NO307380B1 - Polyazamakrocykliske forbindelser, metallionkompleksforbindelser av slike, fremgangsmåte for bestemmelse av intracellulær konsentrasjon av et toverdig metallion, samt anvendelse av nevnte polyazamakrocykliske metallkompleksforbindelser - Google Patents

Polyazamakrocykliske forbindelser, metallionkompleksforbindelser av slike, fremgangsmåte for bestemmelse av intracellulær konsentrasjon av et toverdig metallion, samt anvendelse av nevnte polyazamakrocykliske metallkompleksforbindelser

Info

Publication number
NO307380B1
NO307380B1 NO931793A NO931793A NO307380B1 NO 307380 B1 NO307380 B1 NO 307380B1 NO 931793 A NO931793 A NO 931793A NO 931793 A NO931793 A NO 931793A NO 307380 B1 NO307380 B1 NO 307380B1
Authority
NO
Norway
Prior art keywords
polyazamacrocyclic
metal ion
compounds
complex compounds
metal
Prior art date
Application number
NO931793A
Other languages
English (en)
Norwegian (no)
Other versions
NO931793L (no
NO931793D0 (no
Inventor
A Dean Sherry
Istvan Lazar
Ravichandran Ramasamy
Erno Brucher
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/662,075 external-priority patent/US4639365A/en
Application filed by Univ Texas filed Critical Univ Texas
Publication of NO931793L publication Critical patent/NO931793L/no
Publication of NO931793D0 publication Critical patent/NO931793D0/no
Publication of NO307380B1 publication Critical patent/NO307380B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Laminated Bodies (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
NO931793A 1984-10-18 1993-05-18 Polyazamakrocykliske forbindelser, metallionkompleksforbindelser av slike, fremgangsmåte for bestemmelse av intracellulær konsentrasjon av et toverdig metallion, samt anvendelse av nevnte polyazamakrocykliske metallkompleksforbindelser NO307380B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/662,075 US4639365A (en) 1984-10-18 1984-10-18 Gadolinium chelates as NMR contrast agents
US07/615,619 US5342606A (en) 1984-10-18 1990-11-19 Polyazamacrocyclic compounds for complexation of metal ions
PCT/US1991/008438 WO1992008725A1 (en) 1984-10-18 1991-11-12 Polyazamacrocyclic compounds for complexation of metal ions

Publications (3)

Publication Number Publication Date
NO931793L NO931793L (no) 1993-05-18
NO931793D0 NO931793D0 (no) 1993-05-18
NO307380B1 true NO307380B1 (no) 2000-03-27

Family

ID=34922814

Family Applications (1)

Application Number Title Priority Date Filing Date
NO931793A NO307380B1 (no) 1984-10-18 1993-05-18 Polyazamakrocykliske forbindelser, metallionkompleksforbindelser av slike, fremgangsmåte for bestemmelse av intracellulær konsentrasjon av et toverdig metallion, samt anvendelse av nevnte polyazamakrocykliske metallkompleksforbindelser

Country Status (20)

Country Link
US (1) US5342606A (de)
JP (1) JP3334717B2 (de)
CN (2) CN1036717C (de)
AT (1) ATE144522T1 (de)
AU (1) AU654987B2 (de)
CA (1) CA2095615C (de)
DE (1) DE69122881T2 (de)
ES (1) ES2093816T3 (de)
FI (1) FI932231A0 (de)
HK (1) HK88897A (de)
HU (1) HUT64768A (de)
IE (1) IE914001A1 (de)
IL (1) IL100073A (de)
MX (1) MX9102116A (de)
NO (1) NO307380B1 (de)
NZ (1) NZ240626A (de)
PT (1) PT99556B (de)
SG (1) SG48154A1 (de)
WO (1) WO1992008725A1 (de)
ZA (1) ZA919127B (de)

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IE911297A1 (en) * 1990-04-18 1991-10-23 Celltech Therapeutics Ltd Tetra-aza macrocycles, processes for their preparation, and¹their use in magnetic resonance imaging

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DE69122881T2 (de) 1997-04-03
FI932231A (fi) 1993-05-17
CA2095615A1 (en) 1992-05-20
SG48154A1 (en) 1998-04-17
CN1066073A (zh) 1992-11-11
US5342606A (en) 1994-08-30
IL100073A (en) 1997-11-20
AU9077091A (en) 1992-06-11
JP3334717B2 (ja) 2002-10-15
CA2095615C (en) 2003-07-08
WO1992008725A1 (en) 1992-05-29
CN1036717C (zh) 1997-12-17
IE914001A1 (en) 1992-05-20
NO931793L (no) 1993-05-18
PT99556B (pt) 1999-04-30
ES2093816T3 (es) 1997-01-01
IL100073A0 (en) 1992-08-18
JPH06502645A (ja) 1994-03-24
ATE144522T1 (de) 1996-11-15
ZA919127B (en) 1993-05-18
NZ240626A (en) 1994-11-25
NO931793D0 (no) 1993-05-18
HK88897A (en) 1997-06-27
PT99556A (pt) 1992-10-30
HUT64768A (en) 1994-02-28
DE69122881D1 (de) 1996-11-28
AU654987B2 (en) 1994-12-01
HU9301431D0 (en) 1993-12-28
FI932231A0 (fi) 1993-05-17
MX9102116A (es) 1992-06-01
CN1193625A (zh) 1998-09-23

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