NO20004697L - Benzoksazinoner/benzotiazinoner som serin protease inhibitorer - Google Patents
Benzoksazinoner/benzotiazinoner som serin protease inhibitorerInfo
- Publication number
- NO20004697L NO20004697L NO20004697A NO20004697A NO20004697L NO 20004697 L NO20004697 L NO 20004697L NO 20004697 A NO20004697 A NO 20004697A NO 20004697 A NO20004697 A NO 20004697A NO 20004697 L NO20004697 L NO 20004697L
- Authority
- NO
- Norway
- Prior art keywords
- benzothiazinones
- benzoxazinones
- protease inhibitors
- serine protease
- serine
- Prior art date
Links
- MJNPHLBKHKJDEF-UHFFFAOYSA-N 2h-1$l^{4},2-benzothiazine 1-oxide Chemical class C1=CC=C2S(=O)NC=CC2=C1 MJNPHLBKHKJDEF-UHFFFAOYSA-N 0.000 title 1
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical class C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8004298P | 1998-03-31 | 1998-03-31 | |
| PCT/US1998/026704 WO1999050254A1 (en) | 1998-03-31 | 1998-12-15 | Quinoxalinones as serine protease inhibitors such as factor xa and thrombin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20004697D0 NO20004697D0 (no) | 2000-09-20 |
| NO20004697L true NO20004697L (no) | 2000-09-20 |
Family
ID=22154891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004697A NO20004697L (no) | 1998-03-31 | 2000-09-20 | Benzoksazinoner/benzotiazinoner som serin protease inhibitorer |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6410536B1 (no) |
| EP (1) | EP1068190A1 (no) |
| JP (1) | JP2002509923A (no) |
| KR (1) | KR20010042298A (no) |
| AU (1) | AU1917999A (no) |
| BR (1) | BR9815785A (no) |
| CA (1) | CA2319554C (no) |
| HU (1) | HUP0101470A3 (no) |
| IL (1) | IL137655A0 (no) |
| IS (1) | IS5589A (no) |
| NO (1) | NO20004697L (no) |
| PL (1) | PL343321A1 (no) |
| WO (1) | WO1999050254A1 (no) |
| ZA (1) | ZA992447B (no) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
| EP1140862A4 (en) * | 1998-12-23 | 2004-07-28 | Bristol Myers Squibb Pharma Co | THROMBIN OR Xa FACTOR INHIBITORS |
| PL351767A1 (en) * | 1999-02-09 | 2003-06-16 | Dimensional Pharmaceuticals 3 | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors |
| SE9902202D0 (sv) * | 1999-06-10 | 1999-06-10 | Astra Ab | Production of aggregates |
| EP1255741A2 (en) | 2000-02-01 | 2002-11-13 | Cor Therapeutics, Inc. | 2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa |
| PT1569912E (pt) | 2002-12-03 | 2015-09-15 | Pharmacyclics Llc | Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia |
| TWI289141B (en) | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
| WO2004091486A2 (en) * | 2003-04-15 | 2004-10-28 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
| CA2525854C (en) * | 2003-05-20 | 2009-12-15 | Genentech, Inc. | Acylsulfamide inhibitors of factor viia |
| JP2007500221A (ja) * | 2003-05-20 | 2007-01-11 | ジェネンテック・インコーポレーテッド | 第ＶＩＩａ因子のベンゾフラン阻害剤 |
| CA2565832A1 (en) * | 2004-05-05 | 2005-11-10 | Immunopharm Aktiengesellschaft | Preparation for the treatment cancer |
| DE102004023332A1 (de) * | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
| MX2007001615A (es) * | 2004-08-09 | 2007-04-10 | Warner Lambert Co | Nuevos inhibidores de la recaptacion de norepinefrina de quinoxalinona para el tratamiento de trastornos del sistema nervioso central. |
| US7976837B2 (en) | 2004-08-11 | 2011-07-12 | Kowa Company, Ltd. | Method of preventing and treating brain infarction |
| JP4959569B2 (ja) | 2004-10-12 | 2012-06-27 | グレンマーク・ファーマシューティカルズ・エスエー | 新規なジペプチジルペプチダーゼｉｖ阻害剤、それらを含む医薬品組成物、およびそれらを調製するためのプロセス |
| US7893066B2 (en) | 2006-10-05 | 2011-02-22 | Gilead Palo Alto, Inc. | Pyridol[2,3-B]pyrazinones for use as stearoyl CoA desaturase inhibitors |
| RU2009112397A (ru) | 2006-10-05 | 2010-10-10 | Си Ви ТЕРАПЬЮТИКС, ИНК (US) | Бициклические азотсодержащие гетероциклические соединения для применения в качестве ингибиторов стеароил соа десатуразы |
| WO2008123891A1 (en) | 2007-04-09 | 2008-10-16 | Cv Therapeutics, Inc. | PTERIDINONE DERIVATIVES FOR USE AS STEAROYL CoA DESATURASE INHIBITORS |
| NZ580801A (en) * | 2007-05-10 | 2012-09-28 | Bristol Myers Squibb Co | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
| NZ582940A (en) | 2007-08-31 | 2013-01-25 | Purdue Pharma Lp | Substituted-quinoxaline-type piperidine compounds and the uses thereof |
| ES2548583T3 (es) * | 2008-03-05 | 2015-10-19 | Merck Patent Gmbh | Derivados de quinoxalinona como estimuladores de la secreción de insulina, métodos para su obtención y su uso para el tratamiento de la diabetes |
| KR20100125316A (ko) * | 2008-03-26 | 2010-11-30 | 다이이찌 산쿄 가부시키가이샤 | 하이드록시퀴녹살린카르복사마이드 유도체 |
| WO2009126123A1 (en) * | 2008-04-10 | 2009-10-15 | Cv Therapeutics Inc. | Bicyclic nitrogen containing heterocyclic compounds for use as stearoyl coa desaturase inhibitors |
| EP2537844A1 (en) | 2008-07-21 | 2012-12-26 | Purdue Pharma L.P. | Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof |
| JP5872585B2 (ja) | 2010-12-22 | 2016-03-01 | パーデュー、ファーマ、リミテッド、パートナーシップ | リン置換キノキサリンタイプピペリジン化合物とその使用 |
| JP2015501793A (ja) | 2011-11-10 | 2015-01-19 | オーエスアイ・ファーマシューティカルズ，エルエルシー | ジヒドロプテリジノン類 |
| JP2014533744A (ja) | 2011-12-01 | 2014-12-15 | パーデュー、ファーマ、リミテッド、パートナーシップ | アゼチジン置換キノキサリンタイプピペリジン化合物とその使用 |
| US9085561B2 (en) | 2012-07-30 | 2015-07-21 | Purdue Pharma L.P. | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators |
| WO2014102592A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof |
| US9951038B2 (en) | 2012-12-27 | 2018-04-24 | Purdue Pharma L.P. | Quinazolin-4(3H)-one-type piperidine compounds and uses thereof |
| WO2014102588A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
| EP3328839A1 (en) | 2015-07-30 | 2018-06-06 | Bristol-Myers Squibb Company | Aryl substituted bicyclic heteroaryl compounds |
| JP6938510B2 (ja) | 2015-12-24 | 2021-09-22 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｃｆｔｒ制御因子及びこの使用方法 |
| ES2901002T3 (es) | 2015-12-24 | 2022-03-21 | Univ California | Derivados de N-[5-[(3,4-dimetoxifenil)metil]-1,3,4-tiadiazol-2-il]-2-metoxi-bencenoacetamida y compuestos relacionados como activadores de CFTR para tratar estreñimiento o colestasis |
| DK3394046T3 (da) | 2015-12-24 | 2022-04-04 | Univ California | Cftr-regulatorer og fremgangsmåder til anvendelse deraf |
| DE102017005089A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one |
| DE102017005091A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one |
| US11839616B2 (en) | 2017-08-24 | 2023-12-12 | The Regents Of The University Of California | Ocular pharmaceutical compositions |
| WO2023278222A1 (en) * | 2021-06-28 | 2023-01-05 | Merck Sharp & Dohme Llc | Il4i1 inhibitors and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4082736A (en) | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
| US4082735A (en) | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
| JPS63145272A (ja) | 1986-12-09 | 1988-06-17 | Morishita Seiyaku Kk | ４，５−ジヒドロ−６−（４−置換フエニル）−３（２ｈ）−ピリダジノン誘導体 |
| JPS63301874A (ja) * | 1987-03-27 | 1988-12-08 | Fujisawa Pharmaceut Co Ltd | キノキサリン誘導体およびその製造法 |
| JPH0276860A (ja) * | 1987-10-05 | 1990-03-16 | Toyo Jozo Co Ltd | ６−置換アルコキシ−２−オキソ−１，２−ジヒドロキノキサリン誘導体 |
| JPH01254348A (ja) | 1988-04-01 | 1989-10-11 | Matsushita Electric Ind Co Ltd | 成形用型 |
| HUT76640A (en) | 1995-08-17 | 1997-10-28 | Chinoin Gyogyszer Es Vegyeszet | Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use |
| WO1997048706A1 (en) * | 1996-06-18 | 1997-12-24 | Warner-Lambert Company | Pyrrolo[1,2-a]pyrazine-1,4-dione serine protease inhibitors |
| WO1998001428A1 (en) * | 1996-07-08 | 1998-01-15 | Du Pont Pharmaceuticals Company | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN |
| TW472045B (en) * | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
| GB2324729B (en) | 1997-04-30 | 2002-01-02 | Bradford Hospitals Nhs Trust | Lung treatment device |
-
1998
- 1998-12-15 PL PL98343321A patent/PL343321A1/xx not_active Application Discontinuation
- 1998-12-15 HU HU0101470A patent/HUP0101470A3/hu unknown
- 1998-12-15 JP JP2000541158A patent/JP2002509923A/ja active Pending
- 1998-12-15 BR BR9815785-0A patent/BR9815785A/pt not_active Application Discontinuation
- 1998-12-15 EP EP98963961A patent/EP1068190A1/en not_active Withdrawn
- 1998-12-15 WO PCT/US1998/026704 patent/WO1999050254A1/en not_active Ceased
- 1998-12-15 IL IL13765598A patent/IL137655A0/xx unknown
- 1998-12-15 AU AU19179/99A patent/AU1917999A/en not_active Abandoned
- 1998-12-15 CA CA002319554A patent/CA2319554C/en not_active Expired - Fee Related
- 1998-12-15 KR KR1020007010842A patent/KR20010042298A/ko not_active Withdrawn
-
1999
- 1999-03-30 ZA ZA9902447A patent/ZA992447B/xx unknown
-
2000
- 2000-08-03 US US09/601,606 patent/US6410536B1/en not_active Expired - Fee Related
- 2000-08-18 IS IS5589A patent/IS5589A/is unknown
- 2000-09-20 NO NO20004697A patent/NO20004697L/no unknown
-
2002
- 2002-01-04 US US10/038,006 patent/US6916805B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6916805B2 (en) | 2005-07-12 |
| US6410536B1 (en) | 2002-06-25 |
| NO20004697D0 (no) | 2000-09-20 |
| US20020086866A1 (en) | 2002-07-04 |
| BR9815785A (pt) | 2000-12-05 |
| AU1917999A (en) | 1999-10-18 |
| IL137655A0 (en) | 2001-10-31 |
| CA2319554C (en) | 2005-06-28 |
| JP2002509923A (ja) | 2002-04-02 |
| HUP0101470A2 (hu) | 2001-10-28 |
| HUP0101470A3 (en) | 2002-09-30 |
| KR20010042298A (ko) | 2001-05-25 |
| WO1999050254A1 (en) | 1999-10-07 |
| ZA992447B (en) | 2000-10-10 |
| EP1068190A1 (en) | 2001-01-17 |
| PL343321A1 (en) | 2001-08-13 |
| CA2319554A1 (en) | 1999-10-07 |
| IS5589A (is) | 2000-08-18 |
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