprodukte, zusammensetzungen und verfahren
MX9800800A (es) Compuestos, intermedios de naftilo y dihidronaftilo, composiciones y metodos.
HUP0000901A2 (hu) 16-Hidroxi-11-(szubsztituált fenil)ösztra-4,9-dién-származékok, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
TW372969B (en) Pharmaceutical composition for minimizing bone loss
MY113757A (en) Methods of inhibiting endometrial cancer
YU34296A (en) Use a compounds for medicament obtaining and pharmaceutical composition thereof
ATE314375T1 (de) Dihydro-dibenzo(b,e)oxepin-basierte, selektive oestrogen-rezeptor modulatoren, zusammensetzungen und methoden
AU2003247589A8 (en) Pentacyclic oxepines and derivatives thereof, process for their preparation and pharmaceutical compositions containing them
CA2170479A1 (en) Benzothiophene compounds, intermediates, compositions, and methods
MXPA05003166A (es) Derivados de dihidro-dibenzo (a) antracenos y su uso como modulares de receptores de estrogenos selectivos.
MY131931A (en) Methods of inhibiting primary endometrial hyperplasia
YU11896A (sh) Benzotiofenska jedinjenja, intermedijeri, kompozicije koje ih sadrže
TW254937B (en) Benzocycloheptene derivative and process for preparation thereof

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee