NO309602B1 - Nye imidazolinforbindelser, fremgangsmåte ved fremstilling av dem og farmasöytiske sammensetninger som inneholder dem - Google Patents
Nye imidazolinforbindelser, fremgangsmåte ved fremstilling av dem og farmasöytiske sammensetninger som inneholder dem Download PDFInfo
- Publication number
- NO309602B1 NO309602B1 NO975591A NO975591A NO309602B1 NO 309602 B1 NO309602 B1 NO 309602B1 NO 975591 A NO975591 A NO 975591A NO 975591 A NO975591 A NO 975591A NO 309602 B1 NO309602 B1 NO 309602B1
- Authority
- NO
- Norway
- Prior art keywords
- formula
- pharmaceutically acceptable
- compound
- addition salts
- imidazoline
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims description 6
- 150000002462 imidazolines Chemical class 0.000 title description 9
- 150000001875 compounds Chemical class 0.000 claims abstract description 44
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- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical compound C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims description 18
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/06—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/08—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms with alkyl radicals, containing more than four carbon atoms, directly attached to ring carbon atoms
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- C07D233/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9614844A FR2756560A1 (fr) | 1996-12-04 | 1996-12-04 | Nouveaux derives de l'imidazoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO975591D0 NO975591D0 (no) | 1997-12-03 |
| NO975591L NO975591L (no) | 1998-06-05 |
| NO309602B1 true NO309602B1 (no) | 2001-02-26 |
Family
ID=9498304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO975591A NO309602B1 (no) | 1996-12-04 | 1997-12-03 | Nye imidazolinforbindelser, fremgangsmåte ved fremstilling av dem og farmasöytiske sammensetninger som inneholder dem |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5925665A (da) |
| EP (1) | EP0846688B1 (da) |
| JP (1) | JPH10168065A (da) |
| CN (1) | CN1091443C (da) |
| AT (1) | ATE189816T1 (da) |
| BR (1) | BR9706126A (da) |
| CA (1) | CA2223541A1 (da) |
| DE (1) | DE69701307T2 (da) |
| DK (1) | DK0846688T3 (da) |
| ES (1) | ES2145563T3 (da) |
| FR (1) | FR2756560A1 (da) |
| GR (1) | GR3032715T3 (da) |
| HK (1) | HK1011207A1 (da) |
| HU (1) | HUP9702341A3 (da) |
| NO (1) | NO309602B1 (da) |
| NZ (1) | NZ329312A (da) |
| PL (1) | PL323515A1 (da) |
| PT (1) | PT846688E (da) |
| ZA (1) | ZA9710918B (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999032112A1 (en) * | 1997-12-19 | 1999-07-01 | Eli Lilly And Company | Method for treating diabetes |
| EP1266897A3 (en) * | 1997-12-19 | 2003-12-03 | Eli Lilly And Company | Hypoglycemic imidazoline compounds |
| FR2787451B1 (fr) * | 1998-12-18 | 2001-01-26 | Adir | Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| GB9914255D0 (en) * | 1999-06-18 | 1999-08-18 | Lilly Forschung Gmbh | Pharmaceutical compounds |
| GB2351082A (en) * | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Synthesis of Cyclic Substituted Amidines |
| GB2351081A (en) * | 1999-06-18 | 2000-12-20 | Lilly Forschung Gmbh | Pharmaceutically active imidazoline compounds and analogues thereof |
| US20040009976A1 (en) * | 2002-04-30 | 2004-01-15 | Kumiko Takeuchi | Hypoglycemic imidazoline compounds |
| PL372695A1 (en) * | 2002-06-19 | 2005-07-25 | Solvay Pharmaceuticals Gmbh | Medicament for the treatment of diseases requiring inhibition or a reduction in the activity of ph value-regulating bicarbonate transporter proteins |
| DE10315640A1 (de) * | 2003-04-04 | 2004-10-14 | Ignatov, Konstantin | Verfahren zur kontrollierten Freisetzung von Komponenten in eine Lösung |
| KR20080027969A (ko) * | 2004-05-18 | 2008-03-28 | 에프. 호프만-라 로슈 아게 | 신규 ｃｉｓ-이미다졸린 |
| CN103275011A (zh) * | 2013-06-13 | 2013-09-04 | 南京工业大学 | 咪唑烷类杂环的新合成方法 |
| JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス，インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
| CN112624975A (zh) * | 2020-11-27 | 2021-04-09 | 华南农业大学 | 一种妥拉唑林半抗原、人工抗原、抗体及其制备和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140859A (en) * | 1974-11-04 | 1979-02-20 | Sandoz, Inc. | Dilithiated 2-(o-tolyl)-2-imidazolines |
| DE2854428A1 (de) * | 1978-12-16 | 1980-06-26 | Basf Ag | Verfahren zur herstellung von 2-imidazolinen |
| US4910206A (en) * | 1986-07-14 | 1990-03-20 | Sandoz Pharmaceuticals Corp. | 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and their use as PAF receptor antagonists |
| JP2545646B2 (ja) * | 1990-11-22 | 1996-10-23 | 松下電器産業株式会社 | 非線形光学材料 |
| US5574059A (en) * | 1995-10-27 | 1996-11-12 | Cornell Research Foundation, Inc. | Treating disorders mediated by vascular smooth muscle cell proliferation |
-
1996
- 1996-12-04 FR FR9614844A patent/FR2756560A1/fr not_active Withdrawn
-
1997
- 1997-12-01 JP JP9330116A patent/JPH10168065A/ja active Pending
- 1997-12-02 ES ES97402891T patent/ES2145563T3/es not_active Expired - Lifetime
- 1997-12-02 DK DK97402891T patent/DK0846688T3/da active
- 1997-12-02 EP EP97402891A patent/EP0846688B1/fr not_active Expired - Lifetime
- 1997-12-02 PT PT97402891T patent/PT846688E/pt unknown
- 1997-12-02 DE DE69701307T patent/DE69701307T2/de not_active Expired - Fee Related
- 1997-12-02 AT AT97402891T patent/ATE189816T1/de not_active IP Right Cessation
- 1997-12-02 CA CA002223541A patent/CA2223541A1/fr not_active Abandoned
- 1997-12-03 CN CN97125774A patent/CN1091443C/zh not_active Expired - Fee Related
- 1997-12-03 NZ NZ329312A patent/NZ329312A/en unknown
- 1997-12-03 BR BR9706126A patent/BR9706126A/pt unknown
- 1997-12-03 US US08/984,673 patent/US5925665A/en not_active Expired - Fee Related
- 1997-12-03 HU HU9702341A patent/HUP9702341A3/hu unknown
- 1997-12-03 NO NO975591A patent/NO309602B1/no unknown
- 1997-12-04 PL PL97323515A patent/PL323515A1/xx unknown
- 1997-12-04 ZA ZA9710918A patent/ZA9710918B/xx unknown
-
1998
- 1998-11-24 HK HK98112253A patent/HK1011207A1/xx not_active IP Right Cessation
-
2000
- 2000-02-21 GR GR20000400414T patent/GR3032715T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3032715T3 (en) | 2000-06-30 |
| CA2223541A1 (fr) | 1998-06-04 |
| AU4765297A (en) | 1998-06-11 |
| DK0846688T3 (da) | 2000-07-17 |
| PT846688E (pt) | 2000-05-31 |
| BR9706126A (pt) | 1999-05-18 |
| EP0846688A1 (fr) | 1998-06-10 |
| HU9702341D0 (en) | 1998-03-02 |
| NO975591L (no) | 1998-06-05 |
| FR2756560A1 (fr) | 1998-06-05 |
| HUP9702341A2 (hu) | 1998-07-28 |
| CN1091443C (zh) | 2002-09-25 |
| US5925665A (en) | 1999-07-20 |
| HK1011207A1 (en) | 1999-07-09 |
| AU719145B2 (en) | 2000-05-04 |
| ES2145563T3 (es) | 2000-07-01 |
| EP0846688B1 (fr) | 2000-02-16 |
| HUP9702341A3 (en) | 1999-04-28 |
| ZA9710918B (en) | 1998-06-15 |
| JPH10168065A (ja) | 1998-06-23 |
| CN1186074A (zh) | 1998-07-01 |
| PL323515A1 (en) | 1998-06-08 |
| DE69701307T2 (de) | 2000-09-14 |
| NO975591D0 (no) | 1997-12-03 |
| ATE189816T1 (de) | 2000-03-15 |
| NZ329312A (en) | 1998-07-28 |
| DE69701307D1 (de) | 2000-03-23 |
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