NO20070605L - Nye 2-substituerte D-homoostra-1,3,5(10)-triener som inhibitor av 17(3-hydroksysteroiddehydrogenaser type-1. - Google Patents

Nye 2-substituerte D-homoostra-1,3,5(10)-triener som inhibitor av 17(3-hydroksysteroiddehydrogenaser type-1.

Info

Publication number
NO20070605L
NO20070605L NO20070605A NO20070605A NO20070605L NO 20070605 L NO20070605 L NO 20070605L NO 20070605 A NO20070605 A NO 20070605A NO 20070605 A NO20070605 A NO 20070605A NO 20070605 L NO20070605 L NO 20070605L
Authority
NO
Norway
Prior art keywords
sub
sup
trienes
substituted
homoostra
Prior art date
Application number
NO20070605A
Other languages
English (en)
Inventor
Walter Elger
Jerzy Adamski
Alexander Hillisch
Christian Gege
Wilko Regenhardt
Olaf Peters
Gabriele Moller
Dominga Deluca
Birgitt Schneider
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20070605L publication Critical patent/NO20070605L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Oppfinnelsen vedrører nye 2-substituerte D-homo-østra-l,3,5(10)-triener med generell formel (I), der R2 betyr en C1-C8-alkylgruppe, en C1-C8-alkyloksy-gruppe eller et halogenatom, R13 betyr et hydrogenatom eller en metyl gruppe, R17 betyr et hydrogenatom eller et fluoratom, i tillegg til deres farmasøytisk akseptable salter, og deres fremstilling og anvendelse som farmasøytiske midler til profylakse og terapi av østrogenavhengige sykdommer som kan bli påvirket ved inhibering 17P-hydroksy-steroiddehydrogenase type-1.
NO20070605A 2004-07-02 2007-02-01 Nye 2-substituerte D-homoostra-1,3,5(10)-triener som inhibitor av 17(3-hydroksysteroiddehydrogenaser type-1. NO20070605L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004032673A DE102004032673A1 (de) 2004-07-02 2004-07-02 Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1
PCT/EP2005/007314 WO2006003012A1 (de) 2004-07-02 2005-07-04 NEUE 2-SUBSTITUIERTE D-HOMO ESTRA-1,3,5(10)-TRIENE ALS INHIBITOREN DER 17ß-HYDROXYSTEROIDDEHYDROGENASE TYP 1

Publications (1)

Publication Number Publication Date
NO20070605L true NO20070605L (no) 2007-02-01

Family

ID=35106828

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20070605A NO20070605L (no) 2004-07-02 2007-02-01 Nye 2-substituerte D-homoostra-1,3,5(10)-triener som inhibitor av 17(3-hydroksysteroiddehydrogenaser type-1.

Country Status (25)

Country Link
EP (1) EP1763534B1 (no)
JP (1) JP4871274B2 (no)
KR (1) KR20070035059A (no)
CN (1) CN1980949B (no)
AT (1) ATE458744T1 (no)
AU (1) AU2005259329B8 (no)
BR (1) BRPI0511394A (no)
CA (1) CA2571760C (no)
CR (1) CR8854A (no)
DE (2) DE102004032673A1 (no)
DK (1) DK1763534T3 (no)
EA (1) EA011455B1 (no)
EC (1) ECSP077160A (no)
ES (1) ES2340401T3 (no)
HK (1) HK1103745A1 (no)
HR (1) HRP20100230T1 (no)
IL (1) IL180171A0 (no)
MX (1) MX2007000108A (no)
NO (1) NO20070605L (no)
NZ (1) NZ552515A (no)
PL (1) PL1763534T3 (no)
PT (1) PT1763534E (no)
UA (1) UA92324C2 (no)
WO (1) WO2006003012A1 (no)
ZA (1) ZA200700958B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
US8288367B2 (en) 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
DE102007015169A1 (de) 2007-03-27 2008-10-02 Universität des Saarlandes Campus Saarbrücken 17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
DE102007040243A1 (de) 2007-08-25 2009-02-26 Universität des Saarlandes 17Beta-Hydroxysteriod-Dehydrogenase Typ1 Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
JP6456373B2 (ja) 2013-06-25 2019-01-23 フォレンド ファーマ リミテッド １７β−ヒドロキシステロイドデヒドロゲナーゼ タイプ１の阻害剤として治療活性のあるエストラトリエンチアゾール誘導体
EA201690077A1 (ru) 2013-06-25 2016-09-30 Форендо Фарма Лтд. Терапевтически активные производные эстратриен-тиазола
EP3013845B1 (en) 2013-06-25 2020-03-18 Forendo Pharma Ltd Therapeutically active estratrienthiazole derivatives as inhibitors of 17b-hydroxysteroid dehydrogenase, type 1
US10413557B2 (en) 2014-12-23 2019-09-17 Forendo Pharma Ltd. Prodrugs of 17.BETA.-HSD1-inhibitors
JP6545266B2 (ja) 2014-12-23 2019-07-17 フォレンド ファーマ リミテッド １７β‐ＨＳＤ１抑制剤のプロドラッグ
CZ307437B6 (cs) 2016-06-07 2018-08-22 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
IL294140B2 (en) 2017-06-08 2024-09-01 Forendo Pharma Ltd 15beta-(3-propanamido)-converted ester-1, 3, 5(10)-triane-17-oximes used in the inhibition of 17beta-hydroxysteroid dehydrogenases
BR112021010598A2 (pt) 2018-12-05 2021-08-24 Forendo Pharma Ltd Compostos, método para preparação de um composto e composição farmacêutica

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3005835A (en) * 1960-09-13 1961-10-24 Searle & Co D-homo-18-norestra-1, 3, 5(10)-trien-17alpha-ones and intermediates thereto
GB1346691A (en) * 1970-06-12 1974-02-13 Inst Khim Prirodnykh Soedineny Stereospecific method for preparing estrane compounds of natural configuration
JPH06279488A (ja) * 1993-03-29 1994-10-04 Kuraray Co Ltd 新規なステロイド誘導体および骨粗鬆症治療剤
CN1429104A (zh) * 1998-03-11 2003-07-09 内部研究股份有限公司 5型和3型17β－羟基类固醇脱氢酶的抑制剂及其用法
EP1365768B1 (en) * 2001-02-27 2008-05-07 Bayer Schering Pharma Aktiengesellschaft Use of er-beta selective antagonists as contraceptives
DE10151365A1 (de) * 2001-10-17 2003-04-30 Schering Ag 17-Chlor-D-Homosteroide als selektive Estrogenrezeptorantagonisten
WO2003017974A1 (en) * 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Method of treating benign gynaecological disorders and a pharmaceutical kit for use in such method
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE102004032674A1 (de) * 2004-07-02 2006-01-26 Schering Ag Neue 2-substituierte Estra-1,3,5(10)-trien-17-one als Inhibitoren der 17β-Hydroxysteroiddehydrogenase Typ 1

Also Published As

Publication number Publication date
CR8854A (es) 2007-08-28
BRPI0511394A (pt) 2007-12-04
AU2005259329B8 (en) 2011-11-24
DK1763534T3 (da) 2010-05-17
EA200700103A1 (ru) 2007-08-31
HK1103745A1 (en) 2007-12-28
PL1763534T3 (pl) 2010-07-30
UA92324C2 (en) 2010-10-25
NZ552515A (en) 2010-07-30
WO2006003012A1 (de) 2006-01-12
ZA200700958B (en) 2008-07-30
CN1980949A (zh) 2007-06-13
PT1763534E (pt) 2010-04-27
CA2571760A1 (en) 2006-01-12
AU2005259329A1 (en) 2006-01-12
JP2008504337A (ja) 2008-02-14
ATE458744T1 (de) 2010-03-15
CN1980949B (zh) 2010-05-05
KR20070035059A (ko) 2007-03-29
DE502005009091D1 (de) 2010-04-08
MX2007000108A (es) 2007-03-09
HRP20100230T1 (hr) 2010-06-30
ES2340401T3 (es) 2010-06-02
IL180171A0 (en) 2007-06-03
AU2005259329B2 (en) 2011-11-10
JP4871274B2 (ja) 2012-02-08
CA2571760C (en) 2011-11-22
DE102004032673A1 (de) 2006-01-26
ECSP077160A (es) 2007-02-28
EP1763534A1 (de) 2007-03-21
EP1763534B1 (de) 2010-02-24
EA011455B1 (ru) 2009-04-28

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