IL142893A0 - Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same - Google Patents

Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same

Info

Publication number
IL142893A0
IL142893A0 IL14289399A IL14289399A IL142893A0 IL 142893 A0 IL142893 A0 IL 142893A0 IL 14289399 A IL14289399 A IL 14289399A IL 14289399 A IL14289399 A IL 14289399A IL 142893 A0 IL142893 A0 IL 142893A0
Authority
IL
Israel
Prior art keywords
compositions containing
same
polyclic
fused
pharmaceutical compositions
Prior art date
Application number
IL14289399A
Other languages
English (en)
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of IL142893A0 publication Critical patent/IL142893A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
IL14289399A 1998-11-12 1999-11-12 Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same IL142893A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19107398A 1998-11-12 1998-11-12
US37083799A 1999-08-09 1999-08-09
US40136499A 1999-09-21 1999-09-21
PCT/US1999/027054 WO2000027846A2 (en) 1998-11-12 1999-11-12 Crf receptor antagonists and methods relating thereto

Publications (1)

Publication Number Publication Date
IL142893A0 true IL142893A0 (en) 2002-04-21

Family

ID=27392849

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14289399A IL142893A0 (en) 1998-11-12 1999-11-12 Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same

Country Status (17)

Country Link
US (1) US6514982B1 (xx)
EP (1) EP1129091B1 (xx)
JP (1) JP2002529465A (xx)
KR (1) KR20010080990A (xx)
CN (1) CN1217945C (xx)
AT (1) ATE225349T1 (xx)
AU (1) AU755552B2 (xx)
CA (1) CA2350642A1 (xx)
DE (1) DE69903333T2 (xx)
DK (1) DK1129091T3 (xx)
ES (1) ES2180338T3 (xx)
HK (1) HK1038926B (xx)
IL (1) IL142893A0 (xx)
NO (1) NO20012194L (xx)
NZ (1) NZ510955A (xx)
PT (1) PT1129091E (xx)
WO (1) WO2000027846A2 (xx)

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JP2002529465A (ja) * 1998-11-12 2002-09-10 ニューロクライン バイオサイエンシーズ， インコーポレイテッド Ｃｒｆレセプターアンタゴニストおよびｃｒｆレセプターアンタゴニストに関する方法
US6531475B1 (en) 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
EP1293213A1 (en) * 2000-02-14 2003-03-19 Japan Tobacco Inc. Preventives/remedies for postoperative stress
JP2003533530A (ja) 2000-05-18 2003-11-11 ニューロクライン バイオサイエンシーズ， インコーポレイテッド Ｃｒｆレセプターアンタゴニスト
AU3958902A (en) 2000-11-03 2002-05-27 Neurocrine Biosciences Inc Crf receptor antagonists and methods relating thereto
CA2432148C (en) 2000-12-28 2011-01-18 Ono Pharmaceutical Co., Ltd. Tri-heterocyclic compounds and a pharmaceutical comprising them as an active ingredient
EP1345938A1 (en) 2000-12-28 2003-09-24 Neurocrine Biosciences, Inc. Tricyclic crf receptor antagonists
EP1383498B1 (en) * 2001-04-30 2006-03-15 Glaxo Group Limited Crf receptor antagonists
AU2002257939B2 (en) * 2001-05-21 2006-08-24 Neurocrine Inc Tri-and tetraaza-acenaphthylen derivatives as CRF receptor antagonists
GB0117395D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
US7273871B2 (en) 2001-07-17 2007-09-25 Sb Pharmco Puerto Rico Inc. Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
CN100422186C (zh) 2003-06-25 2008-10-01 小野药品工业株式会社 吡唑并嘧啶化合物的甲磺酸盐、其结晶及其制备方法
US20060024661A1 (en) * 2003-07-30 2006-02-02 The Regents Of The University Of California Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2
WO2005013997A1 (en) * 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists
ES2303130T3 (es) * 2003-12-22 2008-08-01 Sb Pharmco Puerto Rico Inc. Antagonistas del receptor de crf y metodos relacionados con ellos.
DK1718608T3 (da) 2004-02-20 2013-10-14 Boehringer Ingelheim Int Virale polymeraseinhibitorer
WO2005087775A1 (ja) * 2004-03-15 2005-09-22 Ono Pharmaceutical Co., Ltd. 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物
WO2006031322A2 (en) * 2004-08-09 2006-03-23 Research Development Foundation Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis
BRPI0807868A2 (pt) 2007-02-01 2013-10-15 Astrazeneca Ab Composto ou um sal farmaceuticamente aceitável ou n-óxido do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável ou n-óxido, método para o tratamento de um ser humano ou animal que sofre um câncer, e, processo para preparar um composto ou um sal farmaceuticamente aceitável ou n-óxido do mesmo
EP2414359A1 (en) * 2009-03-31 2012-02-08 ArQule, Inc. Peri-fused pyrazolo-pyrimidine compounds
EP2440558B1 (en) 2009-06-08 2015-04-01 Takeda Pharmaceutical Company Limited Dihydropyrrolonaphtyridinone compounds as inhibitors of jak
KR20120124428A (ko) * 2009-12-30 2012-11-13 아르퀼 인코포레이티드 치환된 피롤로-아미노피리미딘 화합물
CN113416191A (zh) * 2021-04-27 2021-09-21 西安交通大学 一种合成三环骨架2-吡啶酮/2-吡啶亚胺类化合物的方法

Family Cites Families (29)

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US4605642A (en) 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US5013737A (en) * 1988-02-22 1991-05-07 American Cyanamid Company 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones
US4904658A (en) 1988-04-15 1990-02-27 American Cyanamid Company Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones
US5063245A (en) 1990-03-28 1991-11-05 Nova Pharmaceutical Corporation Corticotropin-releasing factor antagonism compounds
FR2692893B1 (fr) 1992-06-24 1994-09-02 Sanofi Elf Dérivés alkylamino ramifiés du thiazole, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
JP2781661B2 (ja) 1992-12-17 1998-07-30 フアイザー・インコーポレイテツド Ｃｒｆアンタゴニストとしての置換ピラゾール
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WO1995010506A1 (en) 1993-10-12 1995-04-20 The Du Pont Merck Pharmaceutical Company 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
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KR100256707B1 (ko) 1995-05-12 2000-05-15 해피 페너 데아자푸린 유도체; 새로운 부류의 crf1 특이 리간드
FR2735777B1 (fr) 1995-06-21 1997-09-12 Sanofi Sa Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
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US6326368B1 (en) 1996-03-27 2001-12-04 Dupont Pharmaceuticals Company Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof
US6107300A (en) 1996-03-27 2000-08-22 Dupont Pharmaceuticals Arylamino fused pyrimidines
ZA973884B (en) * 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
WO1998003510A1 (en) 1996-07-24 1998-01-29 Du Pont Pharmaceuticals Company AZOLO TRIAZINES AND PYRIMIDINES
WO1998005661A1 (en) 1996-08-06 1998-02-12 Pfizer Inc. Substituted pyrido- or pyrimido-containing 6,6- or 6,7-bicyclic derivatives
TW477787B (en) 1996-08-27 2002-03-01 Pfizer Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same
ES2273369T3 (es) * 1996-08-28 2007-05-01 Pfizer Inc. Derivados 6,5 heterobiciclicos sustituidos.
JP2001502300A (ja) 1996-09-16 2001-02-20 デュポン ファーマシューティカルズ カンパニー ピラジノン類およびトリアジノン類およびその誘導体類
FR2754258B1 (fr) 1996-10-08 1998-12-31 Sanofi Sa Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
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US5723608A (en) 1996-12-31 1998-03-03 Neurogen Corporation 3-aryl substituted pyrazolo 4,3-d!pyrimidine derivatives; corticotropin-releasing factor receptor (CRF1) specific ligands
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
JP2002529465A (ja) * 1998-11-12 2002-09-10 ニューロクライン バイオサイエンシーズ， インコーポレイテッド Ｃｒｆレセプターアンタゴニストおよびｃｒｆレセプターアンタゴニストに関する方法

Also Published As

Publication number Publication date
DE69903333D1 (de) 2002-11-07
PT1129091E (pt) 2003-02-28
WO2000027846A3 (en) 2000-11-16
KR20010080990A (ko) 2001-08-25
ES2180338T3 (es) 2003-02-01
NO20012194D0 (no) 2001-05-03
HK1038926A1 (en) 2002-05-10
AU755552B2 (en) 2002-12-12
NO20012194L (no) 2001-05-03
WO2000027846A2 (en) 2000-05-18
DK1129091T3 (da) 2002-11-04
EP1129091A2 (en) 2001-09-05
US6514982B1 (en) 2003-02-04
HK1038926B (zh) 2003-07-18
CN1217945C (zh) 2005-09-07
NZ510955A (en) 2003-01-31
JP2002529465A (ja) 2002-09-10
ATE225349T1 (de) 2002-10-15
CA2350642A1 (en) 2000-05-18
AU1725800A (en) 2000-05-29
CN1328559A (zh) 2001-12-26
DE69903333T2 (de) 2003-08-07
EP1129091B1 (en) 2002-10-02

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