NO20072518L - Kjonns stereoid forloper alene eller i kombinasjon med en selektiv ostrogen reseptor modulator og /eller med ostrogener og /eller en type 5 CGMP fosfodiesteraseinhibitor for a forebygge eller behandle vaginal torrhet og seksuell dysfunksjon hos postmenopausale kvinner. - Google Patents

Kjonns stereoid forloper alene eller i kombinasjon med en selektiv ostrogen reseptor modulator og /eller med ostrogener og /eller en type 5 CGMP fosfodiesteraseinhibitor for a forebygge eller behandle vaginal torrhet og seksuell dysfunksjon hos postmenopausale kvinner.

Info

Publication number
NO20072518L
NO20072518L NO20072518A NO20072518A NO20072518L NO 20072518 L NO20072518 L NO 20072518L NO 20072518 A NO20072518 A NO 20072518A NO 20072518 A NO20072518 A NO 20072518A NO 20072518 L NO20072518 L NO 20072518L
Authority
NO
Norway
Prior art keywords
receptor modulator
estrogen receptor
selective estrogen
sexual dysfunction
stereoid
Prior art date
Application number
NO20072518A
Other languages
English (en)
Other versions
NO340123B1 (no
Inventor
Fernand Labrie
Mohamed El-Alfy
Louise Berger
Original Assignee
Endorech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endorech Inc filed Critical Endorech Inc
Publication of NO20072518L publication Critical patent/NO20072518L/no
Publication of NO340123B1 publication Critical patent/NO340123B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Abstract

Det beskrives nye metoder for behandling eller reduksjon av sannsynligheten for å erverve vaginale dysfunksjoner og mer spesielt vaginal tørrhet og dyspareunia, som fører til seksuell dysfunksjon og lavt seksuelt behov og ytelse, i mottakelige varmblodige dyr inkludert mennesker som involverer administrering av en kjønnssteroidforløper. Videre beskrives spesielt administrering av østrogen eller en selektiv østrogenreseptormodulator og særlig en som er valgt fra gruppen bestående av Raloxifene, Arzoxifene, Tamoxifen, Droloxifene, Toremifene, Iodoxifene, GW 5638, TSE-424, ERA-923 og lasofoksifen og mer spesielt forbindelser med den generelle struktur: spesielt er beskrevet for medisinsk behandling og/eller inhibering av utvikling av noen av de ovenfor nevnte sykdommer. Det beskrives videre farmasøytiske preparater for avlevering av den eller de nevnte bestanddeler og det eller de sett som er nyttige ifølge oppfinnelsen.
NO20072518A 2004-10-20 2007-05-16 Anvendelse av kjønnssteroidforløperen dehydroepiandrosteron alene eller i kombinasjon med den selektive østrogenreseptormodulatoren Acolbifene for prevensjon og terapi av vaginal tørrhet og seksuell dysfunksjon hos postmenopausale kvinner NO340123B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62045204P 2004-10-20 2004-10-20
PCT/CA2005/001612 WO2006042409A1 (en) 2004-10-20 2005-10-20 Sex steroid precursors alone or in combination with a selective estrogen receptor modulator and/or with estrogens and/or a type 5 cgmp phosphodiesterase inhibitor for the prevention and treatment of vaginal dryness and sexual dysfunction in postmenopausal women

Publications (2)

Publication Number Publication Date
NO20072518L true NO20072518L (no) 2007-07-19
NO340123B1 NO340123B1 (no) 2017-03-13

Family

ID=36202646

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072518A NO340123B1 (no) 2004-10-20 2007-05-16 Anvendelse av kjønnssteroidforløperen dehydroepiandrosteron alene eller i kombinasjon med den selektive østrogenreseptormodulatoren Acolbifene for prevensjon og terapi av vaginal tørrhet og seksuell dysfunksjon hos postmenopausale kvinner

Country Status (27)

Country Link
US (3) US8835413B2 (no)
EP (1) EP1802312B1 (no)
JP (3) JP5057983B2 (no)
KR (1) KR20070067235A (no)
CN (5) CN106038572A (no)
AP (1) AP2365A (no)
AU (1) AU2005297367B2 (no)
BR (1) BRPI0516243C1 (no)
CA (2) CA2749235C (no)
DK (1) DK1802312T3 (no)
EA (1) EA014878B1 (no)
ES (1) ES2553101T3 (no)
GE (1) GEP20105066B (no)
HK (1) HK1225629A1 (no)
HR (1) HRP20070169B1 (no)
HU (1) HUE025651T2 (no)
IL (3) IL182633A (no)
MA (1) MA29018B1 (no)
MX (3) MX368189B (no)
NO (1) NO340123B1 (no)
NZ (1) NZ554619A (no)
RS (1) RS20070166A (no)
SG (2) SG10201404796QA (no)
TN (1) TNSN07147A1 (no)
UA (1) UA93985C2 (no)
WO (1) WO2006042409A1 (no)
ZA (1) ZA200703198B (no)

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