NO20092469L - Azasykloalkanderivater som inhibitorer av stearoyl-koenzym A-delta-9-desaturase - Google Patents

Azasykloalkanderivater som inhibitorer av stearoyl-koenzym A-delta-9-desaturase

Info

Publication number
NO20092469L
NO20092469L NO20092469A NO20092469A NO20092469L NO 20092469 L NO20092469 L NO 20092469L NO 20092469 A NO20092469 A NO 20092469A NO 20092469 A NO20092469 A NO 20092469A NO 20092469 L NO20092469 L NO 20092469L
Authority
NO
Norway
Prior art keywords
desaturase
delta
coenzyme
inhibitors
azacycloalkane derivatives
Prior art date
Application number
NO20092469A
Other languages
English (en)
Norwegian (no)
Inventor
Nicolas Lachance
Chun Sing Li
Jean-Philippe Leclerc
Yeeman K Ramtohul
Original Assignee
Merck Frosst Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Ltd filed Critical Merck Frosst Canada Ltd
Publication of NO20092469L publication Critical patent/NO20092469L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO20092469A 2006-12-01 2009-06-30 Azasykloalkanderivater som inhibitorer av stearoyl-koenzym A-delta-9-desaturase NO20092469L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87221606P 2006-12-01 2006-12-01
US89890007P 2007-02-01 2007-02-01
PCT/CA2007/002139 WO2008064474A1 (fr) 2006-12-01 2007-11-28 Dérivés d'azacycloalkane utilisés comme inhibiteurs de la coenzyme a delta-9 désaturase-stearoyle

Publications (1)

Publication Number Publication Date
NO20092469L true NO20092469L (no) 2009-08-27

Family

ID=39467388

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092469A NO20092469L (no) 2006-12-01 2009-06-30 Azasykloalkanderivater som inhibitorer av stearoyl-koenzym A-delta-9-desaturase

Country Status (24)

Country Link
US (1) US8063224B2 (fr)
EP (1) EP2099793B1 (fr)
JP (1) JP5050061B2 (fr)
KR (1) KR20090086623A (fr)
AR (1) AR064026A1 (fr)
AT (1) ATE543816T1 (fr)
AU (1) AU2007327276B2 (fr)
BR (1) BRPI0719702A2 (fr)
CA (1) CA2670703C (fr)
CL (1) CL2007003440A1 (fr)
CO (1) CO6190521A2 (fr)
CR (1) CR10858A (fr)
EA (1) EA200970524A1 (fr)
EC (1) ECSP099375A (fr)
GT (1) GT200900144A (fr)
IL (1) IL198824A0 (fr)
MA (1) MA31017B1 (fr)
MX (1) MX2009005713A (fr)
NO (1) NO20092469L (fr)
PE (1) PE20081199A1 (fr)
SV (1) SV2009003275A (fr)
TN (1) TN2009000212A1 (fr)
TW (1) TW200826936A (fr)
WO (1) WO2008064474A1 (fr)

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EP2172560A3 (fr) * 2000-02-24 2010-09-29 Xenon Pharmaceuticals Inc. Méthodes et compositions utilisant la stéaoryl-CoA desaturase pour identifier des agents thérapeutiques reduisant les trigycerides
CA2651700A1 (fr) * 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Derives d'amines cycliques en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9-desaturase
AU2007260527A1 (en) * 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Azetidine derivatives as inhibitors of stearoyl-coenzyme A delta-9 desaturase
CA2654098A1 (fr) 2006-06-13 2007-12-21 Merck Frosst Canada Ltd. Derives de l'azacyclopentane utilises en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase
CA2660114A1 (fr) * 2006-08-09 2008-02-14 Merck Frosst Canada Ltd. Derives d'azacycloalcane en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase
AR064965A1 (es) 2007-01-26 2009-05-06 Merck Frosst Canada Inc Derivados de azacicloalcanos como inhibidores de estearoil - coenzima a delta -9 desaturasa
EP2148878A4 (fr) * 2007-04-20 2011-08-10 Merck Canada Inc Nouveaux composés hétéroaromatiques comme inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
AU2008253512A1 (en) * 2007-05-23 2008-11-27 Merck Frosst Canada Ltd. Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme A delta-9 desaturase
WO2008157844A1 (fr) 2007-06-21 2008-12-24 Forest Laboratories Holdings Limited Nouveaux dérivés de pipérazine en tant qu'inhibiteurs de stéaroyl-coa désaturase
CN101801351B (zh) * 2007-07-19 2012-12-12 武田药品工业株式会社 包含阿格列汀和盐酸二甲双胍的固体制剂
US20100197692A1 (en) * 2007-07-20 2010-08-05 Merck Frosst Canada Ltd. Bicyclic heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US20110152295A1 (en) * 2008-09-08 2011-06-23 Jean-Philippe Leclerc Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
EP2398809B1 (fr) * 2009-02-17 2015-07-08 Merck Canada Inc. Nouveaux composés spiro utiles comme inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
US20110301143A1 (en) * 2009-02-23 2011-12-08 Elise Isabel Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
WO2010108268A1 (fr) * 2009-03-23 2010-09-30 Merck Frosst Canada Ltd. Composés hétérocycliques inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
EP2459568A4 (fr) 2009-07-28 2013-02-27 Merck Frosst Canada Ltd Nouveaux composés spiro utiles en tant qu'inhibiteurs de la stéaroyl-coenzyme a delta-9 désaturase
BR112012027762B1 (pt) 2010-04-28 2018-06-05 Bayer Intellectual Property Gmbh Derivados de cetoheteroarilpiperidina e - piperazina como fungicidas
UA113160C2 (xx) * 2011-01-28 2016-12-26 Інгібування il17 і ifn-гамма для лікування аутоімунного запалення
CA2850836A1 (fr) 2011-10-15 2013-04-18 Genentech, Inc. Procedes d'utilisation d'antagonistes de scd1
WO2013062882A1 (fr) * 2011-10-26 2013-05-02 Merck Canada Inc. Inhibiteurs de la scd pour le traitement du vhc
WO2013134546A1 (fr) 2012-03-07 2013-09-12 Mayo Foundation For Medical Education And Research Procédés et matériaux pour traiter le cancer
RU2014149559A (ru) 2012-05-22 2016-06-27 Ийсум Рисёч Девелопмент Кампани Оф Зэ Хибру Юниверсити Оф Иерусалим Лтд. Селективные ингибиторы недифференцированных клеток
US11970486B2 (en) 2016-10-24 2024-04-30 Janssen Pharmaceutica Nv Compounds and uses thereof
AU2018205275B2 (en) * 2017-01-06 2024-05-02 Janssen Pharmaceutica Nv Methods for the treatment of neurological disorders
WO2019084157A1 (fr) 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Composés et utilisations de ces composés

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AU717744B2 (en) 1996-01-15 2000-03-30 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
EP2316826A1 (fr) 2003-07-30 2011-05-04 Xenon Pharmaceuticals Inc. Dérivés de pyridazine et utilisation de ceux-ci en tant qu'agents thérapeutiques
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BRPI0515477A (pt) 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos bicìclicos e o uso dos mesmos como inibidores de estaroil-coa-desaturase (scd)
GT200600046A (es) 2005-02-09 2006-09-25 Terapia de combinacion
WO2006125181A2 (fr) 2005-05-19 2006-11-23 Xenon Pharmaceuticals Inc. Derives piperidiniques: utilisation comme agents therapeutiques
AU2006255465A1 (en) * 2005-06-09 2006-12-14 Merck Frosst Canada Ltd Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US20090118296A1 (en) 2005-07-20 2009-05-07 Merck Frosst Canada Ltd. Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
AU2006299671A1 (en) 2005-10-05 2007-04-12 Merck Frosst Canada Ltd Substituted quinolines as inhibitors of leukotriene biosynthesis
AU2006315025A1 (en) 2005-11-15 2007-05-24 Merck Frosst Canada Ltd. Azacyclohexane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
AU2006326815A1 (en) 2005-12-20 2007-06-28 Merck Frosst Canada Ltd. Heteroaromatic compounds as inhibitors of stearoyl-coenzyme A delta-9 desaturase
CA2651700A1 (fr) 2006-05-22 2007-11-29 Merck Frosst Canada Ltd. Derives d'amines cycliques en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9-desaturase
AU2007260527A1 (en) 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Azetidine derivatives as inhibitors of stearoyl-coenzyme A delta-9 desaturase
CA2654098A1 (fr) 2006-06-13 2007-12-21 Merck Frosst Canada Ltd. Derives de l'azacyclopentane utilises en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase
CA2660114A1 (fr) 2006-08-09 2008-02-14 Merck Frosst Canada Ltd. Derives d'azacycloalcane en tant qu'inhibiteurs de la stearoyl-coenzyme a delta-9 desaturase
AU2007312866A1 (en) 2006-10-20 2008-04-24 Merck Frosst Canada Ltd. Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme A delta-9 desaturase
AR064965A1 (es) 2007-01-26 2009-05-06 Merck Frosst Canada Inc Derivados de azacicloalcanos como inhibidores de estearoil - coenzima a delta -9 desaturasa

Also Published As

Publication number Publication date
EP2099793B1 (fr) 2012-02-01
IL198824A0 (en) 2010-02-17
WO2008064474A1 (fr) 2008-06-05
MX2009005713A (es) 2009-06-08
EP2099793A4 (fr) 2010-12-29
CO6190521A2 (es) 2010-08-19
MA31017B1 (fr) 2009-12-01
ATE543816T1 (de) 2012-02-15
SV2009003275A (es) 2009-11-18
PE20081199A1 (es) 2008-10-19
AU2007327276A1 (en) 2008-06-05
GT200900144A (es) 2011-06-23
AR064026A1 (es) 2009-03-04
EA200970524A1 (ru) 2009-12-30
EP2099793A1 (fr) 2009-09-16
ECSP099375A (es) 2009-07-31
US20080132542A1 (en) 2008-06-05
TW200826936A (en) 2008-07-01
JP2010510993A (ja) 2010-04-08
US8063224B2 (en) 2011-11-22
CA2670703A1 (fr) 2008-06-05
CR10858A (es) 2009-06-25
CL2007003440A1 (es) 2008-04-04
AU2007327276B2 (en) 2011-06-09
KR20090086623A (ko) 2009-08-13
JP5050061B2 (ja) 2012-10-17
CA2670703C (fr) 2012-05-15
TN2009000212A1 (en) 2010-10-18
BRPI0719702A2 (pt) 2013-12-17

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