NO303398B1 - FremgangsmÕte for fremstilling av rekombinant biologisk aktivt humant erytropoietin, ekspresjonsvektor samt cellelinje til bruk ved fremstillingen - Google Patents
FremgangsmÕte for fremstilling av rekombinant biologisk aktivt humant erytropoietin, ekspresjonsvektor samt cellelinje til bruk ved fremstillingen Download PDFInfo
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- NO303398B1 NO303398B1 NO880863A NO880863A NO303398B1 NO 303398 B1 NO303398 B1 NO 303398B1 NO 880863 A NO880863 A NO 880863A NO 880863 A NO880863 A NO 880863A NO 303398 B1 NO303398 B1 NO 303398B1
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- erythropoietin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10341—Use of virus, viral particle or viral elements as a vector
- C12N2795/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
- C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87942386A | 1986-06-27 | 1986-06-27 | |
| PCT/US1987/001459 WO1988000241A1 (en) | 1986-06-27 | 1987-06-23 | Human erythropoietin gene: high level expression in stably transfected mammalian cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO880863D0 NO880863D0 (no) | 1988-02-26 |
| NO880863L NO880863L (no) | 1988-04-26 |
| NO303398B1 true NO303398B1 (no) | 1998-07-06 |
Family
ID=25374134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO880863A NO303398B1 (no) | 1986-06-27 | 1988-02-26 | FremgangsmÕte for fremstilling av rekombinant biologisk aktivt humant erytropoietin, ekspresjonsvektor samt cellelinje til bruk ved fremstillingen |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US5688679A (pt) |
| EP (1) | EP0255231B1 (pt) |
| JP (1) | JPS63126488A (pt) |
| KR (1) | KR970009935B1 (pt) |
| CN (2) | CN101041819A (pt) |
| AT (1) | ATE76431T1 (pt) |
| AU (1) | AU611088B2 (pt) |
| BR (1) | BR8703269A (pt) |
| CA (1) | CA1341361C (pt) |
| DE (1) | DE3779206D1 (pt) |
| DK (1) | DK173067B1 (pt) |
| ES (1) | ES2037083T3 (pt) |
| FI (1) | FI95393C (pt) |
| GR (1) | GR3004707T3 (pt) |
| NO (1) | NO303398B1 (pt) |
| PT (1) | PT85193B (pt) |
| WO (1) | WO1988000241A1 (pt) |
Families Citing this family (73)
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| DK173067B1 (da) * | 1986-06-27 | 1999-12-13 | Univ Washington | Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa |
| US6048729A (en) | 1987-05-01 | 2000-04-11 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| US4974929A (en) * | 1987-09-22 | 1990-12-04 | Baxter International, Inc. | Fiber optical probe connector for physiologic measurement devices |
| PT101031B (pt) * | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
| US6063630A (en) * | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
| US6054288A (en) * | 1991-11-05 | 2000-04-25 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6692737B1 (en) | 1991-11-05 | 2004-02-17 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| US5733761A (en) * | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6531124B1 (en) | 1992-07-10 | 2003-03-11 | Transkaryotic Therapies, Inc. | In vivo production and delivery of insulinotropin for gene therapy |
| US6670178B1 (en) | 1992-07-10 | 2003-12-30 | Transkaryotic Therapies, Inc. | In Vivo production and delivery of insulinotropin for gene therapy |
| US6153407A (en) * | 1992-07-28 | 2000-11-28 | Beth Israel Deaconess Medical Center | Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics |
| CA2183551A1 (en) * | 1993-11-10 | 1995-05-18 | Babru B. Samal | Gene therapy vector for the treatment of low or defective red blood cell production |
| US5919758A (en) * | 1994-03-22 | 1999-07-06 | Beth Israel Deaconess Medical Center | Modified polypeptides with altered biological activity |
| US5888774A (en) * | 1994-12-19 | 1999-03-30 | Cangene Corporation | Recombinant DNA molecules and expression vectors for erythropoietin |
| US5952226A (en) * | 1996-11-05 | 1999-09-14 | Modex Therapeutiques | Hypoxia responsive EPO producing cells |
| US6187564B1 (en) | 1997-07-10 | 2001-02-13 | Beth Israel Deaconess Medical Center | DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics |
| US20020088019A1 (en) * | 1997-09-02 | 2002-07-04 | Oron Yacoby-Zeevi | Methods of and pharmaceutical compositions for improving implantation of embryos |
| US20040213789A1 (en) * | 1997-09-02 | 2004-10-28 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies |
| US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
| US20030161823A1 (en) * | 1998-08-31 | 2003-08-28 | Neta Ilan | Therapeutic and cosmetic uses of heparanases |
| US6699672B1 (en) | 1997-09-02 | 2004-03-02 | Insight Biopharmaceuticals Ltd. | Heparanase specific molecular probes and their use research and medical applications |
| US6897066B1 (en) * | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| DE69824039T2 (de) | 1997-12-08 | 2005-08-18 | Lexigen Pharmaceuticals Corp., Lexington | Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung |
| US6777205B1 (en) | 1998-11-06 | 2004-08-17 | Sterrenbeld Biotechnologie North America, Inc. | Host cells expressing recombinant human erythropoietin |
| BR9917606A (pt) | 1998-11-06 | 2002-12-31 | Bio Sidus S A | Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento |
| BR9905868A (pt) | 1998-11-06 | 2001-01-23 | Bio Sidus S A | Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento |
| AU2878600A (en) * | 1999-03-01 | 2000-09-21 | Hadasit Medical Research Services & Development Company Ltd | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells |
| RU2225221C2 (ru) * | 1999-04-09 | 2004-03-10 | Орто-Макнейл Фармасьютикал, Инк. | ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ Эритропоэтина |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| DK1200479T3 (da) | 1999-08-09 | 2006-05-15 | Emd Lexigen Res Ct Corp | Multiple cytokin-antistof-komplekser |
| JP2003514552A (ja) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
| CN1406249B (zh) | 2000-02-11 | 2010-06-16 | 默克专利股份有限公司 | 增加基于抗体的融合蛋白的循环半衰期 |
| US7259146B2 (en) | 2000-05-26 | 2007-08-21 | Ortho-Mcneil Pharmaceutical, Inc. | Neuroprotective peptides |
| ATE368475T1 (de) | 2000-06-29 | 2007-08-15 | Emd Lexigen Res Ct Corp | Steigerung von durch antikörper-zytokin- fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme |
| US7078376B1 (en) | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
| DE60138404D1 (de) | 2000-09-25 | 2009-05-28 | Baylor College Medicine | Verbessertes system zur regulation der transgenexpression |
| ATE361089T1 (de) | 2001-02-02 | 2007-05-15 | Ortho Mcneil Pharm Inc | Behandlung von neurologischen funktionsstörungen mit fructopyranosesulfamaten und erythropoetin |
| PL206701B1 (pl) | 2001-03-07 | 2010-09-30 | Merck Patent Gmbh | Immunoglobulinowe białko fuzyjne, kodujący je kwas nukleinowy, replikujący wektor ekspresji zawierający taki kwas nukleinowy, eukariotyczna komórka gospodarza zawierająca taki wektor ekspresji oraz sposób zwiększania ekspresji takiego białka fuzyjnego |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| PL205352B1 (pl) | 2001-05-03 | 2010-04-30 | Merck Patent Gmbh | Rekombinowane przeciwciało specyficzne dla nowotworu |
| US6818613B2 (en) | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
| US6671189B2 (en) * | 2001-11-09 | 2003-12-30 | Minebea Co., Ltd. | Power converter having primary and secondary side switches |
| BR0214557A (pt) * | 2001-11-28 | 2006-06-06 | Ortho Mcneil Pharm Inc | regime de dosagem de eritropoietina para o tratamento de anemia |
| JP4795640B2 (ja) | 2001-12-04 | 2011-10-19 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 調節された選択性を有する免疫サイトカイン |
| AU2003218045A1 (en) * | 2002-03-11 | 2003-09-29 | Ortho Mcneil Pharmaceutical, Inc | Methods for shp1 mediated neuroprotection |
| DE10234192B4 (de) | 2002-07-26 | 2009-11-26 | Epoplus Gmbh Co.Kg | Verwendung von Erythropoetin |
| ES2343518T3 (es) * | 2002-09-09 | 2010-08-03 | Hanall Biopharma Co., Ltd. | Polipeptidos interferon alfa modificados resistentes a proteasas. |
| AU2003298187B2 (en) | 2002-12-17 | 2010-09-16 | Merck Patent Gmbh | Humanized antibody (H14.18) of the mouse 14.18 antibody binding to GD2 and its fusion with IL-2 |
| MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
| US20060269552A1 (en) * | 2003-06-09 | 2006-11-30 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monclonal antibody and other anti-heparanase antibodies |
| US7141544B2 (en) * | 2003-10-10 | 2006-11-28 | Baxter International, Inc. | Stabilization of pharmaceutical protein formulations with small peptides |
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| US7423139B2 (en) * | 2004-01-20 | 2008-09-09 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
| US20050238628A1 (en) * | 2004-04-08 | 2005-10-27 | Blau Carl A | Methods for treating cancer |
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| CN101062407A (zh) | 2006-04-29 | 2007-10-31 | 中国科学院上海生命科学研究院 | 促红细胞生成素在预防或治疗视网膜损伤中的用途 |
| WO2008065372A2 (en) | 2006-11-28 | 2008-06-05 | Nautilus Biotech, S.A. | Modified erythropoietin polypeptides and uses thereof for treatment |
| US20090143255A1 (en) * | 2007-11-30 | 2009-06-04 | Funkhouser Gary P | Methods and Compositions for Improving Well Bore Stability in Subterranean Formations |
| EP2247743B1 (en) | 2008-02-08 | 2016-04-06 | Ambrx, Inc. | Modified leptin polypeptides and their uses |
| ES2435272T3 (es) | 2008-09-23 | 2013-12-17 | F. Hoffmann-La Roche Ag | Purificación de la eritropoyetina |
| MX346001B (es) | 2008-09-26 | 2017-03-01 | Ambrx Inc | Polipeptidos de eritropoyetina animal modificados y sus usos. |
| JP6091752B2 (ja) | 2008-12-04 | 2017-03-08 | クルナ・インコーポレーテッド | Ｅｐｏに対する天然アンチセンス転写物の抑制によるエリスロポエチン（ｅｐｏ）関連疾患の治療 |
| WO2010108503A1 (en) | 2009-03-24 | 2010-09-30 | Life & Brain Gmbh | Promotion of neuronal integration in neural stem cell grafts |
| WO2013120500A1 (en) * | 2012-02-15 | 2013-08-22 | Curevac Gmbh | Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded tumour antigen |
| US10066001B2 (en) | 2013-03-15 | 2018-09-04 | Apotex Inc. | Enhanced liquid formulation stability of erythropoietin alpha through purification processing |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| JP6245299B2 (ja) * | 2016-04-27 | 2017-12-13 | バクスアルタ ゲーエムベーハー | 組換え安定細胞クローン、その産生およびその使用 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6045849B2 (ja) * | 1980-08-25 | 1985-10-12 | 林原 健 | ヒトエリトロポエチンの製造方法 |
| NZ210501A (en) * | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
| US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| IT1185503B (it) * | 1984-01-11 | 1987-11-12 | Univ New York | Cloni di odna di eritropietina umana |
| IL77081A (en) * | 1984-12-04 | 1999-10-28 | Genetics Inst | AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin |
| EP0217822B1 (en) * | 1985-02-13 | 1993-05-12 | Scios Nova Inc. | Human metallothionein-ii promoter in mammalian expression system |
| US4751084A (en) * | 1986-02-26 | 1988-06-14 | Monsanto Company | Tissue plasminogen activator from normal human colon cells |
| EP0236059B1 (en) * | 1986-02-27 | 1994-04-27 | Snow Brand Milk Products Co. Ltd. | Preparation of erythropoietin-producing cells and production process of erythropoietin using same |
| DK173067B1 (da) * | 1986-06-27 | 1999-12-13 | Univ Washington | Humant erythropoietin-gen, fremgangsmåde til ekspression deraf i transficerede cellelinier, de transficerede cellelinier sa |
| US4835260A (en) * | 1987-03-20 | 1989-05-30 | Genetics Institute, Inc. | Erythropoietin composition |
-
1987
- 1987-06-17 DK DK198703093A patent/DK173067B1/da not_active IP Right Cessation
- 1987-06-22 CA CA000616544A patent/CA1341361C/en not_active Expired - Fee Related
- 1987-06-23 WO PCT/US1987/001459 patent/WO1988000241A1/en active IP Right Grant
- 1987-06-25 DE DE8787305672T patent/DE3779206D1/de not_active Expired - Lifetime
- 1987-06-25 ES ES198787305672T patent/ES2037083T3/es not_active Expired - Lifetime
- 1987-06-25 EP EP87305672A patent/EP0255231B1/en not_active Expired - Lifetime
- 1987-06-25 AT AT87305672T patent/ATE76431T1/de not_active IP Right Cessation
- 1987-06-26 CN CNA2006101006871A patent/CN101041819A/zh active Pending
- 1987-06-26 BR BR8703269A patent/BR8703269A/pt not_active Application Discontinuation
- 1987-06-26 CN CN87104424A patent/CN1044133C/zh not_active Expired - Lifetime
- 1987-06-26 AU AU74757/87A patent/AU611088B2/en not_active Expired
- 1987-06-26 PT PT85193A patent/PT85193B/pt not_active IP Right Cessation
- 1987-06-27 KR KR1019870006561A patent/KR970009935B1/ko not_active IP Right Cessation
- 1987-06-27 JP JP62160799A patent/JPS63126488A/ja active Pending
-
1988
- 1988-02-26 FI FI880899A patent/FI95393C/fi not_active IP Right Cessation
- 1988-02-26 NO NO880863A patent/NO303398B1/no not_active IP Right Cessation
-
1992
- 1992-05-26 GR GR920401043T patent/GR3004707T3/el unknown
-
1993
- 1993-10-06 US US08/132,489 patent/US5688679A/en not_active Expired - Lifetime
-
2001
- 2001-10-10 US US09/975,063 patent/US6867020B2/en not_active Expired - Fee Related
- 2001-11-05 US US10/011,858 patent/US6682910B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI95393B (fi) | 1995-10-13 |
| JPS63126488A (ja) | 1988-05-30 |
| DK309387A (da) | 1987-12-28 |
| ES2037083T3 (es) | 1993-06-16 |
| GR3004707T3 (pt) | 1993-04-28 |
| DK173067B1 (da) | 1999-12-13 |
| NO880863D0 (no) | 1988-02-26 |
| ATE76431T1 (de) | 1992-06-15 |
| FI880899A (fi) | 1988-02-26 |
| CA1341361C (en) | 2002-05-21 |
| CN87104424A (zh) | 1988-04-27 |
| NO880863L (no) | 1988-04-26 |
| US6682910B2 (en) | 2004-01-27 |
| FI95393C (fi) | 1996-01-25 |
| US20020137145A1 (en) | 2002-09-26 |
| EP0255231A1 (en) | 1988-02-03 |
| EP0255231B1 (en) | 1992-05-20 |
| US6867020B2 (en) | 2005-03-15 |
| AU611088B2 (en) | 1991-06-06 |
| KR880007726A (ko) | 1988-08-29 |
| KR970009935B1 (ko) | 1997-06-19 |
| FI880899A0 (fi) | 1988-02-26 |
| WO1988000241A1 (en) | 1988-01-14 |
| AU7475787A (en) | 1988-01-07 |
| US5688679A (en) | 1997-11-18 |
| DE3779206D1 (de) | 1992-06-25 |
| BR8703269A (pt) | 1988-03-15 |
| US20020045255A1 (en) | 2002-04-18 |
| CN1044133C (zh) | 1999-07-14 |
| PT85193B (pt) | 1990-08-31 |
| CN101041819A (zh) | 2007-09-26 |
| PT85193A (en) | 1987-07-01 |
| DK309387D0 (da) | 1987-06-17 |
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