ATE111519T1 - Familie von modifizierten antikörpern mit hoher affinität zur behandlung von krebs. - Google Patents

Familie von modifizierten antikörpern mit hoher affinität zur behandlung von krebs.

Info

Publication number
ATE111519T1
ATE111519T1 AT89119361T AT89119361T ATE111519T1 AT E111519 T1 ATE111519 T1 AT E111519T1 AT 89119361 T AT89119361 T AT 89119361T AT 89119361 T AT89119361 T AT 89119361T AT E111519 T1 ATE111519 T1 AT E111519T1
Authority
AT
Austria
Prior art keywords
cancer
family
treatment
high affinity
modified antibodies
Prior art date
Application number
AT89119361T
Other languages
English (en)
Inventor
Peter Mezes
Brian Gourlie
Mark Rixon
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of ATE111519T1 publication Critical patent/ATE111519T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/462—Igs containing a variable region (Fv) from one specie and a constant region (Fc) from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6875—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin
    • A61K47/6877—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody being a hybrid immunoglobulin the antibody being an immunoglobulin containing regions, domains or residues from different species
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/1087—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin the immunoglobulin comprises domains from different animal species, e.g. chimeric immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Optics & Photonics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT89119361T 1988-10-19 1989-10-18 Familie von modifizierten antikörpern mit hoher affinität zur behandlung von krebs. ATE111519T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25994388A 1988-10-19 1988-10-19

Publications (1)

Publication Number Publication Date
ATE111519T1 true ATE111519T1 (de) 1994-09-15

Family

ID=22987104

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89119361T ATE111519T1 (de) 1988-10-19 1989-10-18 Familie von modifizierten antikörpern mit hoher affinität zur behandlung von krebs.

Country Status (21)

Country Link
EP (2) EP0397821A4 (de)
JP (1) JP2935520B2 (de)
KR (1) KR0161525B1 (de)
AR (1) AR242434A1 (de)
AT (1) ATE111519T1 (de)
AU (2) AU4429989A (de)
BR (1) BR8907126A (de)
CA (1) CA2000913C (de)
DE (1) DE68918217T2 (de)
DK (1) DK173089B1 (de)
ES (1) ES2059670T3 (de)
FI (1) FI103181B1 (de)
HK (1) HK162795A (de)
HU (1) HU218093B (de)
IE (1) IE64966B1 (de)
IL (1) IL92037A (de)
NO (1) NO301075B1 (de)
NZ (1) NZ231012A (de)
PT (1) PT92013B (de)
WO (1) WO1990004410A1 (de)
ZA (1) ZA897858B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5869620A (en) * 1986-09-02 1999-02-09 Enzon, Inc. Multivalent antigen-binding proteins
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5976531A (en) * 1990-04-19 1999-11-02 The Dow Chemical Company Composite antibodies of human subgroup IV light chain capable of binding to tag-72
US6495137B1 (en) * 1990-04-19 2002-12-17 The Dow Chemical Company Humanized anti-tag-72 monoclonal antibodies using human subgroup 4 kappa light chains
US6407213B1 (en) 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
IE922287A1 (en) * 1991-07-15 1993-01-27 Wellcome Found Production of antibodies
US6025165A (en) * 1991-11-25 2000-02-15 Enzon, Inc. Methods for producing multivalent antigen-binding proteins
EP0618969B1 (de) * 1991-12-13 2003-06-25 The Dow Chemical Company An tag-72 bindende zusammengesetzte antikörper mit der humanen leichten kette der untergruppe-iv
AU696627B2 (en) * 1991-12-13 1998-09-17 Dow Chemical Company, The Composite antibodies of human subgroup IV light chain capable of binding to TAG-72
WO1994012520A1 (en) * 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
JP3312357B2 (ja) 1992-12-11 2002-08-05 ザ ダウ ケミカル カンパニー 多価の一本鎖抗体
US6348581B1 (en) 1996-10-31 2002-02-19 The Dow Chemical Company High affinity humanized anti-TAG-72 monoclonalantibodies
CA2321932A1 (en) * 1998-02-25 1999-09-02 The Dow Chemical Company High affinity humanized anti-tag-72 monoclonal antibodies
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
US7560534B2 (en) 2000-05-08 2009-07-14 Celldex Research Corporation Molecular conjugates comprising human monoclonal antibodies to dendritic cells
US7319139B2 (en) 2001-01-29 2008-01-15 Biogen Idec, Inc. TAG-72 specific CH2 domain deleted antibodies
WO2004003155A2 (en) 2002-06-28 2004-01-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Humanized anti-tag-72 cc49 for diagnosis and therapy of human tumors
DE10311248A1 (de) * 2003-03-14 2004-09-30 Müller-Hermelink, Hans Konrad, Prof. Dr. Humaner monoklonaler Antikörper
WO2005021594A2 (en) 2003-08-29 2005-03-10 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Minimally immunogenic variants of sdr-grafted humanized antibody cc49 and their use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US73685A (en) * 1868-01-21 Improvement in ploughs
GB8720833D0 (en) * 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
FR2788040B1 (fr) * 1998-12-31 2001-03-23 Airsec Sa Distributeur d'objets

Also Published As

Publication number Publication date
AR242434A1 (es) 1993-03-31
CA2000913A1 (en) 1990-04-19
PT92013B (pt) 1995-07-06
ES2059670T3 (es) 1994-11-16
HU896255D0 (en) 1991-09-30
HK162795A (en) 1995-10-27
NO902696D0 (no) 1990-06-18
NO902696L (no) 1990-08-16
HUT56878A (en) 1991-10-28
PT92013A (pt) 1990-04-30
IL92037A (en) 1998-03-10
FI903056A0 (fi) 1990-06-18
KR900701302A (ko) 1990-12-01
EP0365997A3 (de) 1992-03-04
DE68918217T2 (de) 1995-02-09
JPH03502889A (ja) 1991-07-04
EP0397821A4 (en) 1992-03-18
DK173089B1 (da) 2000-01-10
IE64966B1 (en) 1995-09-20
EP0365997B1 (de) 1994-09-14
NZ231012A (en) 1993-02-25
IE893347L (en) 1990-04-19
EP0365997A2 (de) 1990-05-02
AU633026B2 (en) 1993-01-21
AU4429989A (en) 1990-05-14
AU4354089A (en) 1990-04-26
DE68918217D1 (de) 1994-10-20
EP0397821A1 (de) 1990-11-22
ZA897858B (en) 1991-06-26
CA2000913C (en) 1999-02-16
HU218093B (hu) 2000-05-28
FI103181B (fi) 1999-05-14
BR8907126A (pt) 1991-02-13
FI103181B1 (fi) 1999-05-14
KR0161525B1 (ko) 1998-12-01
WO1990004410A1 (en) 1990-05-03
DK149990D0 (da) 1990-06-19
IL92037A0 (en) 1990-07-12
DK149990A (da) 1990-08-17
JP2935520B2 (ja) 1999-08-16
NO301075B1 (no) 1997-09-08

Similar Documents

Publication Publication Date Title
ATE111519T1 (de) Familie von modifizierten antikörpern mit hoher affinität zur behandlung von krebs.
DE68907795T2 (de) Verfahren zur Herstellung von Bisphenolen.
DE69003009D1 (de) Verfahren zur Behandlung von Fasermaterialien.
DE68921655D1 (de) Verfahren zur Herstellung von Mustern.
DE59004274D1 (de) Verfahren zur Herstellung von Alkylhalogensilanen.
DE68912039T2 (de) Verfahren zur Herstellung von Bisphenolen.
DE68909106T2 (de) Verfahren zur Herstellung von Katalysatorteilchen.
DE68911776T2 (de) Konjugierte Oxybutenolide zur Behandlung von Ulcera.
DE68912885T2 (de) Verfahren zur Herstellung von L-Threonin.
DE3885262D1 (de) Verfahren zur Herstellung von 2-Chlor-5-methyl-pyridin.
DE68903208D1 (de) Verfahren zur thermischen behandlung von laktoferrin.
DE58908736D1 (de) Verfahren zur Herstellung von Cyclopropylamin.
DE68920298T2 (de) Verfahren zur Herstellung von 4-Acetoxyazetidinonen.
DE58907097D1 (de) Verfahren zur Herstellung von 4-Chlorpyrazolen.
DE58905664D1 (de) Verfahren zur Herstellung von N-Hydroxypyrazolen.
DE58905592D1 (de) Verfahren zur Herstellung von N-Hydroxypyrazolen.
DE59004279D1 (de) Verfahren zur C-terminalen Modifizierung von Proteinen.
DE69000960D1 (de) Zusammensetzung zur behandlung von pigmentierung.
DE68916375D1 (de) Verfahren zur Herstellung von 3-Iminonitrilen.
DE58908915D1 (de) Verfahren zur Herstellung von 2-Chlor-5-chlormethylpyridin.
DE3668116D1 (de) Zusammensetzung zur behandlung von infektionen.
DE69011065T2 (de) Verfahren zur Behandlung von Nickel-Magnesium-Silikaterzen.
DE58907407D1 (de) Verfahren zur Herstellung von 1-Amino-2-brom-4-hydroxy-anthrachinon.
DE69008488D1 (de) Verfahren zur Herstellung von N-Alkylaminophenolen und von N,N-Dialkylaminophenolen.
DE69006964D1 (de) Behandlung von Hyperlipidemia mit 15-keto-Prostaglandin-Verbindungen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee