NO20004946L - Humanisert antistoff mot human vevsfaktor (TF) og fremgangsmåte ved fremstilling av det humaniserte antistoff - Google Patents

Humanisert antistoff mot human vevsfaktor (TF) og fremgangsmåte ved fremstilling av det humaniserte antistoff

Info

Publication number
NO20004946L
NO20004946L NO20004946A NO20004946A NO20004946L NO 20004946 L NO20004946 L NO 20004946L NO 20004946 A NO20004946 A NO 20004946A NO 20004946 A NO20004946 A NO 20004946A NO 20004946 L NO20004946 L NO 20004946L
Authority
NO
Norway
Prior art keywords
chain
humanized antibody
region
humanized
antibody
Prior art date
Application number
NO20004946A
Other languages
English (en)
Norwegian (no)
Other versions
NO20004946D0 (no
Inventor
Koh Sato
Hideki Adachi
Naohiro Yabuta
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of NO20004946D0 publication Critical patent/NO20004946D0/no
Publication of NO20004946L publication Critical patent/NO20004946L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
NO20004946A 1998-04-03 2000-10-02 Humanisert antistoff mot human vevsfaktor (TF) og fremgangsmåte ved fremstilling av det humaniserte antistoff NO20004946L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9185098 1998-04-03
PCT/JP1999/001768 WO1999051743A1 (fr) 1998-04-03 1999-04-02 Anticorps humanise contre le facteur tissulaire humain (tf) et procede de production d'anticorps humanises

Publications (2)

Publication Number Publication Date
NO20004946D0 NO20004946D0 (no) 2000-10-02
NO20004946L true NO20004946L (no) 2000-12-04

Family

ID=14038058

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20004946A NO20004946L (no) 1998-04-03 2000-10-02 Humanisert antistoff mot human vevsfaktor (TF) og fremgangsmåte ved fremstilling av det humaniserte antistoff

Country Status (19)

Country Link
US (2) US6677436B1 (fr)
EP (2) EP1069185B1 (fr)
JP (2) JP3998419B2 (fr)
KR (1) KR20010042435A (fr)
CN (1) CN1303431A (fr)
AT (1) ATE512225T1 (fr)
AU (1) AU752730B2 (fr)
BR (1) BR9909382A (fr)
CA (1) CA2325346A1 (fr)
DK (1) DK1069185T3 (fr)
ES (1) ES2364266T3 (fr)
HU (1) HUP0101160A2 (fr)
IL (1) IL138801A0 (fr)
NO (1) NO20004946L (fr)
PL (1) PL343322A1 (fr)
PT (1) PT1069185E (fr)
SK (1) SK14812000A3 (fr)
TR (2) TR200101541T2 (fr)
WO (1) WO1999051743A1 (fr)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716282B2 (en) 1995-06-07 2000-02-24 Johnson & Johnson Research Pty. Limited CDR-grafted anti-tissue factor antibodies and methods of use thereof
US6703197B1 (en) * 1996-11-27 2004-03-09 Martinex R&D, Inc. Human methionine synthase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer
US7749498B2 (en) * 1997-03-10 2010-07-06 Genentech, Inc. Antibodies for inhibiting blood coagulation and methods of use thereof
US20030109680A1 (en) * 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US5986065A (en) * 1997-03-10 1999-11-16 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
US20060235209A9 (en) * 1997-03-10 2006-10-19 Jin-An Jiao Use of anti-tissue factor antibodies for treating thromboses
US7764130B2 (en) * 1999-01-22 2010-07-27 Multigig Inc. Electronic circuitry
AU7450600A (en) * 1999-10-01 2001-05-10 Chugai Seiyaku Kabushiki Kaisha Prevention and treatment of diseases associated with blood coagulation
DE19962583A1 (de) * 1999-12-23 2001-06-28 Mueller Hermelink Hans Konrad Antikörper gegen Plasmazellen
JP2003527861A (ja) * 2000-03-16 2003-09-24 ジェネンテック・インコーポレーテッド 増強した抗血液凝固能を持つ抗組織因子抗体
US6703494B2 (en) 2000-03-16 2004-03-09 Genentech, Inc. Anti-tissue factor antibodies with enhanced anticoagulant potency
US8632778B2 (en) 2000-08-11 2014-01-21 Chugai Seiyaku Kabushiki Kaisha Stabilized anti-interleukin-6 antibody-containing preparations
EP3088412B1 (fr) 2001-03-09 2021-05-05 Chugai Seiyaku Kabushiki Kaisha Procédé de purification de protéines
WO2002078738A1 (fr) * 2001-03-26 2002-10-10 Koji Suzuki Agents ameliorant la rheologie sanguine
EP1428537B1 (fr) * 2001-08-29 2008-11-19 Chugai Seiyaku Kabushiki Kaisha Preparations stabilisees contenant un anticorps
JP2005512970A (ja) * 2001-10-02 2005-05-12 ノボ ノルディスク アクティーゼルスカブ ヒト組織因子抗体
US20030190705A1 (en) * 2001-10-29 2003-10-09 Sunol Molecular Corporation Method of humanizing immune system molecules
EP1464702A4 (fr) 2001-12-28 2005-09-21 Chugai Pharmaceutical Co Ltd Procede de stabilisation d'une proteine
MXPA04010851A (es) * 2002-05-01 2005-02-14 Schering Ag Proteinas de fusion de trombomodulina dirigidas al factor tisular novedoso como anticoagulantes.
GB0210783D0 (en) * 2002-05-10 2002-06-19 Polonelli Luciano Anti-microbial polypeptides
WO2003099324A1 (fr) * 2002-05-23 2003-12-04 Chugai Seiyaku Kabushiki Kaisha Agent neutralisant l'inhibiteur du facteur tissulaire et agent neutralisant la preparation du facteur viii active de coagulation sanguine
WO2004019966A1 (fr) 2002-08-27 2004-03-11 Chugai Seiyaku Kabushiki Kaisha Methode de stabilisation de preparations de solution de proteines
KR101119448B1 (ko) 2002-09-11 2012-03-15 추가이 세이야쿠 가부시키가이샤 단백질 정제 방법
AU2003277832A1 (en) * 2002-10-31 2004-05-25 Novo Nordisk A/S Humanized tissue factor antibodies
EP1608684A2 (fr) * 2003-02-07 2005-12-28 Protein Design Labs, Inc. Anticorps anti-amphireguline (ar) et leur utilisation dans le traitement du cancer et du psoriasis
AU2004216298B2 (en) * 2003-02-28 2009-04-23 Chugai Seiyaku Kabushiki Kaisha Stabilized protein-containing formulations
US7425328B2 (en) * 2003-04-22 2008-09-16 Purdue Pharma L.P. Tissue factor antibodies and uses thereof
US9708410B2 (en) 2003-05-30 2017-07-18 Janssen Biotech, Inc. Anti-tissue factor antibodies and compositions
US7605235B2 (en) 2003-05-30 2009-10-20 Centocor, Inc. Anti-tissue factor antibodies and compositions
CA2527621A1 (fr) * 2003-05-30 2004-12-23 Centocor, Inc. Procede pour inhiber la croissance tumorale avec des anticorps a facteurs anti-tissulaires
CN1863556B (zh) * 2003-06-19 2012-05-16 吉宁特有限公司 用于治疗凝血相关紊乱的组合物和方法
AU2004268648A1 (en) * 2003-08-29 2005-03-10 Centocor, Inc. Method of promoting graft survival with anti-tissue factor antibodies
AU2003271174A1 (en) 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
JPWO2005035754A1 (ja) 2003-10-14 2006-12-21 中外製薬株式会社 機能蛋白質を代替する二種特異性抗体
US9296820B2 (en) * 2003-11-05 2016-03-29 Roche Glycart Ag Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
CA2582683A1 (fr) 2004-10-01 2006-04-13 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Nouveaux anticorps diriges contre la proteine de canal ionique eag1 mammifere
EP1676574A3 (fr) 2004-12-30 2006-07-26 Johnson & Johnson Vision Care, Inc. Procédé favorisant la survie des tissus ou cellules griffées
JP2008533985A (ja) * 2005-03-25 2008-08-28 グリクアート バイオテクノロジー アクチェンゲゼルシャフト MCSPを対象とし、且つ、Fc受容体結合親和性とエフェクター機能を増強した抗原結合分子
EP3050963B1 (fr) 2005-03-31 2019-09-18 Chugai Seiyaku Kabushiki Kaisha Procédé pour la production de polypeptide au moyen de la régulation d'un ensemble
DK2824183T3 (da) 2005-04-08 2020-09-28 Chugai Pharmaceutical Co Ltd Fremgangsmåde til fremstilling af bispecifikke antistoffer
CN101228189A (zh) * 2005-05-09 2008-07-23 格黎卡特生物技术股份公司 具有修饰的fc区域和改变的与fc受体的结合的抗原结合分子
CA2619725C (fr) 2005-08-18 2016-06-07 Ramot At Tel Aviv University Ltd. Anticorps monocatenaires diriges contre le peptide beta-amyloide
AR055137A1 (es) * 2005-08-26 2007-08-08 Glycart Biotechnology Ag Moleculas de union al antigeno modificadas con actividad de senalizacion celular alterada
EP1977763A4 (fr) 2005-12-28 2010-06-02 Chugai Pharmaceutical Co Ltd Préparation stabilisatrice contenant des anticorps
EP3345616A1 (fr) 2006-03-31 2018-07-11 Chugai Seiyaku Kabushiki Kaisha Procédé de modification d'anticorps pour purifier un anticorps bispécifique
IN2014DN10515A (fr) * 2006-03-31 2015-08-21 Chugai Pharmaceutical Co Ltd
US20090285819A1 (en) * 2006-11-15 2009-11-19 Functional Genetics, Inc. Methods and compositions for treating influenza
FR2909092B1 (fr) * 2006-11-24 2012-10-19 Pf Medicament Nouveaux anticorps anti-proliferation
SI2662091T1 (sl) 2006-12-01 2019-01-31 Novartis Ag Protitelesa proti P-selektinu in postopki za njihovo uporabo za zdravljenje vnetnih bolezni
PL3059246T3 (pl) 2007-09-26 2018-11-30 Chugai Seiyaku Kabushiki Kaisha Zmodyfikowany region stały przeciwciała
CA2700701C (fr) 2007-09-26 2020-12-29 Chugai Seiyaku Kabushiki Kaisha Procede permettant de modifier le point isoelectrique d'un anticorps par substitution d'acide amine dans une region determinant la complementarite (cdr)
ES2834741T3 (es) 2007-12-05 2021-06-18 Chugai Pharmaceutical Co Ltd Anticuerpo anti-NR10 y uso del mismo
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
BR122012027456A2 (pt) * 2008-03-14 2015-07-14 Allergan Inc Composição farmacêutica compreendendo sorotipo de neurotoxina botulínica a
CA2721093A1 (fr) 2008-04-11 2009-10-15 Merrimack Pharmaceuticals, Inc. Lieurs d'albumine de serum humain, et ses conjugues
US8187601B2 (en) * 2008-07-01 2012-05-29 Aveo Pharmaceuticals, Inc. Fibroblast growth factor receptor 3 (FGFR3) binding proteins
CN102089004B (zh) 2008-07-10 2018-06-01 东丽株式会社 癌的治疗及预防用药物组合物
DK2322221T3 (da) 2008-08-05 2014-09-01 Toray Industries Farmaceutisk sammensætning til behandling og forebyggelse af cancer
TWI440469B (zh) 2008-09-26 2014-06-11 Chugai Pharmaceutical Co Ltd Improved antibody molecules
CN102282168A (zh) * 2008-11-18 2011-12-14 梅里麦克制药股份有限公司 人血清白蛋白接头以及其结合物
UA109633C2 (uk) 2008-12-09 2015-09-25 Антитіло людини проти тканинного фактора
EP2380976A4 (fr) 2008-12-25 2012-11-07 Univ Osaka Anticorps humain anti-virus de la grippe humaine
EP2409991B1 (fr) 2009-03-19 2017-05-03 Chugai Seiyaku Kabushiki Kaisha Variant d'une région constante d'anticorps
TWI646193B (zh) 2009-03-19 2019-01-01 中外製藥股份有限公司 抗體恆定區域改變體
CN102459344A (zh) 2009-05-15 2012-05-16 中外制药株式会社 抗axl抗体
US20120141501A1 (en) 2009-05-29 2012-06-07 Forerunner Pharma Research Co. Ltd Pharmaceutical Composition Containing Antagonist of EGF Family Ligand as Component
WO2011037158A1 (fr) 2009-09-24 2011-03-31 中外製薬株式会社 Régions constantes modifiées d'un anticorps
CN101717447B (zh) * 2009-12-17 2012-06-27 山西省生物研究所 一种抗人重组组织因子单克隆抗体的制备方法
TWI505838B (zh) 2010-01-20 2015-11-01 Chugai Pharmaceutical Co Ltd Stabilized antibody solution containing
CA2788715C (fr) 2010-02-04 2021-06-08 Toray Industries, Inc. Composition pharmaceutique pour le traitement et/ou la prevention du cancer
DK2532364T3 (en) 2010-02-04 2016-08-15 Toray Industries PHARMACEUTICAL COMPOSITION CONTAINING ANTI CAPRIN-1 ANTIBODIES FOR TREATMENT AND / OR PREVENTION OF CANCER
US8937160B2 (en) 2010-02-04 2015-01-20 Toray Industries, Inc. Pharmaceutical composition for treating and/or preventing cancer
RU2567657C2 (ru) 2010-02-04 2015-11-10 Торэй Индастриз, Инк. Фармацевтическая композиция для лечения и/или профилактики рака
WO2011096534A1 (fr) 2010-02-04 2011-08-11 東レ株式会社 Composition pharmaceutique pour le traitement et/ou la prévention du cancer
JP5889181B2 (ja) 2010-03-04 2016-03-22 中外製薬株式会社 抗体定常領域改変体
EP2582728B1 (fr) 2010-06-15 2017-08-23 Genmab A/S Conjugués anticorps humain-médicament contre le facteur tissulaire
RS57038B1 (sr) 2010-11-17 2018-05-31 Chugai Pharmaceutical Co Ltd Multi-specifičan antigen-vezujući molekul koji ima alternativnu funkciju funkciji faktora viii koagulacije krvi
SG192945A1 (en) 2011-02-25 2013-09-30 Chugai Pharmaceutical Co Ltd Fcgriib-specific fc antibody
US8722044B2 (en) 2011-03-15 2014-05-13 Janssen Biotech, Inc. Human tissue factor antibody and uses thereof
US9574005B2 (en) 2011-07-19 2017-02-21 Chugai Seiyaku Kabushiki Kaisha Stable Protein-containing preparation containing argininamide or analogous compound thereof
KR101968499B1 (ko) 2011-08-04 2019-04-12 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
ES2609859T3 (es) 2011-08-04 2017-04-24 Toray Industries, Inc. Composición de fármaco para el tratamiento y/o la prevención del cáncer
RU2610428C2 (ru) 2011-08-04 2017-02-10 Торэй Индастриз, Инк. Фармацевтическая композиция для лечения и/или профилактики злокачественной опухоли
MX359235B (es) 2011-09-01 2018-09-20 Chugai Pharmaceutical Co Ltd Metodo para preparar una composicion que comprende anticuerpos altamente concentrados por ultrafiltracion.
EP3939996A1 (fr) 2011-09-30 2022-01-19 Chugai Seiyaku Kabushiki Kaisha Molécule se liant à l'antigène favorisant la disparition des antigènes ayant une pluralité d'activités biologiques
TW201817744A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之FcRn結合域的治療性抗原結合分子
TWI593705B (zh) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
ES2739380T3 (es) 2012-02-21 2020-01-30 Toray Industries Composición farmacéutica para el tratamiento del cáncer
PT2818482T (pt) 2012-02-21 2019-08-06 Toray Industries Composição farmacêutica para o tratamento de cancro
WO2013125630A1 (fr) 2012-02-21 2013-08-29 東レ株式会社 Composition pharmaceutique pour le traitement et/ou la prévention du cancer
IN2014KN01715A (fr) 2012-02-21 2015-10-23 Toray Industries
RU2640245C2 (ru) 2012-03-30 2017-12-27 Торэй Индастриз, Инк. Фармацевтическая композиция для лечения и/или предотвращения рака печени
JP6107655B2 (ja) 2012-03-30 2017-04-05 東レ株式会社 胆嚢癌の治療及び/又は予防用医薬組成物
PL3489261T3 (pl) 2012-08-24 2021-08-16 The Regents Of The University Of California Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu
WO2014036520A1 (fr) 2012-08-30 2014-03-06 Merrimack Pharmaceuticals, Inc. Polythérapies comprenant des agents anti-erbb3
CA2886326C (fr) 2012-09-28 2021-11-02 Chugai Seiyaku Kabushiki Kaisha Procede d'evaluation de reaction de coagulation du sang
HUE042081T2 (hu) 2013-08-09 2019-06-28 Toray Industries Gyógyászati készítmény rák kezelésére és/vagy megelõzésére
SG10201803449VA (en) 2013-09-27 2018-05-30 Chugai Pharmaceutical Co Ltd Method for producing polypeptide heteromultimer
JP6722455B2 (ja) 2013-12-27 2020-07-15 中外製薬株式会社 等電点の低い抗体の精製方法
US10538591B2 (en) 2014-03-10 2020-01-21 The Brigham And Women's Hospital, Inc. Anti-fibulin-3 antibodies and uses thereof
TW201625299A (zh) 2014-06-20 2016-07-16 Chugai Pharmaceutical Co Ltd 用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
EP4056993A1 (fr) 2014-08-20 2022-09-14 Chugai Seiyaku Kabushiki Kaisha Procédé de mesure de viscosité d'une solution de protéine
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
WO2016065245A1 (fr) 2014-10-24 2016-04-28 Incept, Llc Échafaudage extraluminal
EP3209769B1 (fr) 2014-10-24 2020-08-05 The Board of Trustees of the Leland Stanford Junior University Compositions et procédés pour induire la phagocytose de cellules positives de classe i du cmh et pour contrer la résistance aux agents anti-cd47/sirpa
US9765135B2 (en) 2014-12-19 2017-09-19 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies
CR20170326A (es) 2014-12-19 2017-08-22 Chugai Pharmaceutical Co Ltd Anticuerpos antimiostatina, polipéptidos que contienen regiones fc variantes, y métodos de uso
WO2016125495A1 (fr) 2015-02-05 2016-08-11 Chugai Seiyaku Kabushiki Kaisha Anticorps comprenant un domaine se liant à l'antigène dépendant de la concentration d'ions, variants de la région fc, anticorps se liant à l'il-8, et leurs utilisations
WO2016136933A1 (fr) 2015-02-27 2016-09-01 中外製薬株式会社 Composition pour le traitement de maladies associées à il-6
JP7082484B2 (ja) 2015-04-01 2022-06-08 中外製薬株式会社 ポリペプチド異種多量体の製造方法
AU2016248817A1 (en) 2015-04-17 2017-08-17 F. Hoffmann-La Roche Ag Combination therapy with coagulation factors and multispecific antibodies
CA3004830A1 (fr) 2015-11-11 2017-05-18 Opi Vi- Ip Holdco Llc Composition et methodes pour anticorps anti-tnfr2
EP3395835B1 (fr) 2015-12-25 2021-02-03 Chugai Seiyaku Kabushiki Kaisha Anticorps présentant une activité accrue et son procédé de modification
WO2017110981A1 (fr) 2015-12-25 2017-06-29 Chugai Seiyaku Kabushiki Kaisha Anticorps anti-myostatine et procédés d'utilisation
SG11201803989WA (en) 2015-12-28 2018-06-28 Chugai Pharmaceutical Co Ltd Method for promoting efficiency of purification of fc region-containing polypeptide
WO2017159287A1 (fr) 2016-03-14 2017-09-21 中外製薬株式会社 Médicament thérapeutique induisant des lésions cellulaires à utiliser dans le traitement du cancer
JP6939555B2 (ja) 2016-03-28 2021-09-22 東レ株式会社 癌の治療及び/又は予防用医薬組成物
CA3029003A1 (fr) 2016-06-27 2018-01-04 The Regents Of The University Of California Associations medicamenteuses pour le traitement du cancer
KR20230079499A (ko) 2016-08-05 2023-06-07 추가이 세이야쿠 가부시키가이샤 Il-8 관련 질환의 치료용 또는 예방용 조성물
US20200054762A1 (en) 2016-10-28 2020-02-20 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
TW201836636A (zh) 2017-03-31 2018-10-16 公立大學法人奈良縣立醫科大學 含有替代凝血因子viii功能之多特異性抗原結合分子之用於預防和/或治療凝血因子ix異常症的醫藥組合物
US20200109390A1 (en) 2017-04-27 2020-04-09 Chugai Seiyaku Kabushiki Kaisha Coagulation factor ix with improved pharmacokinetics
EP3620531A4 (fr) 2017-05-02 2021-03-17 National Center of Neurology and Psychiatry Procédé de prédiction et d'évaluation d'un effet thérapeutique dans des maladies associées à il-6 et à des neutrophiles
TW201922796A (zh) * 2017-10-30 2019-06-16 國立研究開發法人國立癌症研究中心 可用於實體腫瘤治療之抗體及其抗體-藥物共軛物以及含其之抗癌劑
CA3083345A1 (fr) * 2017-11-27 2019-05-31 Purdue Pharma L.P. Anticorps humanises ciblant le facteur tissulaire humain
CA3087537A1 (fr) 2018-01-04 2019-07-11 Jan-willem THEUNISSEN Anticorps anti-facteur tissulaire, conjugues anticorps-medicament et procedes associes
BR112020019935A2 (pt) 2018-03-30 2021-01-26 Toray Industries, Inc. medicamento para o tratamento e/ou prevenção do câncer, agentes que aumentam a eficácia de um fármaco e método de tratamento e/ou prevenção do câncer
WO2019225568A1 (fr) 2018-05-21 2019-11-28 中外製薬株式会社 Formulation lyophilisée scellée dans un flacon en verre
US11708186B2 (en) 2018-05-28 2023-07-25 Chugai Seiyaku Kabushiki Kaisha Filling nozzle
AU2020258025A1 (en) 2019-04-18 2021-11-25 Ac Immune Sa Novel molecules for therapy and diagnosis
WO2021110995A1 (fr) 2019-12-04 2021-06-10 Ac Immune Sa Nouvelles molécules de thérapie et de diagnostic
KR20220152309A (ko) 2020-03-12 2022-11-15 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
KR20220151684A (ko) 2020-03-12 2022-11-15 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
KR20220152318A (ko) 2020-03-12 2022-11-15 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
BR112022018171A2 (pt) 2020-03-12 2022-10-25 Toray Industries Medicamento para o tratamento e/ou a prevenção de câncer, agentes aumentando a eficácia de droga de uma composição farmacêutica e método para tratar e/ou prevenir câncer
WO2021182570A1 (fr) 2020-03-12 2021-09-16 東レ株式会社 Médicament pour le traitement et/ou la prévention du cancer
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
TW202144429A (zh) 2020-05-14 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 抗cd25抗體、其抗原結合片段及其醫藥用途
US20230183376A1 (en) 2020-05-22 2023-06-15 Chugai Seiyaku Kabushiki Kaisha Antibody for neutralizing substance having coagulation factor viii (f.viii) function-substituting activity
EP4229082A1 (fr) 2020-10-16 2023-08-23 AC Immune SA Anticorps se liant à l'alpha-synucléine à usage thérapeutique et diagnostique
IL303758A (en) 2020-12-18 2023-08-01 Ac Immune Sa Antibody transport
CN117460532A (zh) 2021-06-23 2024-01-26 东丽株式会社 用于癌的治疗和/或预防的药品
BR112023026985A2 (pt) 2021-06-23 2024-03-12 Toray Industries Medicamento para o tratamento e/ou prevenção do câncer, agente que aumenta a eficácia do medicamento em uma composição farmacêutica, agente para aumentar a eficácia do medicamento em uma composição farmacêutica e método para tratar e/ou prevenir o câncer
CN117693363A (zh) 2021-07-27 2024-03-12 东丽株式会社 用于癌的治疗和/或预防的药品
AU2022316644A1 (en) 2021-07-27 2024-02-29 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
CA3227706A1 (fr) 2021-07-27 2023-02-02 Toray Industries, Inc. Medicament pour le traitement et/ou la prevention du cancer
WO2023033129A1 (fr) 2021-09-03 2023-03-09 東レ株式会社 Composition pharmaceutique pour le traitement et/ou la prévention du cancer
TW202333781A (zh) 2021-10-08 2023-09-01 日商中外製藥股份有限公司 抗hla-dq2﹒5抗體製劑

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5437864A (en) 1987-03-31 1995-08-01 The Scripps Research Institute Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor
US5223427A (en) * 1987-03-31 1993-06-29 The Scripps Research Institute Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
GB9009548D0 (en) 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
TW205553B (fr) 1991-04-25 1993-05-11 Chugai Pharmaceutical Co Ltd
WO1994005328A1 (fr) * 1992-08-28 1994-03-17 The Scripps Research Institute Inhibitions des metastases tumorales par neutralisation de la fonction de la thromboplastine tissulaire
US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
AU716282B2 (en) * 1995-06-07 2000-02-24 Johnson & Johnson Research Pty. Limited CDR-grafted anti-tissue factor antibodies and methods of use thereof

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CA2325346A1 (fr) 1999-10-14
PT1069185E (pt) 2011-08-11
EP1069185A4 (fr) 2005-01-19
EP2363484A3 (fr) 2012-04-25
JP3998419B2 (ja) 2007-10-24
ATE512225T1 (de) 2011-06-15
BR9909382A (pt) 2000-12-05
JP4180106B2 (ja) 2008-11-12
EP2363484A2 (fr) 2011-09-07
AU3055699A (en) 1999-10-25
TR200101541T2 (tr) 2002-06-21
US7494647B2 (en) 2009-02-24
AU752730B2 (en) 2002-09-26
EP1069185A1 (fr) 2001-01-17
SK14812000A3 (sk) 2001-08-06
TR200002885T2 (tr) 2000-12-21
HUP0101160A2 (hu) 2001-08-28
ES2364266T3 (es) 2011-08-30
US20040044187A1 (en) 2004-03-04
IL138801A0 (en) 2001-10-31
CN1303431A (zh) 2001-07-11
PL343322A1 (en) 2001-08-13
NO20004946D0 (no) 2000-10-02
KR20010042435A (ko) 2001-05-25
EP1069185B1 (fr) 2011-06-08
JP2008161198A (ja) 2008-07-17
US6677436B1 (en) 2004-01-13
DK1069185T3 (da) 2011-06-27
WO1999051743A1 (fr) 1999-10-14

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