NO20053775L - Diazepinoindol derivater som kinaseinhibitorer. - Google Patents

Diazepinoindol derivater som kinaseinhibitorer.

Info

Publication number
NO20053775L
NO20053775L NO20053775A NO20053775A NO20053775L NO 20053775 L NO20053775 L NO 20053775L NO 20053775 A NO20053775 A NO 20053775A NO 20053775 A NO20053775 A NO 20053775A NO 20053775 L NO20053775 L NO 20053775L
Authority
NO
Norway
Prior art keywords
kinase inhibitors
diazepinoindole
derivatives
compounds
diazepinoindole derivatives
Prior art date
Application number
NO20053775A
Other languages
English (en)
Norwegian (no)
Other versions
NO20053775D0 (no
Inventor
Min Teng
Sacha Ninkovic
Michael John Bennett
Yuanjin Eugene Rui
Fen Wang
Suzanne Pritchett Benedict
Yong Wang
Jinjiang Zhu
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO20053775D0 publication Critical patent/NO20053775D0/no
Publication of NO20053775L publication Critical patent/NO20053775L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20053775A 2003-01-09 2005-08-08 Diazepinoindol derivater som kinaseinhibitorer. NO20053775L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43939603P 2003-01-09 2003-01-09
PCT/IB2004/000026 WO2004063198A1 (en) 2003-01-09 2004-01-05 Diazepinoindole derivatives as kinase inhibitors

Publications (2)

Publication Number Publication Date
NO20053775D0 NO20053775D0 (no) 2005-08-08
NO20053775L true NO20053775L (no) 2005-09-16

Family

ID=32713475

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20053775A NO20053775L (no) 2003-01-09 2005-08-08 Diazepinoindol derivater som kinaseinhibitorer.

Country Status (35)

Country Link
US (3) US6967198B2 (de)
EP (2) EP1585749B1 (de)
JP (1) JP3990718B2 (de)
KR (1) KR100697746B1 (de)
CN (1) CN1759118B (de)
AP (1) AP2048A (de)
AT (1) ATE404564T1 (de)
AU (1) AU2004203977B2 (de)
BR (1) BRPI0406701A (de)
CA (1) CA2512683C (de)
CR (1) CR7899A (de)
CY (1) CY1108408T1 (de)
DE (1) DE602004015724D1 (de)
DK (1) DK1585749T3 (de)
EA (1) EA009337B1 (de)
EC (1) ECSP055911A (de)
ES (1) ES2309484T3 (de)
GE (1) GEP20084367B (de)
HK (1) HK1086257A1 (de)
HR (1) HRP20050624A2 (de)
IL (1) IL169082A (de)
IS (1) IS7884A (de)
MA (1) MA27703A1 (de)
MX (1) MXPA05007352A (de)
NO (1) NO20053775L (de)
NZ (1) NZ540638A (de)
OA (1) OA13017A (de)
PL (1) PL378372A1 (de)
PT (1) PT1585749E (de)
RS (1) RS20050522A (de)
SI (1) SI1585749T1 (de)
TN (1) TNSN05176A1 (de)
UA (1) UA80733C2 (de)
WO (1) WO2004063198A1 (de)
ZA (1) ZA200504674B (de)

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CA2835195A1 (en) 2011-05-06 2012-11-15 Zafgen, Inc. Tricyclic sulfonamide compounds and methods of making and using same
JP2015500885A (ja) * 2011-12-22 2015-01-08 スレッショルド ファーマシューティカルズ，インコーポレイテッド 癌を治療するためのｃｈｋ１阻害剤と組み合わせた低酸素活性化プロドラッグの投与
CN106083849A (zh) 2011-12-31 2016-11-09 百济神州有限公司 作为parp抑制剂的稠合的四元或五元环吡啶并酞嗪酮类化合物
SG11201401726VA (en) 2011-12-31 2014-10-30 Beigene Ltd Fused tetra or penta-cyclic dihydrodiazepinocarbazolones as parp inhibitors
CN102746211B (zh) * 2012-06-27 2015-05-27 上海泰坦化学有限公司 一种取代吲哚-3-甲醛类化合物的制备方法
TWI633107B (zh) * 2013-05-22 2018-08-21 開曼群島商百濟神州生物科技有限公司 作為ｐａｒｐ抑制劑的稠合四或五環二氫二氮呯并咔唑酮
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US10071109B2 (en) 2013-11-06 2018-09-11 Molecular Templates, Inc. Predictive biomarker for hypoxia-activated prodrug therapy
PL3157566T3 (pl) 2014-06-17 2019-10-31 Vertex Pharma Metoda leczenia nowotworu przy użyciu kombinacji inhibitorów chk1 i atr
WO2017032289A1 (en) 2015-08-25 2017-03-02 Beigene, Ltd. Process for preparing parp inhibitor, crystalline forms, and uses thereof
WO2017059357A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
US11202782B2 (en) 2016-09-27 2021-12-21 Beigene, Ltd. Treatment cancers using a combination comprising PARP inhibitors
JP6541635B2 (ja) * 2016-10-28 2019-07-10 ベイジーン リミテッド Ｐａｒｐ阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン
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US11661581B2 (en) * 2017-05-25 2023-05-30 University Of Massachusetts Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells
BR112020005489A2 (pt) * 2017-09-22 2020-09-24 Jubilant Epipad Llc, composto da fórmula (i), composto de fórmula (ii), composto de fórmula (iii), processo de preparação de compostos de fórmula (i), processo de preparação de compostos de fórmula (ii), processo de preparação de compostos de fórmula (iii), composição farmacêutica, método para inibir uma ou mais famílias pad em uma célula, método para tratar uma afeção mediada por um ou mais pads, utilização do composto, método para o tratamento e/ou prevenção de uma afeção mediada por um ou mais distúrbios da família pad, método para o tratamento de artrite reumatoide e método de tratamento de câncer
EP3461480A1 (de) 2017-09-27 2019-04-03 Onxeo Kombination von checkpoint-hemmern des dna-schädigungsantwort-zellzyklus und belinostat zur behandlung von krebs
JP2022523028A (ja) * 2019-01-25 2022-04-21 ヌメディー， インコーポレイテッド 特発性肺線維症を処置するための方法
WO2021018298A1 (zh) * 2019-08-01 2021-02-04 南京明德新药研发有限公司 作为parp抑制剂吲哚并七元酰肟化合物
WO2021104461A1 (zh) 2019-11-29 2021-06-03 南京明德新药研发有限公司 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用
WO2022011458A1 (en) * 2020-07-13 2022-01-20 Ontario Institute For Cancer Research (Oicr) Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof
JP2023537220A (ja) * 2020-07-31 2023-08-31 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド Ｐａｒｐ阻害剤としてのインドロヘプタアシルオキシム類似体の結晶及びその製造方法

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Also Published As

Publication number Publication date
NZ540638A (en) 2007-12-21
EA200500893A1 (ru) 2006-02-24
HRP20050624A2 (en) 2006-02-28
KR20050092397A (ko) 2005-09-21
CA2512683A1 (en) 2004-07-29
EP1947102A1 (de) 2008-07-23
AU2004203977B2 (en) 2010-06-17
ZA200504674B (en) 2006-07-26
MA27703A1 (fr) 2006-01-02
US7462713B2 (en) 2008-12-09
CY1108408T1 (el) 2014-02-12
WO2004063198A1 (en) 2004-07-29
NO20053775D0 (no) 2005-08-08
US20070135415A1 (en) 2007-06-14
BRPI0406701A (pt) 2005-12-20
CR7899A (es) 2005-08-05
ATE404564T1 (de) 2008-08-15
CN1759118A (zh) 2006-04-12
ECSP055911A (es) 2005-11-22
AP2048A (en) 2009-09-24
IS7884A (is) 2005-06-09
EA009337B1 (ru) 2007-12-28
PL378372A1 (pl) 2006-04-03
UA80733C2 (en) 2007-10-25
US7132533B2 (en) 2006-11-07
US20050075499A1 (en) 2005-04-07
OA13017A (en) 2006-11-10
PT1585749E (pt) 2008-10-23
CA2512683C (en) 2010-03-16
TNSN05176A1 (fr) 2007-06-11
DK1585749T3 (da) 2008-09-22
AP2005003353A0 (en) 2005-09-30
JP2006516274A (ja) 2006-06-29
HK1086257A1 (en) 2006-09-15
US6967198B2 (en) 2005-11-22
MXPA05007352A (es) 2006-02-17
KR100697746B1 (ko) 2007-03-22
ES2309484T3 (es) 2008-12-16
IL169082A (en) 2011-02-28
DE602004015724D1 (de) 2008-09-25
US20060004052A1 (en) 2006-01-05
JP3990718B2 (ja) 2007-10-17
SI1585749T1 (sl) 2008-10-31
CN1759118B (zh) 2010-12-08
GEP20084367B (en) 2008-05-13
EP1585749A1 (de) 2005-10-19
RS20050522A (en) 2007-12-31
AU2004203977A1 (en) 2004-07-29
EP1585749B1 (de) 2008-08-13

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