NO20101144L - Faste former av ortataxel - Google Patents

Faste former av ortataxel

Info

Publication number
NO20101144L
NO20101144L NO20101144A NO20101144A NO20101144L NO 20101144 L NO20101144 L NO 20101144L NO 20101144 A NO20101144 A NO 20101144A NO 20101144 A NO20101144 A NO 20101144A NO 20101144 L NO20101144 L NO 20101144L
Authority
NO
Norway
Prior art keywords
mixtures
ortataxel
water
solid forms
orthotaxis
Prior art date
Application number
NO20101144A
Other languages
English (en)
Other versions
NO342387B1 (no
Inventor
Bruno Gabetta
Daniele Ciceri
Nicola Sardone
Maurizio Ricotti
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of NO20101144L publication Critical patent/NO20101144L/no
Publication of NO342387B1 publication Critical patent/NO342387B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Den foreliggende oppfinnelsen angår faste former av 13-(N-Boc-ß-isobutylserinyl)-14-ß-hydroksybaccatin III 1,14-karbonat (Ortataxel). Amorf Form A, krystallinsk Form B, blandinger derav og fremgangsmåter for å fremstille dem er vist. Amorf Form A blir fremstilt ved rask utfelling av Ortataxel fra en blanding av aceton og vann. Form A transformerer til Form B når den blir suspendert og rørt i en blanding av etanol og vann i 4-8 timer. Hvis suspensjonen blir rørt i mindre enn 4 timer, blir blandinger av Form B og Form A oppnådd. Form B eller blandinger Formene A og B kan også oppnås ved å løse Ortataxel i et protisk organisk løsemiddel, etterfulgt av tilsetning av vann.
NO20101144A 2008-01-18 2010-08-12 Faste former av ortataxel NO342387B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08000904A EP2080764B1 (en) 2008-01-18 2008-01-18 Solid forms of ortataxel
PCT/EP2009/000112 WO2009090024A1 (en) 2008-01-18 2009-01-12 Solid forms of ortataxel

Publications (2)

Publication Number Publication Date
NO20101144L true NO20101144L (no) 2010-08-12
NO342387B1 NO342387B1 (no) 2018-05-14

Family

ID=39205210

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20101144A NO342387B1 (no) 2008-01-18 2010-08-12 Faste former av ortataxel

Country Status (19)

Country Link
US (2) US20110054015A1 (no)
EP (1) EP2080764B1 (no)
JP (1) JP2011509957A (no)
KR (1) KR101583098B1 (no)
CN (1) CN101952297A (no)
AR (1) AR070185A1 (no)
AU (1) AU2009204559B2 (no)
BR (1) BRPI0906698A2 (no)
CA (1) CA2711690C (no)
DK (1) DK2080764T3 (no)
ES (1) ES2389518T3 (no)
HK (1) HK1131782A1 (no)
IL (1) IL207045A (no)
MX (1) MX2010007850A (no)
NO (1) NO342387B1 (no)
RU (1) RU2488586C2 (no)
TW (1) TWI432437B (no)
WO (1) WO2009090024A1 (no)
ZA (1) ZA201004507B (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3938480A1 (de) 1989-11-20 1991-05-23 Hell Rudolf Dr Ing Gmbh Vorrichtung zum aufspannen von blattfoermigem aufzeichnungsmaterial
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
MX9102128A (es) 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
IT1254517B (it) 1992-03-06 1995-09-25 Indena Spa 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico
US5698712A (en) 1992-03-06 1997-12-16 Indena S.P.A. Baccatine III derivatives
FR2688499B1 (fr) 1992-03-10 1994-05-06 Rhone Poulenc Rorer Sa Procede de preparation de la beta-phenylisoserine et de ses analogues.
US5200534A (en) * 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
FR2696460B1 (fr) 1992-10-05 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
IL107950A (en) 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them
CA2111527C (en) 1992-12-24 2000-07-18 Jerzy Golik Phosphonooxymethyl ethers of taxane derivatives
US5475011A (en) 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
IT1261667B (it) 1993-05-20 1996-05-29 Tassano ad attivita' antitumorale.
ES2145829T3 (es) 1993-06-11 2000-07-16 Upjohn Co Uso antineoplasico de delta 6,7-taxoles y composiciones farmaceuticas que los contienen.
IL109926A (en) 1993-06-15 2000-02-29 Bristol Myers Squibb Co Methods for the preparation of taxanes and microorganisms and enzymes utilized therein
FR2722191B1 (fr) * 1994-07-08 1996-08-23 Rhone Poulenc Rorer Sa Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
IT1275936B1 (it) 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
FR2732341A1 (fr) 1995-03-27 1996-10-04 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
IT1275435B (it) 1995-05-19 1997-08-07 Indena Spa Derivati della 10-desacetil-14beta-idrossibaccatina iii,loro metodo di preparazione e formulazioni che li contengono
IT1283633B1 (it) 1996-05-10 1998-04-23 Indena Spa Derivati tassanici loro sintesi e formulazioni che li contengono
US5811452A (en) 1997-01-08 1998-09-22 The Research Foundation Of State University Of New York Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
ITMI991483A1 (it) 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
IT1318678B1 (it) 2000-08-10 2003-08-27 Indena Spa Procedimento per la preparazione di derivati della baccatina iii.
IT1320107B1 (it) * 2000-11-28 2003-11-18 Indena Spa Procedimento per la preparazione di derivati tassanici.
ITMI20012185A1 (it) 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
ITMI20012186A1 (it) 2001-10-19 2003-04-19 Indena Spa Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato
WO2005061474A1 (en) 2003-12-12 2005-07-07 Quiral Química Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
WO2006058121A1 (en) 2004-11-23 2006-06-01 Bristol-Myers Squibb Company Crystalline forms of 3'-tert-butyl-3'-n-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-n-debenzoyl-4-o-methoxycarbonyl-paclitaxel
KR100995390B1 (ko) * 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
US7919108B2 (en) * 2006-03-10 2011-04-05 Cook Incorporated Taxane coatings for implantable medical devices
US7232916B1 (en) 2006-05-11 2007-06-19 Indena S.P.A. Process for the preparation of a taxane derivative
DK1854799T3 (da) 2006-05-12 2011-07-18 Indena Spa Fremgangsmåde til fremstilling af et taxanderivat
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel

Also Published As

Publication number Publication date
IL207045A0 (en) 2010-12-30
JP2011509957A (ja) 2011-03-31
WO2009090024A1 (en) 2009-07-23
EP2080764B1 (en) 2012-08-22
HK1131782A1 (en) 2010-02-05
DK2080764T3 (da) 2012-09-24
US9127018B2 (en) 2015-09-08
MX2010007850A (es) 2010-11-09
NO342387B1 (no) 2018-05-14
AU2009204559B2 (en) 2013-09-26
EP2080764A1 (en) 2009-07-22
AU2009204559A1 (en) 2009-07-23
RU2488586C2 (ru) 2013-07-27
ES2389518T3 (es) 2012-10-26
TWI432437B (zh) 2014-04-01
US20140128459A1 (en) 2014-05-08
CA2711690C (en) 2017-05-16
TW200936594A (en) 2009-09-01
US20110054015A1 (en) 2011-03-03
ZA201004507B (en) 2011-04-28
IL207045A (en) 2014-08-31
BRPI0906698A2 (pt) 2015-07-07
CN101952297A (zh) 2011-01-19
KR20100102160A (ko) 2010-09-20
CA2711690A1 (en) 2009-07-23
RU2010134415A (ru) 2012-02-27
AR070185A1 (es) 2010-03-17
KR101583098B1 (ko) 2016-01-07

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