NO307829B1 - Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat - Google Patents

Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat

Info

Publication number
NO307829B1
NO307829B1 NO943629A NO943629A NO307829B1 NO 307829 B1 NO307829 B1 NO 307829B1 NO 943629 A NO943629 A NO 943629A NO 943629 A NO943629 A NO 943629A NO 307829 B1 NO307829 B1 NO 307829B1
Authority
NO
Norway
Prior art keywords
compounds
quinazolines
antiproliferative
preparation
pharmaceutical composition
Prior art date
Application number
NO943629A
Other languages
English (en)
Norwegian (no)
Other versions
NO943629L (no
NO943629D0 (no
Inventor
Stephen E Webber
Ted M Bleckman
John Attard
Terence R Jones
Michael D Varney
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of NO943629L publication Critical patent/NO943629L/no
Publication of NO943629D0 publication Critical patent/NO943629D0/no
Publication of NO307829B1 publication Critical patent/NO307829B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/93—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO943629A 1992-03-31 1994-09-29 Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat NO307829B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/861,030 US5430148A (en) 1992-03-31 1992-03-31 Antiproliferative quinazolines
PCT/US1993/002636 WO1993020055A1 (en) 1992-03-31 1993-03-26 Antiproliferative quinazolines

Publications (3)

Publication Number Publication Date
NO943629L NO943629L (no) 1994-09-29
NO943629D0 NO943629D0 (no) 1994-09-29
NO307829B1 true NO307829B1 (no) 2000-06-05

Family

ID=25334675

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943629A NO307829B1 (no) 1992-03-31 1994-09-29 Antiproliferative quinazoliner, anvendelse, fremgangsmÕte for fremstilling derav samt farmasøytisk preparat

Country Status (20)

Country Link
US (3) US5430148A (da)
EP (1) EP0637300B1 (da)
JP (1) JP3272357B2 (da)
KR (1) KR100226114B1 (da)
AT (1) ATE205197T1 (da)
AU (1) AU681075B2 (da)
CA (2) CA2474211C (da)
DE (1) DE69330715T2 (da)
DK (1) DK0637300T3 (da)
ES (1) ES2162818T3 (da)
FI (1) FI113765B (da)
HU (1) HU222523B1 (da)
MD (1) MD1638G2 (da)
NO (1) NO307829B1 (da)
NZ (1) NZ251804A (da)
PT (1) PT637300E (da)
RU (1) RU2135481C1 (da)
SG (2) SG46672A1 (da)
TJ (1) TJ272B (da)
WO (1) WO1993020055A1 (da)

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US7371778B2 (en) * 2002-06-21 2008-05-13 Medicines For Malaria Venture Mmv Spiro and dispiro 1,2,4-trioxolane antimalarials
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Also Published As

Publication number Publication date
TJ272B (en) 2000-10-05
FI113765B (fi) 2004-06-15
WO1993020055A1 (en) 1993-10-14
NO943629L (no) 1994-09-29
ES2162818T3 (es) 2002-01-16
FI944525A (fi) 1994-09-29
CA2474211C (en) 2006-10-03
AU681075B2 (en) 1997-08-21
US5430148A (en) 1995-07-04
SG46672A1 (en) 1998-02-20
MD1638F2 (en) 2001-03-31
CA2132514C (en) 2004-10-26
DK0637300T3 (da) 2001-12-10
PT637300E (pt) 2002-01-30
JP3272357B2 (ja) 2002-04-08
CA2474211A1 (en) 1993-10-14
HUT68580A (en) 1995-06-28
CA2132514A1 (en) 1993-10-14
US5885996A (en) 1999-03-23
DE69330715D1 (de) 2001-10-11
RU2135481C1 (ru) 1999-08-27
AU3966493A (en) 1993-11-08
FI944525A0 (fi) 1994-09-29
HU9402799D0 (en) 1994-12-28
HU222523B1 (hu) 2003-08-28
KR100226114B1 (ko) 1999-10-15
NZ251804A (en) 1997-06-24
MD1638G2 (ro) 2001-09-30
RU94045251A (ru) 1996-07-20
US5707992A (en) 1998-01-13
JPH07505395A (ja) 1995-06-15
DE69330715T2 (de) 2002-02-14
SG93183A1 (en) 2002-12-17
NO943629D0 (no) 1994-09-29
EP0637300B1 (en) 2001-09-05
ATE205197T1 (de) 2001-09-15
EP0637300A1 (en) 1995-02-08

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