NO301075B1 - Antistoff som er selektive for TAG-72 for diagnostisk bruk, DNA-sekvens som koder for det, ekspresjonsbærer og celle som kan uttrykke det samt blanding som omfatter antistoffet - Google Patents
Antistoff som er selektive for TAG-72 for diagnostisk bruk, DNA-sekvens som koder for det, ekspresjonsbærer og celle som kan uttrykke det samt blanding som omfatter antistoffet Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
- A61K47/6877—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the antibody being an immunoglobulin containing regions, domains or residues from different species
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
- A61K51/1087—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin the immunoglobulin comprises domains from different animal species, e.g. chimeric immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Optics & Photonics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO19960274A NO316023B1 (no) | 1988-10-19 | 1996-01-23 | Fremgangsmåte for fremstilling av et terapeutisk aktivt antistoff eller etterapeutisk aktivt fragment derav som er selektive for TAG-72 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25994388A | 1988-10-19 | 1988-10-19 | |
| PCT/US1989/004402 WO1990004410A1 (en) | 1988-10-19 | 1989-10-04 | A novel family of high affinity, modified antibodies for cancer treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO902696D0 NO902696D0 (no) | 1990-06-18 |
| NO902696L NO902696L (no) | 1990-08-16 |
| NO301075B1 true NO301075B1 (no) | 1997-09-08 |
Family
ID=22987104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO902696A NO301075B1 (no) | 1988-10-19 | 1990-06-18 | Antistoff som er selektive for TAG-72 for diagnostisk bruk, DNA-sekvens som koder for det, ekspresjonsbærer og celle som kan uttrykke det samt blanding som omfatter antistoffet |
Country Status (21)
| Country | Link |
|---|---|
| EP (2) | EP0397821A4 (fi) |
| JP (1) | JP2935520B2 (fi) |
| KR (1) | KR0161525B1 (fi) |
| AR (1) | AR242434A1 (fi) |
| AT (1) | ATE111519T1 (fi) |
| AU (2) | AU4429989A (fi) |
| BR (1) | BR8907126A (fi) |
| CA (1) | CA2000913C (fi) |
| DE (1) | DE68918217T2 (fi) |
| DK (1) | DK173089B1 (fi) |
| ES (1) | ES2059670T3 (fi) |
| FI (1) | FI103181B1 (fi) |
| HK (1) | HK162795A (fi) |
| HU (1) | HU218093B (fi) |
| IE (1) | IE64966B1 (fi) |
| IL (1) | IL92037A (fi) |
| NO (1) | NO301075B1 (fi) |
| NZ (1) | NZ231012A (fi) |
| PT (1) | PT92013B (fi) |
| WO (1) | WO1990004410A1 (fi) |
| ZA (1) | ZA897858B (fi) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5869620A (en) * | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5976531A (en) * | 1990-04-19 | 1999-11-02 | The Dow Chemical Company | Composite antibodies of human subgroup IV light chain capable of binding to tag-72 |
| US6495137B1 (en) * | 1990-04-19 | 2002-12-17 | The Dow Chemical Company | Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa light chains |
| US6407213B1 (en) | 1991-06-14 | 2002-06-18 | Genentech, Inc. | Method for making humanized antibodies |
| US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| IE922287A1 (en) * | 1991-07-15 | 1993-01-27 | Wellcome Found | Production of antibodies |
| US6025165A (en) * | 1991-11-25 | 2000-02-15 | Enzon, Inc. | Methods for producing multivalent antigen-binding proteins |
| EP0618969B1 (en) * | 1991-12-13 | 2003-06-25 | The Dow Chemical Company | Composite antibodies of human subgroup iv light chain capable of binding to tag-72 |
| AU696627B2 (en) * | 1991-12-13 | 1998-09-17 | Dow Chemical Company, The | Composite antibodies of human subgroup IV light chain capable of binding to TAG-72 |
| WO1994012520A1 (en) * | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| JP3312357B2 (ja) | 1992-12-11 | 2002-08-05 | ザ ダウ ケミカル カンパニー | 多価の一本鎖抗体 |
| US6348581B1 (en) | 1996-10-31 | 2002-02-19 | The Dow Chemical Company | High affinity humanized anti-TAG-72 monoclonalantibodies |
| CA2321932A1 (en) * | 1998-02-25 | 1999-09-02 | The Dow Chemical Company | High affinity humanized anti-tag-72 monoclonal antibodies |
| US6818749B1 (en) | 1998-10-31 | 2004-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Variants of humanized anti carcinoma monoclonal antibody cc49 |
| US7560534B2 (en) | 2000-05-08 | 2009-07-14 | Celldex Research Corporation | Molecular conjugates comprising human monoclonal antibodies to dendritic cells |
| US7319139B2 (en) | 2001-01-29 | 2008-01-15 | Biogen Idec, Inc. | TAG-72 specific CH2 domain deleted antibodies |
| WO2004003155A2 (en) | 2002-06-28 | 2004-01-08 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Humanized anti-tag-72 cc49 for diagnosis and therapy of human tumors |
| DE10311248A1 (de) * | 2003-03-14 | 2004-09-30 | Müller-Hermelink, Hans Konrad, Prof. Dr. | Humaner monoklonaler Antikörper |
| WO2005021594A2 (en) | 2003-08-29 | 2005-03-10 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Minimally immunogenic variants of sdr-grafted humanized antibody cc49 and their use |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US73685A (en) * | 1868-01-21 | Improvement in ploughs | ||
| GB8720833D0 (en) * | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
| FR2788040B1 (fr) * | 1998-12-31 | 2001-03-23 | Airsec Sa | Distributeur d'objets |
-
1989
- 1989-10-04 BR BR898907126A patent/BR8907126A/pt not_active Application Discontinuation
- 1989-10-04 JP JP1511127A patent/JP2935520B2/ja not_active Expired - Fee Related
- 1989-10-04 IE IE334789A patent/IE64966B1/en not_active IP Right Cessation
- 1989-10-04 AU AU44299/89A patent/AU4429989A/en not_active Abandoned
- 1989-10-04 EP EP19890911974 patent/EP0397821A4/en not_active Withdrawn
- 1989-10-04 KR KR1019900701297A patent/KR0161525B1/ko not_active IP Right Cessation
- 1989-10-04 WO PCT/US1989/004402 patent/WO1990004410A1/en active IP Right Grant
- 1989-10-04 HU HU255/89A patent/HU218093B/hu not_active IP Right Cessation
- 1989-10-13 NZ NZ231012A patent/NZ231012A/en unknown
- 1989-10-17 PT PT92013A patent/PT92013B/pt not_active IP Right Cessation
- 1989-10-17 ZA ZA897858A patent/ZA897858B/xx unknown
- 1989-10-18 DE DE68918217T patent/DE68918217T2/de not_active Expired - Fee Related
- 1989-10-18 EP EP89119361A patent/EP0365997B1/en not_active Expired - Lifetime
- 1989-10-18 IL IL92037A patent/IL92037A/en not_active IP Right Cessation
- 1989-10-18 CA CA002000913A patent/CA2000913C/en not_active Expired - Fee Related
- 1989-10-18 ES ES89119361T patent/ES2059670T3/es not_active Expired - Lifetime
- 1989-10-18 AT AT89119361T patent/ATE111519T1/de not_active IP Right Cessation
- 1989-10-19 AU AU43540/89A patent/AU633026B2/en not_active Ceased
- 1989-10-19 AR AR89315213A patent/AR242434A1/es active
-
1990
- 1990-06-18 NO NO902696A patent/NO301075B1/no not_active IP Right Cessation
- 1990-06-18 FI FI903056A patent/FI103181B1/fi active IP Right Grant
- 1990-06-19 DK DK199001499A patent/DK173089B1/da not_active IP Right Cessation
-
1995
- 1995-10-19 HK HK162795A patent/HK162795A/xx not_active IP Right Cessation
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