NO20012194L - CRF-reseptorantagonister og tilhörende fremgangsmåter - Google Patents
CRF-reseptorantagonister og tilhörende fremgangsmåterInfo
- Publication number
- NO20012194L NO20012194L NO20012194A NO20012194A NO20012194L NO 20012194 L NO20012194 L NO 20012194L NO 20012194 A NO20012194 A NO 20012194A NO 20012194 A NO20012194 A NO 20012194A NO 20012194 L NO20012194 L NO 20012194L
- Authority
- NO
- Norway
- Prior art keywords
- crf receptor
- receptor antagonists
- associated methods
- crf
- pharmaceutically acceptable
- Prior art date
Links
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title abstract 3
- 239000002464 receptor antagonist Substances 0.000 title abstract 3
- 229940044551 receptor antagonist Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000002769 corticotropin releasing factor antagonist Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19107398A | 1998-11-12 | 1998-11-12 | |
| US37083799A | 1999-08-09 | 1999-08-09 | |
| US40136499A | 1999-09-21 | 1999-09-21 | |
| PCT/US1999/027054 WO2000027846A2 (en) | 1998-11-12 | 1999-11-12 | Crf receptor antagonists and methods relating thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20012194D0 NO20012194D0 (no) | 2001-05-03 |
| NO20012194L true NO20012194L (no) | 2001-05-03 |
Family
ID=27392849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20012194A NO20012194L (no) | 1998-11-12 | 2001-05-03 | CRF-reseptorantagonister og tilhörende fremgangsmåter |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6514982B1 (https=) |
| EP (1) | EP1129091B1 (https=) |
| JP (1) | JP2002529465A (https=) |
| KR (1) | KR20010080990A (https=) |
| CN (1) | CN1217945C (https=) |
| AT (1) | ATE225349T1 (https=) |
| AU (1) | AU755552B2 (https=) |
| CA (1) | CA2350642A1 (https=) |
| DE (1) | DE69903333T2 (https=) |
| DK (1) | DK1129091T3 (https=) |
| ES (1) | ES2180338T3 (https=) |
| HK (1) | HK1038926B (https=) |
| IL (1) | IL142893A0 (https=) |
| NO (1) | NO20012194L (https=) |
| NZ (1) | NZ510955A (https=) |
| PT (1) | PT1129091E (https=) |
| WO (1) | WO2000027846A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6531475B1 (en) * | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
| IL142893A0 (en) * | 1998-11-12 | 2002-04-21 | Neurocrine Biosciences Inc | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
| CA2398956A1 (en) * | 2000-02-14 | 2001-08-16 | Japan Tobacco Inc. | A pharmaceutical composition for prophylaxis or therapy of a postoperative stress |
| WO2001087892A1 (en) * | 2000-05-18 | 2001-11-22 | Neurocrine Biosciences, Inc. | Crf receptor antagonists |
| KR20030060927A (ko) * | 2000-11-03 | 2003-07-16 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | Ｃｒｆ 수용체 길항제 및 이와 관련된 방법 |
| DE60130924T2 (de) | 2000-12-28 | 2008-07-17 | Ono Pharmaceutical Co. Ltd. | Cyclopentaädüpyrazoloä1,5-aüpyrimidin-verbindung als crf-rezeptor antagonist |
| WO2002064592A1 (en) * | 2000-12-28 | 2002-08-22 | Neurocrine Biosciences, Inc. | Tricyclic crf receptor antagonists |
| ES2255610T3 (es) | 2001-04-30 | 2006-07-01 | Glaxo Group Limited | Antagonistas de los receptores de crf. |
| JP2004530702A (ja) * | 2001-05-21 | 2004-10-07 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | Ｃｒｆ受容体アンタゴニストとしてのトリ−およびテトラアザ−アセナフチレン誘導体 |
| GB0117395D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
| US7273871B2 (en) | 2001-07-17 | 2007-09-25 | Sb Pharmco Puerto Rico Inc. | Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists |
| EP2335700A1 (en) | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C virus polymerase inhibitors with a heterobicylic structure |
| CN100422186C (zh) | 2003-06-25 | 2008-10-01 | 小野药品工业株式会社 | 吡唑并嘧啶化合物的甲磺酸盐、其结晶及其制备方法 |
| US20060024661A1 (en) * | 2003-07-30 | 2006-02-02 | The Regents Of The University Of California | Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2 |
| CA2535249A1 (en) * | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists |
| ATE388150T1 (de) * | 2003-12-22 | 2008-03-15 | Sb Pharmco Inc | Crf-rezeptorantagonisten und diese betreffende verfahren |
| HRP20130971T1 (hr) | 2004-02-20 | 2013-11-08 | Boehringer Ingelheim International Gmbh | Inhibitori virusne polimeraze |
| WO2005087775A1 (ja) * | 2004-03-15 | 2005-09-22 | Ono Pharmaceutical Co., Ltd. | 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物 |
| CA2576435A1 (en) * | 2004-08-09 | 2006-03-23 | Research Development Foundation | Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis |
| MX2009008084A (es) | 2007-02-01 | 2009-10-12 | Astrazeneca Ab | Derivados de 5,6,7,8-tetrahidropteridina como inhibidores de hsp90. |
| TW201102390A (en) * | 2009-03-31 | 2011-01-16 | Arqule Inc | Substituted pyrazolo-pyrimidine compounds |
| ES2540964T3 (es) | 2009-06-08 | 2015-07-15 | Takeda Pharmaceutical Company Limited | Compuestos de dihidropirrolonaftiridinona como inhibidores de JAK |
| JP2013516420A (ja) * | 2009-12-30 | 2013-05-13 | アークル インコーポレイテッド | 置換されたピロロ−アミノピリミジン化合物 |
| CN113416191A (zh) * | 2021-04-27 | 2021-09-21 | 西安交通大学 | 一种合成三环骨架2-吡啶酮/2-吡啶亚胺类化合物的方法 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| US5013737A (en) * | 1988-02-22 | 1991-05-07 | American Cyanamid Company | 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones |
| US4904658A (en) | 1988-04-15 | 1990-02-27 | American Cyanamid Company | Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones |
| US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| FR2692893B1 (fr) | 1992-06-24 | 1994-09-02 | Sanofi Elf | Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent. |
| TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
| KR100190730B1 (ko) | 1992-12-17 | 1999-06-01 | 디. 제이. 우드, 스피겔 알렌 제이 | 부신피질 호르몬 유리인자(crf) 길항물질로서 치환된 피라졸 |
| ATE177101T1 (de) * | 1992-12-17 | 1999-03-15 | Pfizer | Pyrrolopyrimidine als crf antagonisten |
| TW370529B (en) | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| DK0674624T3 (da) | 1992-12-17 | 1999-09-13 | Pfizer | Pyrazoler med CRF-antagonistisk aktivitet |
| RU2153494C2 (ru) | 1993-10-12 | 2000-07-27 | Дзе Дюпон Мерк Фармасьютикал Компани | 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция |
| TW530047B (en) | 1994-06-08 | 2003-05-01 | Pfizer | Corticotropin releasing factor antagonists |
| WO1995034563A1 (en) | 1994-06-16 | 1995-12-21 | Pfizer Inc. | Pyrazolo and pyrrolopyridines |
| US6020492A (en) | 1995-05-12 | 2000-02-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
| FR2735777B1 (fr) | 1995-06-21 | 1997-09-12 | Sanofi Sa | Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| EP0901476A4 (en) | 1996-03-26 | 2001-08-16 | Du Pont Pharm Co | PYRIDINES AND PYRIMIDINES FUSION ARYLOXY AND ARYLTHIO AND DERIVATIVES THEREOF |
| US6107300A (en) | 1996-03-27 | 2000-08-22 | Dupont Pharmaceuticals | Arylamino fused pyrimidines |
| US6326368B1 (en) | 1996-03-27 | 2001-12-04 | Dupont Pharmaceuticals Company | Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof |
| ZA973884B (en) * | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| HU228962B1 (en) | 1996-07-24 | 2013-07-29 | Bristol Myers Squibb Pharma Co | Azolo triazines, pharmaceutical compositions containing them and use of the compounds |
| US6492520B1 (en) | 1996-08-06 | 2002-12-10 | Pfizer Inc | Substituted pyrido-or pyrimido-containing 6,6- or 6,7-bicyclic derivatives |
| TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
| IL127566A0 (en) | 1996-08-28 | 1999-10-28 | Pfizer | Substituted 6,5-hetero- bicyclic derivatives |
| US6159980A (en) | 1996-09-16 | 2000-12-12 | Dupont Pharmaceuticals Company | Pyrazinones and triazinones and their derivatives thereof |
| FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US5760225A (en) | 1996-11-15 | 1998-06-02 | Neurogen Corporation | Certain pyrazole derivatives as corticotropin-releasing factor receptor CRF1 specific ligands |
| US5723608A (en) | 1996-12-31 | 1998-03-03 | Neurogen Corporation | 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands |
| US6187777B1 (en) | 1998-02-06 | 2001-02-13 | Amgen Inc. | Compounds and methods which modulate feeding behavior and related diseases |
| IL142893A0 (en) * | 1998-11-12 | 2002-04-21 | Neurocrine Biosciences Inc | Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same |
-
1999
- 1999-11-12 IL IL14289399A patent/IL142893A0/xx unknown
- 1999-11-12 EP EP99960363A patent/EP1129091B1/en not_active Expired - Lifetime
- 1999-11-12 AT AT99960363T patent/ATE225349T1/de not_active IP Right Cessation
- 1999-11-12 CN CN998131717A patent/CN1217945C/zh not_active Expired - Fee Related
- 1999-11-12 ES ES99960363T patent/ES2180338T3/es not_active Expired - Lifetime
- 1999-11-12 KR KR1020017005924A patent/KR20010080990A/ko not_active Ceased
- 1999-11-12 NZ NZ510955A patent/NZ510955A/xx unknown
- 1999-11-12 AU AU17258/00A patent/AU755552B2/en not_active Ceased
- 1999-11-12 JP JP2000581024A patent/JP2002529465A/ja active Pending
- 1999-11-12 DE DE69903333T patent/DE69903333T2/de not_active Expired - Lifetime
- 1999-11-12 PT PT99960363T patent/PT1129091E/pt unknown
- 1999-11-12 HK HK02100690.1A patent/HK1038926B/en not_active IP Right Cessation
- 1999-11-12 WO PCT/US1999/027054 patent/WO2000027846A2/en not_active Ceased
- 1999-11-12 US US09/439,840 patent/US6514982B1/en not_active Expired - Lifetime
- 1999-11-12 CA CA002350642A patent/CA2350642A1/en not_active Abandoned
- 1999-11-12 DK DK99960363T patent/DK1129091T3/da active
-
2001
- 2001-05-03 NO NO20012194A patent/NO20012194L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2180338T3 (es) | 2003-02-01 |
| JP2002529465A (ja) | 2002-09-10 |
| NZ510955A (en) | 2003-01-31 |
| NO20012194D0 (no) | 2001-05-03 |
| WO2000027846A2 (en) | 2000-05-18 |
| WO2000027846A3 (en) | 2000-11-16 |
| DE69903333D1 (de) | 2002-11-07 |
| DK1129091T3 (da) | 2002-11-04 |
| ATE225349T1 (de) | 2002-10-15 |
| CN1217945C (zh) | 2005-09-07 |
| US6514982B1 (en) | 2003-02-04 |
| CN1328559A (zh) | 2001-12-26 |
| CA2350642A1 (en) | 2000-05-18 |
| DE69903333T2 (de) | 2003-08-07 |
| HK1038926B (en) | 2003-07-18 |
| IL142893A0 (en) | 2002-04-21 |
| AU1725800A (en) | 2000-05-29 |
| PT1129091E (pt) | 2003-02-28 |
| KR20010080990A (ko) | 2001-08-25 |
| EP1129091B1 (en) | 2002-10-02 |
| EP1129091A2 (en) | 2001-09-05 |
| HK1038926A1 (en) | 2002-05-10 |
| AU755552B2 (en) | 2002-12-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |