NO20081772L - Ikke-basiske antagonister av melaninkonsentrerende hormon-reseptor-1 - Google Patents
Ikke-basiske antagonister av melaninkonsentrerende hormon-reseptor-1Info
- Publication number
- NO20081772L NO20081772L NO20081772A NO20081772A NO20081772L NO 20081772 L NO20081772 L NO 20081772L NO 20081772 A NO20081772 A NO 20081772A NO 20081772 A NO20081772 A NO 20081772A NO 20081772 L NO20081772 L NO 20081772L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- present application
- melanin
- antagonists
- basic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Foreliggende søknad tilveiebringer forbindelser, inkludert alle stereoisomerer, solvater, prodrugs og farmasøytisk akseptable former derav, i henhold til Formel I. Dessuten tilveiebringer foreliggende søknad farmasøytiske preparater som inneholder minst én forbindelse med formel I og eventuelt minst ett ytterligere terapeutisk middel. Foreliggende søknad tilveiebringer også metoder for behandling av en pasient som lider av en MCHR-1-modulert sykdom eller lidelse, som for eksempel fedme, diabetes, depresjon eller angst, ved administrering av en terapeutisk effektiv dose av en forbindelse med formel I.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73045305P | 2005-10-26 | 2005-10-26 | |
US11/586,255 US8618115B2 (en) | 2005-10-26 | 2006-10-25 | Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them |
PCT/US2006/041725 WO2007050726A2 (en) | 2005-10-26 | 2006-10-26 | Thienopyrimidinone derivatives as melanin concentrating hormone receptor-1 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20081772L true NO20081772L (no) | 2008-05-19 |
Family
ID=37888159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20081772A NO20081772L (no) | 2005-10-26 | 2008-04-11 | Ikke-basiske antagonister av melaninkonsentrerende hormon-reseptor-1 |
Country Status (16)
Country | Link |
---|---|
US (1) | US8618115B2 (no) |
EP (2) | EP1948665B1 (no) |
JP (1) | JP2009513658A (no) |
KR (1) | KR20080067681A (no) |
AR (1) | AR056155A1 (no) |
AU (1) | AU2006306140A1 (no) |
BR (1) | BRPI0617945A2 (no) |
CA (1) | CA2627653A1 (no) |
EA (1) | EA016126B1 (no) |
GE (1) | GEP20115213B (no) |
IL (1) | IL190898A0 (no) |
NO (1) | NO20081772L (no) |
NZ (1) | NZ567659A (no) |
PE (1) | PE20070532A1 (no) |
TW (1) | TW200728289A (no) |
WO (1) | WO2007050726A2 (no) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7285557B2 (en) * | 2001-10-15 | 2007-10-23 | Smithkline Beecham P.L.C. | Pyrimidinones as melanin concentrating hormone receptor 1 |
US7553836B2 (en) * | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
KR20090047458A (ko) | 2006-08-08 | 2009-05-12 | 사노피-아벤티스 | 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도 |
US20080153810A1 (en) * | 2006-11-15 | 2008-06-26 | Forest Laboratories Holdings Limited | Indazole derivatives useful as melanin concentrating receptor ligands |
CN101687882A (zh) | 2007-04-25 | 2010-03-31 | 百时美施贵宝公司 | 非碱性黑色素浓集激素受体-1拮抗剂 |
EP2242745A1 (de) * | 2008-02-07 | 2010-10-27 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
PE20091928A1 (es) * | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
EP2346872B1 (en) * | 2008-10-08 | 2015-11-25 | Bristol-Myers Squibb Company | Azolotriazinone melanin concentrating hormone receptor-1 antagonists |
EP2346873A1 (en) * | 2008-10-08 | 2011-07-27 | Bristol-Myers Squibb Company | Azolopyrrolone melanin concentrating hormone receptor-1 antagonists |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
US8278316B2 (en) | 2009-03-09 | 2012-10-02 | Bristol-Myers Squibb Company | Aza pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
US8563583B2 (en) | 2009-03-09 | 2013-10-22 | Bristol-Myers Squibb Company | Pyridone analogs useful as melanin concentrating hormone receptor-1 antagonists |
WO2011023754A1 (en) | 2009-08-26 | 2011-03-03 | Sanofi-Aventis | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
HUP1100241A3 (en) | 2011-05-06 | 2013-12-30 | Richter Gedeon Nyrt | Oxetane substituted pyrimidones |
CN103130819B (zh) * | 2011-12-01 | 2016-01-20 | 中国科学院上海药物研究所 | 噻吩[3,2-d]并嘧啶-4-酮类化合物、其制备方法、药物组合物及用途 |
CA2891122C (en) | 2012-11-14 | 2021-07-20 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
WO2015114663A1 (en) | 2014-01-30 | 2015-08-06 | Council Of Scientific & Industrial Research | Novel thieno [2,3-d]pyrimidin-4(3h)-one compounds with antimycobacterial properties |
AR103297A1 (es) | 2014-12-30 | 2017-05-03 | Forma Therapeutics Inc | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina |
MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
JP2018504432A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス,インコーポレイテッド | ユビキチン特異的プロテアーゼ7阻害物質としてのイソチアゾロピリミジノン、ピラゾロピリミジノン及びピロロピリミジノン |
EP3253738A1 (en) | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
EP3253765A1 (en) | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors |
RS60834B1 (sr) | 2015-12-09 | 2020-10-30 | Cadent Therapeutics Inc | Modulatori heteroaromatskog nmda receptora i njihove upotrebe |
EP3386990B1 (en) * | 2015-12-09 | 2023-04-19 | Novartis AG | Thienopyrimidinone nmda receptor modulators and uses thereof |
CN107216339B (zh) * | 2016-03-22 | 2021-05-04 | 中国科学院上海药物研究所 | 一种dppiv抑制剂马来酸盐的多晶型及其制备方法 |
JP7332472B2 (ja) | 2016-12-22 | 2023-08-23 | ノバルティス アーゲー | Nmda受容体モジュレーターおよびその使用 |
EA202190431A1 (ru) | 2018-08-03 | 2021-06-11 | Кэйдент Терапьютикс, Инк. | Гетероароматические модуляторы nmda рецептора и их применение |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3674836A (en) | 1968-05-21 | 1972-07-04 | Parke Davis & Co | 2,2-dimethyl-{11 -aryloxy-alkanoic acids and salts and esters thereof |
US4027009A (en) | 1973-06-11 | 1977-05-31 | Merck & Co., Inc. | Compositions and methods for depressing blood serum cholesterol |
JPS5612114B2 (no) | 1974-06-07 | 1981-03-18 | ||
JPS5432794A (en) | 1977-08-18 | 1979-03-10 | Omron Tateisi Electronics Co | Manufacturing method of terminal rack |
NO154918C (no) | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
DE2951135A1 (de) | 1979-12-19 | 1981-06-25 | Hoechst Ag, 6230 Frankfurt | Sulfonylharnstoffe, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
US4450171A (en) | 1980-08-05 | 1984-05-22 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
US4448784A (en) | 1982-04-12 | 1984-05-15 | Hoechst-Roussel Pharmaceuticals, Inc. | 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof |
US5354772A (en) | 1982-11-22 | 1994-10-11 | Sandoz Pharm. Corp. | Indole analogs of mevalonolactone and derivatives thereof |
US4499289A (en) | 1982-12-03 | 1985-02-12 | G. D. Searle & Co. | Octahydronapthalenes |
CA1327360C (en) | 1983-11-14 | 1994-03-01 | William F. Hoffman | Oxo-analogs of mevinolin-like antihypercholesterolemic agents |
US4613610A (en) | 1984-06-22 | 1986-09-23 | Sandoz Pharmaceuticals Corp. | Cholesterol biosynthesis inhibiting pyrazole analogs of mevalonolactone and its derivatives |
US4686237A (en) | 1984-07-24 | 1987-08-11 | Sandoz Pharmaceuticals Corp. | Erythro-(E)-7-[3'-C1-3 alkyl-1'-(3",5"-dimethylphenyl)naphth-2'-yl]-3,5-dihydroxyhept-6-enoic acids and derivatives thereof |
US4647576A (en) | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
EP0216785B1 (en) | 1984-12-04 | 1991-01-30 | Sandoz Ag | Indene analogs of mevalonolactone and derivatives thereof |
US4668794A (en) | 1985-05-22 | 1987-05-26 | Sandoz Pharm. Corp. | Intermediate imidazole acrolein analogs |
EP0221025A1 (en) | 1985-10-25 | 1987-05-06 | Sandoz Ag | Heterocyclic analogs of mevalonolactone and derivatives thereof, processes for their production and their use as pharmaceuticals |
DE3543999A1 (de) | 1985-12-13 | 1987-06-19 | Bayer Ag | Hochreine acarbose |
FR2596393B1 (fr) | 1986-04-01 | 1988-06-03 | Sanofi Sa | Derives de l'acide hydroxy-3 dihydroxyoxophosphorio-4 butanoique, leur procede de preparation, leur application comme medicament et les compositions les renfermant |
US4681893A (en) | 1986-05-30 | 1987-07-21 | Warner-Lambert Company | Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis |
PT87539B (pt) | 1987-05-22 | 1992-09-30 | Squibb & Sons Inc | Processo para a preparacao de inibidores da reductase de hmg-coa contendo fosforo e novos intermediarios |
US4759923A (en) | 1987-06-25 | 1988-07-26 | Hercules Incorporated | Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives |
JP2569746B2 (ja) | 1987-08-20 | 1997-01-08 | 日産化学工業株式会社 | キノリン系メバロノラクトン類 |
US4871721A (en) | 1988-01-11 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
US4924024A (en) | 1988-01-11 | 1990-05-08 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors, new intermediates and method |
NO177005C (no) | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
US5506219A (en) | 1988-08-29 | 1996-04-09 | E. R. Squibb & Sons, Inc. | Pyridine anchors for HMG-CoA reductase inhibitors |
US5753675A (en) | 1989-03-03 | 1998-05-19 | Novartis Pharmaceuticals Corporation | Quinoline analogs of mevalonolactone and derivatives thereof |
FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
US5177080A (en) | 1990-12-14 | 1993-01-05 | Bayer Aktiengesellschaft | Substituted pyridyl-dihydroxy-heptenoic acid and its salts |
JP2648897B2 (ja) | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
DE4129603A1 (de) | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB9209628D0 (en) | 1992-05-05 | 1992-06-17 | Smithkline Beecham Plc | Compounds |
US5470845A (en) | 1992-10-28 | 1995-11-28 | Bristol-Myers Squibb Company | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia |
LT3300B (en) | 1992-12-23 | 1995-06-26 | Schering Corp | Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor |
US5594016A (en) | 1992-12-28 | 1997-01-14 | Mitsubishi Chemical Corporation | Naphthalene derivatives |
US5662934A (en) | 1993-01-05 | 1997-09-02 | Najarian; Thomas | Compositions and methods for lowering cholesterol while maintaining antioxidant levels |
ATE178794T1 (de) | 1993-01-19 | 1999-04-15 | Warner Lambert Co | Stabilisierte, oral anzuwendende zusammensetzung enthaltend die verbindung ci-981 und verfahren |
EP0733048A1 (en) | 1993-12-07 | 1996-09-25 | Smithkline Beecham Plc | Heterocyclic biphenylylamides useful as 5ht1d antagonists |
US5776983A (en) | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
US5488064A (en) | 1994-05-02 | 1996-01-30 | Bristol-Myers Squibb Company | Benzo 1,3 dioxole derivatives |
US5385929A (en) | 1994-05-04 | 1995-01-31 | Warner-Lambert Company | [(Hydroxyphenylamino) carbonyl] pyrroles |
US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
US5491134A (en) | 1994-09-16 | 1996-02-13 | Bristol-Myers Squibb Company | Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives |
US5541204A (en) | 1994-12-02 | 1996-07-30 | Bristol-Myers Squibb Company | Aryloxypropanolamine β 3 adrenergic agonists |
US5698527A (en) | 1995-08-08 | 1997-12-16 | Merck & Co., Inc. | Steroidal glycosides as antihyperlipidemic agents |
EP0873361B1 (en) | 1995-12-13 | 2006-11-02 | The Regents Of The University Of California | Crystals of the ligand-binding domain of the thyroid hormone receptor complexed to a ligand |
IL117702A0 (en) | 1996-03-28 | 1996-07-23 | Tel Aviv Medical Center Resear | Drug for hyperlipoproteinemia |
US5770615A (en) | 1996-04-04 | 1998-06-23 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
DE19622222A1 (de) | 1996-06-03 | 1997-12-04 | Hoechst Ag | Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikament zur Normalisierung der Serumlipide |
WO1997048701A1 (en) | 1996-06-20 | 1997-12-24 | Pfizer Inc. | 4,1-benzoxazepines or 4,1-benzothiazepines and their use as squalene synthetase inhibitors |
HRP970330B1 (en) | 1996-07-08 | 2004-06-30 | Bayer Ag | Cycloalkano pyridines |
DE19653647A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
DE19653645A1 (de) | 1996-12-20 | 1998-06-25 | Hoechst Ag | Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung |
US6482821B2 (en) | 1996-12-20 | 2002-11-19 | Hoechst Aktiengellschaft | Vitronectin receptor antagonists, their preparation and their use |
TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
US6432964B1 (en) | 1997-05-08 | 2002-08-13 | Agrevo Uk Limited | Fungicides |
GB9713739D0 (en) | 1997-06-27 | 1997-09-03 | Karobio Ab | Thyroid receptor ligands |
CN1255386C (zh) | 1997-10-08 | 2006-05-10 | 三共株式会社 | 有取代稠合杂环化合物 |
GEP20033114B (en) | 1998-07-06 | 2003-11-25 | Bristol Myers Squibb Co | Biphenyl Sulfonamides as Dual Angiotensin Endothelin Receptor Antagonists, Method for Their Production and Pharmaceutical Compositions Containing the Same |
WO2000015201A2 (en) | 1998-09-10 | 2000-03-23 | Forbes Medi-Tech Inc. | Compositions comprising one or more phytosterols, phytostanols or mixtures of both and one or more alpha, beta, delta, or gamma tocotrienols or derivatives thereof and use of the compositions in treating or preventing cardiovascular disease, its underlying conditions and other disorders |
US6147089A (en) | 1998-09-17 | 2000-11-14 | Pfizer Inc. | Annulated 4-carboxyamino-2-methyl-1,2,3,4,-tetrahydroquinolines |
BR9915687A (pt) | 1998-11-25 | 2001-12-04 | Nutri Pharma As | Composição compreendendo proteìna de soja,fibras de dieta e um composto fitoestrogênio eseu uso na prevenção e/ou tratamento de doençascardiovasculares |
WO2000038722A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS |
GB9828442D0 (en) | 1998-12-24 | 1999-02-17 | Karobio Ab | Novel thyroid receptor ligands and method II |
EP1155121B1 (en) | 1999-02-24 | 2006-04-26 | The Johns Hopkins University | Compositions and methods for modulating serum cholesterol |
AU5031200A (en) | 1999-05-28 | 2000-12-18 | Vertex Pharmaceuticals Incorporated | Method for preparing 5-substituted oxazoles |
US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
IL153645A0 (en) | 2000-07-31 | 2003-07-06 | Smithkline Beecham Plc | Carboxamide compounds and their use as antagonists of a human 11cby receptor |
WO2002101146A1 (fr) | 2001-05-11 | 2002-12-19 | Arina Nakayama | Papier lumineux et son procede de production et d'utilisation |
GB0124627D0 (en) | 2001-10-15 | 2001-12-05 | Smithkline Beecham Plc | Novel compounds |
RU2004115737A (ru) | 2001-10-25 | 2005-10-10 | Такеда Кемикал Индастриз, Лтд. (JP) | Соединение хинолина |
US20040209897A1 (en) | 2002-12-20 | 2004-10-21 | Pharmacia Corporation | Mitogen activated protein kinase-activated protein kinase-2 inhibiting compounds |
MXPA05010859A (es) | 2003-04-11 | 2005-12-14 | Smithkline Beecham Corp | Antagonistas mchr1 heterociclicos. |
JP2006193426A (ja) | 2003-09-05 | 2006-07-27 | Sankyo Co Ltd | 置換された縮環ピリミジン−4(3h)−オン化合物 |
MXPA06003997A (es) | 2003-10-23 | 2006-07-05 | Glaxo Group Ltd | Derivados de 3-(4-aminofenil) tienopirimid-4-ona como antagonistas mch r1 para el tratamiento de obesidad, diabetes, depresion y ansiedad. |
WO2005047293A1 (en) | 2003-11-07 | 2005-05-26 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
US20050256124A1 (en) | 2004-04-15 | 2005-11-17 | Neurocrine Biosciences, Inc. | Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto |
RU2266906C1 (ru) | 2004-04-29 | 2005-12-27 | Общество с ограниченной ответственностью "Исследовательский Институт Химического Разнообразия" (ООО "Исследовательский Институт Химического Разнообразия") | Анелированные карбамоилазагетероциклы, способы их получения (варианты), фармацевтическая композиция, фокусированная библиотека |
US7745447B2 (en) | 2005-10-26 | 2010-06-29 | Bristol-Myers Squibb Company | Substituted thieno[3,2-D]pyrimidines as non-basic melanin concentrating hormone receptor-1 antagonists |
US7553836B2 (en) | 2006-02-06 | 2009-06-30 | Bristol-Myers Squibb Company | Melanin concentrating hormone receptor-1 antagonists |
-
2006
- 2006-10-25 US US11/586,255 patent/US8618115B2/en active Active
- 2006-10-25 AR ARP060104665A patent/AR056155A1/es not_active Application Discontinuation
- 2006-10-26 CA CA002627653A patent/CA2627653A1/en not_active Abandoned
- 2006-10-26 PE PE2006001304A patent/PE20070532A1/es not_active Application Discontinuation
- 2006-10-26 JP JP2008537932A patent/JP2009513658A/ja not_active Withdrawn
- 2006-10-26 KR KR1020087012373A patent/KR20080067681A/ko not_active Application Discontinuation
- 2006-10-26 EP EP06817387A patent/EP1948665B1/en active Active
- 2006-10-26 EA EA200801165A patent/EA016126B1/ru not_active IP Right Cessation
- 2006-10-26 EP EP10013754A patent/EP2298776A1/en not_active Withdrawn
- 2006-10-26 AU AU2006306140A patent/AU2006306140A1/en not_active Abandoned
- 2006-10-26 TW TW095139575A patent/TW200728289A/zh unknown
- 2006-10-26 GE GEAP200610710A patent/GEP20115213B/en unknown
- 2006-10-26 BR BRPI0617945-2A patent/BRPI0617945A2/pt not_active IP Right Cessation
- 2006-10-26 WO PCT/US2006/041725 patent/WO2007050726A2/en active Application Filing
- 2006-10-26 NZ NZ567659A patent/NZ567659A/en not_active IP Right Cessation
-
2008
- 2008-04-11 NO NO20081772A patent/NO20081772L/no not_active Application Discontinuation
- 2008-04-15 IL IL190898A patent/IL190898A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
NZ567659A (en) | 2011-06-30 |
US8618115B2 (en) | 2013-12-31 |
WO2007050726A3 (en) | 2007-08-30 |
JP2009513658A (ja) | 2009-04-02 |
PE20070532A1 (es) | 2007-06-14 |
BRPI0617945A2 (pt) | 2011-08-09 |
TW200728289A (en) | 2007-08-01 |
KR20080067681A (ko) | 2008-07-21 |
EP1948665A2 (en) | 2008-07-30 |
IL190898A0 (en) | 2008-11-03 |
GEP20115213B (en) | 2011-05-10 |
WO2007050726A2 (en) | 2007-05-03 |
EP2298776A1 (en) | 2011-03-23 |
AR056155A1 (es) | 2007-09-19 |
EA200801165A1 (ru) | 2008-10-30 |
CA2627653A1 (en) | 2007-05-03 |
US20070093509A1 (en) | 2007-04-26 |
AU2006306140A1 (en) | 2007-05-03 |
EP1948665B1 (en) | 2013-02-27 |
EA016126B1 (ru) | 2012-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20081772L (no) | Ikke-basiske antagonister av melaninkonsentrerende hormon-reseptor-1 | |
WO2009009501A3 (en) | Non-basic melanin concentrating hormone receptor-1 antagonists and methods | |
WO2007092416A3 (en) | Melanin concentrating hormone receptor-1 antagonists | |
NO20091938L (no) | 7,8-dihydro-1,6-naftyridin-5(6H)-oner og relaterte bicykliske forbindelser som inhibitorer av dipeptidyl-peptidaser IV og metoder | |
NO20076319L (no) | Farmasoytiske sammensetninger av et neuroaktivt steroid og anvendelse derav | |
NO20062691L (no) | Azabicykliske heterocykler som cannabinoide reseptormodulatorer | |
EP2902025B1 (en) | Therapeutic agent for dyslipidemia | |
NO20062704L (no) | Azabicykliske heterocykler som cannabinoide reseptormodulatorer | |
UA107578C2 (uk) | Комбінована терапія при лікуванні діабету | |
DE602006009095D1 (en) | Diacylglycerol-acyltransferase-hemmer | |
EP2331095A4 (en) | CYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF | |
MY149622A (en) | Pyrazoles as 11-beta-hsd-1 | |
NO20065061L (no) | Benzoksazin for behandling av sykdommer i luftveiene | |
NO20070088L (no) | 1-, (3R)-amino-4-(2-fluor-fenyl)-butyl !-pyrrolidin-(2R)-karboksylsyre-benzyl amin derivater og beslektede forbindelser som dipeptidyl-peptidase IV (DPP??IV) inhibitorer for behandling av type 2 | |
NO20060080L (no) | Pyrrol-2,5-ditionderivater som Lever X reseptormodulatorer | |
ATE397006T1 (de) | Polysulfatierte glykoside und salze davon | |
TW200800979A (en) | Halogenated sulfonamide derivatives | |
NO20076357L (no) | Azabicykliske heterocykler som cannabinoid reseptor modulatorer | |
WO2009025785A3 (en) | Cb2 receptor ligands for the treatment of pain | |
MX2009011543A (es) | Metodo para la produccion de la 2,4'-dimetil-3-piperidino-propiofe nona (tolperisona), altamente pura, composiciones farmaceuticas que contienen la misma al igual que formulaciones de ingrediente activo que contienen la tolperisona. | |
PH12014502448A1 (en) | Pharmaceutical combinations for the treatment of metabolic disorders | |
NO20065501L (no) | Lxr reseptor modulstorer. | |
TW200637552A (en) | Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases | |
WO2007114902A3 (en) | Alkylthiobenzylpiperidine compounds | |
DK1511496T3 (da) | Fremgangsmåde til behandling eller forebyggelse af immunmedierede sygdomme og farmaceutisk præparat til anvendelse heri |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |