NO2018025I1 - Antistoff mot human FGF23 eller et funksjonelt fragment derav mot human FGF23 omfattende en tung kjede aminosyresekvens omfattende en aminosyresekvens fra e ved posisjon 20 til S ved posisjon 136 av SEQ ID NO: 12 og en lett kjede aminosyresekvens omfattende en aminosyresekvens fra A ved posisjon 23 til K ved posisjon 128 av SEQ ID NO: 14 (Burosumab) - Google Patents

Antistoff mot human FGF23 eller et funksjonelt fragment derav mot human FGF23 omfattende en tung kjede aminosyresekvens omfattende en aminosyresekvens fra e ved posisjon 20 til S ved posisjon 136 av SEQ ID NO: 12 og en lett kjede aminosyresekvens omfattende en aminosyresekvens fra A ved posisjon 23 til K ved posisjon 128 av SEQ ID NO: 14 (Burosumab)

Info

Publication number
NO2018025I1
NO2018025I1 NO2018025C NO2018025C NO2018025I1 NO 2018025 I1 NO2018025 I1 NO 2018025I1 NO 2018025 C NO2018025 C NO 2018025C NO 2018025 C NO2018025 C NO 2018025C NO 2018025 I1 NO2018025 I1 NO 2018025I1
Authority
NO
Norway
Prior art keywords
amino acid
acid sequence
seq
human fgf23
chain amino
Prior art date
Application number
NO2018025C
Other languages
English (en)
Original Assignee
Kyowa Kirin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39690189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2018025(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyowa Kirin Co Ltd filed Critical Kyowa Kirin Co Ltd
Publication of NO2018025I1 publication Critical patent/NO2018025I1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
NO2018025C 2007-02-14 2018-08-09 Antistoff mot human FGF23 eller et funksjonelt fragment derav mot human FGF23 omfattende en tung kjede aminosyresekvens omfattende en aminosyresekvens fra e ved posisjon 20 til S ved posisjon 136 av SEQ ID NO: 12 og en lett kjede aminosyresekvens omfattende en aminosyresekvens fra A ved posisjon 23 til K ved posisjon 128 av SEQ ID NO: 14 (Burosumab) NO2018025I1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007034018 2007-02-14
PCT/JP2008/052918 WO2008099969A1 (ja) 2007-02-14 2008-02-14 抗fgf23抗体及びそれを含む医薬組成物

Publications (1)

Publication Number Publication Date
NO2018025I1 true NO2018025I1 (no) 2018-08-09

Family

ID=39690189

Family Applications (1)

Application Number Title Priority Date Filing Date
NO2018025C NO2018025I1 (no) 2007-02-14 2018-08-09 Antistoff mot human FGF23 eller et funksjonelt fragment derav mot human FGF23 omfattende en tung kjede aminosyresekvens omfattende en aminosyresekvens fra e ved posisjon 20 til S ved posisjon 136 av SEQ ID NO: 12 og en lett kjede aminosyresekvens omfattende en aminosyresekvens fra A ved posisjon 23 til K ved posisjon 128 av SEQ ID NO: 14 (Burosumab)

Country Status (23)

Country Link
US (4) US7883705B2 (no)
EP (3) EP3181691B1 (no)
JP (1) JP4800396B2 (no)
KR (1) KR101462291B1 (no)
CN (2) CN101652476B (no)
AU (1) AU2008215346B2 (no)
CA (1) CA2677782C (no)
CY (3) CY1118835T1 (no)
DK (3) DK2502996T3 (no)
ES (3) ES2625823T3 (no)
FR (1) FR18C1032I2 (no)
HK (2) HK1140228A1 (no)
HR (2) HRP20170548T1 (no)
HU (3) HUE050517T2 (no)
LT (3) LT2502996T (no)
LU (2) LUC00081I2 (no)
NL (1) NL300945I2 (no)
NO (1) NO2018025I1 (no)
PL (3) PL3181691T3 (no)
PT (3) PT2128253E (no)
SI (2) SI2502996T1 (no)
TW (1) TWI422593B (no)
WO (1) WO2008099969A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100387713C (zh) * 2000-08-11 2008-05-14 麒麟医药株式会社 调节磷酸代谢,钙代谢,钙化和维生素d代谢的多肽及其编码dna
EP1466925B1 (en) * 2001-12-28 2009-09-02 Kyowa Hakko Kirin Co., Ltd. Antibodies against fibroblast growth factor 23
US7883705B2 (en) * 2007-02-14 2011-02-08 Kyowa Hakko Kirin Co., Ltd. Anti FGF23 antibody and a pharmaceutical composition comprising the same
WO2012050673A1 (en) * 2010-10-14 2012-04-19 Wisconsin Alumni Research Foundation Methods for the treatment of x-linked hypophosphatemia and related disorders
WO2012177481A2 (en) 2011-06-24 2012-12-27 University Of Miami Fibroblast growth factor receptor inhibition for the treatment of disease
AU2015275128C1 (en) * 2014-06-09 2020-02-13 Kyowa Kirin Co., Ltd. The effective and efficient control of serum phosphate for optimal bone formation
WO2018069232A1 (en) 2016-10-10 2018-04-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of having cardiac hypertrophy
JP7023932B2 (ja) 2017-03-30 2022-02-22 シスメックス株式会社 抗ＡｐｏＡ１抗体
BR112021019337A2 (pt) * 2019-03-29 2021-12-07 Atarga Llc Anticorpo anti-fgf23
WO2024034638A1 (ja) * 2022-08-10 2024-02-15 協和キリン株式会社 抗ｆｇｆ２３抗体又は該抗体断片

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5623587A (en) 1979-08-03 1981-03-05 Mitsuwa Seiki Co Ltd Vane type compressor
WO1985003934A1 (en) 1984-03-06 1985-09-12 Takeda Chemical Industries, Ltd. Chemically modified protein and process for its preparation
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS61178926U (no) 1985-04-23 1986-11-08
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
NZ226694A (en) 1987-10-28 1994-04-27 Oncogen Human immunoglobulin produced by recombinant dna techniques
JP2958019B2 (ja) 1988-05-06 1999-10-06 住友製薬株式会社 ポリエチレングリコール誘導体、修飾ペプチドおよびその製造方法
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5958879A (en) 1989-10-12 1999-09-28 Ohio University/Edison Biotechnology Institute Growth hormone receptor antagonists and methods of reducing growth hormone activity in a mammal
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US6001358A (en) 1995-11-07 1999-12-14 Idec Pharmaceuticals Corporation Humanized antibodies to human gp39, compositions containing thereof
DE69935220T2 (de) 1998-05-18 2007-11-15 University College London Von menschlichem tumor stammendes polypeptidhormon phosphatonin
TWI255853B (en) 1998-08-21 2006-06-01 Kirin Brewery Method for modifying chromosomes
WO2000060085A1 (en) 1999-04-02 2000-10-12 Millennium Pharmaceuticals, Inc. Fibroblast growth factor-20
US6596849B1 (en) 1999-05-28 2003-07-22 Academia Sinica Monoclonal-antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules
CA2383254A1 (en) 1999-06-02 2000-12-07 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
JP2004522404A (ja) 1999-12-01 2004-07-29 ジェネンテック・インコーポレーテッド 分泌及び膜貫通ポリペプチドとそれをコードしている核酸
JP2003516150A (ja) 1999-12-08 2003-05-13 ジェンセット 潜在性分泌タンパク質をコードする全長ヒトｃＤＮＡ
EP1246843A1 (en) 2000-01-05 2002-10-09 ZymoGenetics, Inc. Novel fgf homolog zfgf12
JP2003523190A (ja) 2000-02-14 2003-08-05 スミスクライン・ビーチャム・コーポレイション 新規化合物
AU3976701A (en) 2000-02-15 2001-08-27 Amgen, Inc. Fibroblast growth factor-23 molecules and uses thereof
US20060160181A1 (en) * 2000-02-15 2006-07-20 Amgen Inc. Fibroblast Growth Factor-23 molecules and uses thereof
US20030105302A1 (en) 2000-03-08 2003-06-05 Nobuyuki Itoh Human FGF-23 gene and gene expression products
EP1261638A2 (en) 2000-03-08 2002-12-04 Chiron Corporation Human fgf-23 gene and gene expression products
ATE461213T1 (de) 2000-07-19 2010-04-15 Advanced Res & Tech Inst Neuer fibroblastwachstumsfaktor (fgf23) und methoden zur verwendung
CN100387713C (zh) 2000-08-11 2008-05-14 麒麟医药株式会社 调节磷酸代谢,钙代谢,钙化和维生素d代谢的多肽及其编码dna
CA2430013C (en) 2000-11-30 2011-11-22 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
WO2002076467A1 (en) 2001-03-22 2002-10-03 Genzyme Corporation Compositions and methods to regulate bone and mineral metabolism
CA2443719A1 (en) 2001-04-26 2002-11-07 Geneprot, Inc. Human fibroblast growth factor-related compositions
EP2009027B1 (en) * 2001-04-27 2014-05-21 Kyowa Hakko Kirin Co., Ltd. Anti-CD40 monoclonal antibody
EP1466925B1 (en) 2001-12-28 2009-09-02 Kyowa Hakko Kirin Co., Ltd. Antibodies against fibroblast growth factor 23
US7094551B2 (en) 2002-09-17 2006-08-22 Zahradnik Richard J Immunoassays, assay methods, antibodies and method of creating antibodies for detecting FGF-23
JPWO2004083425A1 (ja) * 2003-03-17 2006-06-22 麒麟麦酒株式会社 歯周病治療剤
EA010350B1 (ru) * 2004-06-03 2008-08-29 Новиммун С.А. Антитела против cd3 и способы их применения
CN102942631B (zh) * 2004-08-05 2015-03-25 健泰科生物技术公司 人源化抗c-met拮抗剂
EP1801208A4 (en) * 2004-09-06 2009-04-01 Kirin Pharma Kk ANTI-A33 ANTIBODIES
JPWO2006078072A1 (ja) 2005-01-21 2008-06-19 キリンファーマ株式会社 キメラ非ヒト動物およびその使用
EP2054521A4 (en) 2006-10-03 2012-12-19 Novo Nordisk As METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES
WO2008092019A1 (en) * 2007-01-25 2008-07-31 Mayo Foundation For Medical Education And Research Fgf-23 polypeptides
US7883705B2 (en) * 2007-02-14 2011-02-08 Kyowa Hakko Kirin Co., Ltd. Anti FGF23 antibody and a pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
TWI422593B (zh) 2014-01-11
JPWO2008099969A1 (ja) 2010-05-27
US10202446B2 (en) 2019-02-12
PL3181691T3 (pl) 2020-11-02
ES2625823T3 (es) 2017-07-20
CN101652476A (zh) 2010-02-17
ES2530670T3 (es) 2015-03-04
NL300945I1 (en) 2018-08-15
CA2677782C (en) 2016-07-26
CA2677782A1 (en) 2008-08-21
EP2128253A4 (en) 2010-03-10
WO2008099969A1 (ja) 2008-08-21
EP2502996B1 (en) 2017-03-29
AU2008215346B2 (en) 2013-01-10
EP3181691B1 (en) 2020-07-15
HUE031728T2 (en) 2017-07-28
HRP20170548T1 (hr) 2017-08-25
PT2128253E (pt) 2015-02-04
US20110182913A1 (en) 2011-07-28
DK3181691T3 (da) 2020-08-17
US20160159895A1 (en) 2016-06-09
EP2128253B1 (en) 2014-12-03
AU2008215346A1 (en) 2008-08-21
KR20090114452A (ko) 2009-11-03
CY2018021I2 (el) 2019-07-10
CN102702355A (zh) 2012-10-03
PT3181691T (pt) 2020-08-26
EP2128253A1 (en) 2009-12-02
US20090148461A1 (en) 2009-06-11
US9290569B2 (en) 2016-03-22
CY2018021I1 (el) 2019-07-10
CY1123240T1 (el) 2021-10-29
EP2502996A3 (en) 2013-04-10
HRP20201266T1 (hr) 2021-02-05
NL300945I2 (en) 2020-05-13
CN101652476B (zh) 2012-07-04
CY1118835T1 (el) 2018-01-10
LUC00081I2 (no) 2018-10-01
EP2502996A2 (en) 2012-09-26
JP4800396B2 (ja) 2011-10-26
LT2502996T (lt) 2017-06-26
US20190106485A1 (en) 2019-04-11
FR18C1032I2 (fr) 2019-08-09
PL2502996T3 (pl) 2017-07-31
DK2502996T3 (en) 2017-05-08
KR101462291B1 (ko) 2014-11-14
HUS1800034I1 (hu) 2018-09-28
LTPA2018508I1 (lt) 2018-09-10
LT3181691T (lt) 2020-08-25
DK2128253T3 (en) 2015-01-05
PT2502996T (pt) 2017-05-10
PL2128253T3 (pl) 2015-04-30
ES2811318T3 (es) 2021-03-11
TW200902549A (en) 2009-01-16
US7883705B2 (en) 2011-02-08
SI2502996T1 (sl) 2017-08-31
LUC00082I2 (no) 2018-10-01
LTC2502996I2 (lt) 2019-05-10
HUE050517T2 (hu) 2020-12-28
FR18C1032I1 (no) 2018-08-31
EP3181691A1 (en) 2017-06-21
SI3181691T1 (sl) 2020-09-30
HK1172917A1 (en) 2013-05-03
HK1140228A1 (en) 2010-10-08
CN102702355B (zh) 2014-09-24

Similar Documents

Publication Publication Date Title
NO2018025I1 (no) Antistoff mot human FGF23 eller et funksjonelt fragment derav mot human FGF23 omfattende en tung kjede aminosyresekvens omfattende en aminosyresekvens fra e ved posisjon 20 til S ved posisjon 136 av SEQ ID NO: 12 og en lett kjede aminosyresekvens omfattende en aminosyresekvens fra A ved posisjon 23 til K ved posisjon 128 av SEQ ID NO: 14 (Burosumab)
NO20073655L (no) Antistoffer mot IL-13 reseptor alfa 1 og anvendelser derav
HK1252539A1 (zh) 調節低密度脂蛋白受體相關蛋白6(lrp6)的分子和方法
BRPI0907363A2 (pt) Métodos e composições relativos a peptídeos e proteínas com elementos de c-terminal
IL216796A (en) Isolated nucleic acid molecule encoding an alternative light chain protein (slc) and a method for the expression of slc protein
DK1719116T3 (da) Skift fra ACELP- til TCX-indkodningstilstand
ATE522545T1 (de) Amidiertes insulin glargin
DK2603590T3 (da) Nukleinsyre omfattende eller kodende for et histon stem-loop og en poly(a) se-kvens eller et polyadenyleringssignal til forøgelse af ekspressionen af et kodet protein
DK2121963T3 (da) Fremgangsmåder til identificering af en stamme isoleret fra en klinisk prøve på species- og/eller subspecies-niveau
DE112007000375A5 (de) Umrüstung von Anlagen zur Sauergasentfernung
BRPI0914889A2 (pt) peptídeo glp-1 adicionado de cadeia oligossacarídica
NO20082634L (no) Bindigsproteiner spesifikke for insulin-lignende vekstfaktorer og anvendelser derav
EP2462157A4 (en) PROCESS FOR CLEANING A TARGET PROTEIN OF ONE OR MORE CONTAMINANTS IN A SAMPLE
JP2012507294A5 (no)
DE602007004051D1 (de) Greifbackenmechanismus
WO2007113237A3 (en) Plants having enhanced yield-related traits and a method for making the same
WO2007104738A3 (en) Acylated single chain insulin
CR10523A (es) Cepa bg1 de thermoanaerobacter mathranii
ES2421719T3 (es) Antígeno de gliadina recombinante desamidada
FI20065766A0 (fi) Tekniikoita ennustusjärjestelmän luotettavuuden parantamiseksi
DK1838341T3 (da) Vaccinesammensætning omfattende et fibronectin bindende protein eller et fibronectinbindende peptid
BRPI0815410A2 (pt) Processos para purificar ou detectar uma proteína alvo presente em uma solução e para purificar e para detectar especificamente uma proetína alvo a partir de uma solução.
DK2450815T3 (da) Fremgangsmåde til at identificere peptider og proteiner ud fra massespektrometri-data
EP2080104A4 (en) METHOD AND SYSTEM FOR PARALLELING PIPE-LINE CALCULATIONS
DK2666854T3 (da) Rekombinante elastase-proteiner og fremgangsmåder til fremstilling og anvendelse deraf

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: KYOWA KIRIN CO., JP