NO20085217L - Effektive pyrimidinderivater i behandlingen av kreft - Google Patents

Effektive pyrimidinderivater i behandlingen av kreft

Info

Publication number
NO20085217L
NO20085217L NO20085217A NO20085217A NO20085217L NO 20085217 L NO20085217 L NO 20085217L NO 20085217 A NO20085217 A NO 20085217A NO 20085217 A NO20085217 A NO 20085217A NO 20085217 L NO20085217 L NO 20085217L
Authority
NO
Norway
Prior art keywords
cancer
effective
treatment
pyrimidine derivatives
pyrimidine
Prior art date
Application number
NO20085217A
Other languages
English (en)
Norwegian (no)
Inventor
Thorsten Nowak
Andrew Peter Thomas
David Buttar
Kevin Michael Foote
David Alan Rudge
Maria-Elena Theoclitou
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20085217L publication Critical patent/NO20085217L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO20085217A 2006-06-30 2008-12-15 Effektive pyrimidinderivater i behandlingen av kreft NO20085217L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81825906P 2006-06-30 2006-06-30
US90842807P 2007-03-28 2007-03-28
PCT/GB2007/002381 WO2008001070A1 (fr) 2006-06-30 2007-06-27 Dérivés de pyrimidine utiles dans le traitement du cancer

Publications (1)

Publication Number Publication Date
NO20085217L true NO20085217L (no) 2009-01-12

Family

ID=38472858

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20085217A NO20085217L (no) 2006-06-30 2008-12-15 Effektive pyrimidinderivater i behandlingen av kreft

Country Status (13)

Country Link
US (1) US20080004302A1 (fr)
EP (1) EP2044063A1 (fr)
JP (1) JP2009541480A (fr)
KR (1) KR20090024270A (fr)
AR (1) AR061737A1 (fr)
AU (1) AU2007263655A1 (fr)
CA (1) CA2654852A1 (fr)
IL (1) IL195731A0 (fr)
MX (1) MX2008016523A (fr)
NO (1) NO20085217L (fr)
TW (1) TW200817391A (fr)
UY (1) UY30444A1 (fr)
WO (1) WO2008001070A1 (fr)

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PT1846394E (pt) * 2005-02-04 2012-01-05 Astrazeneca Ab Derivados de pirazolilaminopiridina úteis como inibidores da quinase
BRPI0607455A2 (pt) * 2005-02-16 2009-09-01 Astrazeneca Ab composto, processo para a preparação do mesmo, uso de um composto, e composição farmacêutica
EP1899323A2 (fr) * 2005-05-16 2008-03-19 AstraZeneca AB Dérivés de pyrazolylaminopyrimidine utiles comme inhibiteurs de tyrosine kinase
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WO2010005692A2 (fr) * 2008-06-16 2010-01-14 E. I. Du Pont De Nemours And Company Carbonyl-amidines cycliques insecticides
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GB0908772D0 (en) 2009-05-21 2009-07-01 Astrazeneca Ab New salts 756
BRPI1010937A2 (pt) 2009-05-21 2019-09-24 Astrazeneca Ab composto, uso de um composto, e, método para tratar câncer
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NZ603156A (en) 2010-03-30 2014-10-31 Verseon Corp Multisubstituted aromatic compounds as inhibitors of thrombin
RU2528386C2 (ru) 2010-05-21 2014-09-20 Кемилиа Аб Новые производные пиримидина
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WO2012080728A1 (fr) 2010-12-16 2012-06-21 Astrazeneca Ab Dérivé imidazo[4,5-c]quinolin-1-yle utile en thérapie
WO2012088266A2 (fr) 2010-12-22 2012-06-28 Incyte Corporation Imidazopyridazines et benzimidazoles substitués en tant qu'inhibiteurs de fgfr3
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CN103781779B (zh) * 2011-09-05 2016-06-08 浙江海正药业股份有限公司 具有蛋白激酶抑制活性的4-取代-(3-取代-1h-吡唑-5-氨基)-嘧啶衍生物及其用途
BR112014029261A2 (pt) 2012-05-18 2017-06-27 Astrazeneca Ab compostos de ácido carboxílico
WO2014007951A2 (fr) 2012-06-13 2014-01-09 Incyte Corporation Composés tricycliques substitués utilisés comme inhibiteurs de fgfr
WO2014026125A1 (fr) 2012-08-10 2014-02-13 Incyte Corporation Dérivés de pyrazine en tant qu'inhibiteurs de fgfr
JP6183053B2 (ja) * 2012-08-22 2017-08-23 宇部興産株式会社 テトラヒドロピラニルピリミジン化合物の製造方法
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
MX2017002610A (es) 2014-08-29 2017-10-11 Tes Pharma S R L INHIBIDORES DE ACIDO A-AMINO-ß-CARBOXIMUCONICO SEMIALDEHIDO DESCARBOXILASA.
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
NZ773116A (en) 2015-02-20 2024-05-31 Incyte Holdings Corp Bicyclic heterocycles as fgfr inhibitors
US9580423B2 (en) 2015-02-20 2017-02-28 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
MX2017011000A (es) * 2015-02-27 2017-10-20 Verseon Corp Compuestos de pirazol sustituidos como inhibidores de serina proteasa.
CA3020506A1 (fr) 2016-04-28 2017-11-02 Theravance Biopharma R&D Ip, Llc Composes de pyridine a titre d'inhibiteurs de kinases jak
CN110381949B (zh) 2017-01-10 2023-12-08 财团法人卫生研究院 杂环化合物及其用途
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
LT3672965T (lt) 2017-10-27 2022-10-10 Theravance Biopharma R&D Ip, Llc Pirimidino junginys, kaip jak kinazės inhibitorius
SG11202010636VA (en) 2018-05-04 2020-11-27 Incyte Corp Solid forms of an fgfr inhibitor and processes for preparing the same
BR112020022373A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation sais de um inibidor de fgfr
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
JP7470713B2 (ja) 2019-04-24 2024-04-18 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋキナーゼ阻害剤としてのエステルおよびカルボナートピリミジン化合物
AR118767A1 (es) 2019-04-24 2021-10-27 Theravance Biopharma R&D Ip Llc Pirimidinas sustituidas como inhibidores de jak y su uso para el tratamiento de enfermedades inflamatorias o autoinmunes cutáneas
CN110143939A (zh) * 2019-05-07 2019-08-20 中国科学技术大学 一种由呋喃醛基化合物制备呋喃丙烯酸酯的方法
WO2021007269A1 (fr) 2019-07-09 2021-01-14 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
WO2021067374A1 (fr) 2019-10-01 2021-04-08 Incyte Corporation Hétérocycles bicycliques en tant qu'inhibiteurs de fgfr
BR112022007163A2 (pt) 2019-10-14 2022-08-23 Incyte Corp Heterociclos bicíclicos como inibidores de fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
US11407750B2 (en) 2019-12-04 2022-08-09 Incyte Corporation Derivatives of an FGFR inhibitor
US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2022221170A1 (fr) 2021-04-12 2022-10-20 Incyte Corporation Polythérapie comprenant un inhibiteur de fgfr et un agent de ciblage de nectine-4
EP4352059A1 (fr) 2021-06-09 2024-04-17 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
TW202402288A (zh) 2022-05-26 2024-01-16 義大利商Ｔｅｓ製藥（股份）責任有限公司 用於治療急性炎症之嘧啶酮化合物
CN115466234B (zh) * 2022-10-25 2024-01-30 安徽华业香料股份有限公司 一种γ-庚内酯的制备方法

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US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6610677B2 (en) * 2000-09-15 2003-08-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
US6613776B2 (en) * 2000-09-15 2003-09-02 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
EP1317448B2 (fr) * 2000-09-15 2011-05-04 Vertex Pharmaceuticals Incorporated Composes a base de pyrazole pouvant etre utilises comme inhibiteurs de la proteine kinase
US6660731B2 (en) * 2000-09-15 2003-12-09 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
JP4160395B2 (ja) * 2000-12-21 2008-10-01 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼインヒビターとして有用なピラゾール化合物
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US8211929B2 (en) * 2004-12-30 2012-07-03 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use

Also Published As

Publication number Publication date
MX2008016523A (es) 2009-01-19
AU2007263655A1 (en) 2008-01-03
JP2009541480A (ja) 2009-11-26
US20080004302A1 (en) 2008-01-03
UY30444A1 (es) 2008-01-31
KR20090024270A (ko) 2009-03-06
AR061737A1 (es) 2008-09-17
CA2654852A1 (fr) 2008-01-03
IL195731A0 (en) 2009-09-01
EP2044063A1 (fr) 2009-04-08
WO2008001070A1 (fr) 2008-01-03
TW200817391A (en) 2008-04-16

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