NO20004697L - Benzoksazinoner/benzotiazinoner som serin protease inhibitorer - Google Patents
Benzoksazinoner/benzotiazinoner som serin protease inhibitorerInfo
- Publication number
- NO20004697L NO20004697L NO20004697A NO20004697A NO20004697L NO 20004697 L NO20004697 L NO 20004697L NO 20004697 A NO20004697 A NO 20004697A NO 20004697 A NO20004697 A NO 20004697A NO 20004697 L NO20004697 L NO 20004697L
- Authority
- NO
- Norway
- Prior art keywords
- benzothiazinones
- benzoxazinones
- protease inhibitors
- serine protease
- serine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8004298P | 1998-03-31 | 1998-03-31 | |
| PCT/US1998/026704 WO1999050254A1 (en) | 1998-03-31 | 1998-12-15 | Quinoxalinones as serine protease inhibitors such as factor xa and thrombin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004697L true NO20004697L (no) | 2000-09-20 |
| NO20004697D0 NO20004697D0 (no) | 2000-09-20 |
Family
ID=22154891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004697A NO20004697D0 (no) | 1998-03-31 | 2000-09-20 | Benzoksazinoner/benzotiazinoner som serin protease inhibitorer |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6410536B1 (no) |
| EP (1) | EP1068190A1 (no) |
| JP (1) | JP2002509923A (no) |
| KR (1) | KR20010042298A (no) |
| AU (1) | AU1917999A (no) |
| BR (1) | BR9815785A (no) |
| CA (1) | CA2319554C (no) |
| HU (1) | HUP0101470A3 (no) |
| IL (1) | IL137655A0 (no) |
| IS (1) | IS5589A (no) |
| NO (1) | NO20004697D0 (no) |
| PL (1) | PL343321A1 (no) |
| WO (1) | WO1999050254A1 (no) |
| ZA (1) | ZA992447B (no) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
| AU3127900A (en) * | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
| CN1337961A (zh) * | 1999-02-09 | 2002-02-27 | 三维药物公司 | 用作蛋白酶抑制剂的杂芳基脒、甲基脒和胍 |
| SE9902202D0 (sv) * | 1999-06-10 | 1999-06-10 | Astra Ab | Production of aggregates |
| US6777413B2 (en) | 2000-02-01 | 2004-08-17 | Millennium Pharmaceuticals, Inc. | 2-[1H]-quinolone and 2-[1H]-quinoxalone inhibitors of factor Xa |
| AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
| TWI289141B (en) | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
| NZ542739A (en) * | 2003-04-15 | 2007-02-23 | Wellstat Therapeutics Corp | Compounds for the treatment of metabolic disorders |
| JP2007500221A (ja) * | 2003-05-20 | 2007-01-11 | ジェネンテック・インコーポレーテッド | 第ＶＩＩａ因子のベンゾフラン阻害剤 |
| CA2525854C (en) * | 2003-05-20 | 2009-12-15 | Genentech, Inc. | Acylsulfamide inhibitors of factor viia |
| US20080200424A1 (en) * | 2004-05-05 | 2008-08-21 | Christine Grimm | Preparation for Treating Cancer |
| DE102004023332A1 (de) * | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| BRPI0513386A (pt) * | 2004-08-09 | 2008-05-06 | Warner Lambert Co | inibidores de reabsorção de norepinefrina de quinoxalinona para o tratamento de distúrbios do sistema nervoso central |
| EP1776964A4 (en) * | 2004-08-11 | 2009-08-19 | Kowa Co | METHOD FOR THE PREVENTION AND TREATMENT OF BRAIN INFARC |
| AP2007003973A0 (en) * | 2004-10-12 | 2007-07-30 | Glenmark Pharmaceuticals Sa | Novel dideptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and proces for their preparation |
| US7893066B2 (en) | 2006-10-05 | 2011-02-22 | Gilead Palo Alto, Inc. | Pyridol[2,3-B]pyrazinones for use as stearoyl CoA desaturase inhibitors |
| BRPI0717502A2 (pt) * | 2006-10-05 | 2015-06-16 | Cv Therapeutics Inc | Compostos heterocíclicos contendo nitrogênio bacíclico para uso como inibidores de estearoil-coa desaturase. |
| EP2131844A1 (en) | 2007-04-09 | 2009-12-16 | CV Therapeutics Inc. | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
| KR20100017766A (ko) * | 2007-05-10 | 2010-02-16 | 에이엠알 테크놀로지, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤조-1,4-디아제핀 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 이의 용도 |
| EP2433936A1 (en) | 2007-08-31 | 2012-03-28 | Purdue Pharma LP | Substituted-quinoxaline-type-piperidine compounds and the uses thereof |
| EP2247580B1 (en) * | 2008-03-05 | 2015-07-08 | Merck Patent GmbH | Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
| JPWO2009119537A1 (ja) * | 2008-03-26 | 2011-07-21 | 第一三共株式会社 | ヒドロキシキノキサリンカルボキサミド誘導体 |
| CA2719650A1 (en) * | 2008-04-10 | 2009-10-15 | Gilead Sciences, Inc. | Bicyclic nitrogen-containing heterocyclic compounds for use as stearoyl coa desaturase inhibitors |
| MX2011000872A (es) | 2008-07-21 | 2011-07-29 | Purdue Pharma Lp | Compuestos de piperidina puenteada tipo quinoxalina sustituida y los usos de los mismos. |
| AU2011346749A1 (en) | 2010-12-22 | 2013-05-02 | Purdue Pharma L.P. | Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof |
| EP2776444A4 (en) | 2011-11-10 | 2015-07-22 | Osi Pharmaceuticals Llc | dihydropteridinones |
| US9290488B2 (en) | 2011-12-01 | 2016-03-22 | Purdue Pharma L.P. | Azetidine-substituted quinoxalines as opioid receptor like-1 modulators |
| US9085561B2 (en) | 2012-07-30 | 2015-07-21 | Purdue Pharma L.P. | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators |
| WO2014102592A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof |
| US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
| WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| WO2014102594A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| JP2018525371A (ja) * | 2015-07-30 | 2018-09-06 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | アリール置換された二環式ヘテロアリール化合物 |
| CN108699107B (zh) | 2015-12-24 | 2022-05-10 | 加利福尼亚大学董事会 | Cftr调节剂及其使用方法 |
| KR20180102590A (ko) | 2015-12-24 | 2018-09-17 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Cftr 조절제 및 이의 사용방법 |
| CN108699040B (zh) * | 2015-12-24 | 2021-08-10 | 加利福尼亚大学董事会 | Cftr调节剂及其使用方法 |
| DE102017005091A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one |
| DE102017005089A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one |
| CN111629730A (zh) | 2017-08-24 | 2020-09-04 | 加利福尼亚大学董事会 | 眼部药物组合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082735A (en) | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
| US4082736A (en) | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
| JPS63145272A (ja) | 1986-12-09 | 1988-06-17 | Morishita Seiyaku Kk | ４，５−ジヒドロ−６−（４−置換フエニル）−３（２ｈ）−ピリダジノン誘導体 |
| JPS63301874A (ja) * | 1987-03-27 | 1988-12-08 | Fujisawa Pharmaceut Co Ltd | キノキサリン誘導体およびその製造法 |
| JPH0276860A (ja) * | 1987-10-05 | 1990-03-16 | Toyo Jozo Co Ltd | ６−置換アルコキシ−２−オキソ−１，２−ジヒドロキノキサリン誘導体 |
| JPH01254348A (ja) | 1988-04-01 | 1989-10-11 | Matsushita Electric Ind Co Ltd | 成形用型 |
| HUT76640A (en) | 1995-08-17 | 1997-10-28 | Chinoin Gyogyszer Es Vegyeszet | Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use |
| WO1997048706A1 (en) * | 1996-06-18 | 1997-12-24 | Warner-Lambert Company | Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors |
| NZ333696A (en) * | 1996-07-08 | 2000-06-23 | Du Pont Pharm Co | Amidinoindoles, amidinoazoles, and analogs thereof as inhibitors of trypsin like protease enzymes like thrombin and Xa factor |
| TW472045B (en) * | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
| GB2324729B (en) | 1997-04-30 | 2002-01-02 | Bradford Hospitals Nhs Trust | Lung treatment device |
-
1998
- 1998-12-15 PL PL98343321A patent/PL343321A1/xx not_active Application Discontinuation
- 1998-12-15 BR BR9815785-0A patent/BR9815785A/pt not_active Application Discontinuation
- 1998-12-15 JP JP2000541158A patent/JP2002509923A/ja active Pending
- 1998-12-15 EP EP98963961A patent/EP1068190A1/en not_active Withdrawn
- 1998-12-15 HU HU0101470A patent/HUP0101470A3/hu unknown
- 1998-12-15 AU AU19179/99A patent/AU1917999A/en not_active Abandoned
- 1998-12-15 WO PCT/US1998/026704 patent/WO1999050254A1/en not_active Application Discontinuation
- 1998-12-15 IL IL13765598A patent/IL137655A0/xx unknown
- 1998-12-15 KR KR1020007010842A patent/KR20010042298A/ko not_active Application Discontinuation
- 1998-12-15 CA CA002319554A patent/CA2319554C/en not_active Expired - Fee Related
-
1999
- 1999-03-30 ZA ZA9902447A patent/ZA992447B/xx unknown
-
2000
- 2000-08-03 US US09/601,606 patent/US6410536B1/en not_active Expired - Fee Related
- 2000-08-18 IS IS5589A patent/IS5589A/is unknown
- 2000-09-20 NO NO20004697A patent/NO20004697D0/no unknown
-
2002
- 2002-01-04 US US10/038,006 patent/US6916805B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL343321A1 (en) | 2001-08-13 |
| WO1999050254A1 (en) | 1999-10-07 |
| IL137655A0 (en) | 2001-10-31 |
| BR9815785A (pt) | 2000-12-05 |
| CA2319554A1 (en) | 1999-10-07 |
| NO20004697D0 (no) | 2000-09-20 |
| CA2319554C (en) | 2005-06-28 |
| KR20010042298A (ko) | 2001-05-25 |
| US6410536B1 (en) | 2002-06-25 |
| US20020086866A1 (en) | 2002-07-04 |
| ZA992447B (en) | 2000-10-10 |
| HUP0101470A3 (en) | 2002-09-30 |
| AU1917999A (en) | 1999-10-18 |
| EP1068190A1 (en) | 2001-01-17 |
| JP2002509923A (ja) | 2002-04-02 |
| US6916805B2 (en) | 2005-07-12 |
| HUP0101470A2 (hu) | 2001-10-28 |
| IS5589A (is) | 2000-08-18 |
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