MXPA05003166A - Derivados de dihidro-dibenzo (a) antracenos y su uso como modulares de receptores de estrogenos selectivos. - Google Patents

Derivados de dihidro-dibenzo (a) antracenos y su uso como modulares de receptores de estrogenos selectivos.

Info

Publication number
MXPA05003166A
MXPA05003166A MXPA05003166A MXPA05003166A MXPA05003166A MX PA05003166 A MXPA05003166 A MX PA05003166A MX PA05003166 A MXPA05003166 A MX PA05003166A MX PA05003166 A MXPA05003166 A MX PA05003166A MX PA05003166 A MXPA05003166 A MX PA05003166A
Authority
MX
Mexico
Prior art keywords
alkyl
anthracenes
dibenzo
dihydro
derivative
Prior art date
Application number
MXPA05003166A
Other languages
English (en)
Inventor
Brendan Wallace Owen
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MXPA05003166A publication Critical patent/MXPA05003166A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente invencion proporciona un compuesto de la formula (I) en donde R1 es -H, -OH- -O(C1-C4 aquilo), -OCOC6H5 -OCO(C1-C6 aquilo), u -OSO2(C2-C6 aquilo); R0, R2 y R3 son cada uno independientemente -H, -OH, -O(C1-C4 aquilo), -OCOC6H5, -OCO(C1-C6 aquilo), u -OSO2(C2-C6 aquilo) o halo; R4 es 1-piperidinilo, 1-pirrolidinilo, metil-1-pirrolidinilo, dimetil-1-pirrolidinilo, 4-morfolino, dimetilamino, dietilamino, diisopropilamino o 1-hexametilenimino; n es 2 o 3; X es -S- o -HC=CH-; y o una sal farmaceuticamente aceptable del mismo; composiciones farmaceuticas del mismo, opcionalmente en combinacion con estrogeno y progestina; metodos para inhibir una enfermedad asociada con privacion de estrogeno; y metodos para inhibir una enfermedad asociada con una respuesta fisiologica aberrante a estrogeno endogeno (ver formula (I).
MXPA05003166A 2002-09-25 2003-09-22 Derivados de dihidro-dibenzo (a) antracenos y su uso como modulares de receptores de estrogenos selectivos. MXPA05003166A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41360902P 2002-09-25 2002-09-25
PCT/US2003/026304 WO2004029047A1 (en) 2002-09-25 2003-09-22 Derivative of dihydro-dibenzo (a) anthracenes and their use as selective estrogen receptor modulators

Publications (1)

Publication Number Publication Date
MXPA05003166A true MXPA05003166A (es) 2005-06-08

Family

ID=32043270

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05003166A MXPA05003166A (es) 2002-09-25 2003-09-22 Derivados de dihidro-dibenzo (a) antracenos y su uso como modulares de receptores de estrogenos selectivos.

Country Status (9)

Country Link
US (1) US7119206B2 (es)
EP (1) EP1546139A1 (es)
JP (1) JP2006508066A (es)
CN (1) CN1684958A (es)
AU (1) AU2003265581A1 (es)
BR (1) BR0314594A (es)
CA (1) CA2497627A1 (es)
MX (1) MXPA05003166A (es)
WO (1) WO2004029047A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101309903B (zh) * 2005-11-16 2012-10-03 弗·哈夫曼-拉罗切有限公司 制备thoc的新方法
CN105358586A (zh) 2013-07-17 2016-02-24 埃克森美孚化学专利公司 环丙基取代的茂金属催化剂

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2214715C3 (de) * 1972-03-25 1983-03-17 Gerhard 7166 Sulzbach-Laufen Hansen Schneckenstrangpresse für Kunststoffe
US4222726A (en) * 1978-12-04 1980-09-16 Wehr Corporation Brick press including a removable plunger assembly and method for removing the plunger assembly
AT368737B (de) * 1980-07-31 1982-11-10 Oesterr Schiffswerften Vorrichtung zum aufbereiten von thermoplastischem kunststoffgut
AT398937B (de) * 1992-06-12 1995-02-27 Erema Vorrichtung zum plastifizieren von thermoplastischem kunststoffgut
US5728724A (en) * 1995-08-17 1998-03-17 Eli Lilly And Company Benzothiophene compounds
US5726186A (en) 1995-09-08 1998-03-10 Eli Lilly And Company Pentacyclic compounds, intermediates, processes, compositions, and methods
US6126100A (en) * 1996-10-14 2000-10-03 Barth; Gerold Processing device for crushing, conveying and plastifying thermoplastic synthetic material
CN1447791A (zh) 2000-08-23 2003-10-08 阿克佐诺贝尔公司 药用的10－芳基－11H－苯并[b]芴衍生物和类似物

Also Published As

Publication number Publication date
AU2003265581A1 (en) 2004-04-19
WO2004029047A1 (en) 2004-04-08
CA2497627A1 (en) 2004-04-08
BR0314594A (pt) 2005-08-09
US7119206B2 (en) 2006-10-10
JP2006508066A (ja) 2006-03-09
EP1546139A1 (en) 2005-06-29
US20060122386A1 (en) 2006-06-08
CN1684958A (zh) 2005-10-19

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