ZA992447B - Quinoxalinones as serine protease inhibitors. - Google Patents
Quinoxalinones as serine protease inhibitors.Info
- Publication number
- ZA992447B ZA992447B ZA9902447A ZA992447A ZA992447B ZA 992447 B ZA992447 B ZA 992447B ZA 9902447 A ZA9902447 A ZA 9902447A ZA 992447 A ZA992447 A ZA 992447A ZA 992447 B ZA992447 B ZA 992447B
- Authority
- ZA
- South Africa
- Prior art keywords
- quinoxalinones
- protease inhibitors
- serine protease
- serine
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8004298P | 1998-03-31 | 1998-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA992447B true ZA992447B (en) | 2000-10-10 |
Family
ID=22154891
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9902447A ZA992447B (en) | 1998-03-31 | 1999-03-30 | Quinoxalinones as serine protease inhibitors. |
Country Status (14)
Country | Link |
---|---|
US (2) | US6410536B1 (xx) |
EP (1) | EP1068190A1 (xx) |
JP (1) | JP2002509923A (xx) |
KR (1) | KR20010042298A (xx) |
AU (1) | AU1917999A (xx) |
BR (1) | BR9815785A (xx) |
CA (1) | CA2319554C (xx) |
HU (1) | HUP0101470A3 (xx) |
IL (1) | IL137655A0 (xx) |
IS (1) | IS5589A (xx) |
NO (1) | NO20004697D0 (xx) |
PL (1) | PL343321A1 (xx) |
WO (1) | WO1999050254A1 (xx) |
ZA (1) | ZA992447B (xx) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
CA2320730A1 (en) * | 1998-12-23 | 2000-07-06 | Renhua Li | Thrombin or factor xa inhibitors |
EP1150979A1 (en) * | 1999-02-09 | 2001-11-07 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors |
SE9902202D0 (sv) * | 1999-06-10 | 1999-06-10 | Astra Ab | Production of aggregates |
EP1255741A2 (en) * | 2000-02-01 | 2002-11-13 | Cor Therapeutics, Inc. | 2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa |
HUE025683T2 (hu) | 2002-12-03 | 2016-04-28 | Pharmacyclics Llc | VIIA faktor inhibitor 2-(2-hidroxi-bifenil-3-il)-1H-benzoimidazol-5-karboxamidin-származékok |
TWI289141B (en) | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
WO2004091486A2 (en) * | 2003-04-15 | 2004-10-28 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
JP2007505160A (ja) * | 2003-05-20 | 2007-03-08 | ジェネンテック・インコーポレーテッド | 第VIIa因子のアシルスルファミド阻害剤 |
CA2525713A1 (en) * | 2003-05-20 | 2004-12-29 | Genentech, Inc. | Benzofuran inhibitors of factor viia |
US20080200424A1 (en) * | 2004-05-05 | 2008-08-21 | Christine Grimm | Preparation for Treating Cancer |
DE102004023332A1 (de) * | 2004-05-12 | 2006-01-19 | Bayer Cropscience Gmbh | Chinoxalin-2-on-derivate, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung und deren Verwendung |
WO2006016278A1 (en) * | 2004-08-09 | 2006-02-16 | Warner-Lambert Company Llc | Novel quinoxalinone norepinephrine reuptake inhibitors for the treatment of central nervous system disorders |
WO2006016450A1 (ja) | 2004-08-11 | 2006-02-16 | Kowa Company, Ltd. | 脳梗塞の予防・治療方法 |
AP2007003973A0 (en) * | 2004-10-12 | 2007-07-30 | Glenmark Pharmaceuticals Sa | Novel dideptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and proces for their preparation |
CA2665476A1 (en) | 2006-10-05 | 2008-04-10 | Cv Therapeutics, Inc. | Bicyclic nitrogen-containing heterocyclic compounds for use as stearoyl coa desaturase inhibitors |
US7893066B2 (en) | 2006-10-05 | 2011-02-22 | Gilead Palo Alto, Inc. | Pyridol[2,3-B]pyrazinones for use as stearoyl CoA desaturase inhibitors |
JP2010523653A (ja) | 2007-04-09 | 2010-07-15 | ギリアード・パロ・アルト・インコーポレイテッド | ステアロイルCoAデサチュラーゼのインヒビターとして使用するためのプテリジノン誘導体 |
JP2010526825A (ja) * | 2007-05-10 | 2010-08-05 | エーエムアール テクノロジー インコーポレイテッド | アリール置換およびヘテロアリール置換テトラヒドロベンゾ−1,4−ジアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用 |
KR20140139125A (ko) | 2007-08-31 | 2014-12-04 | 퍼듀 퍼머 엘피 | 치환-퀴녹살린-형 피페리딘 화합물 및 그의 용도 |
EP2247580B1 (en) * | 2008-03-05 | 2015-07-08 | Merck Patent GmbH | Quinoxalinone derivatives as insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes |
MX2010010504A (es) * | 2008-03-26 | 2010-12-15 | Daiichi Sankyo Co Ltd | Derivado de hidroxi-quinoxalin-carboxamida. |
EP2276748A1 (en) * | 2008-04-10 | 2011-01-26 | Gilead Sciences, Inc. | Bicyclic nitrogen containing heterocyclic compounds for use as stearoyl coa desaturase inhibitors |
BRPI0911031B8 (pt) | 2008-07-21 | 2021-05-25 | Purdue Pharma Lp | compostos de piperidina ligada do tipo quinoxalina substituídos e os usos destes |
EP2654751B1 (en) | 2010-12-22 | 2016-11-23 | Purdue Pharma L.P. | Phosphorus-substituted quinoxaline-type piperidine compounds and uses thereof |
JP2015501793A (ja) | 2011-11-10 | 2015-01-19 | オーエスアイ・ファーマシューティカルズ,エルエルシー | ジヒドロプテリジノン類 |
AU2012324015A1 (en) | 2011-12-01 | 2013-06-20 | Purdue Pharma L.P. | Azetidine-substituted quinoxaline-type piperidine compounds and uses thererof |
US9085561B2 (en) | 2012-07-30 | 2015-07-21 | Purdue Pharma L.P. | Cyclic urea- or lactam-substituted quinoxaline-type piperidines as ORL-1 modulators |
US9090618B2 (en) | 2012-12-27 | 2015-07-28 | Purdue Pharma L.P. | Substituted benzimidazole-type piperidine compounds and uses thereof |
US9963458B2 (en) | 2012-12-27 | 2018-05-08 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
WO2014102589A1 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Quinazolin-4(3h)-one-type piperidine compounds and uses thereof |
WO2014102592A2 (en) | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Oxime/substituted quinoxaline-type piperidine compounds and uses thereof |
EP3328839A1 (en) * | 2015-07-30 | 2018-06-06 | Bristol-Myers Squibb Company | Aryl substituted bicyclic heteroaryl compounds |
PL3394046T3 (pl) | 2015-12-24 | 2022-06-13 | The Regents Of The University Of California | Regulatory cftr i sposoby ich zastosowania |
PL3394040T3 (pl) | 2015-12-24 | 2022-05-02 | The Regents Of The University Of California | Regulatory cftr i sposoby ich zastosowania |
KR20180101415A (ko) | 2015-12-24 | 2018-09-12 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Cftr 조절제 및 이의 사용 방법 |
DE102017005089A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one |
DE102017005091A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one |
KR20200044873A (ko) | 2017-08-24 | 2020-04-29 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 안구 제약학적 조성물 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4082735A (en) | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
US4082736A (en) | 1976-04-26 | 1978-04-04 | Syntex (U.S.A.) Inc. | Novel immunological adjuvant compounds and methods of preparation thereof |
JPS63145272A (ja) | 1986-12-09 | 1988-06-17 | Morishita Seiyaku Kk | 4,5−ジヒドロ−6−(4−置換フエニル)−3(2h)−ピリダジノン誘導体 |
JPS63301874A (ja) * | 1987-03-27 | 1988-12-08 | Fujisawa Pharmaceut Co Ltd | キノキサリン誘導体およびその製造法 |
JPH0276860A (ja) * | 1987-10-05 | 1990-03-16 | Toyo Jozo Co Ltd | 6−置換アルコキシ−2−オキソ−1,2−ジヒドロキノキサリン誘導体 |
JPH01254348A (ja) | 1988-04-01 | 1989-10-11 | Matsushita Electric Ind Co Ltd | 成形用型 |
HUT76640A (en) | 1995-08-17 | 1997-10-28 | Chinoin Gyogyszer Es Vegyeszet | Compounds of pharmaceutical activity cyclic amide derivatives, pharmaceutical compositions containing them, process for producing them and their use |
AU3232597A (en) * | 1996-06-18 | 1998-01-07 | Warner-Lambert Company | Pyrrolo{1,2-a}pyrazine-1,4-dione serine protease inhibitors |
JP2002514162A (ja) * | 1996-07-08 | 2002-05-14 | デュポン ファーマシューティカルズ カンパニー | Xa因子阻害薬およびトロンビン阻害薬としてのアミジノインドール類、アミジノアゾール類、およびそれらの類似体 |
TW472045B (en) * | 1996-09-25 | 2002-01-11 | Astra Ab | Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation |
GB2324729B (en) | 1997-04-30 | 2002-01-02 | Bradford Hospitals Nhs Trust | Lung treatment device |
-
1998
- 1998-12-15 KR KR1020007010842A patent/KR20010042298A/ko not_active Application Discontinuation
- 1998-12-15 HU HU0101470A patent/HUP0101470A3/hu unknown
- 1998-12-15 EP EP98963961A patent/EP1068190A1/en not_active Withdrawn
- 1998-12-15 CA CA002319554A patent/CA2319554C/en not_active Expired - Fee Related
- 1998-12-15 WO PCT/US1998/026704 patent/WO1999050254A1/en not_active Application Discontinuation
- 1998-12-15 IL IL13765598A patent/IL137655A0/xx unknown
- 1998-12-15 BR BR9815785-0A patent/BR9815785A/pt not_active Application Discontinuation
- 1998-12-15 PL PL98343321A patent/PL343321A1/xx not_active Application Discontinuation
- 1998-12-15 AU AU19179/99A patent/AU1917999A/en not_active Abandoned
- 1998-12-15 JP JP2000541158A patent/JP2002509923A/ja active Pending
-
1999
- 1999-03-30 ZA ZA9902447A patent/ZA992447B/xx unknown
-
2000
- 2000-08-03 US US09/601,606 patent/US6410536B1/en not_active Expired - Fee Related
- 2000-08-18 IS IS5589A patent/IS5589A/is unknown
- 2000-09-20 NO NO20004697A patent/NO20004697D0/no unknown
-
2002
- 2002-01-04 US US10/038,006 patent/US6916805B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1999050254A1 (en) | 1999-10-07 |
PL343321A1 (en) | 2001-08-13 |
CA2319554C (en) | 2005-06-28 |
HUP0101470A3 (en) | 2002-09-30 |
NO20004697L (no) | 2000-09-20 |
BR9815785A (pt) | 2000-12-05 |
US6410536B1 (en) | 2002-06-25 |
HUP0101470A2 (hu) | 2001-10-28 |
US6916805B2 (en) | 2005-07-12 |
NO20004697D0 (no) | 2000-09-20 |
EP1068190A1 (en) | 2001-01-17 |
JP2002509923A (ja) | 2002-04-02 |
IL137655A0 (en) | 2001-10-31 |
US20020086866A1 (en) | 2002-07-04 |
IS5589A (is) | 2000-08-18 |
AU1917999A (en) | 1999-10-18 |
CA2319554A1 (en) | 1999-10-07 |
KR20010042298A (ko) | 2001-05-25 |
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