MX359235B - Metodo para preparar una composicion que comprende anticuerpos altamente concentrados por ultrafiltracion. - Google Patents

Metodo para preparar una composicion que comprende anticuerpos altamente concentrados por ultrafiltracion.

Info

Publication number
MX359235B
MX359235B MX2014002253A MX2014002253A MX359235B MX 359235 B MX359235 B MX 359235B MX 2014002253 A MX2014002253 A MX 2014002253A MX 2014002253 A MX2014002253 A MX 2014002253A MX 359235 B MX359235 B MX 359235B
Authority
MX
Mexico
Prior art keywords
ultrafiltration
preparing
composition
highly concentrated
concentrated antibodies
Prior art date
Application number
MX2014002253A
Other languages
English (en)
Other versions
MX2014002253A (es
Inventor
Lau Kelby
Bender Jean
Tanaka Saeko
Wakayama Rumiko
Yamada Hidenari
Isoda Tomonori
Oh-Eda Masayoshi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2014002253A publication Critical patent/MX2014002253A/es
Publication of MX359235B publication Critical patent/MX359235B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/14—Pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B01D2311/165—Cross-flow velocity control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/14—Batch-systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2321/00—Details relating to membrane cleaning, regeneration, sterilization or to the prevention of fouling
    • B01D2321/02—Forward flushing

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método para preparar una composición que comprende anticuerpos altamente concentrados por ultrafiltración en un modo de concentración por lotes con un primer paso con velocidad de alimentación constante y un segundo paso con velocidad de alimentación controlada.
MX2014002253A 2011-09-01 2012-08-31 Metodo para preparar una composicion que comprende anticuerpos altamente concentrados por ultrafiltracion. MX359235B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161530158P 2011-09-01 2011-09-01
PCT/JP2012/005536 WO2013031237A1 (en) 2011-09-01 2012-08-31 Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration

Publications (2)

Publication Number Publication Date
MX2014002253A MX2014002253A (es) 2014-04-30
MX359235B true MX359235B (es) 2018-09-20

Family

ID=46982845

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014002253A MX359235B (es) 2011-09-01 2012-08-31 Metodo para preparar una composicion que comprende anticuerpos altamente concentrados por ultrafiltracion.

Country Status (15)

Country Link
US (3) US9630988B2 (es)
EP (2) EP2750784A1 (es)
JP (2) JP6363017B2 (es)
KR (1) KR101993488B1 (es)
CN (1) CN103889555B (es)
AU (2) AU2012303372A1 (es)
BR (1) BR112014004828B8 (es)
CA (1) CA2847302C (es)
IL (1) IL231128B (es)
MX (1) MX359235B (es)
MY (1) MY182178A (es)
RU (1) RU2638859C9 (es)
SG (1) SG11201400260TA (es)
WO (1) WO2013031237A1 (es)
ZA (1) ZA201401184B (es)

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PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
BR112012009828B8 (pt) 2009-10-26 2022-10-25 Hoffmann La Roche Método para a produção de uma imunoglobulina glicosilada e seu uso
CA2817216A1 (en) 2010-11-08 2012-05-18 F. Hoffmann-La Roche Ag Subcutaneously administered anti-il-6 receptor antibody
PT2739157T (pt) * 2011-08-03 2018-01-09 Prolacta Bioscience Inc Microfiltração de leite humano para reduzir a contaminação bacteriana
JP6563910B2 (ja) 2013-07-04 2019-08-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 血清サンプル中の抗薬物抗体を検出するための干渉抑制イムノアッセイ
WO2016067177A1 (en) 2014-10-27 2016-05-06 Tmci Padovan S.P.A. Improved filtration plant and relative method
CN104673666A (zh) * 2015-03-10 2015-06-03 华东理工大学 一种微型切向流过滤模拟装置
GB201600287D0 (en) * 2016-01-07 2016-02-24 Fujifilm Diosynth Biotechnologies Uk Ltd Process
SG10202102258QA (en) 2016-09-15 2021-04-29 Evoqua Water Tech Llc Method and system for treating ultrapure water
JP6399723B1 (ja) * 2018-02-21 2018-10-03 株式会社グロータック 自転車用変速操作装置
TW202007399A (zh) 2018-07-27 2020-02-16 加拿大商Ａｒｃ醫療器材公司 用於治療纖維性粘連的經高度純化聚海藻糖
JP7483679B2 (ja) * 2018-08-14 2024-05-15 ブリストル－マイヤーズ スクイブ カンパニー 改善されたタンパク質の回収
DE102019101745A1 (de) * 2019-01-24 2020-07-30 Putsch Gmbh & Co. Kg Verfahren zum Betrieb einer Membranfilteranlage
EP3934795A4 (en) * 2019-03-05 2023-01-11 Arc Medical Devices, Inc. SYSTEMS AND METHODS FOR TANGENTIAL FLOW FILTRATION OF VISCOSE COMPOSITIONS
CN111018968B (zh) * 2019-12-16 2021-07-27 兴盟生物医药(苏州)有限公司 一种通过超滤浓缩制备高浓度抗体制剂的方法

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JPH0778025B2 (ja) * 1990-03-20 1995-08-23 日本赤十字社 免疫グロブリンｇの製造方法
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Also Published As

Publication number Publication date
US20200172569A1 (en) 2020-06-04
IL231128B (en) 2019-03-31
BR112014004828B8 (pt) 2022-03-29
EP3235557A1 (en) 2017-10-25
JP2017131886A (ja) 2017-08-03
ZA201401184B (en) 2014-12-23
US9630988B2 (en) 2017-04-25
CN103889555B (zh) 2018-10-26
EP2750784A1 (en) 2014-07-09
BR112014004828B1 (pt) 2021-03-09
US10590164B2 (en) 2020-03-17
RU2638859C2 (ru) 2017-12-18
WO2013031237A1 (en) 2013-03-07
JP6363017B2 (ja) 2018-07-25
AU2017204395A1 (en) 2017-07-20
CN103889555A (zh) 2014-06-25
IL231128A0 (en) 2014-03-31
BR112014004828A2 (pt) 2017-04-04
JP6363751B2 (ja) 2018-07-25
US20170204135A1 (en) 2017-07-20
AU2017204395B2 (en) 2018-11-08
CA2847302A1 (en) 2013-03-07
KR20140078642A (ko) 2014-06-25
MX2014002253A (es) 2014-04-30
AU2012303372A1 (en) 2014-02-20
US20150037319A1 (en) 2015-02-05
KR101993488B1 (ko) 2019-06-26
SG11201400260TA (en) 2014-03-28
CA2847302C (en) 2021-02-16
NZ621902A (en) 2016-06-24
RU2014112230A (ru) 2015-10-10
MY182178A (en) 2021-01-18
RU2638859C9 (ru) 2018-01-31
JP2014526371A (ja) 2014-10-06

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