ATE447572T1 - Phenylmethanonderivate und ihre verwendung als glycin-transporter-1-hemmer - Google Patents
Phenylmethanonderivate und ihre verwendung als glycin-transporter-1-hemmerInfo
- Publication number
- ATE447572T1 ATE447572T1 AT06706263T AT06706263T ATE447572T1 AT E447572 T1 ATE447572 T1 AT E447572T1 AT 06706263 T AT06706263 T AT 06706263T AT 06706263 T AT06706263 T AT 06706263T AT E447572 T1 ATE447572 T1 AT E447572T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- glycine transporter
- phenylmethanone
- derivatives
- phenylmethanone derivatives
- Prior art date
Links
- 102000010726 Glycine Plasma Membrane Transport Proteins Human genes 0.000 title 1
- 108010063380 Glycine Plasma Membrane Transport Proteins Proteins 0.000 title 1
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical class O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05100473 | 2005-01-26 | ||
| PCT/EP2006/000361 WO2006079467A1 (en) | 2005-01-26 | 2006-01-17 | Phenyl methanone derivatives and their use as glycine transporter 1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE447572T1 true ATE447572T1 (de) | 2009-11-15 |
Family
ID=36121826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06706263T ATE447572T1 (de) | 2005-01-26 | 2006-01-17 | Phenylmethanonderivate und ihre verwendung als glycin-transporter-1-hemmer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7442710B2 (de) |
| EP (1) | EP1844045B1 (de) |
| JP (1) | JP4829900B2 (de) |
| KR (1) | KR100915472B1 (de) |
| CN (1) | CN101146808B (de) |
| AR (1) | AR052662A1 (de) |
| AT (1) | ATE447572T1 (de) |
| AU (1) | AU2006208547B2 (de) |
| BR (1) | BRPI0607241A2 (de) |
| CA (1) | CA2595605A1 (de) |
| DE (1) | DE602006010175D1 (de) |
| ES (1) | ES2332529T3 (de) |
| IL (1) | IL184561A (de) |
| MX (1) | MX2007008918A (de) |
| NO (1) | NO20073717L (de) |
| RU (1) | RU2007126951A (de) |
| TW (1) | TW200637859A (de) |
| WO (1) | WO2006079467A1 (de) |
| ZA (1) | ZA200705898B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
| US9045459B2 (en) * | 2010-08-13 | 2015-06-02 | AbbVie Deutschland GmbH & Co. KG | Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy |
| WO2016029454A1 (en) | 2014-08-29 | 2016-03-03 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE |
| CN111393366B (zh) * | 2020-06-05 | 2020-09-01 | 北京华氏开元医药科技有限公司 | 四氢异喹啉类衍生物、制备方法、药物组合物及应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5017800B1 (de) * | 1967-08-02 | 1975-06-24 | ||
| JPS5017999B1 (de) * | 1970-06-02 | 1975-06-25 | ||
| JPS5017998B1 (de) * | 1970-06-02 | 1975-06-25 | ||
| DE2423847A1 (de) | 1973-05-28 | 1975-01-02 | Ciba Geigy Ag | Neue sulfamoylbenzoesaeureamide |
| DE2611705A1 (de) | 1976-03-18 | 1977-09-22 | Josef Dipl Chem Dr Rer N Klosa | N-5-(nitrofurfuryliden-)-1-amino- hydantoin enthaltende kristalloesungsmittel |
| IT1176613B (it) | 1984-08-14 | 1987-08-18 | Ravizza Spa | Derivati piperazinici farmacologicamente attivi e processo per la loro preparazione |
| RU2124511C1 (ru) | 1993-05-14 | 1999-01-10 | Фармасьютикал Ко., Лтд | Производные пиперазина |
| US6001854A (en) | 1996-05-31 | 1999-12-14 | Allelix Neuroscience Inc. | Pharmaceutical for treating of neurological and neuropsychiatric disorders |
| WO1999044596A2 (en) | 1998-03-06 | 1999-09-10 | Janssen Pharmaceutica N.V. | Glycine transport inhibitors |
| AU3254499A (en) | 1998-03-06 | 1999-09-20 | Janssen Pharmaceutica N.V. | Glycine transport inhibitors |
| CN1425008A (zh) * | 2000-01-24 | 2003-06-18 | 沃尼尔·朗伯公司 | 3－氨基喹唑啉－2,4－二酮抗菌剂 |
| WO2001081308A2 (en) | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
| GB0021419D0 (en) | 2000-08-31 | 2000-10-18 | Oxford Glycosciences Uk Ltd | Compounds |
| US6946474B2 (en) * | 2000-09-14 | 2005-09-20 | Merck & Co., Inc. | Nitrogen-containing compounds and their use as glycine transport inhibitors |
| JP2005502623A (ja) | 2001-07-02 | 2005-01-27 | ノボ ノルディスク アクティーゼルスカブ | 置換ピペラジンおよびジアゼパン |
| WO2003035602A1 (fr) | 2001-10-25 | 2003-05-01 | Sankyo Company, Limited | Modulateurs lipidiques |
| JP2006511486A (ja) * | 2002-10-21 | 2006-04-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | Ｃｒｔｈ２拮抗剤としてのテトラヒドロキノリン誘導体 |
| WO2004037800A1 (en) | 2002-10-22 | 2004-05-06 | Glaxo Group Limited | Aryloxyalkylamine derivates as h3 receptor ligands |
| EP1489071A1 (de) * | 2003-06-18 | 2004-12-22 | 4Sc Ag | N-Substituierten, 3,4-Dihydro-1H-Isochinolin Derivate als Kaliumkanal-Modulatoren |
| US20050070570A1 (en) * | 2003-06-18 | 2005-03-31 | 4Sc Ag | Novel potassium channels modulators |
| GB0314479D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Compounds |
| DK1656361T3 (da) | 2003-08-11 | 2008-05-05 | Hoffmann La Roche | Piperazin med OR-substitueret phenylgruppe og anvendelse deraf som GLYT1-inhibitorer |
| DK1663232T3 (da) | 2003-09-09 | 2008-02-04 | Hoffmann La Roche | Benzimidazolderivater som human chymase-inhibitorer |
| NZ545613A (en) | 2003-09-09 | 2009-11-27 | Hoffmann La Roche | 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses |
| GB0329362D0 (en) | 2003-12-18 | 2004-01-21 | Glaxo Group Ltd | Compounds |
| JP4851345B2 (ja) * | 2004-01-09 | 2012-01-11 | コーセプト セラピューティクス， インコーポレイテッド | アザデカリン糖質コルチコイド受容体モジュレーター |
| DE102004020908A1 (de) * | 2004-04-28 | 2005-11-17 | Grünenthal GmbH | Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen |
| JP2007535538A (ja) | 2004-04-29 | 2007-12-06 | メルク エンド カムパニー インコーポレーテッド | アゼチジングリシン輸送体インヒビター |
| US7402596B2 (en) * | 2005-03-24 | 2008-07-22 | Renovis, Inc. | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof |
-
2006
- 2006-01-17 WO PCT/EP2006/000361 patent/WO2006079467A1/en active Application Filing
- 2006-01-17 AU AU2006208547A patent/AU2006208547B2/en not_active Ceased
- 2006-01-17 RU RU2007126951/04A patent/RU2007126951A/ru not_active Application Discontinuation
- 2006-01-17 JP JP2007552553A patent/JP4829900B2/ja not_active Expired - Fee Related
- 2006-01-17 BR BRPI0607241-0A patent/BRPI0607241A2/pt not_active IP Right Cessation
- 2006-01-17 MX MX2007008918A patent/MX2007008918A/es active IP Right Grant
- 2006-01-17 AT AT06706263T patent/ATE447572T1/de active
- 2006-01-17 ES ES06706263T patent/ES2332529T3/es active Active
- 2006-01-17 CA CA002595605A patent/CA2595605A1/en not_active Abandoned
- 2006-01-17 EP EP06706263A patent/EP1844045B1/de not_active Not-in-force
- 2006-01-17 DE DE602006010175T patent/DE602006010175D1/de active Active
- 2006-01-17 CN CN2006800097689A patent/CN101146808B/zh not_active Expired - Fee Related
- 2006-01-17 KR KR1020077019354A patent/KR100915472B1/ko not_active IP Right Cessation
- 2006-01-23 TW TW095102414A patent/TW200637859A/zh unknown
- 2006-01-24 US US11/338,266 patent/US7442710B2/en not_active Expired - Fee Related
- 2006-01-26 AR ARP060100286A patent/AR052662A1/es unknown
-
2007
- 2007-07-12 IL IL184561A patent/IL184561A/en not_active IP Right Cessation
- 2007-07-18 NO NO20073717A patent/NO20073717L/no not_active Application Discontinuation
- 2007-07-18 ZA ZA200705898A patent/ZA200705898B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200705898B (en) | 2009-07-29 |
| AU2006208547A1 (en) | 2006-08-03 |
| MX2007008918A (es) | 2007-08-21 |
| IL184561A (en) | 2011-03-31 |
| DE602006010175D1 (de) | 2009-12-17 |
| CN101146808B (zh) | 2011-10-12 |
| TW200637859A (en) | 2006-11-01 |
| CA2595605A1 (en) | 2006-08-03 |
| IL184561A0 (en) | 2007-10-31 |
| CN101146808A (zh) | 2008-03-19 |
| AU2006208547B2 (en) | 2011-02-10 |
| EP1844045B1 (de) | 2009-11-04 |
| NO20073717L (no) | 2007-08-23 |
| BRPI0607241A2 (pt) | 2009-08-25 |
| ES2332529T3 (es) | 2010-02-08 |
| KR20070099030A (ko) | 2007-10-08 |
| RU2007126951A (ru) | 2009-03-10 |
| AR052662A1 (es) | 2007-03-28 |
| JP4829900B2 (ja) | 2011-12-07 |
| JP2008528526A (ja) | 2008-07-31 |
| WO2006079467A1 (en) | 2006-08-03 |
| US7442710B2 (en) | 2008-10-28 |
| KR100915472B1 (ko) | 2009-09-03 |
| EP1844045A1 (de) | 2007-10-17 |
| US20060167023A1 (en) | 2006-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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