IS5590A - Bensoxasínón/bensóþíasínón notuð sem serínprótínkljúfatálmar - Google Patents
Bensoxasínón/bensóþíasínón notuð sem serínprótínkljúfatálmarInfo
- Publication number
- IS5590A IS5590A IS5590A IS5590A IS5590A IS 5590 A IS5590 A IS 5590A IS 5590 A IS5590 A IS 5590A IS 5590 A IS5590 A IS 5590A IS 5590 A IS5590 A IS 5590A
- Authority
- IS
- Iceland
- Prior art keywords
- benzothiazinone
- benzoxazinone
- protease inhibitors
- serine protease
- serine
- Prior art date
Links
- MJNPHLBKHKJDEF-UHFFFAOYSA-N 2h-1$l^{4},2-benzothiazine 1-oxide Chemical compound C1=CC=C2S(=O)NC=CC2=C1 MJNPHLBKHKJDEF-UHFFFAOYSA-N 0.000 title 1
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical compound C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8014298P | 1998-03-31 | 1998-03-31 | |
| PCT/US1998/026708 WO1999050257A1 (en) | 1998-03-31 | 1998-12-15 | Benzoxazinones/benzothiazinones as serine protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS5590A true IS5590A (is) | 2000-08-18 |
Family
ID=22155527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS5590A IS5590A (is) | 1998-03-31 | 2000-08-18 | Bensoxasínón/bensóþíasínón notuð sem serínprótínkljúfatálmar |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6509335B1 (is) |
| EP (1) | EP1068191A1 (is) |
| JP (1) | JP2002509925A (is) |
| KR (1) | KR20010042296A (is) |
| AU (1) | AU765223C (is) |
| BR (1) | BR9815784A (is) |
| CA (1) | CA2319551A1 (is) |
| HU (1) | HUP0101699A3 (is) |
| IL (1) | IL137656A0 (is) |
| IS (1) | IS5590A (is) |
| NO (1) | NO20004698L (is) |
| NZ (1) | NZ506985A (is) |
| PL (1) | PL343317A1 (is) |
| WO (1) | WO1999050257A1 (is) |
| ZA (1) | ZA992445B (is) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
| BR9917036A (pt) * | 1999-02-09 | 2002-07-30 | Dimensional Pharm Inc | Amidinas heteroarila, metilamidinas e guanidinas como inibidores de protease |
| FR2801885B1 (fr) * | 1999-12-06 | 2002-01-11 | Adir | Nouveaux derives (dihydro)benzoxaziniques et (dihydro) benzothiaziniques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1255741A2 (en) | 2000-02-01 | 2002-11-13 | Cor Therapeutics, Inc. | 2- 1H]-QUINOLONE AND 2- 1H]-QUINOXALONE INHIBITORS OF FACTOR Xa |
| EP1255743A1 (en) * | 2000-02-01 | 2002-11-13 | Millenium Pharmaceuticals, Inc. | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE INHIBITORS OF FACTOR Xa |
| US6998408B2 (en) | 2001-03-23 | 2006-02-14 | Bristol-Myers Squibb Pharma Company | 6-5, 6-6, or 6-7 Heterobicycles as factor Xa inhibitors |
| WO2002080853A2 (en) | 2001-04-09 | 2002-10-17 | Bristol-Myers Squibb Company | Fused heterocyclic inhibitors of factor xa |
| US6794385B2 (en) | 2001-08-08 | 2004-09-21 | Pharmacia & Upjohn, S.P.A. | Benzoxazine derivatives useful as integrin receptor antagonists |
| US6750215B2 (en) | 2001-08-08 | 2004-06-15 | Pharmacia & Upjohn, S.P.A. | Substituted benzoxazines as integrin antagonists |
| US6916398B2 (en) | 2001-10-26 | 2005-07-12 | Applied Materials, Inc. | Gas delivery apparatus and method for atomic layer deposition |
| US7307075B2 (en) * | 2001-12-28 | 2007-12-11 | Acadia Pharmaceuticals Inc. | Tetrahydroquinoline analogues as muscarinic agonists |
| US6759298B2 (en) * | 2002-06-24 | 2004-07-06 | Micron Technology, Inc. | Methods of forming an array of flash field effect transistors and circuitry peripheral to such array |
| DK1569912T3 (en) | 2002-12-03 | 2015-06-29 | Pharmacyclics Inc | 2- (2-hydroxybiphenyl-3-yl) -1h-benzoimidazole-5-carboxamidine derivatives as factor VIIa inhibitors. |
| TWI289141B (en) | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
| DE602004014170D1 (de) * | 2003-10-03 | 2008-07-10 | Merck & Co Inc | Benzylether- und benzylamino-beta-sekretase-hemmer zur behandlung von alzheimer-krankheit |
| SI21658A (sl) * | 2003-11-28 | 2005-06-30 | Univerza V Ljubljani | Antitrombotične učinkovine z dualnim mehanizmom delovanja na osnovi 3,4-dihidro-2H-1,4-benzoksazinskega skeleta |
| MX2007004305A (es) * | 2004-10-12 | 2007-06-18 | Glenmark Pharmaceuticals Sa | Inhibidores novedosos de dipeptidil peptidasa iv, composiciones farmaceuticas que los contienen y procedimientos para su preparacion. |
| WO2006050054A2 (en) * | 2004-11-01 | 2006-05-11 | Nuada, Llc | Compounds and methods of use thereof |
| GB0515323D0 (en) | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
| US20070197512A1 (en) * | 2006-01-27 | 2007-08-23 | Japan Tobacco Inc. | Carboxylic Acid Compounds and Use Thereof |
| WO2011024987A1 (ja) * | 2009-08-31 | 2011-03-03 | 塩野義製薬株式会社 | 芳香族縮合へテロ環誘導体およびそれらを含有する医薬組成物 |
| JP2014515029A (ja) * | 2011-04-29 | 2014-06-26 | アイカーン・スクール・オブ・メディシン・アト・マウント・シナイ | キナーゼ阻害剤 |
| JP6497808B2 (ja) * | 2015-06-12 | 2019-04-10 | アグロカネショウ株式会社 | １，４−ベンゾチアジン−１，３−ジオン又は−１，１，３−トリオン誘導体およびこれを有効成分とする殺菌剤 |
| US11643420B2 (en) | 2019-10-01 | 2023-05-09 | Molecular Skin Therapeutics, Inc. | Benzoxazinone compounds as KLK5/7 dual inhibitors |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3124577A (en) * | 1964-03-10 | Hydroxyalkyl cyclic amlno | ||
| US3006916A (en) * | 1961-10-31 | W-dialkylaminoalkyl | ||
| US3089872A (en) * | 1961-03-31 | 1963-05-14 | Olin Mathieson | Benzothiazine and benzothiazepine compounds |
| US3401166A (en) | 1966-08-01 | 1968-09-10 | Squibb & Sons Inc | Therapeutically active benzothiazines |
| GB1174626A (en) * | 1967-05-23 | 1969-12-17 | Bellon Labor Sa Roger | New Benzoxazine Derivatives |
| DE2044530A1 (de) * | 1970-02-04 | 1971-08-19 | VEB Deutsches Hydrierwerk Rodleben, χ 4530 Roßlau | Verfahren zur Herstellung basisch substituierter 2,3 Dihydro 1,4 benzoxazm 3 one |
| US3725403A (en) * | 1970-10-20 | 1973-04-03 | Squibb & Sons Inc | Benzothiazine derivatives |
| JPS5265280A (en) * | 1975-11-26 | 1977-05-30 | Squibb & Sons Inc | Benzoxadinones and their production |
| US4584300A (en) | 1983-02-07 | 1986-04-22 | Santen Pharmaceutical Co., Ltd. | Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor |
| JPS60166674A (ja) | 1984-02-09 | 1985-08-29 | Santen Pharmaceut Co Ltd | ベンゾチアジン誘導体 |
| US4786635A (en) * | 1985-07-29 | 1988-11-22 | Santen Pharmaceutical Co., Ltd. | Novel benzothiazine derivatives |
| JPH01272524A (ja) | 1988-04-21 | 1989-10-31 | Japan Found Cancer Res | 癌化学療法剤 |
| JP2886570B2 (ja) | 1989-09-29 | 1999-04-26 | エーザイ株式会社 | 縮合ヘテロ環を有する化合物 |
| US5652237A (en) * | 1994-09-09 | 1997-07-29 | Warner-Lambert Company | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes |
| JPH09227561A (ja) | 1996-02-21 | 1997-09-02 | Tanabe Seiyaku Co Ltd | キサンチン誘導体 |
| JP2002514192A (ja) * | 1996-11-13 | 2002-05-14 | セフアロン・インコーポレーテツド | ベンゾチアゾおよび関連の複素環基を含有するシステインおよびセリンプロテアーゼ阻害剤 |
| ATE336485T1 (de) * | 1997-05-02 | 2006-09-15 | Schering Ag | Substituierte heterocyclen und deren verwendung in arzneimitteln |
-
1998
- 1998-12-15 KR KR1020007010839A patent/KR20010042296A/ko not_active Application Discontinuation
- 1998-12-15 AU AU19183/99A patent/AU765223C/en not_active Expired - Fee Related
- 1998-12-15 WO PCT/US1998/026708 patent/WO1999050257A1/en not_active Application Discontinuation
- 1998-12-15 NZ NZ506985A patent/NZ506985A/en unknown
- 1998-12-15 CA CA002319551A patent/CA2319551A1/en not_active Abandoned
- 1998-12-15 BR BR9815784-1A patent/BR9815784A/pt not_active Application Discontinuation
- 1998-12-15 PL PL98343317A patent/PL343317A1/xx not_active Application Discontinuation
- 1998-12-15 EP EP98963965A patent/EP1068191A1/en not_active Withdrawn
- 1998-12-15 JP JP2000541161A patent/JP2002509925A/ja active Pending
- 1998-12-15 HU HU0101699A patent/HUP0101699A3/hu unknown
- 1998-12-15 US US09/622,265 patent/US6509335B1/en not_active Expired - Fee Related
- 1998-12-15 IL IL13765698A patent/IL137656A0/xx unknown
-
1999
- 1999-03-30 ZA ZA9902445A patent/ZA992445B/xx unknown
-
2000
- 2000-08-18 IS IS5590A patent/IS5590A/is unknown
- 2000-09-20 NO NO20004698A patent/NO20004698L/no unknown
-
2002
- 2002-11-12 US US10/292,771 patent/US20030187256A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0101699A3 (en) | 2002-05-28 |
| BR9815784A (pt) | 2000-11-21 |
| PL343317A1 (en) | 2001-08-13 |
| JP2002509925A (ja) | 2002-04-02 |
| ZA992445B (en) | 1999-10-01 |
| US20030187256A1 (en) | 2003-10-02 |
| HUP0101699A2 (hu) | 2002-04-29 |
| EP1068191A1 (en) | 2001-01-17 |
| NZ506985A (en) | 2003-10-31 |
| CA2319551A1 (en) | 1999-10-07 |
| WO1999050257A1 (en) | 1999-10-07 |
| IL137656A0 (en) | 2001-10-31 |
| NO20004698D0 (no) | 2000-09-20 |
| AU765223B2 (en) | 2003-09-11 |
| KR20010042296A (ko) | 2001-05-25 |
| AU765223C (en) | 2004-03-18 |
| AU1918399A (en) | 1999-10-18 |
| US6509335B1 (en) | 2003-01-21 |
| NO20004698L (no) | 2000-09-20 |
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