NO20013855L - Fast tilstandsform av celecoxib med ökt biotilgjengelighet - Google Patents

Fast tilstandsform av celecoxib med ökt biotilgjengelighet

Info

Publication number
NO20013855L
NO20013855L NO20013855A NO20013855A NO20013855L NO 20013855 L NO20013855 L NO 20013855L NO 20013855 A NO20013855 A NO 20013855A NO 20013855 A NO20013855 A NO 20013855A NO 20013855 L NO20013855 L NO 20013855L
Authority
NO
Norway
Prior art keywords
celecoxib
amorphous
drug substance
solid state
state form
Prior art date
Application number
NO20013855A
Other languages
English (en)
Other versions
NO20013855D0 (no
NO320844B1 (no
Inventor
Michael J Hageman
Xiaorong He
Tugrul T Kararli
Lesley A Mackin
Patricia J Miyake
Brian R Rohrs
Kevin J Stefanski
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26865450&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20013855(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of NO20013855D0 publication Critical patent/NO20013855D0/no
Publication of NO20013855L publication Critical patent/NO20013855L/no
Publication of NO320844B1 publication Critical patent/NO320844B1/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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NO20013855A 1999-12-08 2001-08-08 Celecoxibpreparat, fremgangsmate for fremstilling av dette og av farmasoytisk preparat som omfatter det og anvendelse av celeboxibpreparatet for fremstilling av preparat og medikament. NO320844B1 (no)

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US16985699P 1999-12-08 1999-12-08
US09/730,663 US6964978B2 (en) 1999-12-08 2000-12-06 Solid-state form of celecoxib having enhanced bioavailability
PCT/US2000/032435 WO2001042221A1 (en) 1999-12-08 2000-12-06 Solid-state form of celecoxib having enhanced bioavailability

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Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500358A (ja) * 1999-12-08 2004-01-08 ファルマシア　コーポレイション バイオアベイラビリティーが増加した固体状態のセレコキシブ
UA74539C2 (en) * 1999-12-08 2006-01-16 Pharmacia Corp Crystalline polymorphous forms of celecoxib (variants), a method for the preparation thereof (variants), a pharmaceutical composition (variants)
DZ3227A1 (fr) 1999-12-23 2001-07-05 Pfizer Prod Inc Compositions pharmaceutiques fournissant des concentrations de medicaments ameliorees
US6589557B2 (en) 2000-06-15 2003-07-08 Acusphere, Inc. Porous celecoxib matrices and methods of manufacture thereof
US6800297B2 (en) * 2000-06-15 2004-10-05 Acusphere, Inc. Porous COX-2 inhibitor matrices and methods of manufacture thereof
US20020119193A1 (en) * 2000-08-18 2002-08-29 Le Trang T. Oral fast-melt formulation of a cyclooxygenase-2 inhibitor
JP2004534812A (ja) 2001-06-22 2004-11-18 ファイザー・プロダクツ・インク 薬物および中性ポリマーの分散物の医薬組成物
JP2005523262A (ja) 2002-02-01 2005-08-04 ファイザー・プロダクツ・インク 薬物及び親油性ミクロ相形成物質の非晶質分散物の医薬組成物
WO2004026235A2 (en) * 2002-09-20 2004-04-01 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US20090088443A1 (en) * 2002-02-15 2009-04-02 Julius Remenar Novel crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
US20100311701A1 (en) * 2002-02-15 2010-12-09 Transform Pharmaceuticals, Inc Pharmaceutical Co-Crystal Compositions
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
CA2477923C (en) * 2002-03-01 2021-02-23 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
MY139721A (en) * 2002-04-19 2009-10-30 Cpex Pharmaceuticals Inc Pharmaceutical composition
JP2006511499A (ja) * 2002-05-13 2006-04-06 ファルマシア コーポレイション 安定な無定形セレコキシブ複合物およびその製法
MXPA05000232A (es) 2002-06-21 2005-06-17 Transform Pharmaceuticals Inc Composiciones farmaceuticas con disolucion mejorada.
AU2003295846A1 (en) * 2002-11-26 2004-06-18 Transform Pharmaceuticals, Inc. Pharmaceutical formulations of celcoxib
EP2339328A3 (en) 2002-12-30 2011-07-13 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of celecoxib
US8183290B2 (en) * 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
US20040156894A1 (en) * 2003-02-07 2004-08-12 Grother Leon Paul Use of edible acids in fast-dispersing pharmaceutical solid dosage forms
EP1631260A2 (en) * 2003-02-28 2006-03-08 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
US8512727B2 (en) 2003-03-03 2013-08-20 Alkermes Pharma Ireland Limited Nanoparticulate meloxicam formulations
BRPI0413277A (pt) 2003-08-04 2006-10-10 Pfizer Prod Inc composições farmacêuticas de adsorvatos de medicamentos amorfos e materiais que formam microfases lipofìlicas
WO2005037271A2 (en) * 2003-10-17 2005-04-28 Tanabe Seiyaku Co., Ltd. Large conductance calcium-activated k channel opener
JP2007517015A (ja) * 2003-12-31 2007-06-28 ファイザー・プロダクツ・インク 低溶解性薬物、ポロキサマーおよび安定化ポリマーの安定化された医薬用固体組成物
BRPI0418330A (pt) * 2003-12-31 2007-05-02 Pfizer Prod Inc composições sólidas de drogas de solubilidade baixa e poloxámeros
FR2879075B1 (fr) * 2004-12-15 2007-01-19 Adisseo France Sas Soc Par Act Procede de preparation de granules de principe actif hydrophile par extrusion
FR2881049B1 (fr) * 2005-01-24 2008-12-26 Vetoquinol Sa Sa Medicament destine a etre administre par voie orale comprenant un inhibiteur de la cyclo-oxygenase-2, et son procede de preparation
WO2007036809A2 (en) * 2005-05-24 2007-04-05 Flamel Technologies S.A. Novel acetylsalicylic acid formulations
AU2007275033A1 (en) * 2006-07-21 2008-01-24 Lab International Srl Hydrophobic abuse deterrent delivery system
PE20081506A1 (es) 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
WO2008085674A1 (en) * 2007-01-04 2008-07-17 Transform Pharmaceuticals, Inc. Pharmaceutical compositions comprising celecoxib co-crystals
WO2009063367A1 (en) * 2007-11-15 2009-05-22 Pfizer Products Inc. Dosage forms comprising celecoxib providing both rapid and sustained pain relief
EP2105130A1 (de) * 2008-03-25 2009-09-30 Ratiopharm GmbH Pharmazeutische Formulierung und Verfahren zu deren Herstellung
EP2133068A1 (de) * 2008-06-13 2009-12-16 Ratiopharm GmbH Verfahren zur Auswahl eines geeigneten Hilfsstoffs für die Herstellung von festen Dispersionen für pharmazeutische Formulierungen
JP5714492B2 (ja) * 2008-09-17 2015-05-07 マイラン インコーポレイテッド 粒状体、それらの調製方法、およびそれらを含む医薬品
EP2442794A1 (en) * 2009-06-19 2012-04-25 Nanoform Hungary Ltd. Nanoparticulate telmisartan compositions and process for the preparation thereof
WO2010150144A2 (en) 2009-06-25 2010-12-29 Wockhardt Research Centre Low dose pharmaceutical compositions of celecoxib
WO2011055233A2 (en) 2009-11-03 2011-05-12 Actavis Group Ptc Ehf Improved process for preparing celecoxib polymorph
US20110213159A1 (en) 2010-03-01 2011-09-01 Vamsee Krishna Muppidi Process for preparation of celecoxib crystalline form
CN102764264A (zh) * 2012-07-25 2012-11-07 杭州和泽医药科技有限公司 一种具高溶出度的塞来昔布固体组合物、制备方法及应用
CN103655478A (zh) * 2012-09-26 2014-03-26 北京星昊医药股份有限公司 一种塞来昔布固体分散体及其制备方法和应用
ES2802050T3 (es) * 2012-11-14 2021-01-15 Abon Pharmaceuticals Llc Sistema de administración de fármacos por vía transmucosa oral
KR101890649B1 (ko) * 2013-07-30 2018-09-28 라이온 가부시키가이샤 정제
JP2017512811A (ja) * 2014-04-03 2017-05-25 サンド・アクチエンゲゼルシヤフト 非晶質ソホスブビルを含む固体組成物
JP6605047B2 (ja) * 2015-05-28 2019-11-13 ドクター・レディーズ・ラボラトリーズ・リミテッド 疼痛治療のためのセレコキシブの経口用組成物
MX2018004306A (es) * 2015-10-07 2018-09-18 Sandoz Ag Composicion farmaceutica solida que comprende sofosbuvir amorfo.
HUP1500618A2 (en) 2015-12-16 2017-06-28 Druggability Tech Ip Holdco Ltd Complexes of celecoxib and its salts and derivatives, process for the preparation thereof and pharmaceutical composition containing them
WO2018031577A1 (en) * 2016-08-09 2018-02-15 Autotelic Llc Fixed dose combination for pain relief without edema
US10736905B1 (en) 2016-09-09 2020-08-11 Shahin Fatholahi Nefopam dosage forms and methods of treatment
KR102002906B1 (ko) * 2016-10-18 2019-07-23 경동제약 주식회사 셀레콕시브를 포함하는 정제
JP2020510625A (ja) 2016-12-14 2020-04-09 ナンジェネックス ナノテクノロジー インコーポレーテッドＮａｎｇｅｎｅｘ Ｎａｎｏｔｅｃｈｎｏｌｏｇｙ Ｉｎｃｏｒｐｏｒａｔｅｄ セレコキシブを含有する医薬組成物
US10736874B1 (en) 2017-09-08 2020-08-11 Shahin Fatholahi Methods for treating pain associated with sickle cell disease
US11446311B2 (en) 2017-09-08 2022-09-20 Shahin Fatholahi Methods for treating pain associated with sickle cell disease
WO2020214791A1 (en) * 2019-04-18 2020-10-22 Nangenex Nanotechnology Incorporated Celecoxib compositions and methods for their use
CN111505058A (zh) * 2020-03-05 2020-08-07 艾普康(香港)有限公司 乳房炎检测分析仪
CN112358492B (zh) * 2020-11-13 2022-04-15 兰州大学 碳硼烷基塞来昔布及其制备和在头颈癌硼中子俘获治疗药物中的应用
KR102459968B1 (ko) * 2022-01-21 2022-10-27 주식회사 큐어팜텍 기능성 약물이 함유된 생분해성 수지 제조방법 및 이에 의해 제조된 생분해성 수지
CN116942630B (zh) * 2023-09-19 2023-12-26 北京福元医药股份有限公司 一种塞来昔布胶囊剂及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525108B1 (fr) * 1982-04-19 1989-05-12 Elan Corp Ltd Medicaments a haut degre de solubilite et procede pour leur obtention
JPS60139688A (ja) * 1983-12-28 1985-07-24 Tokyo Tanabe Co Ltd 無定形ジヒドロピリジン粉末製剤
US5466823A (en) * 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
DK0924201T3 (da) * 1993-11-30 2002-05-21 Searle & Co Tricyclisk substitueret pyrazolylbenzensulfonamider og deres anvendelse som cyclooxygenase II-inhibitorer
AU708964B2 (en) * 1995-05-25 1999-08-19 G.D. Searle & Co. Method of preparing 3-haloalkyl-1h-pyrazoles
WO1998019708A2 (en) 1996-11-04 1998-05-14 Union Carbide Chemicals & Plastics Technology Corporation Method for enhancing the solubility of substantially water-insoluble compounds
KR100187959B1 (ko) * 1997-03-31 1999-06-01 윤재승 저융점 무정형 세푸록심 악세틸의 제조방법
SE9802333D0 (sv) * 1998-06-29 1998-06-29 Astra Pharma Prod Novel combination
CA2348979A1 (en) * 1998-11-02 2000-05-11 Merck & Co., Inc. Method of treating migraines and pharmaceutical compositions
SA99191255B1 (ar) * 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
AU760888B2 (en) 1999-01-14 2003-05-22 Merck Frosst Canada & Co. Synthesis of 4-((5-substituted or unsubstituted phenyl) -3-substituted -1H-pyrazol -1-yl) benzenesulfonamides
WO2000066562A1 (en) 1999-05-03 2000-11-09 Dr. Reddy's Research Foundation Pyrazoles having antiinflammatory activity
US6395300B1 (en) * 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
GB9920558D0 (en) 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
JP2004500358A (ja) * 1999-12-08 2004-01-08 ファルマシア　コーポレイション バイオアベイラビリティーが増加した固体状態のセレコキシブ
JP2006511499A (ja) * 2002-05-13 2006-04-06 ファルマシア コーポレイション 安定な無定形セレコキシブ複合物およびその製法

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EP1150959A1 (en) 2001-11-07
WO2001042221A1 (en) 2001-06-14
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BR0008058A (pt) 2002-03-26
NO20013855D0 (no) 2001-08-08
AU784572B2 (en) 2006-05-04
AU1931101A (en) 2001-06-18
DK1150959T3 (da) 2008-06-02
ATE387431T1 (de) 2008-03-15
EA200100873A1 (ru) 2002-02-28
EP1150959B1 (en) 2008-02-27
ES2299441T3 (es) 2008-06-01
HUP0201450A3 (en) 2003-02-28
EA003612B1 (ru) 2003-06-26
CA2362673A1 (en) 2001-06-14
PL203262B1 (pl) 2009-09-30
PL349223A1 (en) 2002-07-01
US20070202160A1 (en) 2007-08-30
CN1376146B (zh) 2011-04-06
US7220867B2 (en) 2007-05-22
NO320844B1 (no) 2006-02-06
US20020006951A1 (en) 2002-01-17
IL144761A (en) 2007-07-24
IL144761A0 (en) 2002-08-14
DE60038162T2 (de) 2009-02-26
DE60038162D1 (de) 2008-04-10
JP2004500358A (ja) 2004-01-08
CY1107389T1 (el) 2012-12-19
CN1376146A (zh) 2002-10-23
US6964978B2 (en) 2005-11-15
US20050267190A1 (en) 2005-12-01
HUP0201450A2 (hu) 2002-12-28

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