NO20024355L - Nukleosidforbindelser og anvendelser derav - Google Patents

Nukleosidforbindelser og anvendelser derav

Info

Publication number
NO20024355L
NO20024355L NO20024355A NO20024355A NO20024355L NO 20024355 L NO20024355 L NO 20024355L NO 20024355 A NO20024355 A NO 20024355A NO 20024355 A NO20024355 A NO 20024355A NO 20024355 L NO20024355 L NO 20024355L
Authority
NO
Norway
Prior art keywords
nucleoside compounds
nucleoside
compounds
Prior art date
Application number
NO20024355A
Other languages
English (en)
Norwegian (no)
Other versions
NO20024355D0 (no
Inventor
Guangyi Wang
Kanda Ramasamy
Lau Johnson
Original Assignee
Icn Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals
Publication of NO20024355D0 publication Critical patent/NO20024355D0/no
Publication of NO20024355L publication Critical patent/NO20024355L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO20024355A 2000-03-15 2002-09-12 Nukleosidforbindelser og anvendelser derav NO20024355L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18967200P 2000-03-15 2000-03-15
US09/594,410 US6495677B1 (en) 2000-02-15 2000-06-16 Nucleoside compounds
PCT/US2001/008713 WO2001068663A1 (fr) 2000-03-15 2001-03-15 Composes nucleosidiques et leurs utilisations

Publications (2)

Publication Number Publication Date
NO20024355D0 NO20024355D0 (no) 2002-09-12
NO20024355L true NO20024355L (no) 2002-11-12

Family

ID=26885400

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20024355A NO20024355L (no) 2000-03-15 2002-09-12 Nukleosidforbindelser og anvendelser derav
NO20024385A NO20024385L (no) 2000-03-15 2002-09-13 Antivirale pro-legemidler

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20024385A NO20024385L (no) 2000-03-15 2002-09-13 Antivirale pro-legemidler

Country Status (18)

Country Link
US (1) US6495677B1 (fr)
EP (2) EP1268504A1 (fr)
JP (2) JP2003530322A (fr)
KR (2) KR20030032927A (fr)
CN (2) CN1424913A (fr)
AU (2) AU4755601A (fr)
BR (2) BR0109143A (fr)
CA (2) CA2400043A1 (fr)
CZ (2) CZ20023051A3 (fr)
DE (1) DE20121305U1 (fr)
HU (2) HUP0302334A2 (fr)
IL (1) IL151073A0 (fr)
MX (2) MXPA02008608A (fr)
NO (2) NO20024355L (fr)
PL (2) PL365985A1 (fr)
RU (2) RU2002121631A (fr)
SK (2) SK11522002A3 (fr)
WO (2) WO2001068034A2 (fr)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
AU2001259068A1 (en) 2000-04-13 2001-10-30 Pharmasset, Ltd. 3'-or 2'-hydroxymethyl substituted nucleoside derivatives for treatment of hepatitis virus infections
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
EP1294735A2 (fr) 2000-05-26 2003-03-26 Novirio Pharmaceuticals Limited Procedes et compositions de traitement des flavivirus et des pestivirus
US6815542B2 (en) * 2000-06-16 2004-11-09 Ribapharm, Inc. Nucleoside compounds and uses thereof
DE10112926B4 (de) * 2001-03-13 2005-11-10 Schebo Biotech Ag Verwendung von Aminooxyacetat zur Tumorbehandlung
US7138376B2 (en) * 2001-09-28 2006-11-21 Idenix Pharmaceuticals, Inc. Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides
CA2477795A1 (fr) * 2002-02-28 2003-09-12 Kandasamy Sakthivel Analogues de nucleoside 5'-monophosphate et leurs promedicaments
CA2479906C (fr) * 2002-04-03 2011-02-08 Topotarget Uk Limited Composes d'acide carbamique comprenant un chainon de piperazine tels que les inhibiteurs hdac
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
MXPA04012802A (es) 2002-06-28 2005-04-19 Idenix Cayman Ltd Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae.
SG174624A1 (en) 2002-08-01 2011-10-28 Pharmasset Inc Compounds with the bicyclo[4.2.1]nonane system for the treatment of flaviviridae infections
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
TWI332507B (en) 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
EP1572710A2 (fr) * 2002-12-10 2005-09-14 F. Hoffmann-La Roche Ag Derives de nucleoside antiviraux
WO2004052899A2 (fr) 2002-12-12 2004-06-24 Idenix (Cayman) Limited Procede de production de nucleosides ramifies en position 2'
CN100335492C (zh) * 2002-12-23 2007-09-05 埃迪尼克斯(开曼)有限公司 生产3’－核苷前体药物的方法
US20060276419A1 (en) * 2003-02-25 2006-12-07 Applied Research Systems Ars Holding N.V. Combined use of ribavirin and interferon beta in demyelinating diseases
CA2529311A1 (fr) * 2003-03-28 2004-10-07 Pharmasset, Inc. Composes permettant de traiter les infections par flavivirus
PT1633766T (pt) 2003-05-30 2019-06-04 Gilead Pharmasset Llc Análogos de nucleósido fluorado modificado
US6930093B2 (en) * 2003-07-10 2005-08-16 Valeant Research & Development Use of ribofuranose derivatives against inflammatory bowel diseases
ATE478886T1 (de) * 2003-07-25 2010-09-15 Idenix Pharmaceuticals Inc Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
WO2005018330A1 (fr) * 2003-08-18 2005-03-03 Pharmasset, Inc. Regime de dosage pour therapie contre flaviviridae
JP2007505071A (ja) * 2003-09-11 2007-03-08 エフ．ホフマン−ラ　ロシュ　アーゲー 結晶多形性ヌクレオシド化合物
CN1878783A (zh) * 2003-09-11 2006-12-13 弗·哈夫曼-拉罗切有限公司 制备抗病毒核苷衍生物的方法
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
WO2005123087A2 (fr) 2004-06-15 2005-12-29 Merck & Co., Inc. Analogues nucleosidiques de c-purine, servant d'inhibiteurs d'arn-polymerase virale arn-dependante
RU2007102281A (ru) * 2004-06-23 2008-07-27 Айденикс (Кайман) Лимитед (Ky) 5-аза-7-деазапуриновые производные для лечения заболеваний, связанных с flaviviridae
CA2571079A1 (fr) 2004-06-24 2006-02-02 Merck & Co., Inc. Phosphoramidates d'aryle nucleosidiques pour le traitement d'infection virale arn dependante de l'arn
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
WO2006031725A2 (fr) 2004-09-14 2006-03-23 Pharmasset, Inc. Preparation de ribofuranosyle pyrimidines et purines a substitution 2'-fluoro-2'- alkyl- ou eventuellement a autre substitution ainsi que derives de celles-ci
CN1314702C (zh) * 2004-11-11 2007-05-09 中国人民解放军军事医学科学院放射与辐射医学研究所 核苷类似物胆固醇衍生物
EP1879607B1 (fr) 2005-05-02 2014-11-12 Merck Sharp & Dohme Corp. Inhibiteurs de la protease ns3 du vhc
US7470664B2 (en) 2005-07-20 2008-12-30 Merck & Co., Inc. HCV NS3 protease inhibitors
RU2008107972A (ru) 2005-08-01 2009-09-10 Мерк энд Ко., Инк. (US) Макроциклические пептиды в качестве ингибиторов ns3-протеазы hcv
US7781576B2 (en) 2005-12-23 2010-08-24 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
GB0612423D0 (en) 2006-06-23 2006-08-02 Angeletti P Ist Richerche Bio Therapeutic agents
CA2663618A1 (fr) * 2006-09-11 2008-06-05 Southern Research Institute Nucleosides d'azole et utilisation en tant qu'inhibiteurs de polymerases d'arn et d'adn viral
AU2007309544B2 (en) 2006-10-24 2012-05-31 Msd Italia S.R.L. HCV NS3 protease inhibitors
US8377873B2 (en) 2006-10-24 2013-02-19 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
CA2667266C (fr) 2006-10-24 2015-11-24 Merck & Co., Inc. Inhibiteurs de la protease ns3 du hcv
CA2667032A1 (fr) 2006-10-27 2008-05-15 Merck & Co., Inc. Inhibiteurs de protease ns3 du vhc
BRPI0718161A2 (pt) 2006-10-27 2013-11-26 Merck & Co Inc Composto, composição farmacêutica, e, uso do composto.
US8101595B2 (en) 2006-12-20 2012-01-24 Istituto di Ricerche di Biologia Molecolare P. Angletti SpA Antiviral indoles
GB0625345D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0625349D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2008085508A2 (fr) 2007-01-05 2008-07-17 Merck & Co., Inc. Phosphoramidates d'aryle nucléosidiques destinés au traitement de l'infection virale d'arn arn dépendante
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
AU2008277440A1 (en) 2007-07-17 2009-01-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa Macrocyclic indole derivatives for the treatment of hepatitis C infections
CA2699891C (fr) 2007-07-19 2013-10-22 Nigel Liverton Composes macrocycliques servant d'agents antiviraux
CA2698812A1 (fr) 2007-09-14 2009-03-19 Nitto Denko Corporation Vecteurs de medicament
CN102014911A (zh) 2008-04-28 2011-04-13 默沙东公司 Hcv ns3蛋白酶抑制剂
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
RS52534B (en) 2008-07-22 2013-04-30 Merck Sharp & Dohme Corp. MACROCYCLIC COMPOUNDS OF HINOXALINE AS HCV NS3 PROTEASE INHIBITORS
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
EP2376088B1 (fr) 2008-12-23 2017-02-22 Gilead Pharmasset LLC Phosphoramidates de nucléosides de type 2-amino-purine 6-O-substituée
TW201031675A (en) 2008-12-23 2010-09-01 Pharmasset Inc Synthesis of purine nucleosides
EP2376514A2 (fr) 2008-12-23 2011-10-19 Pharmasset, Inc. Analogues de nucléoside
WO2010082050A1 (fr) 2009-01-16 2010-07-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Composés benzoxazocines substitués 7-aminoalkyle macrocycycliques destinés au traitement des infections par hépatite c
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
JP2012521359A (ja) 2009-03-20 2012-09-13 アリオス バイオファーマ インク． 置換されたヌクレオシドアナログおよびヌクレオチドアナログ
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US9744183B2 (en) 2009-07-06 2017-08-29 Wave Life Sciences Ltd. Nucleic acid prodrugs and methods of use thereof
WO2011014487A1 (fr) 2009-07-30 2011-02-03 Merck Sharp & Dohme Corp. Inhibiteurs de protéase ns3 du virus de l'hépatite c
US20110027229A1 (en) 2009-07-31 2011-02-03 Medtronic, Inc. Continuous subcutaneous administration of interferon-alpha to hepatitis c infected patients
WO2011076923A1 (fr) 2009-12-23 2011-06-30 Institut National De La Sante Et De La Recherche Medicale Inhibiteur de l'inosine monophosphate (imp) déshydrogénase et/ou de l'arn polymérase viral utile(s) pour le traitement de l'hépatite e
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
UY33311A (es) 2010-03-31 2011-10-31 Pharmasset Inc Fosforamidatos de nucleosidos
CN103209987B (zh) 2010-09-22 2017-06-06 艾丽奥斯生物制药有限公司 取代的核苷酸类似物
DK2620428T3 (da) 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
DK2734208T3 (en) 2011-07-19 2017-06-19 Wave Life Sciences Ltd PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
SI2709613T2 (sl) 2011-09-16 2020-12-31 Gilead Pharmasset LLC c/o Gilead Sciences, Inc. Postopki za zdravljenje HCV
EP2780026B1 (fr) 2011-11-15 2019-10-23 Merck Sharp & Dohme Corp. Inhibiteurs de la protéase ns3 du vhc
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US9073960B2 (en) 2011-12-22 2015-07-07 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
AU2012358804B2 (en) 2011-12-22 2018-04-19 Alios Biopharma, Inc. Substituted phosphorothioate nucleotide analogs
WO2013106344A1 (fr) 2012-01-12 2013-07-18 Ligand Pharmaceuticals, Inc. Nucléosides 2'-c-méthyl comprenant un diester de phosphate cyclique de 1,3-propanediol (2-oxo-[1,3,2]-dioxaphosphorinane à la position 5'
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2013142124A1 (fr) 2012-03-21 2013-09-26 Vertex Pharmaceuticals Incorporated Formes solides d'un promédicament nucléotidique thiophosphoramidate
EP2827876A4 (fr) 2012-03-22 2015-10-28 Alios Biopharma Inc Combinaisons pharmaceutiques comprenant un analogue thionucléotidique
EP2861611B1 (fr) 2012-05-25 2016-07-13 Janssen Sciences Ireland UC Nucléosides dýuracyle spirooxetane
EP2872485B1 (fr) 2012-07-13 2020-12-16 Wave Life Sciences Ltd. Groupe auxiliaire asymétrique
RS61767B1 (sr) 2012-12-21 2021-05-31 Janssen Biopharma Inc 4'-fluor-nukleozidi, 4'-fluor-nukleotidi i njihovi analozi za lečenje hcv
SG11201506021XA (en) 2013-01-31 2015-08-28 Gilead Pharmasset Llc Combination formulation of two antiviral compounds
WO2014121417A1 (fr) 2013-02-07 2014-08-14 Merck Sharp & Dohme Corp. Composés hétérocycliques tétracycliques et leurs procédés d'utilisation pour le traitement de l'hépatite c
WO2014121418A1 (fr) 2013-02-07 2014-08-14 Merck Sharp & Dohme Corp. Composés hétérocycliques tétracycliques et leurs méthodes d'utilisation pour le traitement de l'hépatite c
MX2016002185A (es) 2013-08-27 2016-06-06 Gilead Pharmasset Llc Formulacion combinada de dos compuestos antivirales.
SG10201804835VA (en) 2013-10-11 2018-07-30 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
PT3094728T (pt) 2014-01-16 2022-05-19 Wave Life Sciences Ltd Desenho quiral
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
EP3164136A4 (fr) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Composés de promédicaments et leurs utilisations
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
AU2020417293A1 (en) 2020-01-03 2022-09-01 Berg Llc Polycyclic amides as UBE2K modulators for treating cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3991078A (en) 1971-06-01 1976-11-09 Icn Pharmaceuticals, Inc. N-substituted 1,2,4-triazoles
US3984396A (en) 1971-06-01 1976-10-05 Icn Pharmaceuticals, Inc. 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters
US3798209A (en) 1971-06-01 1974-03-19 Icn Pharmaceuticals 1,2,4-triazole nucleosides
USRE29835E (en) 1971-06-01 1978-11-14 Icn Pharmaceuticals 1,2,4-Triazole nucleosides
US4093624A (en) 1977-01-31 1978-06-06 Icn Pharmaceuticals, Inc. 1,2,4-Thiadiazolidine-3,5-dione
JPS6426593A (en) 1987-07-21 1989-01-27 Asahi Glass Co Ltd Nucleoside derivative
PT1027359E (pt) 1996-10-16 2003-09-30 Ribapharm Inc L-nucleosideos monociclicos analogos e suas utilizacoes

Also Published As

Publication number Publication date
CA2400370A1 (fr) 2001-09-20
CN1416431A (zh) 2003-05-07
AU5088101A (en) 2001-09-24
NO20024355D0 (no) 2002-09-12
KR20030032927A (ko) 2003-04-26
CZ20023119A3 (cs) 2003-05-14
AU4755601A (en) 2001-09-24
RU2002121628A (ru) 2004-02-27
BR0109143A (pt) 2006-02-21
WO2001068034A3 (fr) 2002-03-21
RU2002121631A (ru) 2004-03-10
CZ20023051A3 (cs) 2003-04-16
JP2004505889A (ja) 2004-02-26
EP1268504A1 (fr) 2003-01-02
CN1424913A (zh) 2003-06-18
WO2001068034A2 (fr) 2001-09-20
BR0109144A (pt) 2006-02-21
WO2001068663B1 (fr) 2002-02-14
MXPA02008609A (es) 2004-09-06
IL151073A0 (en) 2006-12-31
SK11522002A3 (sk) 2003-04-01
HUP0302334A2 (hu) 2003-10-28
EP1207890A4 (fr) 2003-01-15
NO20024385L (no) 2002-11-13
DE20121305U1 (de) 2002-09-19
MXPA02008608A (es) 2004-09-06
SK11502002A3 (sk) 2003-03-04
WO2001068663A1 (fr) 2001-09-20
JP2003530322A (ja) 2003-10-14
US6495677B1 (en) 2002-12-17
EP1207890A2 (fr) 2002-05-29
HUP0301730A2 (hu) 2003-09-29
PL366038A1 (en) 2005-01-24
NO20024385D0 (no) 2002-09-13
KR20030062227A (ko) 2003-07-23
WO2001068034B1 (fr) 2002-05-10
PL365985A1 (en) 2005-01-24
CA2400043A1 (fr) 2001-09-20

Similar Documents

Publication Publication Date Title
NO20024355D0 (no) Nukleosidforbindelser og anvendelser derav
DK1122244T3 (da) Uracilforbindelser og anvendelse deraf
DK1417175T3 (da) Substituerede dihydro-3-halo-1h-pyrazol-5-carboxylater og fremstillingog anvendelse heraf
ATE290000T1 (de) Muscarinagonisten
ATE252099T1 (de) Biarylcarboxamide
ATE312098T1 (de) Thiazinoxazolidinon
ATA2932001A (de) Schneefräse
NO20030917D0 (no) Anvendelse
ATE262530T1 (de) Indolochinazolinone
DK1106607T3 (da) Uracilforbindelser og anvendelse deraf
AR028336A1 (es) 4-hidroxi-tetrahidropiridonas fenilsubstituidas
ATE509008T1 (de) Sulfonylguanidine
NO20013085D0 (no) Fosfororganiske forbindelser og deres anvendelse
AR028061A1 (es) 2-enamino-cetonitrilos fenil-substituidos
DE50113112D1 (de) Schaltungsanordnung
AR027931A1 (es) Antitranspirantes
ATE476423T1 (de) Benzoylpyridazine
DE10052925B4 (de) Schaukelbett
DE10085445T1 (de) Drahterodierbearbeitungseinrichtung
DE60117096D1 (de) Dihydroindol- und tetrahydrochinolinderivate
AR027982A1 (es) Aril- y heteroarilsulfonatos
ATE284887T1 (de) Thienopyrrolidinone
NO20025135D0 (no) Antihypertensive midler og anvendelse
DE10054120B4 (de) Aufsparrendämmelement
DE60219418D1 (de) Silanylphenole und -naphthole

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application