NO20082382L - Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri - Google Patents

Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri

Info

Publication number
NO20082382L
NO20082382L NO20082382A NO20082382A NO20082382L NO 20082382 L NO20082382 L NO 20082382L NO 20082382 A NO20082382 A NO 20082382A NO 20082382 A NO20082382 A NO 20082382A NO 20082382 L NO20082382 L NO 20082382L
Authority
NO
Norway
Prior art keywords
rapamycin
methods
crystallinity
painting
differential scanning
Prior art date
Application number
NO20082382A
Other languages
English (en)
Norwegian (no)
Inventor
Subodh S Deshmukh
Mahmoud Mirmehrabi
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of NO20082382L publication Critical patent/NO20082382L/no

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N25/00—Investigating or analyzing materials by the use of thermal means
    • G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
    • G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
    • G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
    • G01N25/4866—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample by using a differential method

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Combustion & Propulsion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
NO20082382A 2005-12-07 2008-05-26 Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri NO20082382L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74800505P 2005-12-07 2005-12-07
PCT/US2006/046445 WO2007067566A2 (en) 2005-12-07 2006-12-06 Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry

Publications (1)

Publication Number Publication Date
NO20082382L true NO20082382L (no) 2008-09-04

Family

ID=38117222

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20082382A NO20082382L (no) 2005-12-07 2008-05-26 Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri

Country Status (17)

Country Link
US (1) US20070128731A1 (zh)
EP (1) EP1957964A2 (zh)
JP (1) JP2009518648A (zh)
KR (1) KR20080077147A (zh)
CN (1) CN101351702A (zh)
AR (1) AR058283A1 (zh)
AU (1) AU2006322030A1 (zh)
BR (1) BRPI0619592A2 (zh)
CA (1) CA2630786A1 (zh)
CR (1) CR9985A (zh)
EC (1) ECSP088519A (zh)
IL (1) IL191545A0 (zh)
NO (1) NO20082382L (zh)
PE (1) PE20071000A1 (zh)
RU (1) RU2008120712A (zh)
TW (1) TW200736603A (zh)
WO (1) WO2007067566A2 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102282457A (zh) * 2009-01-21 2011-12-14 拜康有限公司 确定西罗莫司稳定性的方法和制备其稳定形式的工艺
FR2943539B1 (fr) 2009-03-31 2011-07-22 Ethypharm Sa Composition pharmaceutique comprenant un macrolide immunosuppresseur de la famille des limus.
WO2013022418A1 (en) * 2011-08-05 2013-02-14 Crucible Intellectual Property Llc Nondestructive method to determine crystallinity in amorphous alloy
US20150139270A1 (en) * 2012-04-23 2015-05-21 Apple Inc. Non-destructive determination of volumetric crystallinity of bulk amorphous alloy
ES2897473T3 (es) 2013-03-15 2022-03-01 Biosensors Int Group Ltd Purificación de derivados de la rapamicina
US9439892B2 (en) 2013-05-16 2016-09-13 Surmodics, Inc. Macrolide particulates, methods for preparation, and medical devices associated therewith
WO2014201236A1 (en) * 2013-06-12 2014-12-18 Surmodics, Inc. Solvent methods for preparing crystalline macrolide particulates, compositions, and articles containing particulates
DE102013110294B4 (de) * 2013-09-18 2016-07-07 Innora Gmbh Limus-Depot-Formulierung auf Ballonkathetern
WO2015181826A1 (en) 2014-05-27 2015-12-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Crystalline coating and release of bioactive agents
CN105116013A (zh) * 2015-04-23 2015-12-02 山东农业大学 一种确定金属离子对蛋白酶水解大豆分离蛋白影响的方法
JP6531488B2 (ja) * 2015-05-22 2019-06-19 日産自動車株式会社 リチウムイオン二次電池の熱履歴検知方法
US10098846B2 (en) 2016-03-31 2018-10-16 Surmodics, Inc. Drug-containing particulate composition with cationic agent, associated medical devices, and methods for treatment
US11123459B2 (en) 2016-12-16 2021-09-21 Surmodics, Inc. Hydrophobic active agent particle coatings and methods for treatment
US11629222B2 (en) * 2019-07-01 2023-04-18 Ethicon, Inc. Calorimetric crystallization method for evaluation of monomer purity
WO2023158308A1 (en) 2022-02-18 2023-08-24 Technische Universiteit Delft Novel method for analyzing dsc data
NL2031004B1 (en) * 2022-02-18 2023-09-05 Univ Delft Tech Novel method for analyzing DSC data

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US5358909A (en) * 1991-02-27 1994-10-25 Nippon Steel Corporation Method of manufacturing field-emitter
US5358908A (en) * 1992-02-14 1994-10-25 Micron Technology, Inc. Method of creating sharp points and other features on the surface of a semiconductor substrate
GB9313650D0 (en) * 1993-07-01 1993-08-18 Glaxo Group Ltd Method and apparatus for the formation of particles
US5385909A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5385908A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5362718A (en) * 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
DE19825472B4 (de) * 1997-06-06 2005-05-25 Netzsch-Gerätebau GmbH Vorrichtung zur Differential-Scanning-Kalorimetrie
GB9826882D0 (en) * 1998-12-07 1999-01-27 Novartis Ag Organic compounds
US6277983B1 (en) * 2000-09-27 2001-08-21 American Home Products Corporation Regioselective synthesis of rapamycin derivatives
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
EP1319008B1 (en) * 2000-09-19 2008-10-15 Wyeth Water soluble rapamycin esters
CN1571691A (zh) * 2001-10-17 2005-01-26 纳幕尔杜邦公司 产生微粒用的转子－定子设备和方法
US20060169199A1 (en) * 2003-03-31 2006-08-03 Vilmos Keri Crystallization and purification of macrolides
KR20060052874A (ko) * 2003-07-24 2006-05-19 테바 기오기스제르갸르 레스즈베니타르사사그 마크로라이드의 정제 방법
DK1658295T3 (da) * 2003-08-07 2007-09-24 Wyeth Corp Regioselektiv syntese af CCI-779
RU2345999C2 (ru) * 2003-09-03 2009-02-10 Уайт Аморфный 42-эфир рапамицина и 3-гидрокси-2(гидроксиметил)-2-метилпропионовой кислоты и содержащие его фармацевтические композиции
US7268144B2 (en) * 2004-04-14 2007-09-11 Wyeth Regiospecific synthesis of rapamycin 42-ester derivatives
US7445916B2 (en) * 2004-04-14 2008-11-04 Wyeth Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies
MX2007001676A (es) * 2004-08-10 2007-04-12 Wyeth Corp Derivados de 42-ester de rapamicina con acido 2,2-bis(hidroximetil)propionico y metodos para hacer los mismos.
WO2006068932A2 (en) * 2004-12-20 2006-06-29 Wyeth Rapamycin analogues and the uses thereof in the treatment of neurological, proliferative, and inflammatory disorders
RU2007119585A (ru) * 2004-12-20 2009-01-27 Вайет (Us) Производные рапамицина и их применение при лечении неврологических заболеваний
JP2008530090A (ja) * 2005-02-09 2008-08-07 ワイス Ｃｃｉ−７７９多形及びその使用
KR20070107072A (ko) * 2005-03-02 2007-11-06 와이어쓰 모액으로부터의 ｃｃｉ-７７９의 회수
WO2006096325A1 (en) * 2005-03-07 2006-09-14 Wyeth Oxepane isomer of 42-o-(2-hydroxy)ethyl-rapamycin

Also Published As

Publication number Publication date
ECSP088519A (es) 2008-07-30
WO2007067566A2 (en) 2007-06-14
CA2630786A1 (en) 2007-06-14
BRPI0619592A2 (pt) 2016-09-06
KR20080077147A (ko) 2008-08-21
TW200736603A (en) 2007-10-01
CR9985A (es) 2008-08-21
PE20071000A1 (es) 2007-10-10
JP2009518648A (ja) 2009-05-07
EP1957964A2 (en) 2008-08-20
US20070128731A1 (en) 2007-06-07
AU2006322030A1 (en) 2007-06-14
RU2008120712A (ru) 2010-01-20
CN101351702A (zh) 2009-01-21
IL191545A0 (en) 2008-12-29
WO2007067566A3 (en) 2008-01-24
AR058283A1 (es) 2008-01-30

Similar Documents

Publication Publication Date Title
NO20082382L (no) Fremgangsmater for fremstilling av krystallinsk rapamycin og for maling av krystallinitet av rapamycinforbindelser ved anvendelse av differentiell skanning-kalorimetri
NO20092960L (no) Krystallinsk minocycline base og framgangsmater for framstilling av denne
NO20080784L (no) Histondeacetylaseinhibitorer
AU2006319247A8 (en) Heteroaryl substituted piperidine derivatives as L-CPT1 inhibitors
WO2007079197A3 (en) Kit for taking biopsies, autopsies, excisions, and resections and methods thereof
WO2007136510A3 (en) Polymorphic forms of imatinib mesylate and processes for their preparation as well as of amorphous imatinib mesylate and form alpha
NO20071707L (no) Fremstilling av 4,5-dihydro-pyrazolo[3,4-C]Pyrid-2-oner
DK1695709T3 (da) Krystalinsk gammad-form af ivabradin-hydrochlorid, fremgangsmåde til fremstilling heraf og farmaceutiske sammensætninger indeholdende denne
EP1851869A4 (en) SYSTEM, APPARATUS AND METHOD FOR ADAPTIVE INTERFERENCE-WEIGHTED ADAPTIVE CANCELLATION BY PARALLEL RESIDUE COMPENSATION
DK1695965T3 (da) Krystallinsk betaform af ivabradin-hydrochlorid, fremgangsmåde til fremstilling heraf og famceutiske sammensætninger indeholdende denne
AU2003259227A1 (en) Cellulose support for seed
WO2007146622A8 (en) Molecular sieve ssz-75 composition of matter and synthesis thereof
WO2006005741A3 (en) Piperdine derivatives as renin inhibitors
GB2431927A9 (en) 1,2-Disubstituted indoles & derivatives thereof astherapeutic 5-iipoxygenase-activating protein (fl ap) inhibitors
IL189466A0 (en) Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine
PT1713801E (pt) Processo para a preparação de 1-(2s,3s)-2-benzidril-n-(5- -terc-butil-2-metoxibenzil)-quinuclidina-3-amina
EP1881975B8 (en) N,n-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors
ZA200801890B (en) Novel crystalline form of a pyridazino (4, 5-B) indole derivative
WO2008021342A3 (en) Amorphous and crystalline forms of 9-hydroxy-risperidone ( paliperidone )
IL185135A0 (en) Process for preparing 2,3-disubstituted indoles
NO20091817L (no) Kinase inhibitorer
NO20071634L (no) Effektiv syntese av 4,5-dihydro-pyrazolo(3,4-C)pyrid-2-oner
WO2006079720A8 (fr) Nouveaux derives d1oximes heterocycliques, leur procede de preparation et leur utilisation comme agents hypoglycemiants et hypoli pemiants
TW200708512A (en) Crystal of aminopyrrolidine derivative and production method thereof
DE602007012935D1 (de) Aminothiazolmakrocyclen, ihre verwendung als antibakterielle verbindungen und verfahren zu ihrer herstellung

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application