NO300503B1 - Fremgangsmåte for rensing av albumin - Google Patents
Fremgangsmåte for rensing av albumin Download PDFInfo
- Publication number
- NO300503B1 NO300503B1 NO915101A NO915101A NO300503B1 NO 300503 B1 NO300503 B1 NO 300503B1 NO 915101 A NO915101 A NO 915101A NO 915101 A NO915101 A NO 915101A NO 300503 B1 NO300503 B1 NO 300503B1
- Authority
- NO
- Norway
- Prior art keywords
- metal ions
- albumin
- multivalent metal
- solution
- multivalent
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 26
- 102000009027 Albumins Human genes 0.000 title claims description 38
- 108010088751 Albumins Proteins 0.000 title claims description 38
- 229910021645 metal ion Inorganic materials 0.000 claims abstract description 62
- 238000011026 diafiltration Methods 0.000 claims abstract description 12
- 239000000243 solution Substances 0.000 claims description 40
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 22
- 229910052782 aluminium Inorganic materials 0.000 claims description 15
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 14
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 12
- 239000011780 sodium chloride Substances 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 9
- 229910052742 iron Inorganic materials 0.000 claims description 7
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 6
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 6
- 239000004411 aluminium Substances 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 abstract description 24
- 108090000623 proteins and genes Proteins 0.000 abstract description 24
- 238000002523 gelfiltration Methods 0.000 abstract description 10
- 150000002500 ions Chemical class 0.000 abstract description 4
- 229910052751 metal Inorganic materials 0.000 description 17
- 239000002184 metal Substances 0.000 description 17
- 238000001914 filtration Methods 0.000 description 11
- 150000002739 metals Chemical class 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 150000003839 salts Chemical class 0.000 description 9
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 6
- 229910052804 chromium Inorganic materials 0.000 description 5
- 239000011651 chromium Substances 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 239000011133 lead Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- -1 citrate ions Chemical class 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 229910052759 nickel Inorganic materials 0.000 description 3
- 239000012266 salt solution Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 229910052802 copper Inorganic materials 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000010612 desalination reaction Methods 0.000 description 2
- 238000011033 desalting Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000012460 protein solution Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 208000032274 Encephalopathy Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010062237 Renal impairment Diseases 0.000 description 1
- 206010039966 Senile dementia Diseases 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910001413 alkali metal ion Inorganic materials 0.000 description 1
- 230000002009 allergenic effect Effects 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000003914 blood derivative Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000008139 complexing agent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000005977 kidney dysfunction Effects 0.000 description 1
- 229910052745 lead Inorganic materials 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Water Supply & Treatment (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
- Manufacturing Of Electric Cables (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8902317A SE500110C2 (sv) | 1989-06-27 | 1989-06-27 | Sätt att rena ett protein från därtill bundna flervärda metalljoner |
| PCT/SE1990/000442 WO1991000290A1 (en) | 1989-06-27 | 1990-06-20 | Method of cleansing proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO915101D0 NO915101D0 (no) | 1991-12-23 |
| NO915101L NO915101L (no) | 1991-12-23 |
| NO300503B1 true NO300503B1 (no) | 1997-06-09 |
Family
ID=20376405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO915101A NO300503B1 (no) | 1989-06-27 | 1991-12-23 | Fremgangsmåte for rensing av albumin |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | USRE37286E1 (ja) |
| EP (1) | EP0484464B2 (ja) |
| JP (1) | JPH0822873B2 (ja) |
| AT (1) | ATE132905T1 (ja) |
| AU (1) | AU632147B2 (ja) |
| CA (1) | CA2058958C (ja) |
| DE (2) | DE69024806T3 (ja) |
| DK (1) | DK0484464T4 (ja) |
| ES (1) | ES2031438T5 (ja) |
| FI (1) | FI101151B (ja) |
| NO (1) | NO300503B1 (ja) |
| SE (1) | SE500110C2 (ja) |
| WO (1) | WO1991000290A1 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2949846B2 (ja) * | 1990-11-30 | 1999-09-20 | 吉富製薬株式会社 | アルブミン製剤の保存方法 |
| US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
| US5840851A (en) * | 1993-07-23 | 1998-11-24 | Plomer; J. Jeffrey | Purification of hemoglobin |
| US5578564A (en) * | 1993-07-23 | 1996-11-26 | Somatogen, Inc. | Nickel-free hemoglobin and methods for producing such hemoglobin |
| ES2103236B1 (es) * | 1996-01-30 | 1998-04-16 | Grifols Grupo Sa | Albumina humana terapeutica con baja capacidad para la fijacion de aluminio. |
| AT403989B (de) * | 1996-09-16 | 1998-07-27 | Immuno Ag | Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels |
| GB9902000D0 (en) | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
| US6693173B2 (en) | 2000-12-26 | 2004-02-17 | Alpha Therapeutic Corporation | Method to remove citrate and aluminum from proteins |
| GB0117879D0 (en) | 2001-07-21 | 2001-09-12 | Common Services Agency | Storage of liquid compositions |
| PT104861A (pt) | 2009-12-07 | 2011-06-07 | Univ Aveiro | Cerâmicos produzidos a partir de escórias de incineração de resíduos sólidos |
| WO2018033482A1 (en) | 2016-08-17 | 2018-02-22 | Boehringer Ingelheim International Gmbh | Process for the preparation of highly concentrated liquid formulations containing biomolecules |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4116948A (en) * | 1975-03-24 | 1978-09-26 | Hellmut Mittenzwei | Process for removal of inorganic salts from peptide/salt-containing substances |
| JPS55124719A (en) * | 1979-03-22 | 1980-09-26 | Kowa Co | Preparation of immune globulin administrable by intravenous injection |
| US5250663A (en) | 1990-04-19 | 1993-10-05 | Miles Inc. | Preparing essentially monomeric normal human serum albumin |
-
1989
- 1989-06-27 SE SE8902317A patent/SE500110C2/sv not_active IP Right Cessation
-
1990
- 1990-06-20 WO PCT/SE1990/000442 patent/WO1991000290A1/en active IP Right Grant
- 1990-06-20 ES ES90917874T patent/ES2031438T5/es not_active Expired - Lifetime
- 1990-06-20 AU AU59464/90A patent/AU632147B2/en not_active Expired
- 1990-06-20 US US09/410,958 patent/USRE37286E1/en not_active Expired - Lifetime
- 1990-06-20 CA CA002058958A patent/CA2058958C/en not_active Expired - Lifetime
- 1990-06-20 JP JP2509479A patent/JPH0822873B2/ja not_active Expired - Lifetime
- 1990-06-20 DK DK90917874T patent/DK0484464T4/da active
- 1990-06-20 DE DE69024806T patent/DE69024806T3/de not_active Expired - Lifetime
- 1990-06-20 DE DE199090917874T patent/DE484464T1/de active Pending
- 1990-06-20 AT AT90917874T patent/ATE132905T1/de not_active IP Right Cessation
- 1990-06-20 US US07/778,870 patent/US5229498A/en not_active Ceased
- 1990-06-20 EP EP90917874A patent/EP0484464B2/en not_active Expired - Lifetime
-
1991
- 1991-12-19 FI FI916000A patent/FI101151B/fi active
- 1991-12-23 NO NO915101A patent/NO300503B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SE500110C2 (sv) | 1994-04-18 |
| SE8902317D0 (sv) | 1989-06-27 |
| AU5946490A (en) | 1991-01-17 |
| ES2031438T1 (es) | 1992-12-16 |
| DE69024806T3 (de) | 2004-10-07 |
| USRE37286E1 (en) | 2001-07-17 |
| JPH0822873B2 (ja) | 1996-03-06 |
| NO915101D0 (no) | 1991-12-23 |
| FI916000A0 (fi) | 1991-12-19 |
| ATE132905T1 (de) | 1996-01-15 |
| ES2031438T5 (es) | 2004-09-16 |
| CA2058958C (en) | 2000-12-12 |
| DK0484464T3 (da) | 1996-02-12 |
| DE69024806T2 (de) | 1996-05-23 |
| CA2058958A1 (en) | 1990-12-28 |
| EP0484464A1 (en) | 1992-05-13 |
| ES2031438T3 (es) | 1996-03-16 |
| SE8902317L (sv) | 1990-12-28 |
| DK0484464T4 (da) | 2004-05-03 |
| DE69024806D1 (de) | 1996-02-22 |
| NO915101L (no) | 1991-12-23 |
| JPH04506349A (ja) | 1992-11-05 |
| DE484464T1 (de) | 1992-08-13 |
| EP0484464B2 (en) | 2004-02-11 |
| AU632147B2 (en) | 1992-12-17 |
| WO1991000290A1 (en) | 1991-01-10 |
| FI101151B (fi) | 1998-04-30 |
| US5229498A (en) | 1993-07-20 |
| EP0484464B1 (en) | 1996-01-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| D25 | Change according to b1 publication after opposition (par. 25 patents act) |
Effective date: 20020624 |
|
| MK1K | Patent expired |