NO20053105L - Oral, analgesisk doseringsform med forlenget frigivelse for administrering ±n gang pr. dag. - Google Patents

Oral, analgesisk doseringsform med forlenget frigivelse for administrering ±n gang pr. dag.

Info

Publication number
NO20053105L
NO20053105L NO20053105A NO20053105A NO20053105L NO 20053105 L NO20053105 L NO 20053105L NO 20053105 A NO20053105 A NO 20053105A NO 20053105 A NO20053105 A NO 20053105A NO 20053105 L NO20053105 L NO 20053105L
Authority
NO
Norway
Prior art keywords
day
oral
dosage form
extended
administration
Prior art date
Application number
NO20053105A
Other languages
English (en)
Other versions
NO20053105D0 (no
Inventor
Benjamin Oshlack
Mark Chasin
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO20053105L publication Critical patent/NO20053105L/no
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of NO20053105D0 publication Critical patent/NO20053105D0/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Oral, analgesisk doseringsform med forlenget fiigivelse for administiering én gang per dag, som omfatter en enhetsdose av opioid, analgesisk middel, hvilken enhetsdose omfatter et flertaU substiater i form av en multi-partikkelformet matriks med en forlenget fiigivelse omfattende det opioide, analgesiske middelet i en form for forlenget frigivelse, hvor hvert substiat har en diameter fra 0,1 mm til 3 mm, og hvori enhetsdosen innbefatter en mengde av det opioide, analgesiske middel i en form med umiddelbar frigivelse, og som er biotilgjengelig og tilveiebringer effektive blodnivåer av angitte opioide, analgesiske middel i minst 24 timer.
NO20053105A 1993-10-07 2005-06-24 Oral, analgesisk doseringsform med forlenget frigivelse for administrering ±n gang pr. dag. NO20053105D0 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13350393A 1993-10-07 1993-10-07

Publications (2)

Publication Number Publication Date
NO20053105L true NO20053105L (no) 1995-04-10
NO20053105D0 NO20053105D0 (no) 2005-06-24

Family

ID=22458920

Family Applications (4)

Application Number Title Priority Date Filing Date
NO19943761A NO320307B1 (no) 1993-10-07 1994-10-06 Biotilgjengelig, oral, analgetisk doseringsform med forlenget frigivelse for administrering en gang pr. dag
NO20053105A NO20053105D0 (no) 1993-10-07 2005-06-24 Oral, analgesisk doseringsform med forlenget frigivelse for administrering ±n gang pr. dag.
NO20053106A NO20053106D0 (no) 1993-10-07 2005-06-24 Oral, analgesisk doseringsform med forlenget frigivelse.
NO20053104A NO20053104D0 (no) 1993-10-07 2005-06-24 Oral, analgesisk doseringsform med forlenget frigivelse for administrering ±n gang pr. dag.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO19943761A NO320307B1 (no) 1993-10-07 1994-10-06 Biotilgjengelig, oral, analgetisk doseringsform med forlenget frigivelse for administrering en gang pr. dag

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO20053106A NO20053106D0 (no) 1993-10-07 2005-06-24 Oral, analgesisk doseringsform med forlenget frigivelse.
NO20053104A NO20053104D0 (no) 1993-10-07 2005-06-24 Oral, analgesisk doseringsform med forlenget frigivelse for administrering ±n gang pr. dag.

Country Status (9)

Country Link
EP (3) EP0647448A1 (no)
JP (3) JP3280810B2 (no)
KR (1) KR950010881A (no)
AU (2) AU7445594A (no)
CA (1) CA2133503C (no)
FI (1) FI944712A (no)
HU (1) HU218673B (no)
NO (4) NO320307B1 (no)
ZA (1) ZA947742B (no)

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EP2036558A3 (en) 2010-04-28
NO20053104L (no) 1995-04-10
FI944712A0 (fi) 1994-10-07
NO20053104D0 (no) 2005-06-24
JP3280810B2 (ja) 2002-05-13
HU218673B (hu) 2000-10-28
HU9402807D0 (en) 1995-01-30
CA2133503C (en) 1999-09-28
JP3825991B2 (ja) 2006-09-27
AU7445594A (en) 1995-05-11
EP0647448A1 (en) 1995-04-12
JPH07206679A (ja) 1995-08-08
NO943761D0 (no) 1994-10-06
KR950010881A (ko) 1995-05-15
JP2002012544A (ja) 2002-01-15
FI944712A (fi) 1995-04-08
EP2036558A2 (en) 2009-03-18
HUT74916A (en) 1997-03-28
CA2133503A1 (en) 1995-04-08
NO943761L (no) 1995-04-10
AU1780797A (en) 1997-06-05
NO20053106D0 (no) 2005-06-24
NO320307B1 (no) 2005-11-21
EP1442745A1 (en) 2004-08-04
JP2006151990A (ja) 2006-06-15
NO20053105D0 (no) 2005-06-24
NO20053106L (no) 1995-04-10
ZA947742B (en) 1995-05-18

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