NO20073717L - Fenylmetanonderivater og deres anvendelse som glycin-transportor-1-inhibitorer - Google Patents

Fenylmetanonderivater og deres anvendelse som glycin-transportor-1-inhibitorer

Info

Publication number
NO20073717L
NO20073717L NO20073717A NO20073717A NO20073717L NO 20073717 L NO20073717 L NO 20073717L NO 20073717 A NO20073717 A NO 20073717A NO 20073717 A NO20073717 A NO 20073717A NO 20073717 L NO20073717 L NO 20073717L
Authority
NO
Norway
Prior art keywords
inhibitors
glycine transporter
phenylmethanone
derivatives
phenylmethanone derivatives
Prior art date
Application number
NO20073717A
Other languages
English (en)
Inventor
Emmanuel Pinard
Synese Jolidon
Roger David Norcross
Robert Narquizian
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20073717L publication Critical patent/NO20073717L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår forbindelser med generell formel IA eller IB eller Forbindelsene kan anvendes for behandling av sykdommer relatert til glysintransportør-inhibitoren.
NO20073717A 2005-01-26 2007-07-18 Fenylmetanonderivater og deres anvendelse som glycin-transportor-1-inhibitorer NO20073717L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05100473 2005-01-26
PCT/EP2006/000361 WO2006079467A1 (en) 2005-01-26 2006-01-17 Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors

Publications (1)

Publication Number Publication Date
NO20073717L true NO20073717L (no) 2007-08-23

Family

ID=36121826

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20073717A NO20073717L (no) 2005-01-26 2007-07-18 Fenylmetanonderivater og deres anvendelse som glycin-transportor-1-inhibitorer

Country Status (19)

Country Link
US (1) US7442710B2 (no)
EP (1) EP1844045B1 (no)
JP (1) JP4829900B2 (no)
KR (1) KR100915472B1 (no)
CN (1) CN101146808B (no)
AR (1) AR052662A1 (no)
AT (1) ATE447572T1 (no)
AU (1) AU2006208547B2 (no)
BR (1) BRPI0607241A2 (no)
CA (1) CA2595605A1 (no)
DE (1) DE602006010175D1 (no)
ES (1) ES2332529T3 (no)
IL (1) IL184561A (no)
MX (1) MX2007008918A (no)
NO (1) NO20073717L (no)
RU (1) RU2007126951A (no)
TW (1) TW200637859A (no)
WO (1) WO2006079467A1 (no)
ZA (1) ZA200705898B (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR080374A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparcion de 2-(ciclohexilmetil)-n-(2-((2s)-1-metilpirrolidin-2-il) etil)- 1,2,3,4-tetrahidroisoquinolin-7- sulfonamida
US9045459B2 (en) * 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2016029454A1 (en) 2014-08-29 2016-03-03 Merck Sharp & Dohme Corp. TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE
CN111393366B (zh) * 2020-06-05 2020-09-01 北京华氏开元医药科技有限公司 四氢异喹啉类衍生物、制备方法、药物组合物及应用

Family Cites Families (29)

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JPS5017800B1 (no) * 1967-08-02 1975-06-24
JPS5017999B1 (no) * 1970-06-02 1975-06-25
JPS5017998B1 (no) * 1970-06-02 1975-06-25
DE2423847A1 (de) * 1973-05-28 1975-01-02 Ciba Geigy Ag Neue sulfamoylbenzoesaeureamide
DE2611705A1 (de) * 1976-03-18 1977-09-22 Josef Dipl Chem Dr Rer N Klosa N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel
IT1176613B (it) 1984-08-14 1987-08-18 Ravizza Spa Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione
RU2124511C1 (ru) 1993-05-14 1999-01-10 Фармасьютикал Ко., Лтд Производные пиперазина
US6001854A (en) * 1996-05-31 1999-12-14 Allelix Neuroscience Inc. Pharmaceutical for treating of neurological and neuropsychiatric disorders
AU3254499A (en) 1998-03-06 1999-09-20 Janssen Pharmaceutica N.V. Glycine transport inhibitors
JP2002505277A (ja) 1998-03-06 2002-02-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ グリシン輸送阻害剤
JP4811978B2 (ja) * 2000-01-24 2011-11-09 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー ３−アミノキナゾリン−２，４−ジオン抗菌剤
EP1296950A2 (en) 2000-04-20 2003-04-02 NPS Allelix Corp. Aminopiperidines for use as glyt-1 inhibitors
GB0021419D0 (en) 2000-08-31 2000-10-18 Oxford Glycosciences Uk Ltd Compounds
CA2422044A1 (en) * 2000-09-14 2002-03-21 Gliatech, Inc. Nitrogen-containing compounds and their use as glycine transport inhibitors
WO2003004480A2 (en) 2001-07-02 2003-01-16 Novo Nordisk A/S Substituted piperazine and diazepanes as histamine h3 receptor agonists
WO2003035602A1 (fr) 2001-10-25 2003-05-01 Sankyo Company, Limited Modulateurs lipidiques
ES2263015T3 (es) * 2002-10-21 2006-12-01 Warner-Lambert Company Llc Derivados de tetrahidroquinolina como antagonistas de crth2.
WO2004037800A1 (en) 2002-10-22 2004-05-06 Glaxo Group Limited Aryloxyalkylamine derivates as h3 receptor ligands
EP1489071A1 (en) * 2003-06-18 2004-12-22 4Sc Ag N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators
US20050070570A1 (en) * 2003-06-18 2005-03-31 4Sc Ag Novel potassium channels modulators
GB0314479D0 (en) * 2003-06-20 2003-07-23 Glaxo Group Ltd Compounds
DK1656361T3 (da) * 2003-08-11 2008-05-05 Hoffmann La Roche Piperazin med OR-substitueret phenylgruppe og anvendelse deraf som GLYT1-inhibitorer
DK1703909T3 (da) * 2003-09-09 2009-06-22 Hoffmann La Roche 1-benzoyl-piperazinderivater som glycinoptagelsesinhibitorer til behandling af psykoser
DK1663232T3 (da) * 2003-09-09 2008-02-04 Hoffmann La Roche Benzimidazolderivater som human chymase-inhibitorer
GB0329362D0 (en) 2003-12-18 2004-01-21 Glaxo Group Ltd Compounds
CN101119970A (zh) * 2004-01-09 2008-02-06 科赛普特治疗学股份有限公司 氮杂萘烷糖皮质激素受体调节剂
DE102004020908A1 (de) * 2004-04-28 2005-11-17 Grünenthal GmbH Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen
JP2007535538A (ja) 2004-04-29 2007-12-06 メルク　エンド　カムパニー　インコーポレーテッド アゼチジングリシン輸送体インヒビター
US7297700B2 (en) * 2005-03-24 2007-11-20 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof

Also Published As

Publication number Publication date
JP4829900B2 (ja) 2011-12-07
BRPI0607241A2 (pt) 2009-08-25
TW200637859A (en) 2006-11-01
AU2006208547A1 (en) 2006-08-03
KR20070099030A (ko) 2007-10-08
WO2006079467A1 (en) 2006-08-03
KR100915472B1 (ko) 2009-09-03
JP2008528526A (ja) 2008-07-31
CN101146808A (zh) 2008-03-19
ZA200705898B (en) 2009-07-29
ATE447572T1 (de) 2009-11-15
IL184561A0 (en) 2007-10-31
EP1844045A1 (en) 2007-10-17
EP1844045B1 (en) 2009-11-04
AU2006208547B2 (en) 2011-02-10
ES2332529T3 (es) 2010-02-08
AR052662A1 (es) 2007-03-28
MX2007008918A (es) 2007-08-21
US7442710B2 (en) 2008-10-28
US20060167023A1 (en) 2006-07-27
RU2007126951A (ru) 2009-03-10
CN101146808B (zh) 2011-10-12
IL184561A (en) 2011-03-31
DE602006010175D1 (de) 2009-12-17
CA2595605A1 (en) 2006-08-03

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