IS5590A - Bensoxasínón/bensóþíasínón notuð sem serínprótínkljúfatálmar - Google Patents

Bensoxasínón/bensóþíasínón notuð sem serínprótínkljúfatálmar

Info

Publication number
IS5590A
IS5590A IS5590A IS5590A IS5590A IS 5590 A IS5590 A IS 5590A IS 5590 A IS5590 A IS 5590A IS 5590 A IS5590 A IS 5590A IS 5590 A IS5590 A IS 5590A
Authority
IS
Iceland
Prior art keywords
benzothiazinone
benzoxazinone
protease inhibitors
serine protease
serine
Prior art date
Application number
IS5590A
Other languages
English (en)
Inventor
Alan Berryman Kent
Michael Downing Dennis
Andrea Dudley Danette
John Edmunds Jeremy
Sourirajan Narasimhan Lakshmi
Taras Rapundalo Stephen
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of IS5590A publication Critical patent/IS5590A/is

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/341,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/361,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/101,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/141,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/161,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
IS5590A 1998-03-31 2000-08-18 Bensoxasínón/bensóþíasínón notuð sem serínprótínkljúfatálmar IS5590A (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8014298P 1998-03-31 1998-03-31
PCT/US1998/026708 WO1999050257A1 (en) 1998-03-31 1998-12-15 Benzoxazinones/benzothiazinones as serine protease inhibitors

Publications (1)

Publication Number Publication Date
IS5590A true IS5590A (is) 2000-08-18

Family

ID=22155527

Family Applications (1)

Application Number Title Priority Date Filing Date
IS5590A IS5590A (is) 1998-03-31 2000-08-18 Bensoxasínón/bensóþíasínón notuð sem serínprótínkljúfatálmar

Country Status (15)

Country Link
US (2) US6509335B1 (is)
EP (1) EP1068191A1 (is)
JP (1) JP2002509925A (is)
KR (1) KR20010042296A (is)
AU (1) AU765223C (is)
BR (1) BR9815784A (is)
CA (1) CA2319551A1 (is)
HU (1) HUP0101699A3 (is)
IL (1) IL137656A0 (is)
IS (1) IS5590A (is)
NO (1) NO20004698L (is)
NZ (1) NZ506985A (is)
PL (1) PL343317A1 (is)
WO (1) WO1999050257A1 (is)
ZA (1) ZA992445B (is)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291514B1 (en) 1998-02-09 2001-09-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
BR9917036A (pt) * 1999-02-09 2002-07-30 Dimensional Pharm Inc Amidinas heteroarila, metilamidinas e guanidinas como inibidores de protease
FR2801885B1 (fr) * 1999-12-06 2002-01-11 Adir Nouveaux derives (dihydro)benzoxaziniques et (dihydro) benzothiaziniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1255741A2 (en) 2000-02-01 2002-11-13 Cor Therapeutics, Inc. 2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa
EP1255743A1 (en) * 2000-02-01 2002-11-13 Millenium Pharmaceuticals, Inc. 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa
US6998408B2 (en) 2001-03-23 2006-02-14 Bristol-Myers Squibb Pharma Company 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors
WO2002080853A2 (en) 2001-04-09 2002-10-17 Bristol-Myers Squibb Company Fused heterocyclic inhibitors of factor xa
US6794385B2 (en) 2001-08-08 2004-09-21 Pharmacia & Upjohn, S.P.A. Benzoxazine derivatives useful as integrin receptor antagonists
US6750215B2 (en) 2001-08-08 2004-06-15 Pharmacia & Upjohn, S.P.A. Substituted benzoxazines as integrin antagonists
US6916398B2 (en) 2001-10-26 2005-07-12 Applied Materials, Inc. Gas delivery apparatus and method for atomic layer deposition
US7307075B2 (en) * 2001-12-28 2007-12-11 Acadia Pharmaceuticals Inc. Tetrahydroquinoline analogues as muscarinic agonists
US6759298B2 (en) * 2002-06-24 2004-07-06 Micron Technology, Inc. Methods of forming an array of flash field effect transistors and circuitry peripheral to such array
DK1569912T3 (en) 2002-12-03 2015-06-29 Pharmacyclics Inc 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors.
TWI289141B (en) 2003-03-11 2007-11-01 Hoffmann La Roche F. Ag. Quinolinone derivatives and uses thereof
DE602004014170D1 (de) * 2003-10-03 2008-07-10 Merck & Co Inc Benzylether- und benzylamino-beta-sekretase-hemmer zur behandlung von alzheimer-krankheit
SI21658A (sl) * 2003-11-28 2005-06-30 Univerza V Ljubljani Antitrombotične učinkovine z dualnim mehanizmom delovanja na osnovi 3,4-dihidro-2H-1,4-benzoksazinskega skeleta
MX2007004305A (es) * 2004-10-12 2007-06-18 Glenmark Pharmaceuticals Sa Inhibidores novedosos de dipeptidil peptidasa iv, composiciones farmaceuticas que los contienen y procedimientos para su preparacion.
WO2006050054A2 (en) * 2004-11-01 2006-05-11 Nuada, Llc Compounds and methods of use thereof
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
US20070197512A1 (en) * 2006-01-27 2007-08-23 Japan Tobacco Inc. Carboxylic Acid Compounds and Use Thereof
WO2011024987A1 (ja) * 2009-08-31 2011-03-03 塩野義製薬株式会社 芳香族縮合へテロ環誘導体およびそれらを含有する医薬組成物
JP2014515029A (ja) * 2011-04-29 2014-06-26 アイカーン・スクール・オブ・メディシン・アト・マウント・シナイ キナーゼ阻害剤
JP6497808B2 (ja) * 2015-06-12 2019-04-10 アグロカネショウ株式会社 1,4−ベンゾチアジン−1,3−ジオン又は−1,1,3−トリオン誘導体およびこれを有効成分とする殺菌剤
US11643420B2 (en) 2019-10-01 2023-05-09 Molecular Skin Therapeutics, Inc. Benzoxazinone compounds as KLK5/7 dual inhibitors

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3124577A (en) * 1964-03-10 Hydroxyalkyl cyclic amlno
US3006916A (en) * 1961-10-31 W-dialkylaminoalkyl
US3089872A (en) * 1961-03-31 1963-05-14 Olin Mathieson Benzothiazine and benzothiazepine compounds
US3401166A (en) 1966-08-01 1968-09-10 Squibb & Sons Inc Therapeutically active benzothiazines
GB1174626A (en) * 1967-05-23 1969-12-17 Bellon Labor Sa Roger New Benzoxazine Derivatives
DE2044530A1 (de) * 1970-02-04 1971-08-19 VEB Deutsches Hydrierwerk Rodleben, χ 4530 Roßlau Verfahren zur Herstellung basisch substituierter 2,3 Dihydro 1,4 benzoxazm 3 one
US3725403A (en) * 1970-10-20 1973-04-03 Squibb & Sons Inc Benzothiazine derivatives
JPS5265280A (en) * 1975-11-26 1977-05-30 Squibb & Sons Inc Benzoxadinones and their production
US4584300A (en) 1983-02-07 1986-04-22 Santen Pharmaceutical Co., Ltd. Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor
JPS60166674A (ja) 1984-02-09 1985-08-29 Santen Pharmaceut Co Ltd ベンゾチアジン誘導体
US4786635A (en) * 1985-07-29 1988-11-22 Santen Pharmaceutical Co., Ltd. Novel benzothiazine derivatives
JPH01272524A (ja) 1988-04-21 1989-10-31 Japan Found Cancer Res 癌化学療法剤
JP2886570B2 (ja) 1989-09-29 1999-04-26 エーザイ株式会社 縮合ヘテロ環を有する化合物
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
JPH09227561A (ja) 1996-02-21 1997-09-02 Tanabe Seiyaku Co Ltd キサンチン誘導体
JP2002514192A (ja) * 1996-11-13 2002-05-14 セフアロン・インコーポレーテツド ベンゾチアゾおよび関連の複素環基を含有するシステインおよびセリンプロテアーゼ阻害剤
ATE336485T1 (de) * 1997-05-02 2006-09-15 Schering Ag Substituierte heterocyclen und deren verwendung in arzneimitteln

Also Published As

Publication number Publication date
HUP0101699A3 (en) 2002-05-28
BR9815784A (pt) 2000-11-21
PL343317A1 (en) 2001-08-13
JP2002509925A (ja) 2002-04-02
ZA992445B (en) 1999-10-01
US20030187256A1 (en) 2003-10-02
HUP0101699A2 (hu) 2002-04-29
EP1068191A1 (en) 2001-01-17
NZ506985A (en) 2003-10-31
CA2319551A1 (en) 1999-10-07
WO1999050257A1 (en) 1999-10-07
IL137656A0 (en) 2001-10-31
NO20004698D0 (no) 2000-09-20
AU765223B2 (en) 2003-09-11
KR20010042296A (ko) 2001-05-25
AU765223C (en) 2004-03-18
AU1918399A (en) 1999-10-18
US6509335B1 (en) 2003-01-21
NO20004698L (no) 2000-09-20

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