BR0108539A - Novo uso de derivados de fenilheteroalquilamina - Google Patents

Novo uso de derivados de fenilheteroalquilamina

Info

Publication number
BR0108539A
BR0108539A BR0108539-5A BR0108539A BR0108539A BR 0108539 A BR0108539 A BR 0108539A BR 0108539 A BR0108539 A BR 0108539A BR 0108539 A BR0108539 A BR 0108539A
Authority
BR
Brazil
Prior art keywords
sup
phenyletheroalkylamine
derivatives
racemates
enantiomers
Prior art date
Application number
BR0108539-5A
Other languages
English (en)
Inventor
Cheshire
David
Connolly
Stephen
Cox
Millichip
Ian
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR0108539A publication Critical patent/BR0108539A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/29—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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Abstract

"NOVO USO DE DERIVADOS DE FENIL-HETEROALQUILAMINA". A presente invenção se refere ao uso de um composto de fórmula (I): onde R^ 1^, R^ 2^, X, Y, V, W e Z são como definidos no relatório descritivo e sais farmaceuticamente aceitáveis, enantiómeros e racematos dos mesmos, na fabricação de um medicamento para o tratamento ou profilaxia de doenças ou condições doentias, em que a inibição da atividade da sintase de óxido nítrico é benéfica. Certos novos compostos de fórmula (Ia) e sais farmaceuticamente aceitáveis e enantiómeros e racematos dos mesmos são também divulgados, junto com processos indicados para suas preparações, composições contendo os mesmos e seu uso em terapias. Os compostos de fórmulas (I) e (Ia) são inibidores da enzima de sintase de óxido nítrico, dessa forma são particularmente úteis no tratamento ou profilaxia de doenças inflamatórias.,
BR0108539-5A 2000-02-23 2001-02-20 Novo uso de derivados de fenilheteroalquilamina BR0108539A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0004151.7A GB0004151D0 (en) 2000-02-23 2000-02-23 Novel use
PCT/SE2001/000371 WO2001062721A1 (en) 2000-02-23 2001-02-20 Novel use of phenylheteroalkylamine derivatives

Publications (1)

Publication Number Publication Date
BR0108539A true BR0108539A (pt) 2002-10-22

Family

ID=9886163

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108539-5A BR0108539A (pt) 2000-02-23 2001-02-20 Novo uso de derivados de fenilheteroalquilamina

Country Status (17)

Country Link
US (1) US6953797B2 (pt)
EP (1) EP1263718B1 (pt)
JP (1) JP2003523995A (pt)
KR (1) KR100721087B1 (pt)
CN (1) CN1210270C (pt)
AT (1) ATE265428T1 (pt)
AU (1) AU780781B2 (pt)
BR (1) BR0108539A (pt)
CA (1) CA2396960A1 (pt)
CO (1) CO5660084A1 (pt)
DE (1) DE60103035T2 (pt)
GB (1) GB0004151D0 (pt)
IL (1) IL150640A0 (pt)
MX (1) MXPA02008204A (pt)
NO (1) NO20024013L (pt)
WO (1) WO2001062721A1 (pt)
ZA (1) ZA200205801B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0004152D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
AR035700A1 (es) * 2001-05-08 2004-06-23 Astrazeneca Ab Derivados de arilheteroalquilamina, composicion farmaceutica, usos de estos derivados para la fabricacion de medicamentos, metodos de tratamiento, y proceso para la preparacion de estos derivados
WO2002100848A1 (en) * 2001-06-12 2002-12-19 Sk Corporation Novel phenylalkyl diamine and amide analogs
SE0102640D0 (sv) 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
SE0203304D0 (sv) * 2002-11-07 2002-11-07 Astrazeneca Ab Novel Coumpounds

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AU780781B2 (en) 2005-04-14
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DE60103035D1 (de) 2004-06-03
KR100721087B1 (ko) 2007-05-23
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