NO20072210L - Metabolsk aktive mikroorganismer og fremgangsmater for fremstilling derav - Google Patents
Metabolsk aktive mikroorganismer og fremgangsmater for fremstilling deravInfo
- Publication number
- NO20072210L NO20072210L NO20072210A NO20072210A NO20072210L NO 20072210 L NO20072210 L NO 20072210L NO 20072210 A NO20072210 A NO 20072210A NO 20072210 A NO20072210 A NO 20072210A NO 20072210 L NO20072210 L NO 20072210L
- Authority
- NO
- Norway
- Prior art keywords
- preparation
- metabolically active
- processes
- active microorganisms
- microorganisms
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 3
- 239000000758 substrate Substances 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 235000021310 complex sugar Nutrition 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000006041 probiotic Substances 0.000 abstract 1
- 230000000529 probiotic effect Effects 0.000 abstract 1
- 235000018291 probiotics Nutrition 0.000 abstract 1
- 235000021309 simple sugar Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Animal Husbandry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0421448A GB2418431A (en) | 2004-09-27 | 2004-09-27 | Metabolically active micro organisms and methods for their production |
| PCT/GB2005/003715 WO2006035218A1 (en) | 2004-09-27 | 2005-09-27 | Metabolically active micro organisms and methods for their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20072210L true NO20072210L (no) | 2007-04-27 |
Family
ID=33397330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20072210A NO20072210L (no) | 2004-09-27 | 2007-04-27 | Metabolsk aktive mikroorganismer og fremgangsmater for fremstilling derav |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8551473B2 (enExample) |
| EP (2) | EP1794283B1 (enExample) |
| JP (1) | JP5577020B2 (enExample) |
| CN (2) | CN100537740C (enExample) |
| AU (1) | AU2005288751B2 (enExample) |
| CA (1) | CA2580949C (enExample) |
| EA (1) | EA012968B1 (enExample) |
| ES (2) | ES2568955T3 (enExample) |
| GB (1) | GB2418431A (enExample) |
| NO (1) | NO20072210L (enExample) |
| NZ (1) | NZ553858A (enExample) |
| PL (2) | PL3050960T3 (enExample) |
| WO (1) | WO2006035218A1 (enExample) |
| ZA (1) | ZA200702398B (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2418431A (en) * | 2004-09-27 | 2006-03-29 | Multigerm Uk Entpr Ltd | Metabolically active micro organisms and methods for their production |
| SE532899C2 (sv) | 2007-06-08 | 2010-05-04 | Probi Ab | Förfarande genom fermentering med Lactobacillus plantarum för tillhandahållande av en insulinsvarsreducerande produkt och dess användning farmaceutiskt eller i livsmedel |
| BRPI0823218A2 (pt) * | 2008-11-21 | 2014-10-14 | Jose Antonio Cruz Serrano | Método para obter uma mistura de probióticos, prebióticos nutrientes com ação simbiótica sinergística |
| GB201119774D0 (en) * | 2011-11-16 | 2011-12-28 | Multigerm Uk Entpr Ltd | IBS treatment |
| WO2013072654A1 (en) | 2011-11-16 | 2013-05-23 | Multigerm Uk Enterprises Ltd. | Ibs treatment |
| GB201219873D0 (en) * | 2012-11-05 | 2012-12-19 | Multigerm Uk Entpr Ltd | Diverticulitis treatment |
| DE102012110612A1 (de) * | 2012-11-06 | 2014-05-08 | Gelita Ag | Kollagenhydrolysat und dessen Verwendung |
| CN105296541A (zh) * | 2014-07-30 | 2016-02-03 | 无限极（中国）有限公司 | 燕麦发酵液及其制备方法与作为化妆品原料的应用 |
| ES2575828B1 (es) * | 2014-12-31 | 2017-07-07 | Universidad De León | Empleo de probióticos en el incremento de la fertilidad masculina |
| GB201501938D0 (en) | 2015-02-05 | 2015-03-25 | Multigerm Uk Entpr Ltd | Probiotic preparation |
| CA3088630A1 (en) | 2017-12-15 | 2019-06-20 | Solarea Bio, Inc. | Microbial compositions and methods for treating type 2 diabetes, obesity, and metabolic syndrome |
| CN108315279A (zh) * | 2018-04-09 | 2018-07-24 | 河南科技大学 | 一种植物乳杆菌液体制剂的长时间储存方法 |
| CA3103064A1 (en) * | 2018-06-19 | 2019-12-26 | 4D Pharma Research Ltd | Dosage form comprising a live biotherapeutic product |
| JPWO2020013239A1 (ja) * | 2018-07-10 | 2021-05-13 | 学校法人慶應義塾 | Ｄ−プシコース応答性増殖能を有する腸内細菌 |
| US11980647B2 (en) | 2018-09-05 | 2024-05-14 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| CA3111795A1 (en) | 2018-09-05 | 2020-03-12 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases |
| CN109486713B (zh) * | 2018-12-06 | 2021-03-09 | 福建傲农生物科技集团股份有限公司 | 一种液态复合乳酸杆菌制剂及其制备方法与应用 |
| GB201915144D0 (en) | 2019-10-18 | 2019-12-04 | Multigerm Uk Entpr Ltd | Method of promoting SCFA production by gut microbiota |
| WO2021113850A2 (en) * | 2019-12-06 | 2021-06-10 | Nas Bioventures Llc | Onsite installation or manufactured product of eco-friendly bacterial compositions, methods and systems for bioremediation in a short duration in different environments |
| JP2023533513A (ja) * | 2020-06-29 | 2023-08-03 | キャンバイオシン・インコーポレイテッド | 胃腸障害を有する伴侶動物を支援するための組成物および関連する方法 |
| WO2023092150A1 (en) | 2021-11-22 | 2023-05-25 | Solarea Bio, Inc. | Methods and compositions for treating musculoskeletal diseases, treating inflammation, and managing symptoms of menopause |
| US20230190834A1 (en) | 2021-12-21 | 2023-06-22 | Solarea Bio, Inc. | Immunomodulatory compositions comprising microbial entities |
| GB202210523D0 (en) | 2022-07-18 | 2022-08-31 | Multigerm Uk Entpr Ltd | Probiotic compositions and therapeutic uses thereof |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB906212A (en) * | 1960-08-04 | 1962-09-19 | Lilly Co Eli | The antibiotic valacidin and its salts and methods for producing same |
| US3623956A (en) * | 1970-01-21 | 1971-11-30 | Rapidase Sa Soc | Preparation of microbial alkaline protease by fermentation with bacillus subtilis, variety licheniformis |
| US3846397A (en) * | 1970-04-06 | 1974-11-05 | J Ernster | Process for utilizing barley malt |
| US4464402A (en) * | 1978-04-24 | 1984-08-07 | F.I.N.D. Research Corporation | Process for manufacturing a high protein food material |
| US4275164A (en) * | 1979-11-05 | 1981-06-23 | Eastman Kodak Company | Process and nutrient medium for growing microorganism |
| EP0189657B1 (en) * | 1984-12-12 | 1989-03-01 | WHITBREAD & COMPANY PLC | A brewing process |
| JPS63273469A (ja) * | 1986-12-13 | 1988-11-10 | Kyowa Hakko Kogyo Co Ltd | 乳糖資化性を有する新規微生物 |
| DK686187D0 (da) | 1987-12-23 | 1987-12-23 | Hansens Chr Bio Syst | Veterinaert praeparat |
| JP2835894B2 (ja) * | 1991-07-26 | 1998-12-14 | 農林水産省食品総合研究所長 | ビフィズス菌増殖促進剤 |
| JPH08259450A (ja) * | 1995-03-17 | 1996-10-08 | Nichinichi Seiyaku Kk | インターフェロン産生増強剤 |
| IE960360A1 (en) * | 1996-05-23 | 1997-12-31 | Valdosa Limited | A brewing process |
| MXPA99001239A (es) * | 1996-08-05 | 2003-09-12 | Syngenta Mogen Bv | Proceso mejorado para la produccion de bebidas alcoholicas que utilizan semilla de malta. |
| US6811786B1 (en) | 1999-04-01 | 2004-11-02 | Ganeden Biotech, Inc. | Methods for reducing cholesterol using Bacillus coagulans spores, systems and compositions |
| FR2777424B1 (fr) * | 1998-04-15 | 2000-06-16 | Lesaffre & Cie | Levain panaire longue conservation pret a l'emploi |
| US6420146B1 (en) * | 2000-03-30 | 2002-07-16 | Council Of Scientific & Industrial Research | Process for the preparation of stable yeast crystals for enhanced production of ethanol |
| JP4424643B2 (ja) * | 2002-02-13 | 2010-03-03 | 株式会社バイオバンク | 抗真菌剤の製造方法 |
| GB2391554B (en) * | 2002-08-06 | 2005-09-14 | Heineken Ireland Ltd | A stout manufacturing process |
| GB2418431A (en) * | 2004-09-27 | 2006-03-29 | Multigerm Uk Entpr Ltd | Metabolically active micro organisms and methods for their production |
-
2004
- 2004-09-27 GB GB0421448A patent/GB2418431A/en not_active Withdrawn
-
2005
- 2005-09-27 PL PL16155521T patent/PL3050960T3/pl unknown
- 2005-09-27 NZ NZ553858A patent/NZ553858A/en not_active IP Right Cessation
- 2005-09-27 PL PL05786983.6T patent/PL1794283T3/pl unknown
- 2005-09-27 EP EP05786983.6A patent/EP1794283B1/en not_active Expired - Lifetime
- 2005-09-27 CN CNB2005800324851A patent/CN100537740C/zh not_active Expired - Lifetime
- 2005-09-27 CN CN2009101495392A patent/CN101603021B/zh not_active Expired - Lifetime
- 2005-09-27 EA EA200700613A patent/EA012968B1/ru not_active IP Right Cessation
- 2005-09-27 WO PCT/GB2005/003715 patent/WO2006035218A1/en not_active Ceased
- 2005-09-27 AU AU2005288751A patent/AU2005288751B2/en not_active Expired
- 2005-09-27 US US11/663,877 patent/US8551473B2/en active Active
- 2005-09-27 CA CA2580949A patent/CA2580949C/en active Active
- 2005-09-27 ES ES05786983.6T patent/ES2568955T3/es active Active
- 2005-09-27 EP EP16155521.4A patent/EP3050960B1/en not_active Expired - Lifetime
- 2005-09-27 JP JP2007532974A patent/JP5577020B2/ja not_active Expired - Lifetime
- 2005-09-27 ES ES16155521.4T patent/ES2654246T3/es active Active
-
2007
- 2007-03-22 ZA ZA200702398A patent/ZA200702398B/xx unknown
- 2007-04-27 NO NO20072210A patent/NO20072210L/no not_active Application Discontinuation
-
2012
- 2012-09-05 US US13/604,196 patent/US20130011368A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101027387A (zh) | 2007-08-29 |
| JP5577020B2 (ja) | 2014-08-20 |
| US20110158949A1 (en) | 2011-06-30 |
| ES2568955T3 (es) | 2016-05-05 |
| CN101603021B (zh) | 2013-04-24 |
| CA2580949C (en) | 2017-07-25 |
| CN100537740C (zh) | 2009-09-09 |
| GB0421448D0 (en) | 2004-10-27 |
| GB2418431A (en) | 2006-03-29 |
| CA2580949A1 (en) | 2006-04-06 |
| HK1134686A1 (en) | 2010-05-07 |
| WO2006035218A1 (en) | 2006-04-06 |
| JP2008514582A (ja) | 2008-05-08 |
| EP1794283B1 (en) | 2016-04-13 |
| EP3050960A1 (en) | 2016-08-03 |
| PL1794283T3 (pl) | 2016-10-31 |
| NZ553858A (en) | 2009-01-31 |
| ES2654246T3 (es) | 2018-02-12 |
| PL3050960T3 (pl) | 2018-05-30 |
| AU2005288751A1 (en) | 2006-04-06 |
| AU2005288751B2 (en) | 2010-12-23 |
| ZA200702398B (en) | 2008-10-29 |
| US20130011368A1 (en) | 2013-01-10 |
| EA200700613A1 (ru) | 2007-10-26 |
| CN101603021A (zh) | 2009-12-16 |
| EP3050960B1 (en) | 2017-12-13 |
| EP1794283A1 (en) | 2007-06-13 |
| US8551473B2 (en) | 2013-10-08 |
| EA012968B1 (ru) | 2010-02-26 |
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