NO20042185L - Kromatografisk rensing av rekombinant humant erytropoietin - Google Patents

Kromatografisk rensing av rekombinant humant erytropoietin

Info

Publication number
NO20042185L
NO20042185L NO20042185A NO20042185A NO20042185L NO 20042185 L NO20042185 L NO 20042185L NO 20042185 A NO20042185 A NO 20042185A NO 20042185 A NO20042185 A NO 20042185A NO 20042185 L NO20042185 L NO 20042185L
Authority
NO
Norway
Prior art keywords
recombinant human
chromatographic purification
human erythropoietin
erythropoietin
chromatographic
Prior art date
Application number
NO20042185A
Other languages
English (en)
Norwegian (no)
Inventor
Peter Alliger
Norbert Palma
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of NO20042185L publication Critical patent/NO20042185L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
NO20042185A 2001-11-28 2004-05-26 Kromatografisk rensing av rekombinant humant erytropoietin NO20042185L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33383901P 2001-11-28 2001-11-28
PCT/EP2002/013299 WO2003045996A1 (en) 2001-11-28 2002-11-26 Chromatographic purification of recombinant human erythropoietin

Publications (1)

Publication Number Publication Date
NO20042185L true NO20042185L (no) 2004-08-23

Family

ID=23304479

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20042185A NO20042185L (no) 2001-11-28 2004-05-26 Kromatografisk rensing av rekombinant humant erytropoietin

Country Status (20)

Country Link
US (1) US20060099674A1 (es)
EP (1) EP1453857B1 (es)
JP (1) JP4293908B2 (es)
KR (1) KR20040065567A (es)
CN (1) CN1596268A (es)
AU (1) AU2002356733A1 (es)
BR (1) BR0214568A (es)
CA (1) CA2466627A1 (es)
ES (1) ES2525945T3 (es)
HR (1) HRP20040476A2 (es)
HU (1) HUP0500061A2 (es)
IL (1) IL161855A0 (es)
MX (1) MXPA04005189A (es)
NO (1) NO20042185L (es)
NZ (1) NZ533083A (es)
PL (1) PL368755A1 (es)
RU (1) RU2004119818A (es)
SI (1) SI1453857T1 (es)
WO (1) WO2003045996A1 (es)
ZA (1) ZA200403461B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003080852A1 (en) * 2002-03-26 2003-10-02 Lek Pharmaceutical And Chemical Company D.D. Process for the preparation of a desired erythropoietin glyco-isoform profile
DE60228460D1 (de) * 2002-12-13 2008-10-02 Bioceuticals Arzneimittel Ag Verfahren zur Herstellung und Reinigung von Erythropoietin
US7157276B2 (en) * 2003-06-20 2007-01-02 Biogen Idec Inc. Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures
KR100567448B1 (ko) * 2003-11-05 2006-04-04 주식회사 인투젠 형질전환 동물의 유즙 전처리방법 및 이를 통한 인체단백질의 정제방법
DE102004027816A1 (de) 2004-06-08 2006-01-05 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von Erythropoietin
WO2006003926A1 (ja) * 2004-06-30 2006-01-12 Terumo Kabushiki Kaisha ウィルス不活化ヘモグロビンおよびその製造方法
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
KR100988706B1 (ko) * 2007-03-07 2010-10-18 한미홀딩스 주식회사 재조합 에리트로포이에틴의 신규한 정제방법
KR100900033B1 (ko) * 2007-11-21 2009-06-01 한국생명공학연구원 인간 에리스로포이에틴의 정제방법
DE102008002209A1 (de) 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin
US8779110B2 (en) 2008-06-24 2014-07-15 Dr. Reddy's Laboratories Limited Purification of low isoelectric point isoforms of darbepoietin
CA2739392A1 (en) * 2008-10-17 2010-04-22 Percivia Llc Clarification process
DE102008054716A1 (de) * 2008-12-16 2010-06-17 Evonik Degussa Gmbh Inprozesskontrolle in einem Verfahren zur Herstellung von EPO
JP5728016B2 (ja) 2009-09-23 2015-06-03 ラチオファーマ ゲーエムベーハー 組換えヒトエリスロポエチン（ｅｐｏ）を精製するためのプロセス、このようにして精製されたｅｐｏおよびこれを含む医薬組成物
WO2011063195A2 (en) * 2009-11-20 2011-05-26 Dr. Reddy's Laboratories Ltd. Purification of modified cytokines
CN102453087B (zh) * 2010-10-22 2013-12-25 广东赛保尔生物医药技术有限公司 一种单取代peg-epo的纯化及制备方法
AU2011329053A1 (en) * 2010-11-15 2013-06-06 Biogen Inc. Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography
WO2012069474A2 (en) * 2010-11-24 2012-05-31 H. Lundbeck A/S A method for reducing potential virus burden in a sample by cyanate treatment
KR101443257B1 (ko) 2011-10-18 2014-09-19 주식회사 종근당 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
WO2014138921A1 (en) * 2013-03-15 2014-09-18 Apotex Inc. Enhanced liquid formulation stability of erythropoietin alpha through purification processing
CN105358228A (zh) 2013-07-05 2016-02-24 法国血液分割暨生化制品实验室 亲和层析基质
KR101414897B1 (ko) 2013-11-29 2014-07-04 씨제이헬스케어 주식회사 다베포에틴 알파의 정제 방법
WO2015134640A1 (en) * 2014-03-05 2015-09-11 GlycoScientific LLC Isotopically labeled glycans and methods for producing the same
CA2970732C (en) 2014-12-15 2023-05-16 Merck Patent Gmbh Target molecule capture from crude solutions
EP3153522A1 (en) 2015-10-09 2017-04-12 Hetero Drugs Limited Process for the purification of erythropoietin and darbepoetin alfa
CN106770597A (zh) * 2017-03-01 2017-05-31 上海博威生物医药有限公司 用于检测组合物中促红细胞生成素电荷异质体的cze检测方法
CN112940101A (zh) * 2019-12-11 2021-06-11 深圳赛保尔生物药业有限公司 重组人促红细胞生成素的纯化方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
DE69130990T2 (de) * 1990-02-20 1999-12-02 Baxter Int Gereinigtes, virusfreies menschliches Thrombin
DE19504211A1 (de) * 1995-02-09 1996-08-14 Behringwerke Ag Entfernen von Viren durch Ultrafiltration aus Proteinlösungen
TW442492B (en) 1995-07-26 2001-06-23 Novartis Ag Process for the enrichment of interferon
PT889949E (pt) * 1996-03-13 2003-10-31 Delta Biotechnology Ltd Controlo de fermentacao
BR9917606A (pt) 1998-11-06 2002-12-31 Bio Sidus S A Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento

Also Published As

Publication number Publication date
CA2466627A1 (en) 2003-06-05
SI1453857T1 (sl) 2015-01-30
EP1453857B1 (en) 2014-08-13
US20060099674A1 (en) 2006-05-11
PL368755A1 (en) 2005-04-04
IL161855A0 (en) 2005-11-20
EP1453857A1 (en) 2004-09-08
RU2004119818A (ru) 2006-01-10
HUP0500061A2 (hu) 2005-04-28
KR20040065567A (ko) 2004-07-22
NZ533083A (en) 2006-09-29
HRP20040476A2 (en) 2005-10-31
WO2003045996A1 (en) 2003-06-05
AU2002356733A1 (en) 2003-06-10
MXPA04005189A (es) 2005-02-17
ZA200403461B (en) 2006-05-31
BR0214568A (pt) 2004-11-03
ES2525945T3 (es) 2015-01-02
JP2005518196A (ja) 2005-06-23
CN1596268A (zh) 2005-03-16
JP4293908B2 (ja) 2009-07-08

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