NO20045267L - Mikrobicide pyrimidin- eller triazin-forbindelser egnet til a forhindre seksuell overforing av HIV - Google Patents

Mikrobicide pyrimidin- eller triazin-forbindelser egnet til a forhindre seksuell overforing av HIV

Info

Publication number
NO20045267L
NO20045267L NO20045267A NO20045267A NO20045267L NO 20045267 L NO20045267 L NO 20045267L NO 20045267 A NO20045267 A NO 20045267A NO 20045267 A NO20045267 A NO 20045267A NO 20045267 L NO20045267 L NO 20045267L
Authority
NO
Norway
Prior art keywords
hiv
prevent
compounds suitable
triazine compounds
sexual transmission
Prior art date
Application number
NO20045267A
Other languages
English (en)
Other versions
NO331030B1 (no
Inventor
Marie-Pierre T M M G D Bethune
Paul Stoffels
Jens Marcel Van Roey
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of NO20045267L publication Critical patent/NO20045267L/no
Publication of NO331030B1 publication Critical patent/NO331030B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
NO20045267A 2002-05-13 2004-12-01 Pyrimidinforbindelser med inhibitorisk aktivitet overfor ikke-nukleosid revers transkriptase NO331030B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02076897 2002-05-13
PCT/EP2003/050158 WO2003094920A1 (en) 2002-05-13 2003-05-13 Microbicidal pyrimidine or triazine for preventing sexual hiv transmission

Publications (2)

Publication Number Publication Date
NO20045267L true NO20045267L (no) 2005-02-14
NO331030B1 NO331030B1 (no) 2011-09-19

Family

ID=29414777

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20045267A NO331030B1 (no) 2002-05-13 2004-12-01 Pyrimidinforbindelser med inhibitorisk aktivitet overfor ikke-nukleosid revers transkriptase
NO20110298A NO334067B1 (no) 2002-05-13 2011-02-22 Anvendelse av triazinforbindelser for fremstilling av legemidler til forebygging av seksuell overføring av HIV

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20110298A NO334067B1 (no) 2002-05-13 2011-02-22 Anvendelse av triazinforbindelser for fremstilling av legemidler til forebygging av seksuell overføring av HIV

Country Status (27)

Country Link
US (4) US7935710B2 (no)
EP (1) EP1505980B1 (no)
JP (2) JP4530848B2 (no)
KR (1) KR101095358B1 (no)
CN (2) CN102558070B (no)
AP (1) AP2024A (no)
AR (1) AR039540A1 (no)
AT (1) ATE376420T1 (no)
AU (1) AU2003240844B2 (no)
BR (2) BRPI0310021B8 (no)
CA (1) CA2486078C (no)
CY (1) CY1110249T1 (no)
DE (1) DE60317060T2 (no)
DK (1) DK1505980T3 (no)
EA (1) EA011298B1 (no)
ES (1) ES2294291T3 (no)
HK (1) HK1173141A1 (no)
HR (1) HRP20041177B1 (no)
IL (1) IL165174A (no)
MX (1) MXPA04011392A (no)
NO (2) NO331030B1 (no)
NZ (1) NZ536976A (no)
PL (1) PL215128B1 (no)
PT (1) PT1505980E (no)
SI (1) SI1505980T1 (no)
WO (1) WO2003094920A1 (no)
ZA (1) ZA200409984B (no)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
AR039540A1 (es) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
EP1534286B1 (en) 2002-07-29 2009-12-09 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
BRPI0407329A (pt) * 2003-02-07 2006-01-10 Janssen Pharmaceutica Nv Derivados de pirimidina para a prevenção de infecção de hiv
CL2004000306A1 (es) * 2003-02-20 2005-04-08 Tibotec Pharm Ltd Compuestos derivados de pirimidina sustituidas con indano; proceso para su preparacion; composicion farmaceutica que lo comprende; combinacion farmaceutica; y su uso para el tratamiento o profilaxis de una enfermedad infecciosa.
DK1656372T3 (da) 2003-07-30 2013-07-01 Rigel Pharmaceuticals Inc 2,4-pyrimidindiaminforbindelser til anvendelse til behandling eller forebyggelse af autoimmunsygdomme
ITMI20031640A1 (it) 2003-08-08 2005-02-09 Mipharm S P A Base per gel bioadesivi.
UA93354C2 (ru) 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
WO2006068770A1 (en) 2004-11-24 2006-06-29 Rigel Pharmaceuticals, Inc. Spiro-2, 4-pyrimidinediamine compounds and their uses
CA2591948C (en) 2005-01-19 2013-11-12 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
MX2007010051A (es) * 2005-02-18 2007-09-21 Tibotec Pharm Ltd Derivados de oxido de 2-(4-cianofenilamino)pirimidina que inhiben el virus de inmunodeficiencia humana.
JP5225079B2 (ja) 2005-06-08 2013-07-03 ライジェル ファーマシューティカルズ， インコーポレイテッド Ｊａｋ経路の阻害のための組成物および方法
US20070203161A1 (en) 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
CN101245051B (zh) * 2005-12-22 2011-04-20 中国科学院上海药物研究所 2，4-二取代氨基-6-取代-[1，3，5]三嗪类化合物、其制备方法、药物组合物及用途
EP1991532B1 (en) 2006-02-24 2017-01-11 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
KR20090019011A (ko) 2006-06-15 2009-02-24 베링거 인겔하임 인터내셔날 게엠베하 단백질 키나아제 ｃ-알파의 억제제로서의 2-아닐리노-4-(헤테로사이클릭)아미노-피리미딘
CA2655315A1 (en) 2006-06-15 2007-12-21 Boehringer Ingelheim International Gmbh 2-anilino-4-aminoalkyleneaminopyrimidines
ES2524009T3 (es) 2006-12-08 2014-12-03 Irm Llc Compuestos y composiciones como inhibidores de la proteína quinasa
ES2550152T3 (es) * 2006-12-13 2015-11-04 F. Hoffmann-La Roche Ag Derivados de 2-(piperidin-4-il)-4-fenoxi-o fenilamino-pirimidina como inhibidores no nucleósidos de transcriptasa inversa
EP2781510B1 (en) * 2006-12-29 2016-12-14 Janssen Sciences Ireland UC Hiv inhibiting 5,6-substituted pyrimidines
BRPI0720858B8 (pt) * 2006-12-29 2021-05-25 Janssen R & D Ireland pirimidinas 6-substituídas inibidoras de hiv e composição farmacêutica que as compreende
US7989465B2 (en) * 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
CA2920996A1 (en) * 2007-10-19 2009-04-23 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
MX2010012703A (es) 2008-05-21 2010-12-21 Ariad Pharma Inc Derivados fosforosos como inhibidores de cinasa.
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
EP3075730B1 (en) 2010-06-04 2018-10-24 Genentech, Inc. Aminopyrimidine derivatives as lrrk2 modulators
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
TW201302733A (zh) 2010-11-10 2013-01-16 Hoffmann La Roche 作為ｌｒｒｋ２調節劑之吡唑胺基嘧啶衍生物
US20130039959A1 (en) * 2011-04-19 2013-02-14 Brian Vincent Sokol Method of inhibiting hiv and barrier-forming composition therefor
CA3079323A1 (en) 2011-04-19 2012-10-26 Arms Pharmaceutical Llc. Method of inhibiting harmful microorganisms and barrier-forming composition therefor
US10426761B2 (en) 2011-04-19 2019-10-01 Arms Pharmaceutical, Llc Method for treatment of disease caused or aggravated by microorganisms or relieving symptoms thereof
AU2012250517B2 (en) 2011-05-04 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
GB201119358D0 (en) 2011-11-10 2011-12-21 Lewi Paulus J Disubstituted triazine dimers for treatment and/or prevention of infectious diseases
GB201204756D0 (en) 2012-03-19 2012-05-02 Lewi Paulus J Triazines with suitable spacers for treatment and/or prevention of HIV infections
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
CN102675212B (zh) * 2012-05-09 2014-11-05 昆明理工大学 N-取代苯基-2-((1h-苯并咪唑-2-基)巯基)乙酰胺类衍生物及其用途
WO2014081689A1 (en) 2012-11-20 2014-05-30 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of indoleamine 2,3-dioxygenase
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
JP6466107B2 (ja) * 2014-09-04 2019-02-06 東ソー・ファインケム株式会社 ４−フェニルチオ−５−（トリフルオロメチル）ピリミジン誘導体及びその製造方法
CN105085410B (zh) * 2015-08-21 2017-10-10 武汉工程大学 一种二芳基嘧啶类hiv‑1抑制剂及其制备方法
WO2017077520A1 (en) 2015-11-06 2017-05-11 Ineb - Instituto Nacional De Engenharia Biomédica A composition for use in a method for prevention or treatment of human immunodeficiency virus infections
CN106478521A (zh) * 2016-10-11 2017-03-08 武汉工程大学 一种二芳基嘧啶类hiv‑1逆转录酶抑制剂及其制备方法
CN106866628A (zh) * 2017-02-27 2017-06-20 武汉工程大学 一种芳基杂芳基嘧啶类hiv‑1逆转录酶抑制剂及其制备方法
EP3612181A4 (en) 2017-04-21 2021-01-06 Epizyme, Inc. COMBINATION THERAPIES WITH EHMT2 INHIBITORS
CN109053613A (zh) * 2018-07-04 2018-12-21 复旦大学 含有联苯结构的二芳基三嗪类化合物及其制备方法和用途
CA3115351C (en) 2018-12-04 2023-06-20 Virox Technologies Inc. An antimicrobial composition comprising an antimicrobial agent consisting of a c3-c5 n-alkyl-gamma-butyrolactam and uses thereof
US20220033851A1 (en) * 2020-08-03 2022-02-03 Roger B. Swartz mRNA, episomal and genomic integrated lentiviral and gammaretroviral vector expression of dimeric immunoglobulin A and polymeric immunoglobulin A to Enable Mucosal and Hematological Based Immunity/Protection via Gene Therapy for Allergens, viruses, HIV, bacteria, pneumonia, infections, pathology associated proteins, systemic pathologies, cancer, toxins and unnatural viruses. CAR engineered and non-CAR engineered immune cell expression of dimeric immunoglobulin A and polymeric immunoglobulin A.
CA3228275A1 (en) 2021-08-03 2023-02-09 Genoveffa Franchini Hiv-1 vaccination and samt-247 microbicide to prevent hiv-1 infection
WO2023220645A1 (en) 2022-05-10 2023-11-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Vaccine for human t-lymphotropic virus-1

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4983393A (en) * 1987-07-21 1991-01-08 Maximed Corporation Intra-vaginal device and method for sustained drug release
NO169123C (no) 1988-01-20 1992-05-13 Univ Minnesota Analogifremgangsmaate til fremstilling av terapeutisk aktive karbocykliske 2',3'-dideoksy-2',3'-didehydropurinnukleosidanaloger
GB8815265D0 (en) 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
JPH075570B2 (ja) 1990-03-29 1995-01-25 三菱化学株式会社 ピリミジンヌクレオシド誘導体及び該誘導体を有効成分とする抗ウイルス剤
WO1992001452A1 (en) 1990-07-19 1992-02-06 The Wellcome Foundation Limited Enzyme inactivators
GB9214720D0 (en) * 1992-07-10 1992-08-19 Wellcome Found Enzyme inhibitors
AU687440B2 (en) 1993-08-24 1998-02-26 Medivir Ab Compounds and methods for inhibition of HIV and related viruses
US6165493A (en) 1997-10-22 2000-12-26 New York Blood Center, Inc. "Methods and compositions for decreasing the frequency of HIV, herpesvirus and sexually transmitted bacterial infections"
EP0945447A1 (en) * 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted 1,3,5-triazine derivatives for treatment of HIV infections
CZ299380B6 (cs) * 1998-03-27 2008-07-09 Janssen Pharmaceutica N. V. Pyrimidinová sloucenina, použití této slouceniny pro prípravu léciva, farmaceutický prostredek tutoslouceninu obsahující, zpusob prípravy tohoto prostredku a uvedené slouceniny a kombinace a produktuvedenou slouceninu obsahující
HU230394B1 (hu) * 1998-11-10 2016-04-28 Janssen Pharmaceutica N.V. HIV-vírus szaporodását gátló pirimidin-származékok
WO2000027828A2 (en) * 1998-11-10 2000-05-18 Janssen Pharmaceutica N.V. 2,4-disubstituted triazine derivatives with anti hiv activity
US6159491A (en) * 1999-02-12 2000-12-12 Biovector Technologies, Inc. Prolonged release bioadhesive vaginal gel dosage form
CA2368593A1 (en) * 1999-05-14 2000-11-23 Regents Of The University Of California Anti-inflammatory therapy for inflammatory mediated infection
BRPI0014271B1 (pt) 1999-09-24 2021-06-22 Janssen Pharmaceutica N.V. Partícula consistindo em uma dispersão de sólidos, uso da dita partícula, dispersão de sólidos, forma de dosagem farmacêutica, bem como processos de preparação de dita partícula, dispersão e forma de dosagem
DE19945982A1 (de) * 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
MXPA02010880A (es) 2000-05-05 2003-03-27 Hoffmann La Roche Virus centinela ii.
CA2406562C (en) * 2000-05-08 2009-09-15 Janssen Pharmaceutica N.V. Hiv replication inhibiting pyrimidines and triazines
ES2559273T3 (es) * 2000-05-08 2016-02-11 Janssen Pharmaceutica Nv Profármacos de pirimidinas que inhiben la replicación del VIH
US6596729B2 (en) * 2000-07-20 2003-07-22 Bristol-Myers Squibb Company Tricyclic-2-pyridone compounds useful as HIV reverse transcriptase inhibitors
JP2004525914A (ja) 2001-03-02 2004-08-26 スミスクライン ビーチャム コーポレーション 逆転写酵素阻害剤としてのベンゾフェノン類
NZ528377A (en) 2001-03-27 2005-05-27 Galen Chemicals Ltd Intravaginal drug delivery devices for the administration of an antimicrobial agent
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
TW200306192A (en) * 2002-01-18 2003-11-16 Bristol Myers Squibb Co Tricyclic 2-pyrimidone compounds useful as HIV reverse transcriptase inhibitors
AR039540A1 (es) * 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina

Also Published As

Publication number Publication date
NO20110298L (no) 2005-02-14
AR039540A1 (es) 2005-02-23
BR122014006936B1 (pt) 2020-11-24
DE60317060T2 (de) 2008-07-24
JP2005526846A (ja) 2005-09-08
AU2003240844A1 (en) 2003-11-11
CY1110249T1 (el) 2015-01-14
NZ536976A (en) 2007-08-31
BR0310021A (pt) 2005-02-15
CN1668305B (zh) 2013-06-12
BRPI0310021B1 (pt) 2018-03-13
PL215128B1 (pl) 2013-10-31
AP2024A (en) 2009-08-11
BR122014006936B8 (pt) 2021-05-25
ZA200409984B (en) 2006-07-26
CA2486078C (en) 2011-08-23
KR20050010798A (ko) 2005-01-28
DK1505980T3 (da) 2008-02-11
NO331030B1 (no) 2011-09-19
CN1668305A (zh) 2005-09-14
JP2010189435A (ja) 2010-09-02
ATE376420T1 (de) 2007-11-15
US20110165093A1 (en) 2011-07-07
NO334067B1 (no) 2013-12-02
CN102558070A (zh) 2012-07-11
EP1505980B1 (en) 2007-10-24
WO2003094920A1 (en) 2003-11-20
JP4530848B2 (ja) 2010-08-25
HRP20041177A2 (hr) 2006-04-30
US7935710B2 (en) 2011-05-03
PL373840A1 (en) 2005-09-19
US20060166943A1 (en) 2006-07-27
HRP20041177B1 (hr) 2013-03-31
EP1505980A1 (en) 2005-02-16
IL165174A0 (en) 2005-12-18
CN102558070B (zh) 2016-01-13
IL165174A (en) 2011-01-31
AP2004003182A0 (en) 2004-12-31
MXPA04011392A (es) 2005-02-17
AU2003240844B2 (en) 2008-09-11
SI1505980T1 (sl) 2008-02-29
EA011298B1 (ru) 2009-02-27
US20170100399A1 (en) 2017-04-13
PT1505980E (pt) 2008-01-17
JP5256244B2 (ja) 2013-08-07
US20200345733A1 (en) 2020-11-05
CA2486078A1 (en) 2003-11-20
ES2294291T3 (es) 2008-04-01
EA200401494A1 (ru) 2005-06-30
KR101095358B1 (ko) 2011-12-16
BRPI0310021B8 (pt) 2021-05-25
HK1173141A1 (zh) 2013-05-10
DE60317060D1 (de) 2007-12-06

Similar Documents

Publication Publication Date Title
NO20045267L (no) Mikrobicide pyrimidin- eller triazin-forbindelser egnet til a forhindre seksuell overforing av HIV
NO20054143D0 (no) Pyrimidinderivater for forhindringen av HIV-infeksjon
CY2012013I2 (el) Παραγωγα πυριμιδινης που αναστελλουν τον hiv
NO20034836L (no) Sammensmeltede pyrimidiner som antagonister av kortikotropinfrigivelsesfaktoren (CRF)
ATE529412T1 (de) Herbizide pyrimidine
DK1549652T3 (da) Kondenserede azolpyrimidinderivater
DK1377556T3 (da) Pyrazolderivater til behandling af HIV
DE60211322D1 (de) Empfängerinitiierte Inkrementierung der Übertragungsrate
ZA200702655B (en) HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines
ATE506353T1 (de) Die hiv-replikation inhibierende indan- substituierte pyrimidine
IS7287A (is) Pýrimídín efnasambönd
DK1417180T3 (da) Fremstilling af aminopyrimidinforbindelser
IS6868A (is) Ný pýrimidínefnasambönd
AU2003258145A8 (en) Substituted phenylindoles for the treatment of hiv
ZA200207233B (en) Use of statins to inhibit formation of osteoclasts.
DK1645165T3 (da) Modtagerenhed til reducering af tilbagekobling
UA6272S (uk) Інтер`єр бару «картопляна хата»
FI20020948A0 (fi) Kiukaan rakenneratkaisu
PT3808743T (pt) Derivados de pirimidinas inibidores do vih
ITTO20020169U1 (it) Struttura migliorata di bullone anti-effrazione.
GB0216310D0 (en) Range safe finder
FI20021857A0 (fi) Menetelmä hiivojen kasvun estämiseksi
FI5852U1 (fi) Väline painovärin leviämisen estämiseksi
UA8563S (uk) Соска спеціальна

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: JANSSEN SCIENCES IRELAND UC, IE

MK1K Patent expired