HRP20040476A2 - Chromatographic purification of recombinant human erythropoietin - Google Patents

Chromatographic purification of recombinant human erythropoietin

Info

Publication number
HRP20040476A2
HRP20040476A2 HR20040476A HRP20040476A HRP20040476A2 HR P20040476 A2 HRP20040476 A2 HR P20040476A2 HR 20040476 A HR20040476 A HR 20040476A HR P20040476 A HRP20040476 A HR P20040476A HR P20040476 A2 HRP20040476 A2 HR P20040476A2
Authority
HR
Croatia
Prior art keywords
recombinant human
chromatographic purification
human erythropoietin
erythropoietin
chromatographic
Prior art date
Application number
HR20040476A
Other languages
English (en)
Inventor
Alliger Peter
Palma Norbert
Original Assignee
Sandoz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Gmbh filed Critical Sandoz Gmbh
Publication of HRP20040476A2 publication Critical patent/HRP20040476A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HR20040476A 2001-11-28 2004-05-27 Chromatographic purification of recombinant human erythropoietin HRP20040476A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33383901P 2001-11-28 2001-11-28
PCT/EP2002/013299 WO2003045996A1 (en) 2001-11-28 2002-11-26 Chromatographic purification of recombinant human erythropoietin

Publications (1)

Publication Number Publication Date
HRP20040476A2 true HRP20040476A2 (en) 2005-10-31

Family

ID=23304479

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040476A HRP20040476A2 (en) 2001-11-28 2004-05-27 Chromatographic purification of recombinant human erythropoietin

Country Status (20)

Country Link
US (1) US20060099674A1 (xx)
EP (1) EP1453857B1 (xx)
JP (1) JP4293908B2 (xx)
KR (1) KR20040065567A (xx)
CN (1) CN1596268A (xx)
AU (1) AU2002356733A1 (xx)
BR (1) BR0214568A (xx)
CA (1) CA2466627A1 (xx)
ES (1) ES2525945T3 (xx)
HR (1) HRP20040476A2 (xx)
HU (1) HUP0500061A2 (xx)
IL (1) IL161855A0 (xx)
MX (1) MXPA04005189A (xx)
NO (1) NO20042185L (xx)
NZ (1) NZ533083A (xx)
PL (1) PL368755A1 (xx)
RU (1) RU2004119818A (xx)
SI (1) SI1453857T1 (xx)
WO (1) WO2003045996A1 (xx)
ZA (1) ZA200403461B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002247896A1 (en) * 2002-03-26 2003-10-08 Lek Pharmaceutical And Chemical Company D.D. Process for the preparation of a desired erythropoietin glyco-isoform profile
SI1428878T1 (sl) * 2002-12-13 2009-02-28 Bioceuticals Arzneimittel Ag Postopek za proizvodnjo in čiščenje eritropoietina
US7157276B2 (en) 2003-06-20 2007-01-02 Biogen Idec Inc. Use of depth filtration in series with continuous centrifugation to clarify mammalian cell cultures
KR100567448B1 (ko) * 2003-11-05 2006-04-04 주식회사 인투젠 형질전환 동물의 유즙 전처리방법 및 이를 통한 인체단백질의 정제방법
DE102004027816A1 (de) * 2004-06-08 2006-01-05 Bioceuticals Arzneimittel Ag Verfahren zur Reinigung von Erythropoietin
JP4742042B2 (ja) * 2004-06-30 2011-08-10 テルモ株式会社 ウィルス不活化ヘモグロビンおよびその製造方法
US7531632B2 (en) * 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
KR100988706B1 (ko) * 2007-03-07 2010-10-18 한미홀딩스 주식회사 재조합 에리트로포이에틴의 신규한 정제방법
KR100900033B1 (ko) * 2007-11-21 2009-06-01 한국생명공학연구원 인간 에리스로포이에틴의 정제방법
DE102008002209A1 (de) 2008-06-04 2009-12-10 Evonik Degussa Gmbh Verfahren zur Aufreinigung von Erythropoietin
MX2010014180A (es) 2008-06-24 2011-02-15 Reddys Lab Inc Dr Purificacion de citocinas modificadas.
CN102203113A (zh) * 2008-10-17 2011-09-28 佩尔希维亚有限责任公司 澄清方法
DE102008054716A1 (de) * 2008-12-16 2010-06-17 Evonik Degussa Gmbh Inprozesskontrolle in einem Verfahren zur Herstellung von EPO
CA2775012A1 (en) 2009-09-23 2011-03-31 Biogenerix Ag Process for the purification of recombinant human erythropoietin (epo), epo thus purified and pharmaceutical compositions comprising same
WO2011063195A2 (en) * 2009-11-20 2011-05-26 Dr. Reddy's Laboratories Ltd. Purification of modified cytokines
CN102453087B (zh) * 2010-10-22 2013-12-25 广东赛保尔生物医药技术有限公司 一种单取代peg-epo的纯化及制备方法
JP2014503495A (ja) * 2010-11-15 2014-02-13 バイオジェン アイデック インコーポレイテッド 過負荷結合および溶出クロマトグラフィによる選択生成物アイソフォームの富化および濃縮
WO2012069474A2 (en) * 2010-11-24 2012-05-31 H. Lundbeck A/S A method for reducing potential virus burden in a sample by cyanate treatment
KR101443257B1 (ko) 2011-10-18 2014-09-19 주식회사 종근당 낮은 등전점을 갖는 에리스로포이에틴 유사체의 정제방법
EP2970420A4 (en) * 2013-03-15 2016-08-17 Apotex Inc STABILITY OF THE ENHANCED LIQUID FORMULATION OF ERYTHROPOIETIN ALPHA VIA A PURIFICATION TREATMENT
CA2916566A1 (fr) 2013-07-05 2015-01-08 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Matrice de chromatographie d'affinite
KR101414897B1 (ko) 2013-11-29 2014-07-04 씨제이헬스케어 주식회사 다베포에틴 알파의 정제 방법
WO2015134640A1 (en) * 2014-03-05 2015-09-11 GlycoScientific LLC Isotopically labeled glycans and methods for producing the same
WO2016096071A1 (en) 2014-12-15 2016-06-23 Merck Patent Gmbh Target molecule capture from crude solutions
EP3153522A1 (en) 2015-10-09 2017-04-12 Hetero Drugs Limited Process for the purification of erythropoietin and darbepoetin alfa
CN106770597A (zh) * 2017-03-01 2017-05-31 上海博威生物医药有限公司 用于检测组合物中促红细胞生成素电荷异质体的cze检测方法
CN112940101A (zh) * 2019-12-11 2021-06-11 深圳赛保尔生物药业有限公司 重组人促红细胞生成素的纯化方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4677195A (en) * 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
US5856298A (en) * 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
EP0443724B1 (en) 1990-02-20 1999-03-17 Baxter International Inc. Viral-safe purified human thrombin
DE19504211A1 (de) 1995-02-09 1996-08-14 Behringwerke Ag Entfernen von Viren durch Ultrafiltration aus Proteinlösungen
TW442492B (en) * 1995-07-26 2001-06-23 Novartis Ag Process for the enrichment of interferon
CA2242323C (en) * 1996-03-13 2002-09-10 Delta Biotechnology Limited Fermentation control
BR9917606A (pt) 1998-11-06 2002-12-31 Bio Sidus S A Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento

Also Published As

Publication number Publication date
US20060099674A1 (en) 2006-05-11
RU2004119818A (ru) 2006-01-10
WO2003045996A1 (en) 2003-06-05
NO20042185L (no) 2004-08-23
MXPA04005189A (es) 2005-02-17
IL161855A0 (en) 2005-11-20
AU2002356733A1 (en) 2003-06-10
EP1453857B1 (en) 2014-08-13
BR0214568A (pt) 2004-11-03
ES2525945T3 (es) 2015-01-02
JP4293908B2 (ja) 2009-07-08
KR20040065567A (ko) 2004-07-22
NZ533083A (en) 2006-09-29
ZA200403461B (en) 2006-05-31
CN1596268A (zh) 2005-03-16
EP1453857A1 (en) 2004-09-08
SI1453857T1 (sl) 2015-01-30
HUP0500061A2 (hu) 2005-04-28
JP2005518196A (ja) 2005-06-23
PL368755A1 (en) 2005-04-04
CA2466627A1 (en) 2003-06-05

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