NO20034168L - Koagulasjonsfaktor VII-derivater - Google Patents
Koagulasjonsfaktor VII-derivaterInfo
- Publication number
- NO20034168L NO20034168L NO20034168A NO20034168A NO20034168L NO 20034168 L NO20034168 L NO 20034168L NO 20034168 A NO20034168 A NO 20034168A NO 20034168 A NO20034168 A NO 20034168A NO 20034168 L NO20034168 L NO 20034168L
- Authority
- NO
- Norway
- Prior art keywords
- factor vii
- coagulation factor
- vii derivatives
- derivatives
- coagulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200100477 | 2001-03-22 | ||
PCT/DK2002/000189 WO2002077218A1 (en) | 2001-03-22 | 2002-03-21 | Coagulation factor vii derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20034168D0 NO20034168D0 (no) | 2003-09-19 |
NO20034168L true NO20034168L (no) | 2003-11-21 |
Family
ID=8160386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20034168A NO20034168L (no) | 2001-03-22 | 2003-09-19 | Koagulasjonsfaktor VII-derivater |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1373493B1 (ko) |
JP (2) | JP2004529640A (ko) |
KR (1) | KR20030085041A (ko) |
CN (1) | CN100567487C (ko) |
AU (1) | AU2002249096B2 (ko) |
BR (1) | BR0208203A (ko) |
CA (1) | CA2441580A1 (ko) |
CZ (1) | CZ20032454A3 (ko) |
ES (1) | ES2432967T3 (ko) |
HU (1) | HUP0401124A3 (ko) |
IL (1) | IL157842A0 (ko) |
MX (1) | MXPA03008590A (ko) |
NO (1) | NO20034168L (ko) |
PL (1) | PL371800A1 (ko) |
RU (1) | RU2338752C2 (ko) |
WO (1) | WO2002077218A1 (ko) |
ZA (1) | ZA200307061B (ko) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7247708B2 (en) | 1997-10-23 | 2007-07-24 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6747003B1 (en) | 1997-10-23 | 2004-06-08 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
AU5807500A (en) | 1999-07-14 | 2001-02-05 | Novo Nordisk A/S | Use of fviia or a tissue factor antagonist for regulating gene expression and cell migration or chemotaxis |
US7812132B2 (en) | 2000-04-28 | 2010-10-12 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US7220837B1 (en) | 2000-04-28 | 2007-05-22 | Regents Of The University Of Minnesota | Modified vitamin K-dependent polypeptides |
US6905683B2 (en) | 2000-05-03 | 2005-06-14 | Novo Nordisk Healthcare A/G | Human coagulation factor VII variants |
US20030211094A1 (en) | 2001-06-26 | 2003-11-13 | Nelsestuen Gary L. | High molecular weight derivatives of vitamin k-dependent polypeptides |
US7173000B2 (en) | 2000-11-09 | 2007-02-06 | The Scripps Research Institute | Modified factor VIIa |
US7052868B2 (en) | 2001-09-27 | 2006-05-30 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7157277B2 (en) | 2001-11-28 | 2007-01-02 | Neose Technologies, Inc. | Factor VIII remodeling and glycoconjugation of Factor VIII |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
ES2490590T3 (es) * | 2001-11-02 | 2014-09-04 | Novo Nordisk Health Care Ag | Polipéptidos de factor VII de coagulación humana |
US6960657B2 (en) | 2001-11-02 | 2005-11-01 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
US7700733B2 (en) | 2002-04-30 | 2010-04-20 | Bayer Healthcare Llc | Factor VII or VIIa polypeptide variants |
DK1517710T3 (da) | 2002-06-21 | 2011-07-18 | Novo Nordisk Healthcare Ag | Pegylerede faktor VII-glycoformer |
WO2004000347A1 (en) | 2002-06-21 | 2003-12-31 | Novo Nordisk A/S | Stabilised solid compositions of factor vii polypeptides |
WO2004029090A1 (en) * | 2002-09-25 | 2004-04-08 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
US6911323B2 (en) | 2002-09-25 | 2005-06-28 | Novo Nordisk Healthcare A/G | Human coagulation factor VII polypeptides |
BRPI0408417A (pt) | 2003-03-18 | 2006-03-21 | Novo Nordisk Healthcare Ag | métodos para a produção de um resìduo de gla purificado contendo serina protease, para a purificação de um resìduo de gla contendo serina protease e para estabilização de um resìduo de gla contendo serina protease, e, composição |
US7771996B2 (en) | 2003-03-20 | 2010-08-10 | Bayer Healthcare Llc | FVII or FVIIa variants |
MXPA05010773A (es) | 2003-04-09 | 2005-12-12 | Neose Technologies Inc | Metodos de glicopegilacion y proteinas/peptidos producidos por los metodos. |
US8791070B2 (en) | 2003-04-09 | 2014-07-29 | Novo Nordisk A/S | Glycopegylated factor IX |
EP2261244A3 (en) | 2003-04-15 | 2011-02-23 | Glaxosmithkline LLC | Human il-18 substitution mutants and their conjugates |
BRPI0411650A (pt) | 2003-06-19 | 2006-08-08 | Maxygen Holdings Ltd | variante polipeptìdica do fator vii (fvii) ou do fator viia (fviia), sequencia de nucleotìdeos , vetor de expressão, célula hospedeira, composição, uso de uma variante, e, método para tratar de um mamìfero tendo uma doença ou um distúrbio em que a formação de coágulo seja desejável |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
CN101870729A (zh) | 2003-09-09 | 2010-10-27 | 诺和诺德医疗保健公司 | 凝固因子ⅶ多肽 |
EP1673453A2 (en) | 2003-10-07 | 2006-06-28 | Novo Nordisk Health Care AG | Hybrid molecules having factor vii/viia activity |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
KR101234170B1 (ko) | 2003-12-01 | 2013-02-18 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 액체 인자 ⅶ 조성물의 바이러스 여과법 |
US20060040856A1 (en) | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
WO2005058283A2 (en) | 2003-12-19 | 2005-06-30 | Novo Nordisk Health Care Ag | Stabilised compositions of factor vii polypeptides |
ES2397241T3 (es) | 2004-01-21 | 2013-03-05 | Novo Nordisk Health Care Ag | Conjugación de péptidos mediante transglutaminasa |
JP2007522805A (ja) * | 2004-02-03 | 2007-08-16 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 新規化合物 |
WO2005107795A1 (en) * | 2004-05-11 | 2005-11-17 | Novo Nordisk Health Care Ag | Use of factor viia for the treatment of burn traumas |
CN101006175A (zh) | 2004-08-17 | 2007-07-25 | Csl百灵有限公司 | 经修饰的维生素k依赖性多肽 |
EP1814573B1 (en) | 2004-10-29 | 2016-03-09 | ratiopharm GmbH | Remodeling and glycopegylation of fibroblast growth factor (fgf) |
SI3130601T1 (sl) * | 2004-11-12 | 2020-11-30 | Bayer Healthcare Llc | Usmerjena modifikacija FVIII |
CN101098883B (zh) | 2004-12-23 | 2013-01-23 | 诺和诺德医疗保健公司 | 减少含有目的维生素k依赖性蛋白质的组合物中的蛋白质污染物的含量 |
ES2449195T3 (es) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Factor estimulante de colonias de granulocitos glicopegilado |
WO2006121569A2 (en) | 2005-04-08 | 2006-11-16 | Neose Technologies, Inc. | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
JP5216580B2 (ja) | 2005-05-25 | 2013-06-19 | ノヴォ ノルディスク アー/エス | グリコペグ化第ix因子 |
EP2360170A3 (en) | 2005-06-17 | 2012-03-28 | Novo Nordisk Health Care AG | Selective reduction and derivatization of engineered proteins comprinsing at least one non-native cysteine |
JP5290753B2 (ja) * | 2005-06-17 | 2013-09-18 | ノボ ノルディスク ヘルス ケア アーゲー | 二量体及び多量体FVIIa化合物 |
WO2007006808A1 (en) | 2005-07-13 | 2007-01-18 | Novo Nordisk Health Care Ag | Host cell protein knock-out cells for production of therapeutic proteins |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
EP1924689B1 (en) | 2005-09-01 | 2014-08-13 | Novo Nordisk Health Care AG | Hydrophobic interaction chromatography purification of factor vii polypeptides |
US20090055942A1 (en) | 2005-09-14 | 2009-02-26 | Novo Nordisk Healthcare A/G | Human Coagulation Factor VII Polypeptides |
WO2007056191A2 (en) | 2005-11-03 | 2007-05-18 | Neose Technologies, Inc. | Nucleotide sugar purification using membranes |
US8178495B2 (en) | 2008-06-27 | 2012-05-15 | Duke University | Therapeutic agents comprising a GLP-1 receptor agonist and elastin-like peptide |
CA2653154A1 (en) | 2006-05-24 | 2007-11-29 | Novo Nordisk Health Care Ag | Prolonged fix analogues and derivatives |
JP2009543841A (ja) * | 2006-07-17 | 2009-12-10 | ノボ ノルディスク ヘルス ケア アーゲー | 増加した活性を有する第viia因子アナログの新規用途 |
WO2008011633A2 (en) | 2006-07-21 | 2008-01-24 | Neose Technologies, Inc. | Glycosylation of peptides via o-linked glycosylation sequences |
WO2008025856A2 (en) | 2006-09-01 | 2008-03-06 | Novo Nordisk Health Care Ag | Modified glycoproteins |
US8969532B2 (en) | 2006-10-03 | 2015-03-03 | Novo Nordisk A/S | Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography |
JP5876208B2 (ja) | 2006-12-15 | 2016-03-02 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 延長されたinvivo半減期を有する第VIIa因子−(ポリ)シアル酸結合体 |
JP5558106B2 (ja) * | 2007-01-03 | 2014-07-23 | ノボ ノルディスク ヘルス ケア アーゲー | 凝固第vii因子関連ポリペプチドの皮下投与 |
CN101796063B (zh) | 2007-04-03 | 2017-03-22 | 拉蒂奥法姆有限责任公司 | 使用糖聚乙二醇化g‑csf的治疗方法 |
EP2481797A1 (en) | 2007-04-13 | 2012-08-01 | Catalyst Biosciences, Inc. | Modified factor VII polypeptides and uses thereof |
ES2551123T3 (es) | 2007-06-12 | 2015-11-16 | Ratiopharm Gmbh | Proceso mejorado para la producción de azúcares de nucleótido |
CN101910408A (zh) | 2007-12-27 | 2010-12-08 | 巴克斯特国际公司 | 细胞培养方法 |
JP5619630B2 (ja) | 2008-02-27 | 2014-11-05 | ノボ・ノルデイスク・エー/エス | 結合型第viii因子分子 |
TWI465247B (zh) | 2008-04-11 | 2014-12-21 | Catalyst Biosciences Inc | 經修飾的因子vii多肽和其用途 |
ES2597954T3 (es) | 2009-07-27 | 2017-01-24 | Baxalta GmbH | Conjugados de proteína de la coagulación sanguínea |
EP3093029A1 (en) | 2009-07-27 | 2016-11-16 | Baxalta GmbH | Blood coagulation protein conjugates |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
KR101912335B1 (ko) | 2009-07-27 | 2018-10-26 | 리폭센 테크놀로지즈 리미티드 | 비혈액 응고 단백질의 글리코폴리시알화 |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
CN102753575A (zh) | 2010-01-28 | 2012-10-24 | 诺沃—诺迪斯克保健股份有限公司 | 因子vii融合多肽 |
GB201007356D0 (en) * | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
EP2588499B1 (en) | 2010-06-30 | 2020-04-08 | Novo Nordisk A/S | Antibodies that are capable of specifically binding tissue factor pathway inhibitor |
MX345608B (es) | 2010-12-22 | 2017-02-07 | Baxalta Inc | Materiales y metodos para conjugar un derivado de acido graso soluble en agua a una proteina. |
RU2013142015A (ru) | 2011-03-02 | 2015-04-10 | Ново Нордиск А/С | Нацеливание факторов свертывания крови на рецептор tlt-1 на поверхности активированных тромбоцитов |
WO2012170969A2 (en) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Pro-coagulant compounds and methods of use thereof |
EP2554161A1 (en) | 2011-08-02 | 2013-02-06 | LFB Biotechnologies | Pharmaceutical composition comprising factor VII encapsulated in micelles |
EP3417881A1 (en) * | 2011-10-06 | 2018-12-26 | Hanmi Science Co., Ltd. | Blood coagulation factor vii and viia derivatives, conjugates and complexes comprising the same, and use thereof |
WO2014057068A1 (en) | 2012-10-10 | 2014-04-17 | Novo Nordisk Health Care Ag | Liquid pharmaceutical composition of factor vii polypeptide |
JP2015533152A (ja) * | 2012-10-15 | 2015-11-19 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 第vii因子コンジュゲート |
EP2906693A1 (en) | 2012-10-15 | 2015-08-19 | Novo Nordisk Health Care AG | Coagulation factor vii polypeptides |
TWI641382B (zh) * | 2013-01-31 | 2018-11-21 | 韓美藥品股份有限公司 | 於包含因子vii之組成物中使病毒失活之方法 |
WO2019067766A1 (en) | 2017-09-27 | 2019-04-04 | Sigilon Therapeutics, Inc. | METHODS, COMPOSITIONS AND IMPLANTABLE ELEMENTS COMPRISING ACTIVE CELLS |
US20210145889A1 (en) | 2018-04-04 | 2021-05-20 | Sigilon Therapeutics, Inc. | Methods, compositions, and implantable elements comprising stem cells |
UY38160A (es) | 2018-04-04 | 2019-11-29 | Sigilon Therapeutics Inc | Partículas implantables y métodos relacionados |
UY38389A (es) | 2018-09-27 | 2020-04-30 | Sigilon Therapeutics Inc | Dispositivos implantables para terapia celular y métodos relacionados |
WO2021030787A1 (en) | 2019-08-15 | 2021-02-18 | Catalyst Biosciences, Inc. | Modified factor vii polypeptides for subcutaneous administration and on-demand treatment |
WO2024081310A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
WO2024081309A1 (en) | 2022-10-11 | 2024-04-18 | Sigilon Therapeutics, Inc. | Engineered cells and implantable elements for treatment of disease |
Family Cites Families (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4203570A (en) | 1978-08-23 | 1980-05-20 | The Western States Machine Company | Power-operated loading gate for centrifugal machines incorporating an auxiliary drive device |
US4386025A (en) | 1980-09-30 | 1983-05-31 | Cutter Laboratories, Inc. | Method of preparing antithrombin |
US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
US4517294A (en) | 1982-03-03 | 1985-05-14 | Genentech, Inc. | Human antithrombin III |
US4500309A (en) | 1982-05-07 | 1985-02-19 | The Kansas University Endowment Association | Method for regional anticoagulation during extracorporeal dialysis |
US4546082A (en) | 1982-06-17 | 1985-10-08 | Regents Of The Univ. Of California | E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins |
US4599311A (en) | 1982-08-13 | 1986-07-08 | Kawasaki Glenn H | Glycolytic promotersfor regulated protein expression: protease inhibitor |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
WO1984004330A1 (en) | 1983-04-22 | 1984-11-08 | Amgen | Secretion of exogenous polypeptides from yeast |
NZ207926A (en) | 1983-04-25 | 1988-04-29 | Genentech Inc | Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast |
US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
US4870008A (en) | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
US4879236A (en) | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
US4931373A (en) | 1984-05-25 | 1990-06-05 | Zymogenetics, Inc. | Stable DNA constructs for expression of α-1 antitrypsin |
DK58285D0 (da) | 1984-05-30 | 1985-02-08 | Novo Industri As | Peptider samt fremstilling og anvendelse deraf |
IL76441A (en) | 1984-09-21 | 1990-07-26 | Boehringer Ingelheim Int | Blood coagulation inhibiting proteins and their preparation |
US4766073A (en) | 1985-02-25 | 1988-08-23 | Zymogenetics Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
US4885249A (en) | 1984-12-05 | 1989-12-05 | Allelix, Inc. | Aspergillus niger transformation system |
GR860984B (en) | 1985-04-17 | 1986-08-18 | Zymogenetics Inc | Expression of factor vii and ix activities in mammalian cells |
US4975282A (en) | 1985-06-26 | 1990-12-04 | The Liposome Company, Inc. | Multilamellar liposomes having improved trapping efficiencies |
US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
NZ217373A (en) | 1985-08-29 | 1990-10-26 | Genencor Inc | Production of heterologous peptide in filamentous fungi, vectors and dna |
CA1265446A (en) | 1985-09-30 | 1990-02-06 | Masahiro Maki | Anticoagulating substance, process for preparing same and anticoagulant comprising same as an effective component |
US4882279A (en) | 1985-10-25 | 1989-11-21 | Phillips Petroleum Company | Site selective genomic modification of yeast of the genus pichia |
JP2523562B2 (ja) | 1985-10-25 | 1996-08-14 | ザイモジェネティックス インコーポレーテッド | 外来タンパク質を分泌することを目的としたbar1の使用法 |
US4935349A (en) | 1986-01-17 | 1990-06-19 | Zymogenetics, Inc. | Expression of higher eucaryotic genes in aspergillus |
DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
GB8615942D0 (en) | 1986-06-30 | 1986-08-06 | Animal & Food Research Council | Peptide production |
NZ221259A (en) | 1986-07-31 | 1990-05-28 | Calgene Inc | Seed specific transcriptional regulation |
DK323587D0 (da) * | 1987-06-25 | 1987-06-25 | Novo Industri As | Protein |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
EP0279582A3 (en) | 1987-02-17 | 1989-10-18 | Pharming B.V. | Dna sequences to target proteins to the mammary gland for efficient secretion |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5024947A (en) | 1987-07-24 | 1991-06-18 | Cetus Corporation | Serum free media for the growth on insect cells and expression of products thereby |
ATE170557T1 (de) | 1987-07-24 | 1998-09-15 | Chiron Corp | Züchtung von insektenzellen mit airlift-reaktoren |
US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
EP0383779B2 (en) | 1987-09-04 | 2000-05-31 | Novo Nordisk A/S | PROCESS FOR THE PRODUCTION OF PROTEIN PRODUCTS IN $i(ASPERGILLUS) AND PROMOTERS FOR USE IN $i(ASPERGILLUS) |
DK463887D0 (da) | 1987-09-07 | 1987-09-07 | Novo Industri As | Gaerleader |
US5037743A (en) | 1988-08-05 | 1991-08-06 | Zymogenetics, Inc. | BAR1 secretion signal |
GB8826446D0 (en) | 1988-11-11 | 1988-12-14 | Agricultural & Food Res | Peptide production |
AU4647889A (en) | 1988-11-18 | 1990-06-12 | Cetus Corporation | Insect signal peptide mediated secretion of recombinant proteins |
US5122614A (en) | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
GB8910962D0 (en) | 1989-05-12 | 1989-06-28 | Natural Environment Res | Novel baculovirus expression vectors and use thereof in the expression of foreign proteins in insects or insect cells |
US5162222A (en) | 1989-07-07 | 1992-11-10 | Guarino Linda A | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses |
US5077214A (en) | 1989-07-07 | 1991-12-31 | The Texas A&M University System | Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells |
US5073964A (en) | 1989-08-04 | 1991-12-17 | Aware, Inc. | Signal processing device and method |
US5155037A (en) | 1989-08-04 | 1992-10-13 | The Texas A&M University System | Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems |
US5023328A (en) | 1989-08-04 | 1991-06-11 | The Texas A&M University System | Lepidopteran AKH signal sequence |
DE69131292T2 (de) | 1990-01-29 | 1999-09-30 | Zymogenetics Inc | Antikoagulierende proteine |
DK300090D0 (da) | 1990-12-19 | 1990-12-19 | Novo Nordisk As | Fremgangsmaade til fremstilling af leadersekvenser |
CA2099562C (en) | 1991-01-11 | 2010-04-20 | William N. Drohan | Expression of active human protein c in mammary tissue of transgenic animals |
US5833982A (en) * | 1991-02-28 | 1998-11-10 | Zymogenetics, Inc. | Modified factor VII |
US5788965A (en) | 1991-02-28 | 1998-08-04 | Novo Nordisk A/S | Modified factor VII |
DE69233398D1 (de) | 1991-02-28 | 2004-09-16 | Novo Nordisk As | Modifizierter faktor-vii |
CA2162726A1 (en) | 1993-05-21 | 1994-12-08 | Kathleen L. Berkner | Modified factor vii |
ATE200030T1 (de) * | 1997-01-29 | 2001-04-15 | Polymasc Pharmaceuticals Plc | Pegylationsverfahren |
WO1999013063A1 (en) * | 1997-09-09 | 1999-03-18 | Nycomed Imaging As | Factor vii fragments and analogs thereof and their use in the treatment of blood clottng disorders |
JP4451514B2 (ja) * | 1999-08-24 | 2010-04-14 | 財団法人化学及血清療法研究所 | 血液凝固第vii因子改変体 |
CN100488562C (zh) * | 2000-02-11 | 2009-05-20 | 拜耳医药保健有限公司 | 凝血因子VⅡ或VⅡa样分子 |
EP2226385B1 (en) * | 2000-09-13 | 2013-07-10 | Novo Nordisk Health Care AG | Human Coagulation Factor VII Variants |
-
2002
- 2002-03-21 ES ES02717998T patent/ES2432967T3/es not_active Expired - Lifetime
- 2002-03-21 EP EP02717998.5A patent/EP1373493B1/en not_active Expired - Lifetime
- 2002-03-21 KR KR10-2003-7012351A patent/KR20030085041A/ko active IP Right Grant
- 2002-03-21 MX MXPA03008590A patent/MXPA03008590A/es active IP Right Grant
- 2002-03-21 CA CA002441580A patent/CA2441580A1/en not_active Abandoned
- 2002-03-21 CZ CZ20032454A patent/CZ20032454A3/cs unknown
- 2002-03-21 BR BR0208203-9A patent/BR0208203A/pt not_active IP Right Cessation
- 2002-03-21 HU HU0401124A patent/HUP0401124A3/hu unknown
- 2002-03-21 RU RU2003131077/13A patent/RU2338752C2/ru active
- 2002-03-21 CN CNB02809638XA patent/CN100567487C/zh not_active Expired - Fee Related
- 2002-03-21 IL IL15784202A patent/IL157842A0/xx unknown
- 2002-03-21 AU AU2002249096A patent/AU2002249096B2/en not_active Ceased
- 2002-03-21 WO PCT/DK2002/000189 patent/WO2002077218A1/en active Application Filing
- 2002-03-21 JP JP2002576661A patent/JP2004529640A/ja not_active Withdrawn
- 2002-03-21 PL PL02371800A patent/PL371800A1/xx not_active Application Discontinuation
-
2003
- 2003-09-10 ZA ZA200307061A patent/ZA200307061B/en unknown
- 2003-09-19 NO NO20034168A patent/NO20034168L/no not_active Application Discontinuation
-
2009
- 2009-02-12 JP JP2009030465A patent/JP5451101B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CZ20032454A3 (en) | 2004-03-17 |
JP5451101B2 (ja) | 2014-03-26 |
ES2432967T3 (es) | 2013-12-05 |
CN100567487C (zh) | 2009-12-09 |
AU2002249096B2 (en) | 2007-06-28 |
EP1373493A1 (en) | 2004-01-02 |
CA2441580A1 (en) | 2002-10-03 |
CN1522299A (zh) | 2004-08-18 |
PL371800A1 (en) | 2005-06-27 |
JP2004529640A (ja) | 2004-09-30 |
IL157842A0 (en) | 2004-03-28 |
JP2009159969A (ja) | 2009-07-23 |
HUP0401124A3 (en) | 2006-01-30 |
KR20030085041A (ko) | 2003-11-01 |
AU2002249096B8 (en) | 2002-10-08 |
MXPA03008590A (es) | 2003-12-08 |
NO20034168D0 (no) | 2003-09-19 |
EP1373493B1 (en) | 2013-07-31 |
HUP0401124A2 (hu) | 2004-08-30 |
BR0208203A (pt) | 2005-04-19 |
RU2338752C2 (ru) | 2008-11-20 |
WO2002077218A1 (en) | 2002-10-03 |
RU2003131077A (ru) | 2005-08-10 |
ZA200307061B (en) | 2005-05-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20034168D0 (no) | Koagulasjonsfaktor VII-derivater | |
ATE319451T1 (de) | Tetrahydrochinolin-derivate | |
ATE312827T1 (de) | 3-substituierte-4-pyrimidonderivate | |
IS7016A (is) | Ný 4-anilínókínólín-3-karboxamíð | |
DK1671949T3 (da) | Substituerede pyridinylaminer | |
PT1411764E (pt) | Cerca | |
DE50206892D1 (de) | Substituierte imidazotriazinone | |
NO20024454D0 (no) | Pappall | |
ATE335486T1 (de) | Hydrazono-malonitrile | |
EE200300447A (et) | Asendatud bensofuraan-2-karboksamiidide derivaadid | |
DK1373228T3 (da) | Substituerede fluoralkoxyphenylsulfonylurinstoffer | |
IS2523B (is) | Turn vindorkuvers | |
DE60223031D1 (de) | Arylpiperazin gebundene tetrahydroindolonderivate | |
ATE355059T1 (de) | Isoxazolopyridinone | |
DK1406858T3 (da) | Substituerede 4-aminocyklohexanoler | |
NO20034488D0 (no) | Rörfôring | |
ATE382601T1 (de) | Substituierte 4-aminocyclohexanolderivate | |
DK1392670T3 (da) | Substituerede C-furan-2-yl-methylamin- og C-thiophen-2-yl-methylamin-derivater | |
DE60200407D1 (de) | Methylendioxy- Derivate | |
ATE319694T1 (de) | Phenylalkyne | |
ATA18372001A (de) | Gelenksbolzenbaueinheit | |
DE60202381D1 (de) | Paroxetin-n-formyl-derivate | |
ATA13992002A (de) | Schlackengranulierungsanlage | |
DE60216967D1 (de) | Substituierte cyclohexanderivate | |
AT500276B8 (de) | Radschwenksystem |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |