PL1763534T3 - Nowe, podstawione D-homo-estra-1,3,5(10)-trieny jako inhibitory 17ß-hydroksysteroidodehydrogenazy - Google Patents

Nowe, podstawione D-homo-estra-1,3,5(10)-trieny jako inhibitory 17ß-hydroksysteroidodehydrogenazy

Info

Publication number
PL1763534T3
PL1763534T3 PL05768705T PL05768705T PL1763534T3 PL 1763534 T3 PL1763534 T3 PL 1763534T3 PL 05768705 T PL05768705 T PL 05768705T PL 05768705 T PL05768705 T PL 05768705T PL 1763534 T3 PL1763534 T3 PL 1763534T3
Authority
PL
Poland
Prior art keywords
sub
sup
trienes
estra
homo
Prior art date
Application number
PL05768705T
Other languages
English (en)
Inventor
Christian Gege
Wilko Regenhardt
Olaf Peters
Alexander Hillisch
Jerzy Adamski
Gabriele Möller
Dominga Deluca
Walter Elger
Birgitt Schneider
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PL1763534T3 publication Critical patent/PL1763534T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL05768705T 2004-07-02 2005-07-04 Nowe, podstawione D-homo-estra-1,3,5(10)-trieny jako inhibitory 17ß-hydroksysteroidodehydrogenazy PL1763534T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004032673A DE102004032673A1 (de) 2004-07-02 2004-07-02 Neue 2-substituierte D-Homo-estra-1,3,5(10)-triene als Inhibitoren der 17ß-Hydroxysteroiddehydrogenase Typ 1
EP05768705A EP1763534B1 (de) 2004-07-02 2005-07-04 NEUE 2-SUBSTITUIERTE D-HOMO ESTRA-1,3,5(10)-TRIENE ALS INHIBITOREN DER 17ß-HYDROXYSTEROIDDEHYDROGENASE TYP 1
PCT/EP2005/007314 WO2006003012A1 (de) 2004-07-02 2005-07-04 NEUE 2-SUBSTITUIERTE D-HOMO ESTRA-1,3,5(10)-TRIENE ALS INHIBITOREN DER 17ß-HYDROXYSTEROIDDEHYDROGENASE TYP 1

Publications (1)

Publication Number Publication Date
PL1763534T3 true PL1763534T3 (pl) 2010-07-30

Family

ID=35106828

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05768705T PL1763534T3 (pl) 2004-07-02 2005-07-04 Nowe, podstawione D-homo-estra-1,3,5(10)-trieny jako inhibitory 17ß-hydroksysteroidodehydrogenazy

Country Status (25)

Country Link
EP (1) EP1763534B1 (pl)
JP (1) JP4871274B2 (pl)
KR (1) KR20070035059A (pl)
CN (1) CN1980949B (pl)
AT (1) ATE458744T1 (pl)
AU (1) AU2005259329B8 (pl)
BR (1) BRPI0511394A (pl)
CA (1) CA2571760C (pl)
CR (1) CR8854A (pl)
DE (2) DE102004032673A1 (pl)
DK (1) DK1763534T3 (pl)
EA (1) EA011455B1 (pl)
EC (1) ECSP077160A (pl)
ES (1) ES2340401T3 (pl)
HK (1) HK1103745A1 (pl)
HR (1) HRP20100230T1 (pl)
IL (1) IL180171A0 (pl)
MX (1) MX2007000108A (pl)
NO (1) NO20070605L (pl)
NZ (1) NZ552515A (pl)
PL (1) PL1763534T3 (pl)
PT (1) PT1763534E (pl)
UA (1) UA92324C2 (pl)
WO (1) WO2006003012A1 (pl)
ZA (1) ZA200700958B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8030298B2 (en) 2005-05-26 2011-10-04 Abbott Products Gmbh 17β-HSD1 and STS inhibitors
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
US8288367B2 (en) 2006-11-30 2012-10-16 Solvay Pharmaceuticals Gmbh Substituted estratriene derivatives as 17BETA HSD inhibitors
DE102007015169A1 (de) 2007-03-27 2008-10-02 Universität des Saarlandes Campus Saarbrücken 17Beta-Hydroxysteroid-Dehydrogenase-Typ1-Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
DE102007040243A1 (de) 2007-08-25 2009-02-26 Universität des Saarlandes 17Beta-Hydroxysteriod-Dehydrogenase Typ1 Inhibitoren zur Behandlung hormonabhängiger Erkrankungen
EP3013847B1 (en) 2013-06-25 2019-08-21 Forendo Pharma Ltd Therapeutically active estratrienthiazole derivatives as inhibitors of 17.beta.-hydroxy-steroid dehydrogenase, type 1
EP3013845B1 (en) 2013-06-25 2020-03-18 Forendo Pharma Ltd Therapeutically active estratrienthiazole derivatives as inhibitors of 17b-hydroxysteroid dehydrogenase, type 1
BR112015031846A8 (pt) 2013-06-25 2018-03-06 Forendo Pharma Ltd derivados de estratrientiazol, seus usos, e composição farmacêutica
CN107207561B (zh) 2014-12-23 2020-03-31 佛恩多制药有限公司 17β-HSD1–抑制剂的前药
EP3237430B1 (en) 2014-12-23 2019-03-20 Forendo Pharma Ltd PRODRUGS OF 17ß -HSD1 -INHIBITORS
CZ307437B6 (cs) 2016-06-07 2018-08-22 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. 15β-substituované deriváty estronu jako selektivní inhibitory 17β-hydroxysteoiddehydrogenáz
NZ760155A (en) 2017-06-08 2022-09-30 Forendo Pharma Ltd 15.beta.-[3-propanamido]-substituted estra-1,3,5
CN113412269A (zh) 2018-12-05 2021-09-17 佛恩多制药有限公司 作为17-hsd1抑制剂的在位置16(17)具有缩合的吡唑环的雌甾-1,3,5(10)-三烯化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3005835A (en) * 1960-09-13 1961-10-24 Searle & Co D-homo-18-norestra-1, 3, 5(10)-trien-17alpha-ones and intermediates thereto
GB1346691A (en) * 1970-06-12 1974-02-13 Inst Khim Prirodnykh Soedineny Stereospecific method for preparing estrane compounds of natural configuration
JPH06279488A (ja) * 1993-03-29 1994-10-04 Kuraray Co Ltd 新規なステロイド誘導体および骨粗鬆症治療剤
WO1999046279A2 (en) * 1998-03-11 1999-09-16 Endorecherche, Inc. INHIBITORS OF TYPE 5 AND TYPE 3 17β-HYDROXYSTEROID DEHYDROGENASE AND METHODS FOR THEIR USE
AU2002240936A1 (en) * 2001-02-27 2002-09-12 Schering Aktiengesellschaft Use of erss-selective ligands for regulating fertility and compounds useful therefore
DE10151365A1 (de) * 2001-10-17 2003-04-30 Schering Ag 17-Chlor-D-Homosteroide als selektive Estrogenrezeptorantagonisten
WO2003017974A1 (en) * 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Method of treating benign gynaecological disorders and a pharmaceutical kit for use in such method
DE10307103A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate
DE102004032674A1 (de) * 2004-07-02 2006-01-26 Schering Ag Neue 2-substituierte Estra-1,3,5(10)-trien-17-one als Inhibitoren der 17β-Hydroxysteroiddehydrogenase Typ 1

Also Published As

Publication number Publication date
EP1763534B1 (de) 2010-02-24
UA92324C2 (en) 2010-10-25
JP4871274B2 (ja) 2012-02-08
KR20070035059A (ko) 2007-03-29
NO20070605L (no) 2007-02-01
NZ552515A (en) 2010-07-30
ECSP077160A (es) 2007-02-28
PT1763534E (pt) 2010-04-27
EP1763534A1 (de) 2007-03-21
EA200700103A1 (ru) 2007-08-31
CA2571760A1 (en) 2006-01-12
CN1980949A (zh) 2007-06-13
ATE458744T1 (de) 2010-03-15
HRP20100230T1 (hr) 2010-06-30
CN1980949B (zh) 2010-05-05
EA011455B1 (ru) 2009-04-28
IL180171A0 (en) 2007-06-03
CA2571760C (en) 2011-11-22
AU2005259329B8 (en) 2011-11-24
DK1763534T3 (da) 2010-05-17
ZA200700958B (en) 2008-07-30
HK1103745A1 (en) 2007-12-28
BRPI0511394A (pt) 2007-12-04
CR8854A (es) 2007-08-28
AU2005259329A1 (en) 2006-01-12
MX2007000108A (es) 2007-03-09
DE502005009091D1 (de) 2010-04-08
AU2005259329B2 (en) 2011-11-10
JP2008504337A (ja) 2008-02-14
DE102004032673A1 (de) 2006-01-26
ES2340401T3 (es) 2010-06-02
WO2006003012A1 (de) 2006-01-12

Similar Documents

Publication Publication Date Title
PL1763534T3 (pl) Nowe, podstawione D-homo-estra-1,3,5(10)-trieny jako inhibitory 17ß-hydroksysteroidodehydrogenazy
NZ561747A (en) (Pyrrol-2-ylmethyl)-indol-1-yl-acetic acid derivatives with PGD2 antagonist activity
TW200833675A (en) Nicotinamide derivatives
MY153393A (en) Amino nicotinic and isonicotinic acid derivatives as dhodh as inhibitors
UA95972C2 (ru) Аминопиридиновые производные с селективной ингибирующей активностью в отношении авроры а
NO20062617L (no) Anvendelse av glukosidase inhibitorer for terapi av mucovisidose
DE60315674D1 (de) Neue imidazopyridine und ihre verwendung
NO20062136L (no) Imidazopyrazintyrosin-kinaseinhibitorer
NO20074057L (no) 2,4-Diaminopyridopyrimidinderivater og deres anvendelse som mTOR-inhibitorer
RS54260B1 (en) AMINODIHYDROTIAZINE DERIVATIVES AS BACE INHIBITORS FOR ALZHEIMER DISEASE TREATMENT
MX2009010884A (es) 2-morfolin-4-il-pirimidinas como inhibidores de fosfatidilinositol-3-cinasa (pi3k).
UA88329C2 (en) Dna-pk inhibitors
NO20091858L (no) Hydrobenzamid derivater som inhibitorer av HSP90
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer
TW200619212A (en) Morpholine derivatives
WO2006003013A3 (de) NEUE 2-SUBSTITUIERTE ESTRA-1,3,5(10)-TRIEN-17-ONE ALS INHIBITOREN DER 17β-HYDROXYSTEROIDDEHYDROGENASE TYP 1
MX2010001566A (es) Derivado de aminopirazolamida.
WO2010091104A8 (en) Glucosylceramide synthase inhibitors
GEP20074256B (en) Novel benzothiadiazine, process for their preparation and pharmaceutical compositions containing
NO20060277L (no) Anvendelse av bisyklo [2.2.1] heptanderivater til fremstilling av nevrobeskyttende farmasoytiske sammensetninger
MX2009006266A (es) Procedimientos de preparacion de 3-(4-(2,4-difluorobenciloxi)-3-br omo-6-metil-2-oxopiridin-1 (2h)-il)-n,4-dimetilbenzamida.
IL161843A (en) Derivatives of 2-amino-4-pyridylmethyl-thiazoline for the preparation of medicaments for use as inhibitors of inducible no-synthase
WO2005053702A3 (en) Anti-inflammatory agents
NO20062307L (no) Spirofuropyridinarylderivater
GEP20125386B (en) Pyrazole analogs