NO20064307L - Inhibitorer av dipeptidylpeptidase IV for regulering av glukose metabolisme - Google Patents
Inhibitorer av dipeptidylpeptidase IV for regulering av glukose metabolismeInfo
- Publication number
- NO20064307L NO20064307L NO20064307A NO20064307A NO20064307L NO 20064307 L NO20064307 L NO 20064307L NO 20064307 A NO20064307 A NO 20064307A NO 20064307 A NO20064307 A NO 20064307A NO 20064307 L NO20064307 L NO 20064307L
- Authority
- NO
- Norway
- Prior art keywords
- inhibitors
- dipeptidyl peptidase
- present
- regulation
- glucose metabolism
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
Abstract
Foreliggende oppfinnelse vedrører inhibitorer av postprolinspaltende enzymer, så som inhibitorer av dipeptidylpeptidase IV, samt farmasøytiske sammensetninger derav, og fremgangsmåter for anvendelse av slike inhibitorer. Inhibitorene ifølge foreliggende oppfinnelse er spesielt forbedret i forhold til de som er tidligere kjente ved seleksjon av bestemte klasser av sidekjeder i P1- og/eller P2-posisjonen av inhibitoren som inneholder en karboksylsyredel. Forbindelsene ifølge foreliggende oppfinnelse kan ha en bedre terapeutisk indeks som skyldes delvis den reduserte toksisiteten og/eller forbedrede spesifisiteten til målsøkt protease.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US54722704P | 2004-02-23 | 2004-02-23 | |
US59933604P | 2004-08-06 | 2004-08-06 | |
PCT/US2005/006128 WO2005082348A2 (en) | 2004-02-23 | 2005-02-23 | Inhibitors of dipeptidylpeptidase iv for regulating glucose metabolism |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20064307L true NO20064307L (no) | 2006-11-15 |
Family
ID=34915595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20064307A NO20064307L (no) | 2004-02-23 | 2006-09-22 | Inhibitorer av dipeptidylpeptidase IV for regulering av glukose metabolisme |
Country Status (13)
Country | Link |
---|---|
US (4) | US20050203027A1 (no) |
EP (1) | EP1729757A2 (no) |
JP (1) | JP4781347B2 (no) |
KR (2) | KR20130016435A (no) |
AU (1) | AU2005216970B2 (no) |
BR (1) | BRPI0507972A (no) |
CA (1) | CA2558106A1 (no) |
IL (2) | IL177644A0 (no) |
MX (1) | MXPA06009589A (no) |
NO (1) | NO20064307L (no) |
RU (1) | RU2379315C2 (no) |
TW (1) | TWI382836B (no) |
WO (1) | WO2005082348A2 (no) |
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ES2285785T3 (es) * | 1997-09-29 | 2007-11-16 | Point Therapeutics, Inc. | Estimulacion de celulas hematopoyeticas in vitro. |
US6979697B1 (en) | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
WO2003045228A2 (en) * | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Methods for treating autoimmune disorders, and reagents related thereto |
JP4771661B2 (ja) * | 2001-11-26 | 2011-09-14 | トラスティーズ オブ タフツ カレッジ | Post−プロリン開裂酵素の擬ペプチド性阻害剤 |
EP1499336A4 (en) * | 2002-04-30 | 2005-06-01 | Tufts College | PROTEASE INHIBITORS |
BRPI0507972A (pt) * | 2004-02-23 | 2007-07-24 | Tufts College | composto ,composição farmacêutica , uso de um composto, método para inibição da atividade proteolìtica de uma enzima de clivagem pós prolina e composição farmacêutica embalada |
US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
US20060094693A1 (en) * | 2004-09-21 | 2006-05-04 | Point Therapeutics, Inc. | Methods and compositions for treating glucose-associated conditions, metabolic syndrome, dyslipidemias and other conditions |
DOP2006000008A (es) | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
US8093017B2 (en) * | 2005-12-07 | 2012-01-10 | Siemens Heathcare Diagnostics Inc. | Detection of soluble adiponectin receptor peptides and use in diagnostics and therapeutics |
EP1962827A4 (en) * | 2005-12-16 | 2011-02-16 | Merck Sharp & Dohme | PHARMACEUTICAL COMPOSITIONS OF COMBINATIONS OF DIPEPTIDYL-PEPTIDASE-4-INHIBITORS WITH METFORMIN |
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US20100105629A1 (en) * | 2007-03-23 | 2010-04-29 | Bachovchin William W | N-Substituted Peptidomimetic Inhibitors of Dipeptidylpeptidase IV |
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AR077642A1 (es) | 2009-07-09 | 2011-09-14 | Arena Pharm Inc | Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo |
AU2010294214B2 (en) | 2009-09-11 | 2015-05-07 | Vivoryon Therapeutics N.V. | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
AU2011226074B2 (en) | 2010-03-10 | 2015-01-22 | Vivoryon Therapeutics N.V. | Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5) |
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EP2560953B1 (en) | 2010-04-21 | 2016-01-06 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
AU2011305525B2 (en) | 2010-09-22 | 2016-08-18 | Arena Pharmaceuticals, Inc. | Modulators of the GPR119 receptor and the treatment of disorders related thereto |
JP6050264B2 (ja) | 2011-03-16 | 2016-12-21 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体 |
US20140018371A1 (en) | 2011-04-01 | 2014-01-16 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
US20140066369A1 (en) | 2011-04-19 | 2014-03-06 | Arena Pharmaceuticals, Inc. | Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto |
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EP2753334B1 (en) | 2011-08-30 | 2022-10-19 | Trustees Of Tufts College | Fap-activated proteasome inhibitors for treating solid tumors |
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WO2014008374A2 (en) * | 2012-07-06 | 2014-01-09 | Thetis Pharmaceuticals Llc | Combination therapies comprising metformin salts and antihyperglycemia agents or antihyperlipidemia agents |
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BRPI0507972A (pt) * | 2004-02-23 | 2007-07-24 | Tufts College | composto ,composição farmacêutica , uso de um composto, método para inibição da atividade proteolìtica de uma enzima de clivagem pós prolina e composição farmacêutica embalada |
US20060063719A1 (en) * | 2004-09-21 | 2006-03-23 | Point Therapeutics, Inc. | Methods for treating diabetes |
TWI297341B (en) * | 2005-09-13 | 2008-06-01 | Univ Nat Taiwan Normal | A copolymer which is used as a dispersing agent for titanate-based ceramic colloids |
-
2005
- 2005-02-23 BR BRPI0507972-1A patent/BRPI0507972A/pt not_active IP Right Cessation
- 2005-02-23 JP JP2007501012A patent/JP4781347B2/ja not_active Expired - Fee Related
- 2005-02-23 RU RU2006133899/04A patent/RU2379315C2/ru not_active IP Right Cessation
- 2005-02-23 MX MXPA06009589A patent/MXPA06009589A/es active IP Right Grant
- 2005-02-23 KR KR1020137002340A patent/KR20130016435A/ko not_active Application Discontinuation
- 2005-02-23 KR KR1020067019660A patent/KR101292707B1/ko not_active IP Right Cessation
- 2005-02-23 TW TW094105369A patent/TWI382836B/zh not_active IP Right Cessation
- 2005-02-23 CA CA002558106A patent/CA2558106A1/en not_active Abandoned
- 2005-02-23 EP EP05723831A patent/EP1729757A2/en not_active Withdrawn
- 2005-02-23 AU AU2005216970A patent/AU2005216970B2/en not_active Ceased
- 2005-02-23 WO PCT/US2005/006128 patent/WO2005082348A2/en active Application Filing
- 2005-02-23 US US11/065,001 patent/US20050203027A1/en not_active Abandoned
-
2006
- 2006-08-22 IL IL177644A patent/IL177644A0/en unknown
- 2006-09-22 NO NO20064307A patent/NO20064307L/no not_active Application Discontinuation
-
2008
- 2008-11-03 US US12/263,679 patent/US20090062235A1/en not_active Abandoned
-
2011
- 2011-05-16 US US13/108,461 patent/US20110218142A1/en not_active Abandoned
-
2012
- 2012-01-31 IL IL217853A patent/IL217853A0/en unknown
-
2013
- 2013-09-24 US US14/035,144 patent/US20140018545A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW200538096A (en) | 2005-12-01 |
MXPA06009589A (es) | 2007-03-26 |
IL217853A0 (en) | 2012-03-29 |
TWI382836B (zh) | 2013-01-21 |
KR20130016435A (ko) | 2013-02-14 |
WO2005082348A3 (en) | 2005-12-29 |
US20110218142A1 (en) | 2011-09-08 |
AU2005216970B2 (en) | 2011-07-07 |
JP4781347B2 (ja) | 2011-09-28 |
IL177644A0 (en) | 2008-04-13 |
AU2005216970A1 (en) | 2005-09-09 |
US20140018545A1 (en) | 2014-01-16 |
CA2558106A1 (en) | 2005-09-09 |
KR20070030181A (ko) | 2007-03-15 |
US20090062235A1 (en) | 2009-03-05 |
BRPI0507972A (pt) | 2007-07-24 |
KR101292707B1 (ko) | 2013-08-02 |
RU2379315C2 (ru) | 2010-01-20 |
RU2006133899A (ru) | 2008-03-27 |
US20050203027A1 (en) | 2005-09-15 |
EP1729757A2 (en) | 2006-12-13 |
WO2005082348A2 (en) | 2005-09-09 |
JP2007523216A (ja) | 2007-08-16 |
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