CN1217945C - Crf受体拮抗剂以及与其有关的方法 - Google Patents

Crf受体拮抗剂以及与其有关的方法 Download PDF

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Publication number
CN1217945C
CN1217945C CN998131717A CN99813171A CN1217945C CN 1217945 C CN1217945 C CN 1217945C CN 998131717 A CN998131717 A CN 998131717A CN 99813171 A CN99813171 A CN 99813171A CN 1217945 C CN1217945 C CN 1217945C
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China
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compound
alkyl
substituted
heterocycle
aryl
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Expired - Fee Related
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CN998131717A
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English (en)
Chinese (zh)
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CN1328559A (zh
Inventor
M·哈达彻
J·耐尔森
B·P·迪克
郭志强
黄青
J·R·穆卡赛
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Neurocrine Biosciences Inc
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Neurocrine Biosciences Inc
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Publication of CN1328559A publication Critical patent/CN1328559A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Input Circuits Of Receivers And Coupling Of Receivers And Audio Equipment (AREA)
CN998131717A 1998-11-12 1999-11-12 Crf受体拮抗剂以及与其有关的方法 Expired - Fee Related CN1217945C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19107398A 1998-11-12 1998-11-12
US09/191,073 1998-11-12
US37083799A 1999-08-09 1999-08-09
US09/370,837 1999-08-09
US40136499A 1999-09-21 1999-09-21
US09/401,364 1999-09-21

Publications (2)

Publication Number Publication Date
CN1328559A CN1328559A (zh) 2001-12-26
CN1217945C true CN1217945C (zh) 2005-09-07

Family

ID=27392849

Family Applications (1)

Application Number Title Priority Date Filing Date
CN998131717A Expired - Fee Related CN1217945C (zh) 1998-11-12 1999-11-12 Crf受体拮抗剂以及与其有关的方法

Country Status (17)

Country Link
US (1) US6514982B1 (https=)
EP (1) EP1129091B1 (https=)
JP (1) JP2002529465A (https=)
KR (1) KR20010080990A (https=)
CN (1) CN1217945C (https=)
AT (1) ATE225349T1 (https=)
AU (1) AU755552B2 (https=)
CA (1) CA2350642A1 (https=)
DE (1) DE69903333T2 (https=)
DK (1) DK1129091T3 (https=)
ES (1) ES2180338T3 (https=)
HK (1) HK1038926B (https=)
IL (1) IL142893A0 (https=)
NO (1) NO20012194L (https=)
NZ (1) NZ510955A (https=)
PT (1) PT1129091E (https=)
WO (1) WO2000027846A2 (https=)

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US6531475B1 (en) * 1998-11-12 2003-03-11 Neurocrine Biosciences, Inc. CRF receptor antagonists and methods relating thereto
IL142893A0 (en) * 1998-11-12 2002-04-21 Neurocrine Biosciences Inc Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same
CA2398956A1 (en) * 2000-02-14 2001-08-16 Japan Tobacco Inc. A pharmaceutical composition for prophylaxis or therapy of a postoperative stress
WO2001087892A1 (en) * 2000-05-18 2001-11-22 Neurocrine Biosciences, Inc. Crf receptor antagonists
KR20030060927A (ko) * 2000-11-03 2003-07-16 뉴로크린 바이오사이언시즈 인코퍼레이티드 Ｃｒｆ 수용체 길항제 및 이와 관련된 방법
DE60130924T2 (de) 2000-12-28 2008-07-17 Ono Pharmaceutical Co. Ltd. Cyclopentaädüpyrazoloä1,5-aüpyrimidin-verbindung als crf-rezeptor antagonist
WO2002064592A1 (en) * 2000-12-28 2002-08-22 Neurocrine Biosciences, Inc. Tricyclic crf receptor antagonists
ES2255610T3 (es) 2001-04-30 2006-07-01 Glaxo Group Limited Antagonistas de los receptores de crf.
JP2004530702A (ja) * 2001-05-21 2004-10-07 ニューロクライン バイオサイエンシーズ， インコーポレイテッド Ｃｒｆ受容体アンタゴニストとしてのトリ−およびテトラアザ−アセナフチレン誘導体
GB0117395D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
US7273871B2 (en) 2001-07-17 2007-09-25 Sb Pharmco Puerto Rico Inc. Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
CN100422186C (zh) 2003-06-25 2008-10-01 小野药品工业株式会社 吡唑并嘧啶化合物的甲磺酸盐、其结晶及其制备方法
US20060024661A1 (en) * 2003-07-30 2006-02-02 The Regents Of The University Of California Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2
CA2535249A1 (en) * 2003-08-12 2005-02-17 F. Hoffmann-La Roche Ag Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists
ATE388150T1 (de) * 2003-12-22 2008-03-15 Sb Pharmco Inc Crf-rezeptorantagonisten und diese betreffende verfahren
HRP20130971T1 (hr) 2004-02-20 2013-11-08 Boehringer Ingelheim International Gmbh Inhibitori virusne polimeraze
WO2005087775A1 (ja) * 2004-03-15 2005-09-22 Ono Pharmaceutical Co., Ltd. 三環式複素環化合物およびその化合物を有効成分として含有する医薬組成物
CA2576435A1 (en) * 2004-08-09 2006-03-23 Research Development Foundation Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis
MX2009008084A (es) 2007-02-01 2009-10-12 Astrazeneca Ab Derivados de 5,6,7,8-tetrahidropteridina como inhibidores de hsp90.
TW201102390A (en) * 2009-03-31 2011-01-16 Arqule Inc Substituted pyrazolo-pyrimidine compounds
ES2540964T3 (es) 2009-06-08 2015-07-15 Takeda Pharmaceutical Company Limited Compuestos de dihidropirrolonaftiridinona como inhibidores de JAK
JP2013516420A (ja) * 2009-12-30 2013-05-13 アークル インコーポレイテッド 置換されたピロロ−アミノピリミジン化合物
CN113416191A (zh) * 2021-04-27 2021-09-21 西安交通大学 一种合成三环骨架2-吡啶酮/2-吡啶亚胺类化合物的方法

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US4605642A (en) 1984-02-23 1986-08-12 The Salk Institute For Biological Studies CRF antagonists
US5013737A (en) * 1988-02-22 1991-05-07 American Cyanamid Company 2,4,8-Trisubstituted-3H,6H-1,4,5A,8A-tetraazaacenaphtylene-3,5-(4H)-diones and 2,4-8-trisubstituted-4,5-dihydro-5-thioxo-3H,6H-1,4,5A,8A-tetrazaacenaphthylen-3-ones
US4904658A (en) 1988-04-15 1990-02-27 American Cyanamid Company Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones
US5063245A (en) 1990-03-28 1991-11-05 Nova Pharmaceutical Corporation Corticotropin-releasing factor antagonism compounds
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ATE177101T1 (de) * 1992-12-17 1999-03-15 Pfizer Pyrrolopyrimidine als crf antagonisten
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RU2153494C2 (ru) 1993-10-12 2000-07-27 Дзе Дюпон Мерк Фармасьютикал Компани 1-n-алкил-n-арилпиримидинамины, способ лечения заболеваний, фармацевтическая композиция
TW530047B (en) 1994-06-08 2003-05-01 Pfizer Corticotropin releasing factor antagonists
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US6020492A (en) 1995-05-12 2000-02-01 Neurogen Corporation Deazapurine derivatives; a new class of CRF1 specific ligands
FR2735777B1 (fr) 1995-06-21 1997-09-12 Sanofi Sa Derives de 4-phenylaminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant
EP0901476A4 (en) 1996-03-26 2001-08-16 Du Pont Pharm Co PYRIDINES AND PYRIMIDINES FUSION ARYLOXY AND ARYLTHIO AND DERIVATIVES THEREOF
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US6326368B1 (en) 1996-03-27 2001-12-04 Dupont Pharmaceuticals Company Aryloxy- and arylthiosubstituted pyrimidines and triazines and derivatives thereof
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IL142893A0 (en) * 1998-11-12 2002-04-21 Neurocrine Biosciences Inc Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
ES2180338T3 (es) 2003-02-01
JP2002529465A (ja) 2002-09-10
NZ510955A (en) 2003-01-31
NO20012194D0 (no) 2001-05-03
WO2000027846A2 (en) 2000-05-18
WO2000027846A3 (en) 2000-11-16
DE69903333D1 (de) 2002-11-07
DK1129091T3 (da) 2002-11-04
ATE225349T1 (de) 2002-10-15
US6514982B1 (en) 2003-02-04
CN1328559A (zh) 2001-12-26
CA2350642A1 (en) 2000-05-18
DE69903333T2 (de) 2003-08-07
HK1038926B (en) 2003-07-18
IL142893A0 (en) 2002-04-21
NO20012194L (no) 2001-05-03
AU1725800A (en) 2000-05-29
PT1129091E (pt) 2003-02-28
KR20010080990A (ko) 2001-08-25
EP1129091B1 (en) 2002-10-02
EP1129091A2 (en) 2001-09-05
HK1038926A1 (en) 2002-05-10
AU755552B2 (en) 2002-12-12

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